Amino acid dipepetide frequency for Thermoplasmatales archaeon I-plasma

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.649AlaAla: 4.649 ± 0.106
0.376AlaCys: 0.376 ± 0.031
2.837AlaAsp: 2.837 ± 0.079
3.414AlaGlu: 3.414 ± 0.083
3.036AlaPhe: 3.036 ± 0.075
4.82AlaGly: 4.82 ± 0.105
0.902AlaHis: 0.902 ± 0.041
5.752AlaIle: 5.752 ± 0.128
3.625AlaLys: 3.625 ± 0.088
6.232AlaLeu: 6.232 ± 0.12
1.882AlaMet: 1.882 ± 0.06
2.184AlaAsn: 2.184 ± 0.068
1.831AlaPro: 1.831 ± 0.06
1.374AlaGln: 1.374 ± 0.054
3.172AlaArg: 3.172 ± 0.093
4.801AlaSer: 4.801 ± 0.114
3.387AlaThr: 3.387 ± 0.134
4.968AlaVal: 4.968 ± 0.1
0.577AlaTrp: 0.577 ± 0.039
2.211AlaTyr: 2.211 ± 0.063
0.002AlaXaa: 0.002 ± 0.002
Cys
0.303CysAla: 0.303 ± 0.025
0.047CysCys: 0.047 ± 0.011
0.327CysAsp: 0.327 ± 0.028
0.337CysGlu: 0.337 ± 0.029
0.177CysPhe: 0.177 ± 0.022
0.689CysGly: 0.689 ± 0.042
0.128CysHis: 0.128 ± 0.016
0.415CysIle: 0.415 ± 0.028
0.345CysLys: 0.345 ± 0.03
0.364CysLeu: 0.364 ± 0.026
0.112CysMet: 0.112 ± 0.016
0.303CysAsn: 0.303 ± 0.028
0.441CysPro: 0.441 ± 0.034
0.124CysGln: 0.124 ± 0.017
0.325CysArg: 0.325 ± 0.023
0.484CysSer: 0.484 ± 0.033
0.287CysThr: 0.287 ± 0.024
0.337CysVal: 0.337 ± 0.024
0.049CysTrp: 0.049 ± 0.011
0.191CysTyr: 0.191 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
2.995AspAla: 2.995 ± 0.078
0.272AspCys: 0.272 ± 0.02
2.341AspAsp: 2.341 ± 0.083
3.757AspGlu: 3.757 ± 0.111
2.816AspPhe: 2.816 ± 0.076
3.483AspGly: 3.483 ± 0.092
0.754AspHis: 0.754 ± 0.04
4.365AspIle: 4.365 ± 0.096
2.973AspLys: 2.973 ± 0.08
4.966AspLeu: 4.966 ± 0.097
1.237AspMet: 1.237 ± 0.051
1.79AspAsn: 1.79 ± 0.073
2.268AspPro: 2.268 ± 0.067
1.166AspGln: 1.166 ± 0.052
2.652AspArg: 2.652 ± 0.083
3.79AspSer: 3.79 ± 0.101
2.044AspThr: 2.044 ± 0.066
3.83AspVal: 3.83 ± 0.102
0.514AspTrp: 0.514 ± 0.035
2.371AspTyr: 2.371 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.013GluAla: 4.013 ± 0.106
0.345GluCys: 0.345 ± 0.027
3.485GluAsp: 3.485 ± 0.094
5.57GluGlu: 5.57 ± 0.137
2.865GluPhe: 2.865 ± 0.09
4.556GluGly: 4.556 ± 0.098
0.91GluHis: 0.91 ± 0.045
6.08GluIle: 6.08 ± 0.115
5.61GluLys: 5.61 ± 0.138
5.496GluLeu: 5.496 ± 0.118
2.14GluMet: 2.14 ± 0.066
3.385GluAsn: 3.385 ± 0.091
1.849GluPro: 1.849 ± 0.073
1.485GluGln: 1.485 ± 0.056
4.218GluArg: 4.218 ± 0.109
4.271GluSer: 4.271 ± 0.092
3.074GluThr: 3.074 ± 0.083
4.537GluVal: 4.537 ± 0.093
0.622GluTrp: 0.622 ± 0.038
2.428GluTyr: 2.428 ± 0.074
0.0GluXaa: 0.0 ± 0.0
Phe
2.678PheAla: 2.678 ± 0.085
0.268PheCys: 0.268 ± 0.024
2.365PheAsp: 2.365 ± 0.069
2.412PheGlu: 2.412 ± 0.077
2.331PhePhe: 2.331 ± 0.086
3.458PheGly: 3.458 ± 0.08
0.827PheHis: 0.827 ± 0.045
3.529PheIle: 3.529 ± 0.1
2.489PheLys: 2.489 ± 0.08
4.954PheLeu: 4.954 ± 0.132
1.134PheMet: 1.134 ± 0.057
2.075PheAsn: 2.075 ± 0.063
2.071PhePro: 2.071 ± 0.074
1.189PheGln: 1.189 ± 0.051
2.369PheArg: 2.369 ± 0.068
4.43PheSer: 4.43 ± 0.099
2.68PheThr: 2.68 ± 0.08
3.552PheVal: 3.552 ± 0.097
0.421PheTrp: 0.421 ± 0.03
2.083PheTyr: 2.083 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
4.592GlyAla: 4.592 ± 0.119
0.488GlyCys: 0.488 ± 0.033
3.377GlyAsp: 3.377 ± 0.072
4.592GlyGlu: 4.592 ± 0.102
3.645GlyPhe: 3.645 ± 0.095
5.586GlyGly: 5.586 ± 0.148
1.179GlyHis: 1.179 ± 0.047
7.136GlyIle: 7.136 ± 0.138
6.269GlyLys: 6.269 ± 0.12
6.443GlyLeu: 6.443 ± 0.129
2.337GlyMet: 2.337 ± 0.073
3.615GlyAsn: 3.615 ± 0.089
2.233GlyPro: 2.233 ± 0.062
1.642GlyGln: 1.642 ± 0.061
3.911GlyArg: 3.911 ± 0.096
5.326GlySer: 5.326 ± 0.127
4.598GlyThr: 4.598 ± 0.179
5.145GlyVal: 5.145 ± 0.116
0.79GlyTrp: 0.79 ± 0.046
3.18GlyTyr: 3.18 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
0.801HisAla: 0.801 ± 0.04
0.126HisCys: 0.126 ± 0.016
0.64HisAsp: 0.64 ± 0.04
0.731HisGlu: 0.731 ± 0.041
0.807HisPhe: 0.807 ± 0.045
1.276HisGly: 1.276 ± 0.051
0.333HisHis: 0.333 ± 0.024
1.13HisIle: 1.13 ± 0.049
0.744HisLys: 0.744 ± 0.042
1.453HisLeu: 1.453 ± 0.058
0.386HisMet: 0.386 ± 0.027
0.656HisAsn: 0.656 ± 0.032
0.894HisPro: 0.894 ± 0.044
0.327HisGln: 0.327 ± 0.025
0.762HisArg: 0.762 ± 0.041
1.138HisSer: 1.138 ± 0.053
0.734HisThr: 0.734 ± 0.04
0.902HisVal: 0.902 ± 0.044
0.118HisTrp: 0.118 ± 0.015
0.648HisTyr: 0.648 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.846IleAla: 5.846 ± 0.125
0.473IleCys: 0.473 ± 0.032
4.334IleAsp: 4.334 ± 0.093
5.289IleGlu: 5.289 ± 0.131
3.767IlePhe: 3.767 ± 0.113
6.035IleGly: 6.035 ± 0.122
1.105IleHis: 1.105 ± 0.052
5.962IleIle: 5.962 ± 0.134
4.686IleLys: 4.686 ± 0.11
7.571IleLeu: 7.571 ± 0.154
1.995IleMet: 1.995 ± 0.07
3.28IleAsn: 3.28 ± 0.069
3.875IlePro: 3.875 ± 0.082
1.668IleGln: 1.668 ± 0.058
4.023IleArg: 4.023 ± 0.098
7.142IleSer: 7.142 ± 0.128
4.419IleThr: 4.419 ± 0.121
6.275IleVal: 6.275 ± 0.135
0.626IleTrp: 0.626 ± 0.035
2.95IleTyr: 2.95 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
3.694LysAla: 3.694 ± 0.087
0.447LysCys: 0.447 ± 0.035
3.649LysAsp: 3.649 ± 0.095
6.199LysGlu: 6.199 ± 0.125
2.863LysPhe: 2.863 ± 0.083
5.177LysGly: 5.177 ± 0.102
0.872LysHis: 0.872 ± 0.046
5.572LysIle: 5.572 ± 0.125
5.539LysLys: 5.539 ± 0.14
5.362LysLeu: 5.362 ± 0.115
2.26LysMet: 2.26 ± 0.083
3.125LysAsn: 3.125 ± 0.083
1.871LysPro: 1.871 ± 0.061
1.39LysGln: 1.39 ± 0.05
3.757LysArg: 3.757 ± 0.09
4.324LysSer: 4.324 ± 0.095
2.958LysThr: 2.958 ± 0.079
5.078LysVal: 5.078 ± 0.109
0.597LysTrp: 0.597 ± 0.033
2.719LysTyr: 2.719 ± 0.083
0.0LysXaa: 0.0 ± 0.0
Leu
6.017LeuAla: 6.017 ± 0.141
0.419LeuCys: 0.419 ± 0.028
4.619LeuAsp: 4.619 ± 0.097
5.992LeuGlu: 5.992 ± 0.127
4.062LeuPhe: 4.062 ± 0.103
6.762LeuGly: 6.762 ± 0.118
1.14LeuHis: 1.14 ± 0.046
7.055LeuIle: 7.055 ± 0.154
6.968LeuLys: 6.968 ± 0.131
8.42LeuLeu: 8.42 ± 0.182
2.341LeuMet: 2.341 ± 0.083
4.188LeuAsn: 4.188 ± 0.104
3.777LeuPro: 3.777 ± 0.093
2.154LeuGln: 2.154 ± 0.056
4.523LeuArg: 4.523 ± 0.109
7.709LeuSer: 7.709 ± 0.149
4.673LeuThr: 4.673 ± 0.103
6.254LeuVal: 6.254 ± 0.13
0.801LeuTrp: 0.801 ± 0.042
3.137LeuTyr: 3.137 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
1.766MetAla: 1.766 ± 0.067
0.1MetCys: 0.1 ± 0.014
1.599MetAsp: 1.599 ± 0.056
2.18MetGlu: 2.18 ± 0.069
0.922MetPhe: 0.922 ± 0.049
2.077MetGly: 2.077 ± 0.072
0.329MetHis: 0.329 ± 0.03
1.983MetIle: 1.983 ± 0.071
2.44MetLys: 2.44 ± 0.068
2.172MetLeu: 2.172 ± 0.081
0.768MetMet: 0.768 ± 0.041
1.451MetAsn: 1.451 ± 0.054
0.949MetPro: 0.949 ± 0.046
0.679MetGln: 0.679 ± 0.036
1.457MetArg: 1.457 ± 0.066
1.79MetSer: 1.79 ± 0.061
1.496MetThr: 1.496 ± 0.051
2.034MetVal: 2.034 ± 0.064
0.181MetTrp: 0.181 ± 0.016
0.644MetTyr: 0.644 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.759AsnAla: 2.759 ± 0.075
0.319AsnCys: 0.319 ± 0.025
2.085AsnAsp: 2.085 ± 0.074
2.875AsnGlu: 2.875 ± 0.077
2.325AsnPhe: 2.325 ± 0.067
3.859AsnGly: 3.859 ± 0.123
0.636AsnHis: 0.636 ± 0.035
3.434AsnIle: 3.434 ± 0.08
2.349AsnLys: 2.349 ± 0.069
4.22AsnLeu: 4.22 ± 0.098
1.036AsnMet: 1.036 ± 0.044
1.808AsnAsn: 1.808 ± 0.069
2.335AsnPro: 2.335 ± 0.08
1.034AsnGln: 1.034 ± 0.051
2.016AsnArg: 2.016 ± 0.067
3.611AsnSer: 3.611 ± 0.116
2.16AsnThr: 2.16 ± 0.076
3.58AsnVal: 3.58 ± 0.102
0.437AsnTrp: 0.437 ± 0.028
1.926AsnTyr: 1.926 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.211ProAla: 2.211 ± 0.06
0.158ProCys: 0.158 ± 0.02
2.239ProAsp: 2.239 ± 0.076
2.938ProGlu: 2.938 ± 0.074
2.101ProPhe: 2.101 ± 0.056
2.853ProGly: 2.853 ± 0.085
0.683ProHis: 0.683 ± 0.032
2.749ProIle: 2.749 ± 0.073
2.022ProLys: 2.022 ± 0.059
3.657ProLeu: 3.657 ± 0.083
0.892ProMet: 0.892 ± 0.042
1.648ProAsn: 1.648 ± 0.063
1.634ProPro: 1.634 ± 0.062
0.985ProGln: 0.985 ± 0.041
1.644ProArg: 1.644 ± 0.057
3.215ProSer: 3.215 ± 0.106
2.038ProThr: 2.038 ± 0.081
3.129ProVal: 3.129 ± 0.086
0.408ProTrp: 0.408 ± 0.033
1.66ProTyr: 1.66 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
1.363GlnAla: 1.363 ± 0.055
0.118GlnCys: 0.118 ± 0.016
1.061GlnAsp: 1.061 ± 0.053
1.597GlnGlu: 1.597 ± 0.065
1.059GlnPhe: 1.059 ± 0.057
1.662GlnGly: 1.662 ± 0.056
0.297GlnHis: 0.297 ± 0.025
1.776GlnIle: 1.776 ± 0.056
1.78GlnLys: 1.78 ± 0.068
2.089GlnLeu: 2.089 ± 0.062
0.786GlnMet: 0.786 ± 0.036
1.181GlnAsn: 1.181 ± 0.055
0.723GlnPro: 0.723 ± 0.047
0.626GlnGln: 0.626 ± 0.037
1.244GlnArg: 1.244 ± 0.046
1.646GlnSer: 1.646 ± 0.078
1.158GlnThr: 1.158 ± 0.057
1.554GlnVal: 1.554 ± 0.059
0.26GlnTrp: 0.26 ± 0.03
0.841GlnTyr: 0.841 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.698ArgAla: 2.698 ± 0.072
0.378ArgCys: 0.378 ± 0.03
2.932ArgAsp: 2.932 ± 0.076
4.338ArgGlu: 4.338 ± 0.101
2.148ArgPhe: 2.148 ± 0.075
3.692ArgGly: 3.692 ± 0.095
0.738ArgHis: 0.738 ± 0.042
4.312ArgIle: 4.312 ± 0.1
4.482ArgLys: 4.482 ± 0.1
3.897ArgLeu: 3.897 ± 0.112
1.617ArgMet: 1.617 ± 0.061
2.812ArgAsn: 2.812 ± 0.081
1.489ArgPro: 1.489 ± 0.065
1.107ArgGln: 1.107 ± 0.047
3.129ArgArg: 3.129 ± 0.09
3.076ArgSer: 3.076 ± 0.087
2.43ArgThr: 2.43 ± 0.074
3.28ArgVal: 3.28 ± 0.088
0.471ArgTrp: 0.471 ± 0.035
1.967ArgTyr: 1.967 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
4.454SerAla: 4.454 ± 0.117
0.358SerCys: 0.358 ± 0.031
3.603SerAsp: 3.603 ± 0.103
4.338SerGlu: 4.338 ± 0.085
3.792SerPhe: 3.792 ± 0.095
6.547SerGly: 6.547 ± 0.184
1.156SerHis: 1.156 ± 0.052
6.726SerIle: 6.726 ± 0.119
4.793SerLys: 4.793 ± 0.102
7.514SerLeu: 7.514 ± 0.143
2.04SerMet: 2.04 ± 0.059
3.389SerAsn: 3.389 ± 0.092
3.219SerPro: 3.219 ± 0.114
1.869SerGln: 1.869 ± 0.074
3.779SerArg: 3.779 ± 0.102
6.968SerSer: 6.968 ± 0.224
4.18SerThr: 4.18 ± 0.166
5.446SerVal: 5.446 ± 0.148
0.752SerTrp: 0.752 ± 0.041
3.288SerTyr: 3.288 ± 0.095
0.0SerXaa: 0.0 ± 0.0
Thr
3.377ThrAla: 3.377 ± 0.123
0.282ThrCys: 0.282 ± 0.022
2.442ThrAsp: 2.442 ± 0.081
2.914ThrGlu: 2.914 ± 0.085
2.753ThrPhe: 2.753 ± 0.099
4.647ThrGly: 4.647 ± 0.137
0.762ThrHis: 0.762 ± 0.045
4.113ThrIle: 4.113 ± 0.12
2.67ThrLys: 2.67 ± 0.079
4.671ThrLeu: 4.671 ± 0.101
1.189ThrMet: 1.189 ± 0.049
2.203ThrAsn: 2.203 ± 0.086
2.325ThrPro: 2.325 ± 0.103
1.181ThrGln: 1.181 ± 0.052
2.203ThrArg: 2.203 ± 0.081
4.306ThrSer: 4.306 ± 0.168
2.841ThrThr: 2.841 ± 0.135
4.537ThrVal: 4.537 ± 0.177
0.465ThrTrp: 0.465 ± 0.032
2.186ThrTyr: 2.186 ± 0.091
0.0ThrXaa: 0.0 ± 0.0
Val
4.97ValAla: 4.97 ± 0.117
0.433ValCys: 0.433 ± 0.029
3.751ValAsp: 3.751 ± 0.09
4.602ValGlu: 4.602 ± 0.109
3.278ValPhe: 3.278 ± 0.094
5.137ValGly: 5.137 ± 0.117
1.04ValHis: 1.04 ± 0.049
6.01ValIle: 6.01 ± 0.12
5.039ValLys: 5.039 ± 0.107
6.72ValLeu: 6.72 ± 0.127
1.916ValMet: 1.916 ± 0.061
3.31ValAsn: 3.31 ± 0.099
3.139ValPro: 3.139 ± 0.082
1.587ValGln: 1.587 ± 0.058
3.406ValArg: 3.406 ± 0.091
5.931ValSer: 5.931 ± 0.126
4.588ValThr: 4.588 ± 0.196
5.677ValVal: 5.677 ± 0.121
0.575ValTrp: 0.575 ± 0.025
2.599ValTyr: 2.599 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.545TrpAla: 0.545 ± 0.035
0.051TrpCys: 0.051 ± 0.009
0.508TrpAsp: 0.508 ± 0.031
0.583TrpGlu: 0.583 ± 0.037
0.402TrpPhe: 0.402 ± 0.028
0.666TrpGly: 0.666 ± 0.038
0.128TrpHis: 0.128 ± 0.017
0.654TrpIle: 0.654 ± 0.036
0.797TrpLys: 0.797 ± 0.046
0.774TrpLeu: 0.774 ± 0.043
0.228TrpMet: 0.228 ± 0.021
0.624TrpAsn: 0.624 ± 0.039
0.284TrpPro: 0.284 ± 0.027
0.256TrpGln: 0.256 ± 0.024
0.449TrpArg: 0.449 ± 0.026
0.616TrpSer: 0.616 ± 0.041
0.486TrpThr: 0.486 ± 0.035
0.62TrpVal: 0.62 ± 0.037
0.114TrpTrp: 0.114 ± 0.017
0.388TrpTyr: 0.388 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.3TyrAla: 2.3 ± 0.076
0.325TyrCys: 0.325 ± 0.027
2.19TyrAsp: 2.19 ± 0.07
2.28TyrGlu: 2.28 ± 0.074
2.166TyrPhe: 2.166 ± 0.062
3.103TyrGly: 3.103 ± 0.095
0.687TyrHis: 0.687 ± 0.034
2.57TyrIle: 2.57 ± 0.084
1.837TyrLys: 1.837 ± 0.056
4.033TyrLeu: 4.033 ± 0.097
0.717TyrMet: 0.717 ± 0.038
1.778TyrAsn: 1.778 ± 0.089
1.658TyrPro: 1.658 ± 0.07
0.977TyrGln: 0.977 ± 0.044
1.957TyrArg: 1.957 ± 0.066
3.637TyrSer: 3.637 ± 0.113
1.833TyrThr: 1.833 ± 0.072
2.973TyrVal: 2.973 ± 0.073
0.394TyrTrp: 0.394 ± 0.032
1.993TyrTyr: 1.993 ± 0.089
0.002TyrXaa: 0.002 ± 0.002
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.002XaaMet: 0.002 ± 0.002
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.002XaaThr: 0.002 ± 0.002
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1693 proteins (492143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski