Amino acid dipepetide frequency for Streptomyces turgidiscabies Car8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.51AlaAla: 19.51 ± 0.117	1.031AlaCys: 1.031 ± 0.019	8.177AlaAsp: 8.177 ± 0.061	8.411AlaGlu: 8.411 ± 0.064	3.363AlaPhe: 3.363 ± 0.033	12.455AlaGly: 12.455 ± 0.08	2.792AlaHis: 2.792 ± 0.031	3.407AlaIle: 3.407 ± 0.04	2.976AlaLys: 2.976 ± 0.046	13.746AlaLeu: 13.746 ± 0.095	2.417AlaMet: 2.417 ± 0.029	2.124AlaAsn: 2.124 ± 0.029	6.775AlaPro: 6.775 ± 0.069	3.815AlaGln: 3.815 ± 0.039	9.778AlaArg: 9.778 ± 0.077	6.261AlaSer: 6.261 ± 0.051	7.298AlaThr: 7.298 ± 0.06	11.795AlaVal: 11.795 ± 0.08	1.87AlaTrp: 1.87 ± 0.024	2.813AlaTyr: 2.813 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.053CysAla: 1.053 ± 0.02	0.101CysCys: 0.101 ± 0.006	0.476CysAsp: 0.476 ± 0.014	0.409CysGlu: 0.409 ± 0.012	0.216CysPhe: 0.216 ± 0.009	0.97CysGly: 0.97 ± 0.018	0.195CysHis: 0.195 ± 0.007	0.162CysIle: 0.162 ± 0.007	0.119CysLys: 0.119 ± 0.007	0.751CysLeu: 0.751 ± 0.017	0.127CysMet: 0.127 ± 0.007	0.133CysAsn: 0.133 ± 0.007	0.498CysPro: 0.498 ± 0.014	0.197CysGln: 0.197 ± 0.008	0.63CysArg: 0.63 ± 0.015	0.461CysSer: 0.461 ± 0.013	0.541CysThr: 0.541 ± 0.013	0.666CysVal: 0.666 ± 0.014	0.141CysTrp: 0.141 ± 0.006	0.15CysTyr: 0.15 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.403AspAla: 7.403 ± 0.061	0.431AspCys: 0.431 ± 0.012	3.772AspAsp: 3.772 ± 0.037	3.873AspGlu: 3.873 ± 0.04	1.708AspPhe: 1.708 ± 0.026	6.389AspGly: 6.389 ± 0.056	1.446AspHis: 1.446 ± 0.023	2.007AspIle: 2.007 ± 0.026	1.255AspLys: 1.255 ± 0.028	6.099AspLeu: 6.099 ± 0.056	0.849AspMet: 0.849 ± 0.018	1.12AspAsn: 1.12 ± 0.019	4.44AspPro: 4.44 ± 0.043	1.658AspGln: 1.658 ± 0.025	4.766AspArg: 4.766 ± 0.044	2.935AspSer: 2.935 ± 0.036	3.436AspThr: 3.436 ± 0.041	4.725AspVal: 4.725 ± 0.037	1.088AspTrp: 1.088 ± 0.019	1.163AspTyr: 1.163 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.09GluAla: 7.09 ± 0.062	0.358GluCys: 0.358 ± 0.011	2.697GluAsp: 2.697 ± 0.033	3.307GluGlu: 3.307 ± 0.04	1.517GluPhe: 1.517 ± 0.026	4.269GluGly: 4.269 ± 0.043	1.484GluHis: 1.484 ± 0.019	2.208GluIle: 2.208 ± 0.03	1.45GluLys: 1.45 ± 0.028	6.623GluLeu: 6.623 ± 0.058	0.875GluMet: 0.875 ± 0.016	1.114GluAsn: 1.114 ± 0.02	3.246GluPro: 3.246 ± 0.039	2.237GluGln: 2.237 ± 0.03	5.157GluArg: 5.157 ± 0.055	2.757GluSer: 2.757 ± 0.036	2.998GluThr: 2.998 ± 0.035	4.317GluVal: 4.317 ± 0.047	0.813GluTrp: 0.813 ± 0.018	1.162GluTyr: 1.162 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.506PheAla: 3.506 ± 0.037	0.256PheCys: 0.256 ± 0.009	1.973PheAsp: 1.973 ± 0.028	1.462PheGlu: 1.462 ± 0.022	0.836PhePhe: 0.836 ± 0.019	2.999PheGly: 2.999 ± 0.038	0.625PheHis: 0.625 ± 0.014	0.713PheIle: 0.713 ± 0.016	0.553PheLys: 0.553 ± 0.014	2.522PheLeu: 2.522 ± 0.033	0.411PheMet: 0.411 ± 0.012	0.604PheAsn: 0.604 ± 0.014	1.404PhePro: 1.404 ± 0.023	0.704PheGln: 0.704 ± 0.015	1.839PheArg: 1.839 ± 0.025	1.496PheSer: 1.496 ± 0.025	2.084PheThr: 2.084 ± 0.031	2.262PheVal: 2.262 ± 0.03	0.432PheTrp: 0.432 ± 0.013	0.614PheTyr: 0.614 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.781GlyAla: 10.781 ± 0.076	0.843GlyCys: 0.843 ± 0.017	5.236GlyAsp: 5.236 ± 0.05	4.996GlyGlu: 4.996 ± 0.043	2.841GlyPhe: 2.841 ± 0.037	8.838GlyGly: 8.838 ± 0.073	2.328GlyHis: 2.328 ± 0.028	3.45GlyIle: 3.45 ± 0.035	2.506GlyLys: 2.506 ± 0.034	9.189GlyLeu: 9.189 ± 0.068	1.95GlyMet: 1.95 ± 0.026	1.928GlyAsn: 1.928 ± 0.029	4.955GlyPro: 4.955 ± 0.051	2.819GlyGln: 2.819 ± 0.034	7.59GlyArg: 7.59 ± 0.066	5.687GlySer: 5.687 ± 0.052	6.712GlyThr: 6.712 ± 0.065	7.429GlyVal: 7.429 ± 0.055	1.724GlyTrp: 1.724 ± 0.025	2.284GlyTyr: 2.284 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.614HisAla: 2.614 ± 0.029	0.22HisCys: 0.22 ± 0.009	1.355HisAsp: 1.355 ± 0.021	1.225HisGlu: 1.225 ± 0.022	0.641HisPhe: 0.641 ± 0.015	2.393HisGly: 2.393 ± 0.031	0.702HisHis: 0.702 ± 0.018	0.724HisIle: 0.724 ± 0.015	0.379HisLys: 0.379 ± 0.011	2.384HisLeu: 2.384 ± 0.031	0.34HisMet: 0.34 ± 0.011	0.4HisAsn: 0.4 ± 0.011	1.813HisPro: 1.813 ± 0.026	0.677HisGln: 0.677 ± 0.015	2.107HisArg: 2.107 ± 0.028	1.052HisSer: 1.052 ± 0.018	1.389HisThr: 1.389 ± 0.021	1.642HisVal: 1.642 ± 0.021	0.382HisTrp: 0.382 ± 0.012	0.503HisTyr: 0.503 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.637IleAla: 4.637 ± 0.043	0.272IleCys: 0.272 ± 0.009	2.276IleAsp: 2.276 ± 0.026	1.915IleGlu: 1.915 ± 0.028	0.691IlePhe: 0.691 ± 0.015	3.442IleGly: 3.442 ± 0.04	0.652IleHis: 0.652 ± 0.014	0.887IleIle: 0.887 ± 0.021	0.768IleLys: 0.768 ± 0.018	2.396IleLeu: 2.396 ± 0.032	0.466IleMet: 0.466 ± 0.013	0.744IleAsn: 0.744 ± 0.016	1.849IlePro: 1.849 ± 0.026	0.793IleGln: 0.793 ± 0.016	2.344IleArg: 2.344 ± 0.031	1.752IleSer: 1.752 ± 0.024	2.317IleThr: 2.317 ± 0.024	2.71IleVal: 2.71 ± 0.037	0.396IleTrp: 0.396 ± 0.011	0.534IleTyr: 0.534 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	3.029LysAla: 3.029 ± 0.043	0.134LysCys: 0.134 ± 0.006	1.388LysAsp: 1.388 ± 0.025	1.187LysGlu: 1.187 ± 0.023	0.5LysPhe: 0.5 ± 0.014	2.003LysGly: 2.003 ± 0.028	0.451LysHis: 0.451 ± 0.012	0.898LysIle: 0.898 ± 0.021	0.889LysLys: 0.889 ± 0.025	2.102LysLeu: 2.102 ± 0.031	0.396LysMet: 0.396 ± 0.012	0.597LysAsn: 0.597 ± 0.018	1.416LysPro: 1.416 ± 0.02	0.753LysGln: 0.753 ± 0.017	1.464LysArg: 1.464 ± 0.024	1.287LysSer: 1.287 ± 0.024	1.374LysThr: 1.374 ± 0.023	2.01LysVal: 2.01 ± 0.035	0.307LysTrp: 0.307 ± 0.01	0.514LysTyr: 0.514 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	14.383LeuAla: 14.383 ± 0.097	0.851LeuCys: 0.851 ± 0.018	6.588LeuAsp: 6.588 ± 0.057	4.348LeuGlu: 4.348 ± 0.049	2.547LeuPhe: 2.547 ± 0.033	8.998LeuGly: 8.998 ± 0.065	2.258LeuHis: 2.258 ± 0.03	3.214LeuIle: 3.214 ± 0.038	2.121LeuLys: 2.121 ± 0.03	10.768LeuLeu: 10.768 ± 0.091	1.65LeuMet: 1.65 ± 0.026	1.795LeuAsn: 1.795 ± 0.022	6.361LeuPro: 6.361 ± 0.047	2.219LeuGln: 2.219 ± 0.025	8.338LeuArg: 8.338 ± 0.064	5.368LeuSer: 5.368 ± 0.043	7.113LeuThr: 7.113 ± 0.053	8.52LeuVal: 8.52 ± 0.069	1.323LeuTrp: 1.323 ± 0.021	1.938LeuTyr: 1.938 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.222MetAla: 2.222 ± 0.026	0.15MetCys: 0.15 ± 0.008	0.87MetAsp: 0.87 ± 0.017	0.756MetGlu: 0.756 ± 0.016	0.48MetPhe: 0.48 ± 0.014	1.338MetGly: 1.338 ± 0.022	0.357MetHis: 0.357 ± 0.01	0.667MetIle: 0.667 ± 0.015	0.447MetLys: 0.447 ± 0.012	1.632MetLeu: 1.632 ± 0.024	0.315MetMet: 0.315 ± 0.011	0.485MetAsn: 0.485 ± 0.013	1.113MetPro: 1.113 ± 0.018	0.445MetGln: 0.445 ± 0.011	1.449MetArg: 1.449 ± 0.023	1.377MetSer: 1.377 ± 0.021	1.606MetThr: 1.606 ± 0.024	1.275MetVal: 1.275 ± 0.021	0.221MetTrp: 0.221 ± 0.007	0.334MetTyr: 0.334 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.337AsnAla: 2.337 ± 0.029	0.182AsnCys: 0.182 ± 0.008	1.073AsnAsp: 1.073 ± 0.021	0.865AsnGlu: 0.865 ± 0.017	0.533AsnPhe: 0.533 ± 0.015	2.12AsnGly: 2.12 ± 0.032	0.429AsnHis: 0.429 ± 0.012	0.686AsnIle: 0.686 ± 0.015	0.466AsnLys: 0.466 ± 0.013	1.766AsnLeu: 1.766 ± 0.029	0.329AsnMet: 0.329 ± 0.01	0.535AsnAsn: 0.535 ± 0.015	1.438AsnPro: 1.438 ± 0.021	0.594AsnGln: 0.594 ± 0.014	1.366AsnArg: 1.366 ± 0.024	1.17AsnSer: 1.17 ± 0.021	1.319AsnThr: 1.319 ± 0.024	1.459AsnVal: 1.459 ± 0.027	0.339AsnTrp: 0.339 ± 0.011	0.477AsnTyr: 0.477 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.17ProAla: 8.17 ± 0.068	0.363ProCys: 0.363 ± 0.01	4.522ProAsp: 4.522 ± 0.047	4.206ProGlu: 4.206 ± 0.045	1.524ProPhe: 1.524 ± 0.021	6.413ProGly: 6.413 ± 0.059	1.381ProHis: 1.381 ± 0.023	1.289ProIle: 1.289 ± 0.023	1.242ProLys: 1.242 ± 0.019	5.246ProLeu: 5.246 ± 0.048	1.033ProMet: 1.033 ± 0.018	1.0ProAsn: 1.0 ± 0.019	3.48ProPro: 3.48 ± 0.045	1.76ProGln: 1.76 ± 0.032	3.853ProArg: 3.853 ± 0.044	3.354ProSer: 3.354 ± 0.04	3.518ProThr: 3.518 ± 0.038	5.547ProVal: 5.547 ± 0.042	0.91ProTrp: 0.91 ± 0.017	1.445ProTyr: 1.445 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.687GlnAla: 3.687 ± 0.037	0.193GlnCys: 0.193 ± 0.009	1.464GlnAsp: 1.464 ± 0.021	1.509GlnGlu: 1.509 ± 0.024	0.741GlnPhe: 0.741 ± 0.016	2.361GlnGly: 2.361 ± 0.03	0.687GlnHis: 0.687 ± 0.018	1.095GlnIle: 1.095 ± 0.019	0.689GlnLys: 0.689 ± 0.018	3.304GlnLeu: 3.304 ± 0.033	0.503GlnMet: 0.503 ± 0.013	0.537GlnAsn: 0.537 ± 0.016	1.713GlnPro: 1.713 ± 0.032	1.357GlnGln: 1.357 ± 0.03	2.403GlnArg: 2.403 ± 0.029	1.398GlnSer: 1.398 ± 0.025	1.5GlnThr: 1.5 ± 0.023	2.437GlnVal: 2.437 ± 0.03	0.5GlnTrp: 0.5 ± 0.014	0.658GlnTyr: 0.658 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.446ArgAla: 9.446 ± 0.068	0.628ArgCys: 0.628 ± 0.014	4.222ArgAsp: 4.222 ± 0.039	4.591ArgGlu: 4.591 ± 0.048	2.299ArgPhe: 2.299 ± 0.025	5.667ArgGly: 5.667 ± 0.053	2.112ArgHis: 2.112 ± 0.027	3.123ArgIle: 3.123 ± 0.029	1.689ArgLys: 1.689 ± 0.028	8.476ArgLeu: 8.476 ± 0.064	1.722ArgMet: 1.722 ± 0.027	1.422ArgAsn: 1.422 ± 0.02	4.895ArgPro: 4.895 ± 0.049	2.383ArgGln: 2.383 ± 0.03	7.605ArgArg: 7.605 ± 0.067	4.151ArgSer: 4.151 ± 0.036	5.524ArgThr: 5.524 ± 0.052	5.875ArgVal: 5.875 ± 0.051	1.345ArgTrp: 1.345 ± 0.021	1.763ArgTyr: 1.763 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	7.101SerAla: 7.101 ± 0.056	0.427SerCys: 0.427 ± 0.014	3.001SerAsp: 3.001 ± 0.033	2.53SerGlu: 2.53 ± 0.029	1.559SerPhe: 1.559 ± 0.023	6.322SerGly: 6.322 ± 0.058	1.07SerHis: 1.07 ± 0.019	1.497SerIle: 1.497 ± 0.022	1.141SerLys: 1.141 ± 0.022	4.953SerLeu: 4.953 ± 0.043	1.163SerMet: 1.163 ± 0.018	0.999SerAsn: 0.999 ± 0.019	3.441SerPro: 3.441 ± 0.041	1.377SerGln: 1.377 ± 0.024	3.793SerArg: 3.793 ± 0.036	3.315SerSer: 3.315 ± 0.045	3.532SerThr: 3.532 ± 0.043	4.566SerVal: 4.566 ± 0.032	0.984SerTrp: 0.984 ± 0.02	1.365SerTyr: 1.365 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	9.093ThrAla: 9.093 ± 0.065	0.452ThrCys: 0.452 ± 0.013	3.971ThrAsp: 3.971 ± 0.039	3.418ThrGlu: 3.418 ± 0.037	1.727ThrPhe: 1.727 ± 0.027	7.049ThrGly: 7.049 ± 0.059	1.283ThrHis: 1.283 ± 0.024	1.827ThrIle: 1.827 ± 0.027	1.331ThrLys: 1.331 ± 0.025	5.812ThrLeu: 5.812 ± 0.042	0.976ThrMet: 0.976 ± 0.018	1.213ThrAsn: 1.213 ± 0.022	4.379ThrPro: 4.379 ± 0.046	1.471ThrGln: 1.471 ± 0.024	4.099ThrArg: 4.099 ± 0.036	3.677ThrSer: 3.677 ± 0.047	4.297ThrThr: 4.297 ± 0.064	6.296ThrVal: 6.296 ± 0.053	1.029ThrTrp: 1.029 ± 0.02	1.523ThrTyr: 1.523 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.307ValAla: 10.307 ± 0.076	0.752ValCys: 0.752 ± 0.017	4.953ValAsp: 4.953 ± 0.043	4.612ValGlu: 4.612 ± 0.041	2.382ValPhe: 2.382 ± 0.032	6.567ValGly: 6.567 ± 0.053	1.908ValHis: 1.908 ± 0.024	2.891ValIle: 2.891 ± 0.037	1.816ValLys: 1.816 ± 0.029	9.069ValLeu: 9.069 ± 0.074	1.434ValMet: 1.434 ± 0.023	1.783ValAsn: 1.783 ± 0.027	5.177ValPro: 5.177 ± 0.042	2.177ValGln: 2.177 ± 0.025	7.213ValArg: 7.213 ± 0.044	4.542ValSer: 4.542 ± 0.04	5.887ValThr: 5.887 ± 0.053	7.673ValVal: 7.673 ± 0.072	1.186ValTrp: 1.186 ± 0.02	1.597ValTyr: 1.597 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.675TrpAla: 1.675 ± 0.025	0.165TrpCys: 0.165 ± 0.007	0.904TrpAsp: 0.904 ± 0.02	0.743TrpGlu: 0.743 ± 0.017	0.524TrpPhe: 0.524 ± 0.014	1.122TrpGly: 1.122 ± 0.019	0.393TrpHis: 0.393 ± 0.009	0.573TrpIle: 0.573 ± 0.012	0.412TrpLys: 0.412 ± 0.012	1.761TrpLeu: 1.761 ± 0.022	0.296TrpMet: 0.296 ± 0.009	0.478TrpAsn: 0.478 ± 0.014	0.804TrpPro: 0.804 ± 0.014	0.645TrpGln: 0.645 ± 0.016	1.334TrpArg: 1.334 ± 0.022	1.008TrpSer: 1.008 ± 0.02	1.164TrpThr: 1.164 ± 0.021	0.981TrpVal: 0.981 ± 0.017	0.346TrpTrp: 0.346 ± 0.011	0.39TrpTyr: 0.39 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.77TyrAla: 2.77 ± 0.029	0.185TyrCys: 0.185 ± 0.008	1.645TyrAsp: 1.645 ± 0.027	1.318TyrGlu: 1.318 ± 0.024	0.67TyrPhe: 0.67 ± 0.015	2.372TyrGly: 2.372 ± 0.027	0.389TyrHis: 0.389 ± 0.011	0.525TyrIle: 0.525 ± 0.014	0.45TyrLys: 0.45 ± 0.012	2.1TyrLeu: 2.1 ± 0.025	0.286TyrMet: 0.286 ± 0.01	0.473TyrAsn: 0.473 ± 0.015	1.062TyrPro: 1.062 ± 0.017	0.653TyrGln: 0.653 ± 0.016	1.809TyrArg: 1.809 ± 0.025	1.09TyrSer: 1.09 ± 0.02	1.312TyrThr: 1.312 ± 0.026	1.738TyrVal: 1.738 ± 0.025	0.381TyrTrp: 0.381 ± 0.012	0.495TyrTyr: 0.495 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10034 proteins (3140125 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---