Amino acid dipepetide frequency for Sphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.193AlaAla: 10.193 ± 0.07	1.085AlaCys: 1.085 ± 0.017	4.497AlaAsp: 4.497 ± 0.032	5.584AlaGlu: 5.584 ± 0.049	3.107AlaPhe: 3.107 ± 0.028	6.207AlaGly: 6.207 ± 0.05	2.001AlaHis: 2.001 ± 0.02	4.275AlaIle: 4.275 ± 0.032	4.366AlaLys: 4.366 ± 0.035	7.863AlaLeu: 7.863 ± 0.053	2.092AlaMet: 2.092 ± 0.021	3.033AlaAsn: 3.033 ± 0.029	5.035AlaPro: 5.035 ± 0.045	3.875AlaGln: 3.875 ± 0.038	5.279AlaArg: 5.279 ± 0.035	7.564AlaSer: 7.564 ± 0.056	5.768AlaThr: 5.768 ± 0.038	5.575AlaVal: 5.575 ± 0.031	1.191AlaTrp: 1.191 ± 0.016	2.296AlaTyr: 2.296 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.975CysAla: 0.975 ± 0.015	0.258CysCys: 0.258 ± 0.011	0.63CysAsp: 0.63 ± 0.011	0.607CysGlu: 0.607 ± 0.013	0.503CysPhe: 0.503 ± 0.011	0.934CysGly: 0.934 ± 0.016	0.335CysHis: 0.335 ± 0.009	0.674CysIle: 0.674 ± 0.013	0.508CysLys: 0.508 ± 0.012	1.156CysLeu: 1.156 ± 0.017	0.28CysMet: 0.28 ± 0.008	0.412CysAsn: 0.412 ± 0.01	0.633CysPro: 0.633 ± 0.014	0.436CysGln: 0.436 ± 0.011	0.752CysArg: 0.752 ± 0.013	0.902CysSer: 0.902 ± 0.016	0.719CysThr: 0.719 ± 0.012	0.756CysVal: 0.756 ± 0.014	0.194CysTrp: 0.194 ± 0.007	0.368CysTyr: 0.368 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.08AspAla: 5.08 ± 0.042	0.631AspCys: 0.631 ± 0.014	4.838AspAsp: 4.838 ± 0.049	4.616AspGlu: 4.616 ± 0.042	2.177AspPhe: 2.177 ± 0.026	4.147AspGly: 4.147 ± 0.033	1.348AspHis: 1.348 ± 0.017	2.805AspIle: 2.805 ± 0.026	2.231AspLys: 2.231 ± 0.026	4.941AspLeu: 4.941 ± 0.029	1.337AspMet: 1.337 ± 0.018	1.789AspAsn: 1.789 ± 0.017	3.046AspPro: 3.046 ± 0.027	1.991AspGln: 1.991 ± 0.022	3.06AspArg: 3.06 ± 0.029	4.013AspSer: 4.013 ± 0.036	2.925AspThr: 2.925 ± 0.023	3.79AspVal: 3.79 ± 0.029	0.869AspTrp: 0.869 ± 0.015	1.569AspTyr: 1.569 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.603GluAla: 5.603 ± 0.045	0.609GluCys: 0.609 ± 0.012	4.37GluAsp: 4.37 ± 0.042	5.899GluGlu: 5.899 ± 0.064	1.749GluPhe: 1.749 ± 0.02	3.881GluGly: 3.881 ± 0.03	1.585GluHis: 1.585 ± 0.022	2.815GluIle: 2.815 ± 0.028	3.785GluLys: 3.785 ± 0.035	5.143GluLeu: 5.143 ± 0.043	1.511GluMet: 1.511 ± 0.017	2.172GluAsn: 2.172 ± 0.024	2.634GluPro: 2.634 ± 0.028	2.926GluGln: 2.926 ± 0.029	4.128GluArg: 4.128 ± 0.04	3.975GluSer: 3.975 ± 0.036	3.237GluThr: 3.237 ± 0.026	3.626GluVal: 3.626 ± 0.03	0.861GluTrp: 0.861 ± 0.015	1.656GluTyr: 1.656 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.145PheAla: 3.145 ± 0.029	0.51PheCys: 0.51 ± 0.012	2.207PheAsp: 2.207 ± 0.025	2.09PheGlu: 2.09 ± 0.021	1.474PhePhe: 1.474 ± 0.022	2.784PheGly: 2.784 ± 0.031	0.892PheHis: 0.892 ± 0.016	1.522PheIle: 1.522 ± 0.019	1.366PheLys: 1.366 ± 0.017	3.13PheLeu: 3.13 ± 0.032	0.76PheMet: 0.76 ± 0.014	1.27PheAsn: 1.27 ± 0.018	1.758PhePro: 1.758 ± 0.022	1.33PheGln: 1.33 ± 0.017	1.819PheArg: 1.819 ± 0.018	2.706PheSer: 2.706 ± 0.027	2.081PheThr: 2.081 ± 0.027	2.256PheVal: 2.256 ± 0.026	0.604PheTrp: 0.604 ± 0.012	1.012PheTyr: 1.012 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.483GlyAla: 5.483 ± 0.045	0.847GlyCys: 0.847 ± 0.014	3.723GlyAsp: 3.723 ± 0.034	3.838GlyGlu: 3.838 ± 0.032	2.687GlyPhe: 2.687 ± 0.029	6.666GlyGly: 6.666 ± 0.072	1.767GlyHis: 1.767 ± 0.02	3.421GlyIle: 3.421 ± 0.033	3.621GlyLys: 3.621 ± 0.031	5.897GlyLeu: 5.897 ± 0.036	1.747GlyMet: 1.747 ± 0.022	2.584GlyAsn: 2.584 ± 0.032	3.212GlyPro: 3.212 ± 0.034	2.663GlyGln: 2.663 ± 0.026	4.203GlyArg: 4.203 ± 0.039	5.691GlySer: 5.691 ± 0.047	4.107GlyThr: 4.107 ± 0.033	4.294GlyVal: 4.294 ± 0.033	1.123GlyTrp: 1.123 ± 0.017	2.106GlyTyr: 2.106 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.221HisAla: 2.221 ± 0.026	0.357HisCys: 0.357 ± 0.009	1.503HisAsp: 1.503 ± 0.021	1.501HisGlu: 1.501 ± 0.021	0.943HisPhe: 0.943 ± 0.014	1.833HisGly: 1.833 ± 0.024	1.098HisHis: 1.098 ± 0.024	1.228HisIle: 1.228 ± 0.017	0.977HisLys: 0.977 ± 0.014	2.275HisLeu: 2.275 ± 0.024	0.551HisMet: 0.551 ± 0.011	0.929HisAsn: 0.929 ± 0.015	1.638HisPro: 1.638 ± 0.022	1.143HisGln: 1.143 ± 0.02	1.581HisArg: 1.581 ± 0.023	1.952HisSer: 1.952 ± 0.024	1.391HisThr: 1.391 ± 0.019	1.548HisVal: 1.548 ± 0.018	0.366HisTrp: 0.366 ± 0.008	0.73HisTyr: 0.73 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.29IleAla: 4.29 ± 0.034	0.701IleCys: 0.701 ± 0.011	2.757IleAsp: 2.757 ± 0.025	2.733IleGlu: 2.733 ± 0.025	1.804IlePhe: 1.804 ± 0.023	3.079IleGly: 3.079 ± 0.032	1.152IleHis: 1.152 ± 0.016	2.235IleIle: 2.235 ± 0.027	2.049IleLys: 2.049 ± 0.023	4.113IleLeu: 4.113 ± 0.033	0.985IleMet: 0.985 ± 0.014	1.649IleAsn: 1.649 ± 0.02	2.798IlePro: 2.798 ± 0.027	1.762IleGln: 1.762 ± 0.019	2.656IleArg: 2.656 ± 0.025	3.604IleSer: 3.604 ± 0.027	2.78IleThr: 2.78 ± 0.031	3.022IleVal: 3.022 ± 0.029	0.7IleTrp: 0.7 ± 0.013	1.341IleTyr: 1.341 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.361LysAla: 4.361 ± 0.038	0.488LysCys: 0.488 ± 0.012	2.755LysAsp: 2.755 ± 0.025	3.371LysGlu: 3.371 ± 0.035	1.367LysPhe: 1.367 ± 0.018	2.9LysGly: 2.9 ± 0.027	1.199LysHis: 1.199 ± 0.016	2.131LysIle: 2.131 ± 0.023	3.654LysLys: 3.654 ± 0.039	4.035LysLeu: 4.035 ± 0.034	1.076LysMet: 1.076 ± 0.015	1.679LysAsn: 1.679 ± 0.02	2.661LysPro: 2.661 ± 0.029	2.109LysGln: 2.109 ± 0.024	3.597LysArg: 3.597 ± 0.031	3.461LysSer: 3.461 ± 0.031	2.848LysThr: 2.848 ± 0.027	2.816LysVal: 2.816 ± 0.028	0.677LysTrp: 0.677 ± 0.013	1.305LysTyr: 1.305 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.979LeuAla: 7.979 ± 0.042	1.162LeuCys: 1.162 ± 0.018	5.005LeuAsp: 5.005 ± 0.038	5.274LeuGlu: 5.274 ± 0.046	3.006LeuPhe: 3.006 ± 0.029	5.669LeuGly: 5.669 ± 0.039	2.413LeuHis: 2.413 ± 0.024	3.619LeuIle: 3.619 ± 0.034	4.0LeuLys: 4.0 ± 0.036	8.057LeuLeu: 8.057 ± 0.052	1.726LeuMet: 1.726 ± 0.02	2.921LeuAsn: 2.921 ± 0.026	5.58LeuPro: 5.58 ± 0.044	4.068LeuGln: 4.068 ± 0.034	5.66LeuArg: 5.66 ± 0.038	6.78LeuSer: 6.78 ± 0.039	4.698LeuThr: 4.698 ± 0.032	5.114LeuVal: 5.114 ± 0.036	1.128LeuTrp: 1.128 ± 0.018	2.27LeuTyr: 2.27 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.308MetAla: 2.308 ± 0.022	0.272MetCys: 0.272 ± 0.008	1.24MetAsp: 1.24 ± 0.017	1.268MetGlu: 1.268 ± 0.018	0.727MetPhe: 0.727 ± 0.012	1.498MetGly: 1.498 ± 0.02	0.544MetHis: 0.544 ± 0.01	0.969MetIle: 0.969 ± 0.016	1.051MetLys: 1.051 ± 0.015	1.969MetLeu: 1.969 ± 0.021	0.645MetMet: 0.645 ± 0.014	0.818MetAsn: 0.818 ± 0.013	1.407MetPro: 1.407 ± 0.022	1.009MetGln: 1.009 ± 0.018	1.361MetArg: 1.361 ± 0.019	1.95MetSer: 1.95 ± 0.02	1.325MetThr: 1.325 ± 0.02	1.27MetVal: 1.27 ± 0.021	0.272MetTrp: 0.272 ± 0.007	0.563MetTyr: 0.563 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.26AsnAla: 3.26 ± 0.029	0.399AsnCys: 0.399 ± 0.01	2.006AsnAsp: 2.006 ± 0.021	1.966AsnGlu: 1.966 ± 0.023	1.306AsnPhe: 1.306 ± 0.017	3.149AsnGly: 3.149 ± 0.033	0.883AsnHis: 0.883 ± 0.015	1.857AsnIle: 1.857 ± 0.022	1.53AsnLys: 1.53 ± 0.019	2.993AsnLeu: 2.993 ± 0.025	0.828AsnMet: 0.828 ± 0.013	1.749AsnAsn: 1.749 ± 0.037	2.171AsnPro: 2.171 ± 0.022	1.238AsnGln: 1.238 ± 0.018	1.835AsnArg: 1.835 ± 0.022	2.661AsnSer: 2.661 ± 0.028	2.217AsnThr: 2.217 ± 0.025	2.318AsnVal: 2.318 ± 0.025	0.525AsnTrp: 0.525 ± 0.01	0.958AsnTyr: 0.958 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.54ProAla: 5.54 ± 0.049	0.498ProCys: 0.498 ± 0.012	3.067ProAsp: 3.067 ± 0.028	3.612ProGlu: 3.612 ± 0.034	1.9ProPhe: 1.9 ± 0.021	3.904ProGly: 3.904 ± 0.033	1.471ProHis: 1.471 ± 0.022	2.414ProIle: 2.414 ± 0.025	2.513ProLys: 2.513 ± 0.027	4.595ProLeu: 4.595 ± 0.035	1.126ProMet: 1.126 ± 0.018	2.038ProAsn: 2.038 ± 0.024	5.419ProPro: 5.419 ± 0.071	2.62ProGln: 2.62 ± 0.034	3.421ProArg: 3.421 ± 0.033	5.694ProSer: 5.694 ± 0.048	4.052ProThr: 4.052 ± 0.037	3.417ProVal: 3.417 ± 0.033	0.688ProTrp: 0.688 ± 0.014	1.503ProTyr: 1.503 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.861GlnAla: 3.861 ± 0.038	0.472GlnCys: 0.472 ± 0.011	2.257GlnAsp: 2.257 ± 0.024	2.546GlnGlu: 2.546 ± 0.024	1.229GlnPhe: 1.229 ± 0.018	2.416GlnGly: 2.416 ± 0.025	1.419GlnHis: 1.419 ± 0.02	1.895GlnIle: 1.895 ± 0.022	2.186GlnLys: 2.186 ± 0.024	3.589GlnLeu: 3.589 ± 0.033	0.959GlnMet: 0.959 ± 0.018	1.576GlnAsn: 1.576 ± 0.018	2.663GlnPro: 2.663 ± 0.034	3.563GlnGln: 3.563 ± 0.068	2.98GlnArg: 2.98 ± 0.03	3.244GlnSer: 3.244 ± 0.029	2.47GlnThr: 2.47 ± 0.026	2.233GlnVal: 2.233 ± 0.023	0.589GlnTrp: 0.589 ± 0.01	1.277GlnTyr: 1.277 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	5.034ArgAla: 5.034 ± 0.035	0.701ArgCys: 0.701 ± 0.013	3.431ArgAsp: 3.431 ± 0.032	3.974ArgGlu: 3.974 ± 0.036	1.962ArgPhe: 1.962 ± 0.018	3.813ArgGly: 3.813 ± 0.037	1.648ArgHis: 1.648 ± 0.02	2.835ArgIle: 2.835 ± 0.025	3.645ArgLys: 3.645 ± 0.031	5.295ArgLeu: 5.295 ± 0.039	1.444ArgMet: 1.444 ± 0.017	2.247ArgAsn: 2.247 ± 0.022	3.595ArgPro: 3.595 ± 0.04	2.829ArgGln: 2.829 ± 0.027	5.241ArgArg: 5.241 ± 0.057	4.866ArgSer: 4.866 ± 0.045	3.506ArgThr: 3.506 ± 0.031	3.255ArgVal: 3.255 ± 0.029	0.88ArgTrp: 0.88 ± 0.015	1.635ArgTyr: 1.635 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.132SerAla: 7.132 ± 0.042	0.865SerCys: 0.865 ± 0.018	4.055SerAsp: 4.055 ± 0.036	4.016SerGlu: 4.016 ± 0.032	2.696SerPhe: 2.696 ± 0.028	5.656SerGly: 5.656 ± 0.046	2.014SerHis: 2.014 ± 0.026	3.731SerIle: 3.731 ± 0.031	3.598SerLys: 3.598 ± 0.03	6.68SerLeu: 6.68 ± 0.04	1.792SerMet: 1.792 ± 0.023	2.957SerAsn: 2.957 ± 0.03	5.344SerPro: 5.344 ± 0.051	3.289SerGln: 3.289 ± 0.027	4.992SerArg: 4.992 ± 0.043	9.4SerSer: 9.4 ± 0.091	5.828SerThr: 5.828 ± 0.045	4.333SerVal: 4.333 ± 0.033	1.043SerTrp: 1.043 ± 0.016	2.027SerTyr: 2.027 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.699ThrAla: 5.699 ± 0.043	0.765ThrCys: 0.765 ± 0.013	2.772ThrAsp: 2.772 ± 0.025	2.984ThrGlu: 2.984 ± 0.03	2.255ThrPhe: 2.255 ± 0.023	4.242ThrGly: 4.242 ± 0.037	1.367ThrHis: 1.367 ± 0.018	3.101ThrIle: 3.101 ± 0.027	2.674ThrLys: 2.674 ± 0.027	5.141ThrLeu: 5.141 ± 0.036	1.275ThrMet: 1.275 ± 0.016	2.187ThrAsn: 2.187 ± 0.024	4.405ThrPro: 4.405 ± 0.04	2.146ThrGln: 2.146 ± 0.02	3.288ThrArg: 3.288 ± 0.028	5.62ThrSer: 5.62 ± 0.048	5.236ThrThr: 5.236 ± 0.063	3.493ThrVal: 3.493 ± 0.031	0.843ThrTrp: 0.843 ± 0.014	1.638ThrTyr: 1.638 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.362ValAla: 5.362 ± 0.035	0.806ValCys: 0.806 ± 0.014	3.593ValAsp: 3.593 ± 0.034	3.928ValGlu: 3.928 ± 0.032	2.223ValPhe: 2.223 ± 0.027	3.95ValGly: 3.95 ± 0.035	1.483ValHis: 1.483 ± 0.019	2.658ValIle: 2.658 ± 0.028	2.895ValLys: 2.895 ± 0.032	5.446ValLeu: 5.446 ± 0.038	1.339ValMet: 1.339 ± 0.017	2.128ValAsn: 2.128 ± 0.023	3.5ValPro: 3.5 ± 0.03	2.566ValGln: 2.566 ± 0.025	3.449ValArg: 3.449 ± 0.032	4.297ValSer: 4.297 ± 0.037	3.358ValThr: 3.358 ± 0.033	4.254ValVal: 4.254 ± 0.042	0.846ValTrp: 0.846 ± 0.017	1.627ValTyr: 1.627 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.063TrpAla: 1.063 ± 0.016	0.198TrpCys: 0.198 ± 0.006	0.808TrpAsp: 0.808 ± 0.016	0.796TrpGlu: 0.796 ± 0.014	0.518TrpPhe: 0.518 ± 0.011	0.804TrpGly: 0.804 ± 0.016	0.378TrpHis: 0.378 ± 0.01	0.712TrpIle: 0.712 ± 0.014	0.798TrpLys: 0.798 ± 0.012	1.311TrpLeu: 1.311 ± 0.019	0.363TrpMet: 0.363 ± 0.01	0.604TrpAsn: 0.604 ± 0.012	0.604TrpPro: 0.604 ± 0.012	0.673TrpGln: 0.673 ± 0.012	0.957TrpArg: 0.957 ± 0.016	1.086TrpSer: 1.086 ± 0.017	0.965TrpThr: 0.965 ± 0.014	0.758TrpVal: 0.758 ± 0.013	0.273TrpTrp: 0.273 ± 0.008	0.438TrpTyr: 0.438 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.296TyrAla: 2.296 ± 0.023	0.408TyrCys: 0.408 ± 0.01	1.688TyrAsp: 1.688 ± 0.02	1.561TyrGlu: 1.561 ± 0.017	1.08TyrPhe: 1.08 ± 0.018	2.15TyrGly: 2.15 ± 0.03	0.769TyrHis: 0.769 ± 0.014	1.315TyrIle: 1.315 ± 0.019	1.042TyrLys: 1.042 ± 0.015	2.499TyrLeu: 2.499 ± 0.027	0.632TyrMet: 0.632 ± 0.011	1.109TyrAsn: 1.109 ± 0.017	1.387TyrPro: 1.387 ± 0.019	1.188TyrGln: 1.188 ± 0.017	1.578TyrArg: 1.578 ± 0.019	1.98TyrSer: 1.98 ± 0.023	1.621TyrThr: 1.621 ± 0.021	1.578TyrVal: 1.578 ± 0.016	0.437TyrTrp: 0.437 ± 0.009	0.943TyrTyr: 0.943 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10154 proteins (4580991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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