Amino acid dipepetide frequency for Lactobacillus psittaci DSM 15354

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.15AlaAla: 6.15 ± 0.174
0.514AlaCys: 0.514 ± 0.045
4.355AlaAsp: 4.355 ± 0.136
4.28AlaGlu: 4.28 ± 0.113
3.276AlaPhe: 3.276 ± 0.113
5.578AlaGly: 5.578 ± 0.133
1.248AlaHis: 1.248 ± 0.063
6.244AlaIle: 6.244 ± 0.152
6.686AlaLys: 6.686 ± 0.161
7.176AlaLeu: 7.176 ± 0.211
1.879AlaMet: 1.879 ± 0.078
3.981AlaAsn: 3.981 ± 0.097
2.114AlaPro: 2.114 ± 0.087
3.065AlaGln: 3.065 ± 0.132
2.672AlaArg: 2.672 ± 0.095
5.264AlaSer: 5.264 ± 0.118
4.612AlaThr: 4.612 ± 0.222
4.939AlaVal: 4.939 ± 0.133
0.677AlaTrp: 0.677 ± 0.048
2.502AlaTyr: 2.502 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.354CysAla: 0.354 ± 0.032
0.044CysCys: 0.044 ± 0.009
0.365CysAsp: 0.365 ± 0.035
0.336CysGlu: 0.336 ± 0.034
0.279CysPhe: 0.279 ± 0.026
0.47CysGly: 0.47 ± 0.037
0.156CysHis: 0.156 ± 0.023
0.308CysIle: 0.308 ± 0.026
0.213CysLys: 0.213 ± 0.024
0.591CysLeu: 0.591 ± 0.046
0.108CysMet: 0.108 ± 0.014
0.204CysAsn: 0.204 ± 0.025
0.22CysPro: 0.22 ± 0.026
0.257CysGln: 0.257 ± 0.025
0.156CysArg: 0.156 ± 0.022
0.308CysSer: 0.308 ± 0.029
0.226CysThr: 0.226 ± 0.026
0.321CysVal: 0.321 ± 0.029
0.048CysTrp: 0.048 ± 0.009
0.228CysTyr: 0.228 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.163AspAla: 4.163 ± 0.191
0.294AspCys: 0.294 ± 0.03
3.201AspAsp: 3.201 ± 0.143
4.091AspGlu: 4.091 ± 0.111
2.992AspPhe: 2.992 ± 0.095
3.759AspGly: 3.759 ± 0.252
1.09AspHis: 1.09 ± 0.051
3.781AspIle: 3.781 ± 0.099
4.722AspLys: 4.722 ± 0.187
6.33AspLeu: 6.33 ± 0.125
1.336AspMet: 1.336 ± 0.063
2.856AspAsn: 2.856 ± 0.106
2.162AspPro: 2.162 ± 0.097
2.459AspGln: 2.459 ± 0.125
1.747AspArg: 1.747 ± 0.072
3.529AspSer: 3.529 ± 0.142
2.986AspThr: 2.986 ± 0.209
3.643AspVal: 3.643 ± 0.192
0.703AspTrp: 0.703 ± 0.053
2.355AspTyr: 2.355 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.715GluAla: 4.715 ± 0.138
0.218GluCys: 0.218 ± 0.025
2.981GluAsp: 2.981 ± 0.083
3.586GluGlu: 3.586 ± 0.139
2.27GluPhe: 2.27 ± 0.095
2.9GluGly: 2.9 ± 0.085
1.081GluHis: 1.081 ± 0.054
4.774GluIle: 4.774 ± 0.121
5.517GluLys: 5.517 ± 0.136
5.919GluLeu: 5.919 ± 0.182
1.556GluMet: 1.556 ± 0.073
3.368GluAsn: 3.368 ± 0.102
1.586GluPro: 1.586 ± 0.067
2.434GluGln: 2.434 ± 0.083
2.092GluArg: 2.092 ± 0.088
2.836GluSer: 2.836 ± 0.098
2.911GluThr: 2.911 ± 0.089
4.33GluVal: 4.33 ± 0.105
0.424GluTrp: 0.424 ± 0.03
1.821GluTyr: 1.821 ± 0.055
0.002GluXaa: 0.002 ± 0.003
Phe
3.366PheAla: 3.366 ± 0.124
0.286PheCys: 0.286 ± 0.029
2.841PheAsp: 2.841 ± 0.086
2.496PheGlu: 2.496 ± 0.091
2.281PhePhe: 2.281 ± 0.109
3.142PheGly: 3.142 ± 0.1
0.677PheHis: 0.677 ± 0.038
3.443PheIle: 3.443 ± 0.149
3.25PheLys: 3.25 ± 0.09
4.337PheLeu: 4.337 ± 0.171
1.101PheMet: 1.101 ± 0.067
2.496PheAsn: 2.496 ± 0.086
1.345PhePro: 1.345 ± 0.061
1.134PheGln: 1.134 ± 0.061
1.202PheArg: 1.202 ± 0.061
3.236PheSer: 3.236 ± 0.105
2.777PheThr: 2.777 ± 0.099
3.036PheVal: 3.036 ± 0.1
0.589PheTrp: 0.589 ± 0.041
1.705PheTyr: 1.705 ± 0.078
0.0PheXaa: 0.0 ± 0.0
Gly
4.535GlyAla: 4.535 ± 0.11
0.358GlyCys: 0.358 ± 0.03
3.469GlyAsp: 3.469 ± 0.139
3.487GlyGlu: 3.487 ± 0.082
2.885GlyPhe: 2.885 ± 0.115
3.757GlyGly: 3.757 ± 0.144
1.395GlyHis: 1.395 ± 0.057
5.203GlyIle: 5.203 ± 0.164
5.508GlyLys: 5.508 ± 0.151
6.347GlyLeu: 6.347 ± 0.209
1.784GlyMet: 1.784 ± 0.066
3.096GlyAsn: 3.096 ± 0.103
1.476GlyPro: 1.476 ± 0.058
2.83GlyGln: 2.83 ± 0.122
2.419GlyArg: 2.419 ± 0.096
4.144GlySer: 4.144 ± 0.122
3.619GlyThr: 3.619 ± 0.165
4.306GlyVal: 4.306 ± 0.118
0.598GlyTrp: 0.598 ± 0.044
2.94GlyTyr: 2.94 ± 0.178
0.0GlyXaa: 0.0 ± 0.0
His
1.197HisAla: 1.197 ± 0.055
0.094HisCys: 0.094 ± 0.016
1.145HisAsp: 1.145 ± 0.055
1.162HisGlu: 1.162 ± 0.054
1.022HisPhe: 1.022 ± 0.068
1.417HisGly: 1.417 ± 0.058
0.547HisHis: 0.547 ± 0.041
1.127HisIle: 1.127 ± 0.047
1.178HisLys: 1.178 ± 0.056
1.859HisLeu: 1.859 ± 0.072
0.455HisMet: 0.455 ± 0.034
1.0HisAsn: 1.0 ± 0.044
0.861HisPro: 0.861 ± 0.054
0.811HisGln: 0.811 ± 0.039
0.743HisArg: 0.743 ± 0.048
0.914HisSer: 0.914 ± 0.047
0.89HisThr: 0.89 ± 0.059
1.206HisVal: 1.206 ± 0.056
0.156HisTrp: 0.156 ± 0.02
0.894HisTyr: 0.894 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.943IleAla: 5.943 ± 0.173
0.624IleCys: 0.624 ± 0.051
4.418IleAsp: 4.418 ± 0.118
3.902IleGlu: 3.902 ± 0.132
3.728IlePhe: 3.728 ± 0.152
4.748IleGly: 4.748 ± 0.152
1.228IleHis: 1.228 ± 0.052
5.673IleIle: 5.673 ± 0.165
5.803IleLys: 5.803 ± 0.118
7.055IleLeu: 7.055 ± 0.277
1.672IleMet: 1.672 ± 0.086
4.146IleAsn: 4.146 ± 0.099
2.97IlePro: 2.97 ± 0.136
2.307IleGln: 2.307 ± 0.091
2.349IleArg: 2.349 ± 0.092
5.179IleSer: 5.179 ± 0.126
4.374IleThr: 4.374 ± 0.219
5.086IleVal: 5.086 ± 0.129
0.655IleTrp: 0.655 ± 0.047
2.47IleTyr: 2.47 ± 0.076
0.002IleXaa: 0.002 ± 0.002
Lys
6.033LysAla: 6.033 ± 0.169
0.248LysCys: 0.248 ± 0.022
4.651LysAsp: 4.651 ± 0.16
5.119LysGlu: 5.119 ± 0.125
2.628LysPhe: 2.628 ± 0.079
3.821LysGly: 3.821 ± 0.104
1.481LysHis: 1.481 ± 0.055
5.697LysIle: 5.697 ± 0.133
6.934LysLys: 6.934 ± 0.172
7.391LysLeu: 7.391 ± 0.159
2.472LysMet: 2.472 ± 0.098
4.579LysAsn: 4.579 ± 0.11
2.654LysPro: 2.654 ± 0.088
3.601LysGln: 3.601 ± 0.096
3.318LysArg: 3.318 ± 0.117
4.335LysSer: 4.335 ± 0.109
4.924LysThr: 4.924 ± 0.186
5.357LysVal: 5.357 ± 0.146
0.677LysTrp: 0.677 ± 0.038
3.094LysTyr: 3.094 ± 0.103
0.0LysXaa: 0.0 ± 0.0
Leu
9.118LeuAla: 9.118 ± 0.252
0.51LeuCys: 0.51 ± 0.038
5.447LeuAsp: 5.447 ± 0.133
4.84LeuGlu: 4.84 ± 0.138
4.28LeuPhe: 4.28 ± 0.177
6.389LeuGly: 6.389 ± 0.179
1.652LeuHis: 1.652 ± 0.064
7.584LeuIle: 7.584 ± 0.269
7.395LeuLys: 7.395 ± 0.214
9.276LeuLeu: 9.276 ± 0.326
2.256LeuMet: 2.256 ± 0.085
5.077LeuAsn: 5.077 ± 0.152
3.799LeuPro: 3.799 ± 0.106
2.924LeuGln: 2.924 ± 0.1
3.214LeuArg: 3.214 ± 0.137
6.743LeuSer: 6.743 ± 0.207
6.725LeuThr: 6.725 ± 0.119
6.853LeuVal: 6.853 ± 0.184
0.732LeuTrp: 0.732 ± 0.047
2.847LeuTyr: 2.847 ± 0.107
0.002LeuXaa: 0.002 ± 0.002
Met
2.111MetAla: 2.111 ± 0.084
0.114MetCys: 0.114 ± 0.015
1.277MetAsp: 1.277 ± 0.059
1.096MetGlu: 1.096 ± 0.055
0.929MetPhe: 0.929 ± 0.053
1.569MetGly: 1.569 ± 0.073
0.503MetHis: 0.503 ± 0.035
1.949MetIle: 1.949 ± 0.097
2.017MetLys: 2.017 ± 0.087
2.215MetLeu: 2.215 ± 0.108
0.734MetMet: 0.734 ± 0.046
1.36MetAsn: 1.36 ± 0.055
1.077MetPro: 1.077 ± 0.054
1.059MetGln: 1.059 ± 0.054
0.94MetArg: 0.94 ± 0.053
1.426MetSer: 1.426 ± 0.069
1.608MetThr: 1.608 ± 0.07
1.617MetVal: 1.617 ± 0.062
0.16MetTrp: 0.16 ± 0.019
0.67MetTyr: 0.67 ± 0.047
0.002MetXaa: 0.002 ± 0.002
Asn
3.441AsnAla: 3.441 ± 0.144
0.29AsnCys: 0.29 ± 0.028
2.885AsnAsp: 2.885 ± 0.088
3.017AsnGlu: 3.017 ± 0.091
2.626AsnPhe: 2.626 ± 0.083
3.7AsnGly: 3.7 ± 0.107
1.149AsnHis: 1.149 ± 0.052
3.373AsnIle: 3.373 ± 0.097
3.926AsnLys: 3.926 ± 0.1
5.693AsnLeu: 5.693 ± 0.159
1.287AsnMet: 1.287 ± 0.062
3.091AsnAsn: 3.091 ± 0.103
2.423AsnPro: 2.423 ± 0.086
2.573AsnGln: 2.573 ± 0.096
1.766AsnArg: 1.766 ± 0.068
3.379AsnSer: 3.379 ± 0.105
2.612AsnThr: 2.612 ± 0.1
3.104AsnVal: 3.104 ± 0.113
0.644AsnTrp: 0.644 ± 0.038
2.432AsnTyr: 2.432 ± 0.085
0.0AsnXaa: 0.0 ± 0.0
Pro
2.656ProAla: 2.656 ± 0.103
0.123ProCys: 0.123 ± 0.016
2.41ProAsp: 2.41 ± 0.122
2.861ProGlu: 2.861 ± 0.088
1.716ProPhe: 1.716 ± 0.082
2.127ProGly: 2.127 ± 0.08
0.567ProHis: 0.567 ± 0.039
2.461ProIle: 2.461 ± 0.083
2.492ProLys: 2.492 ± 0.078
2.946ProLeu: 2.946 ± 0.094
0.666ProMet: 0.666 ± 0.041
1.83ProAsn: 1.83 ± 0.059
0.437ProPro: 0.437 ± 0.033
1.241ProGln: 1.241 ± 0.059
0.932ProArg: 0.932 ± 0.05
2.133ProSer: 2.133 ± 0.104
2.12ProThr: 2.12 ± 0.166
2.687ProVal: 2.687 ± 0.099
0.323ProTrp: 0.323 ± 0.028
1.237ProTyr: 1.237 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
3.59GlnAla: 3.59 ± 0.146
0.07GlnCys: 0.07 ± 0.013
2.158GlnAsp: 2.158 ± 0.07
2.318GlnGlu: 2.318 ± 0.075
1.422GlnPhe: 1.422 ± 0.054
2.226GlnGly: 2.226 ± 0.068
0.58GlnHis: 0.58 ± 0.038
3.111GlnIle: 3.111 ± 0.102
3.647GlnLys: 3.647 ± 0.116
3.856GlnLeu: 3.856 ± 0.12
1.134GlnMet: 1.134 ± 0.06
2.274GlnAsn: 2.274 ± 0.079
0.967GlnPro: 0.967 ± 0.046
1.134GlnGln: 1.134 ± 0.063
1.538GlnArg: 1.538 ± 0.07
1.947GlnSer: 1.947 ± 0.073
2.608GlnThr: 2.608 ± 0.203
3.142GlnVal: 3.142 ± 0.104
0.323GlnTrp: 0.323 ± 0.028
1.301GlnTyr: 1.301 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
2.511ArgAla: 2.511 ± 0.084
0.167ArgCys: 0.167 ± 0.021
1.868ArgAsp: 1.868 ± 0.075
2.162ArgGlu: 2.162 ± 0.095
1.595ArgPhe: 1.595 ± 0.075
1.975ArgGly: 1.975 ± 0.088
0.795ArgHis: 0.795 ± 0.046
2.678ArgIle: 2.678 ± 0.103
2.79ArgLys: 2.79 ± 0.099
3.344ArgLeu: 3.344 ± 0.108
0.94ArgMet: 0.94 ± 0.061
1.714ArgAsn: 1.714 ± 0.065
1.208ArgPro: 1.208 ± 0.054
1.584ArgGln: 1.584 ± 0.064
1.766ArgArg: 1.766 ± 0.085
1.762ArgSer: 1.762 ± 0.067
1.859ArgThr: 1.859 ± 0.173
2.371ArgVal: 2.371 ± 0.09
0.279ArgTrp: 0.279 ± 0.026
1.472ArgTyr: 1.472 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.383SerAla: 4.383 ± 0.118
0.279SerCys: 0.279 ± 0.029
4.133SerAsp: 4.133 ± 0.211
3.731SerGlu: 3.731 ± 0.103
3.094SerPhe: 3.094 ± 0.09
4.684SerGly: 4.684 ± 0.115
1.255SerHis: 1.255 ± 0.06
4.029SerIle: 4.029 ± 0.133
4.623SerLys: 4.623 ± 0.138
6.172SerLeu: 6.172 ± 0.186
1.303SerMet: 1.303 ± 0.062
3.25SerAsn: 3.25 ± 0.124
1.729SerPro: 1.729 ± 0.059
3.058SerGln: 3.058 ± 0.112
2.096SerArg: 2.096 ± 0.079
4.55SerSer: 4.55 ± 0.129
3.344SerThr: 3.344 ± 0.11
3.959SerVal: 3.959 ± 0.128
0.714SerTrp: 0.714 ± 0.044
2.637SerTyr: 2.637 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
4.566ThrAla: 4.566 ± 0.256
0.277ThrCys: 0.277 ± 0.031
3.467ThrAsp: 3.467 ± 0.249
2.894ThrGlu: 2.894 ± 0.096
2.481ThrPhe: 2.481 ± 0.082
4.495ThrGly: 4.495 ± 0.239
1.039ThrHis: 1.039 ± 0.071
4.711ThrIle: 4.711 ± 0.266
4.425ThrLys: 4.425 ± 0.184
5.179ThrLeu: 5.179 ± 0.124
1.208ThrMet: 1.208 ± 0.057
3.065ThrAsn: 3.065 ± 0.116
2.709ThrPro: 2.709 ± 0.213
2.008ThrGln: 2.008 ± 0.13
1.841ThrArg: 1.841 ± 0.172
4.144ThrSer: 4.144 ± 0.146
3.961ThrThr: 3.961 ± 0.276
4.443ThrVal: 4.443 ± 0.413
0.521ThrTrp: 0.521 ± 0.036
2.274ThrTyr: 2.274 ± 0.213
0.0ThrXaa: 0.0 ± 0.0
Val
5.462ValAla: 5.462 ± 0.116
0.395ValCys: 0.395 ± 0.032
4.383ValAsp: 4.383 ± 0.305
3.707ValGlu: 3.707 ± 0.111
2.845ValPhe: 2.845 ± 0.09
4.447ValGly: 4.447 ± 0.104
1.105ValHis: 1.105 ± 0.072
5.339ValIle: 5.339 ± 0.12
5.225ValLys: 5.225 ± 0.111
6.453ValLeu: 6.453 ± 0.162
1.586ValMet: 1.586 ± 0.069
3.535ValAsn: 3.535 ± 0.086
2.518ValPro: 2.518 ± 0.103
2.188ValGln: 2.188 ± 0.08
2.136ValArg: 2.136 ± 0.073
4.3ValSer: 4.3 ± 0.101
4.825ValThr: 4.825 ± 0.524
5.007ValVal: 5.007 ± 0.134
0.589ValTrp: 0.589 ± 0.038
2.276ValTyr: 2.276 ± 0.084
0.0ValXaa: 0.0 ± 0.0
Trp
0.598TrpAla: 0.598 ± 0.033
0.07TrpCys: 0.07 ± 0.011
0.519TrpAsp: 0.519 ± 0.033
0.352TrpGlu: 0.352 ± 0.034
0.472TrpPhe: 0.472 ± 0.038
0.609TrpGly: 0.609 ± 0.043
0.211TrpHis: 0.211 ± 0.02
0.653TrpIle: 0.653 ± 0.045
0.6TrpLys: 0.6 ± 0.039
1.11TrpLeu: 1.11 ± 0.064
0.246TrpMet: 0.246 ± 0.024
0.538TrpAsn: 0.538 ± 0.034
0.316TrpPro: 0.316 ± 0.026
0.532TrpGln: 0.532 ± 0.038
0.365TrpArg: 0.365 ± 0.029
0.576TrpSer: 0.576 ± 0.041
0.519TrpThr: 0.519 ± 0.079
0.545TrpVal: 0.545 ± 0.038
0.119TrpTrp: 0.119 ± 0.016
0.36TrpTyr: 0.36 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.318TyrAla: 2.318 ± 0.081
0.215TyrCys: 0.215 ± 0.025
2.228TyrAsp: 2.228 ± 0.11
1.887TyrGlu: 1.887 ± 0.064
1.92TyrPhe: 1.92 ± 0.065
2.342TyrGly: 2.342 ± 0.075
0.918TyrHis: 0.918 ± 0.044
2.193TyrIle: 2.193 ± 0.077
2.063TyrLys: 2.063 ± 0.108
4.418TyrLeu: 4.418 ± 0.154
0.705TyrMet: 0.705 ± 0.044
1.951TyrAsn: 1.951 ± 0.076
1.393TyrPro: 1.393 ± 0.057
2.144TyrGln: 2.144 ± 0.069
1.551TyrArg: 1.551 ± 0.068
2.318TyrSer: 2.318 ± 0.081
2.206TyrThr: 2.206 ± 0.222
2.366TyrVal: 2.366 ± 0.13
0.378TyrTrp: 0.378 ± 0.03
1.621TyrTyr: 1.621 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.002XaaIle: 0.002 ± 0.003
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.004XaaMet: 0.004 ± 0.003
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.002XaaVal: 0.002 ± 0.002
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1327 proteins (455147 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski