Amino acid dipepetide frequency for Arthrobacter sp. AQ5-06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.783AlaAla: 20.783 ± 0.222
0.815AlaCys: 0.815 ± 0.027
7.34AlaAsp: 7.34 ± 0.097
7.924AlaGlu: 7.924 ± 0.098
3.649AlaPhe: 3.649 ± 0.055
13.394AlaGly: 13.394 ± 0.107
2.269AlaHis: 2.269 ± 0.054
5.175AlaIle: 5.175 ± 0.067
3.763AlaLys: 3.763 ± 0.061
12.849AlaLeu: 12.849 ± 0.116
2.803AlaMet: 2.803 ± 0.053
2.739AlaAsn: 2.739 ± 0.054
6.117AlaPro: 6.117 ± 0.1
3.776AlaGln: 3.776 ± 0.052
7.595AlaArg: 7.595 ± 0.094
7.124AlaSer: 7.124 ± 0.083
6.798AlaThr: 6.798 ± 0.085
11.454AlaVal: 11.454 ± 0.117
1.654AlaTrp: 1.654 ± 0.042
2.274AlaTyr: 2.274 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.709CysAla: 0.709 ± 0.022
0.085CysCys: 0.085 ± 0.01
0.352CysAsp: 0.352 ± 0.017
0.316CysGlu: 0.316 ± 0.016
0.213CysPhe: 0.213 ± 0.014
0.72CysGly: 0.72 ± 0.026
0.138CysHis: 0.138 ± 0.011
0.252CysIle: 0.252 ± 0.014
0.119CysLys: 0.119 ± 0.011
0.624CysLeu: 0.624 ± 0.021
0.105CysMet: 0.105 ± 0.01
0.145CysAsn: 0.145 ± 0.012
0.366CysPro: 0.366 ± 0.019
0.182CysGln: 0.182 ± 0.012
0.411CysArg: 0.411 ± 0.018
0.406CysSer: 0.406 ± 0.02
0.439CysThr: 0.439 ± 0.018
0.452CysVal: 0.452 ± 0.02
0.104CysTrp: 0.104 ± 0.009
0.145CysTyr: 0.145 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.222AspAla: 7.222 ± 0.094
0.339AspCys: 0.339 ± 0.02
3.112AspAsp: 3.112 ± 0.064
3.317AspGlu: 3.317 ± 0.069
1.946AspPhe: 1.946 ± 0.045
5.868AspGly: 5.868 ± 0.076
1.203AspHis: 1.203 ± 0.035
2.459AspIle: 2.459 ± 0.05
1.434AspLys: 1.434 ± 0.04
5.624AspLeu: 5.624 ± 0.078
0.929AspMet: 0.929 ± 0.031
1.217AspAsn: 1.217 ± 0.039
3.637AspPro: 3.637 ± 0.065
1.741AspGln: 1.741 ± 0.044
3.45AspArg: 3.45 ± 0.06
2.971AspSer: 2.971 ± 0.05
2.778AspThr: 2.778 ± 0.053
5.01AspVal: 5.01 ± 0.074
0.867AspTrp: 0.867 ± 0.029
1.299AspTyr: 1.299 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.154GluAla: 7.154 ± 0.092
0.299GluCys: 0.299 ± 0.016
2.982GluAsp: 2.982 ± 0.053
3.092GluGlu: 3.092 ± 0.065
1.77GluPhe: 1.77 ± 0.043
3.864GluGly: 3.864 ± 0.068
1.445GluHis: 1.445 ± 0.037
2.593GluIle: 2.593 ± 0.054
1.692GluLys: 1.692 ± 0.045
6.776GluLeu: 6.776 ± 0.089
1.008GluMet: 1.008 ± 0.029
1.528GluAsn: 1.528 ± 0.034
2.906GluPro: 2.906 ± 0.059
2.243GluGln: 2.243 ± 0.041
4.0GluArg: 4.0 ± 0.079
3.038GluSer: 3.038 ± 0.045
3.009GluThr: 3.009 ± 0.055
4.141GluVal: 4.141 ± 0.06
0.783GluTrp: 0.783 ± 0.025
1.114GluTyr: 1.114 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.997PheAla: 3.997 ± 0.058
0.254PheCys: 0.254 ± 0.015
2.138PheAsp: 2.138 ± 0.042
1.754PheGlu: 1.754 ± 0.042
1.195PhePhe: 1.195 ± 0.035
3.383PheGly: 3.383 ± 0.066
0.636PheHis: 0.636 ± 0.021
1.314PheIle: 1.314 ± 0.037
0.816PheLys: 0.816 ± 0.03
2.996PheLeu: 2.996 ± 0.058
0.596PheMet: 0.596 ± 0.022
0.913PheAsn: 0.913 ± 0.029
1.508PhePro: 1.508 ± 0.041
0.928PheGln: 0.928 ± 0.032
1.887PheArg: 1.887 ± 0.036
1.984PheSer: 1.984 ± 0.041
2.143PheThr: 2.143 ± 0.043
2.586PheVal: 2.586 ± 0.051
0.486PheTrp: 0.486 ± 0.022
0.741PheTyr: 0.741 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
10.062GlyAla: 10.062 ± 0.1
0.641GlyCys: 0.641 ± 0.025
4.285GlyAsp: 4.285 ± 0.065
4.436GlyGlu: 4.436 ± 0.068
3.309GlyPhe: 3.309 ± 0.055
7.742GlyGly: 7.742 ± 0.101
2.09GlyHis: 2.09 ± 0.046
4.753GlyIle: 4.753 ± 0.068
3.152GlyLys: 3.152 ± 0.062
9.321GlyLeu: 9.321 ± 0.085
2.136GlyMet: 2.136 ± 0.045
2.393GlyAsn: 2.393 ± 0.051
4.226GlyPro: 4.226 ± 0.067
3.137GlyGln: 3.137 ± 0.049
5.895GlyArg: 5.895 ± 0.084
5.867GlySer: 5.867 ± 0.088
6.2GlyThr: 6.2 ± 0.075
7.253GlyVal: 7.253 ± 0.087
1.602GlyTrp: 1.602 ± 0.039
2.304GlyTyr: 2.304 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.337HisAla: 2.337 ± 0.048
0.162HisCys: 0.162 ± 0.011
1.127HisAsp: 1.127 ± 0.033
1.177HisGlu: 1.177 ± 0.033
0.72HisPhe: 0.72 ± 0.025
2.083HisGly: 2.083 ± 0.047
0.677HisHis: 0.677 ± 0.026
0.858HisIle: 0.858 ± 0.028
0.461HisLys: 0.461 ± 0.02
2.108HisLeu: 2.108 ± 0.044
0.374HisMet: 0.374 ± 0.016
0.5HisAsn: 0.5 ± 0.021
1.437HisPro: 1.437 ± 0.038
0.678HisGln: 0.678 ± 0.024
1.558HisArg: 1.558 ± 0.044
1.177HisSer: 1.177 ± 0.034
1.138HisThr: 1.138 ± 0.034
1.647HisVal: 1.647 ± 0.04
0.293HisTrp: 0.293 ± 0.017
0.478HisTyr: 0.478 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.765IleAla: 5.765 ± 0.075
0.334IleCys: 0.334 ± 0.018
2.663IleAsp: 2.663 ± 0.055
2.466IleGlu: 2.466 ± 0.049
1.37IlePhe: 1.37 ± 0.036
4.162IleGly: 4.162 ± 0.067
0.848IleHis: 0.848 ± 0.028
1.938IleIle: 1.938 ± 0.042
1.18IleLys: 1.18 ± 0.035
3.974IleLeu: 3.974 ± 0.057
0.825IleMet: 0.825 ± 0.029
1.351IleAsn: 1.351 ± 0.036
2.443IlePro: 2.443 ± 0.051
1.266IleGln: 1.266 ± 0.034
2.877IleArg: 2.877 ± 0.052
2.83IleSer: 2.83 ± 0.053
2.78IleThr: 2.78 ± 0.042
3.611IleVal: 3.611 ± 0.063
0.519IleTrp: 0.519 ± 0.019
0.878IleTyr: 0.878 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.73LysAla: 3.73 ± 0.06
0.111LysCys: 0.111 ± 0.01
1.783LysAsp: 1.783 ± 0.048
1.484LysGlu: 1.484 ± 0.04
0.783LysPhe: 0.783 ± 0.031
2.066LysGly: 2.066 ± 0.054
0.59LysHis: 0.59 ± 0.022
1.32LysIle: 1.32 ± 0.044
1.038LysLys: 1.038 ± 0.04
2.728LysLeu: 2.728 ± 0.059
0.644LysMet: 0.644 ± 0.025
0.803LysAsn: 0.803 ± 0.024
1.69LysPro: 1.69 ± 0.042
0.914LysGln: 0.914 ± 0.028
1.741LysArg: 1.741 ± 0.037
1.717LysSer: 1.717 ± 0.047
1.664LysThr: 1.664 ± 0.041
2.372LysVal: 2.372 ± 0.047
0.323LysTrp: 0.323 ± 0.017
0.703LysTyr: 0.703 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
14.247LeuAla: 14.247 ± 0.133
0.647LeuCys: 0.647 ± 0.022
6.252LeuAsp: 6.252 ± 0.09
5.525LeuGlu: 5.525 ± 0.072
2.913LeuPhe: 2.913 ± 0.057
9.098LeuGly: 9.098 ± 0.099
2.001LeuHis: 2.001 ± 0.046
4.455LeuIle: 4.455 ± 0.076
2.853LeuLys: 2.853 ± 0.054
10.556LeuLeu: 10.556 ± 0.127
2.031LeuMet: 2.031 ± 0.046
2.702LeuAsn: 2.702 ± 0.043
5.742LeuPro: 5.742 ± 0.072
2.959LeuGln: 2.959 ± 0.056
6.743LeuArg: 6.743 ± 0.081
6.125LeuSer: 6.125 ± 0.083
6.255LeuThr: 6.255 ± 0.077
8.349LeuVal: 8.349 ± 0.098
1.227LeuTrp: 1.227 ± 0.038
1.72LeuTyr: 1.72 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.693MetAla: 2.693 ± 0.054
0.139MetCys: 0.139 ± 0.011
1.096MetAsp: 1.096 ± 0.028
0.935MetGlu: 0.935 ± 0.031
0.625MetPhe: 0.625 ± 0.024
1.626MetGly: 1.626 ± 0.041
0.375MetHis: 0.375 ± 0.017
0.915MetIle: 0.915 ± 0.029
0.651MetLys: 0.651 ± 0.023
1.984MetLeu: 1.984 ± 0.042
0.399MetMet: 0.399 ± 0.02
0.609MetAsn: 0.609 ± 0.021
1.179MetPro: 1.179 ± 0.031
0.591MetGln: 0.591 ± 0.022
1.215MetArg: 1.215 ± 0.03
1.512MetSer: 1.512 ± 0.042
1.647MetThr: 1.647 ± 0.036
1.636MetVal: 1.636 ± 0.045
0.228MetTrp: 0.228 ± 0.014
0.363MetTyr: 0.363 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.945AsnAla: 2.945 ± 0.057
0.151AsnCys: 0.151 ± 0.011
1.374AsnAsp: 1.374 ± 0.04
1.222AsnGlu: 1.222 ± 0.036
0.846AsnPhe: 0.846 ± 0.021
2.45AsnGly: 2.45 ± 0.057
0.559AsnHis: 0.559 ± 0.021
1.12AsnIle: 1.12 ± 0.034
0.695AsnLys: 0.695 ± 0.028
2.354AsnLeu: 2.354 ± 0.047
0.505AsnMet: 0.505 ± 0.02
0.739AsnAsn: 0.739 ± 0.028
1.92AsnPro: 1.92 ± 0.042
0.839AsnGln: 0.839 ± 0.032
1.617AsnArg: 1.617 ± 0.033
1.491AsnSer: 1.491 ± 0.041
1.428AsnThr: 1.428 ± 0.037
1.983AsnVal: 1.983 ± 0.045
0.39AsnTrp: 0.39 ± 0.019
0.606AsnTyr: 0.606 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
8.032ProAla: 8.032 ± 0.104
0.225ProCys: 0.225 ± 0.012
3.685ProAsp: 3.685 ± 0.057
4.012ProGlu: 4.012 ± 0.061
1.697ProPhe: 1.697 ± 0.044
5.555ProGly: 5.555 ± 0.079
1.138ProHis: 1.138 ± 0.035
1.64ProIle: 1.64 ± 0.04
1.34ProLys: 1.34 ± 0.039
4.998ProLeu: 4.998 ± 0.078
1.021ProMet: 1.021 ± 0.027
1.174ProAsn: 1.174 ± 0.033
2.257ProPro: 2.257 ± 0.055
1.702ProGln: 1.702 ± 0.038
2.879ProArg: 2.879 ± 0.065
3.237ProSer: 3.237 ± 0.056
2.816ProThr: 2.816 ± 0.055
4.989ProVal: 4.989 ± 0.056
0.795ProTrp: 0.795 ± 0.027
1.055ProTyr: 1.055 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.094GlnAla: 4.094 ± 0.064
0.164GlnCys: 0.164 ± 0.012
1.693GlnAsp: 1.693 ± 0.036
1.669GlnGlu: 1.669 ± 0.044
0.918GlnPhe: 0.918 ± 0.029
2.445GlnGly: 2.445 ± 0.043
0.762GlnHis: 0.762 ± 0.025
1.452GlnIle: 1.452 ± 0.036
0.882GlnLys: 0.882 ± 0.028
3.781GlnLeu: 3.781 ± 0.059
0.649GlnMet: 0.649 ± 0.021
0.757GlnAsn: 0.757 ± 0.026
1.845GlnPro: 1.845 ± 0.042
1.37GlnGln: 1.37 ± 0.037
2.38GlnArg: 2.38 ± 0.049
1.635GlnSer: 1.635 ± 0.039
1.582GlnThr: 1.582 ± 0.037
2.468GlnVal: 2.468 ± 0.049
0.494GlnTrp: 0.494 ± 0.019
0.702GlnTyr: 0.702 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
6.775ArgAla: 6.775 ± 0.09
0.391ArgCys: 0.391 ± 0.021
3.423ArgAsp: 3.423 ± 0.056
3.678ArgGlu: 3.678 ± 0.056
2.202ArgPhe: 2.202 ± 0.047
4.728ArgGly: 4.728 ± 0.069
1.575ArgHis: 1.575 ± 0.04
3.409ArgIle: 3.409 ± 0.058
2.029ArgLys: 2.029 ± 0.045
6.89ArgLeu: 6.89 ± 0.102
1.483ArgMet: 1.483 ± 0.035
1.799ArgAsn: 1.799 ± 0.04
3.386ArgPro: 3.386 ± 0.064
2.382ArgGln: 2.382 ± 0.042
5.299ArgArg: 5.299 ± 0.091
3.893ArgSer: 3.893 ± 0.064
3.994ArgThr: 3.994 ± 0.064
4.519ArgVal: 4.519 ± 0.066
0.996ArgTrp: 0.996 ± 0.03
1.417ArgTyr: 1.417 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
7.58SerAla: 7.58 ± 0.078
0.363SerCys: 0.363 ± 0.019
2.923SerAsp: 2.923 ± 0.047
2.884SerGlu: 2.884 ± 0.054
2.078SerPhe: 2.078 ± 0.044
6.164SerGly: 6.164 ± 0.087
1.183SerHis: 1.183 ± 0.033
2.472SerIle: 2.472 ± 0.048
1.525SerLys: 1.525 ± 0.039
5.92SerLeu: 5.92 ± 0.074
1.359SerMet: 1.359 ± 0.032
1.421SerAsn: 1.421 ± 0.041
3.375SerPro: 3.375 ± 0.053
1.79SerGln: 1.79 ± 0.036
3.843SerArg: 3.843 ± 0.06
3.679SerSer: 3.679 ± 0.066
3.647SerThr: 3.647 ± 0.062
4.92SerVal: 4.92 ± 0.072
0.924SerTrp: 0.924 ± 0.029
1.429SerTyr: 1.429 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
8.094ThrAla: 8.094 ± 0.09
0.329ThrCys: 0.329 ± 0.018
3.284ThrAsp: 3.284 ± 0.054
3.097ThrGlu: 3.097 ± 0.057
1.926ThrPhe: 1.926 ± 0.043
5.939ThrGly: 5.939 ± 0.083
1.154ThrHis: 1.154 ± 0.033
2.563ThrIle: 2.563 ± 0.051
1.484ThrLys: 1.484 ± 0.037
5.716ThrLeu: 5.716 ± 0.067
1.115ThrMet: 1.115 ± 0.031
1.368ThrAsn: 1.368 ± 0.037
3.651ThrPro: 3.651 ± 0.061
1.557ThrGln: 1.557 ± 0.041
3.146ThrArg: 3.146 ± 0.048
3.496ThrSer: 3.496 ± 0.064
3.632ThrThr: 3.632 ± 0.065
5.604ThrVal: 5.604 ± 0.073
0.766ThrTrp: 0.766 ± 0.026
1.179ThrTyr: 1.179 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
10.283ValAla: 10.283 ± 0.115
0.565ValCys: 0.565 ± 0.024
4.94ValAsp: 4.94 ± 0.062
4.688ValGlu: 4.688 ± 0.074
2.691ValPhe: 2.691 ± 0.046
6.498ValGly: 6.498 ± 0.082
1.697ValHis: 1.697 ± 0.04
3.947ValIle: 3.947 ± 0.059
2.114ValLys: 2.114 ± 0.05
9.235ValLeu: 9.235 ± 0.115
1.743ValMet: 1.743 ± 0.039
2.039ValAsn: 2.039 ± 0.047
4.771ValPro: 4.771 ± 0.075
2.439ValGln: 2.439 ± 0.049
5.293ValArg: 5.293 ± 0.077
5.093ValSer: 5.093 ± 0.066
5.141ValThr: 5.141 ± 0.064
7.873ValVal: 7.873 ± 0.096
1.034ValTrp: 1.034 ± 0.028
1.483ValTyr: 1.483 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.432TrpAla: 1.432 ± 0.038
0.109TrpCys: 0.109 ± 0.008
0.781TrpAsp: 0.781 ± 0.028
0.677TrpGlu: 0.677 ± 0.022
0.547TrpPhe: 0.547 ± 0.024
0.975TrpGly: 0.975 ± 0.032
0.299TrpHis: 0.299 ± 0.017
0.707TrpIle: 0.707 ± 0.027
0.44TrpLys: 0.44 ± 0.019
1.768TrpLeu: 1.768 ± 0.045
0.349TrpMet: 0.349 ± 0.017
0.459TrpAsn: 0.459 ± 0.02
0.684TrpPro: 0.684 ± 0.026
0.584TrpGln: 0.584 ± 0.022
0.933TrpArg: 0.933 ± 0.029
0.869TrpSer: 0.869 ± 0.023
0.87TrpThr: 0.87 ± 0.028
1.037TrpVal: 1.037 ± 0.031
0.275TrpTrp: 0.275 ± 0.015
0.28TrpTyr: 0.28 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.361TyrAla: 2.361 ± 0.047
0.16TyrCys: 0.16 ± 0.013
1.191TyrAsp: 1.191 ± 0.033
1.083TyrGlu: 1.083 ± 0.027
0.856TyrPhe: 0.856 ± 0.029
2.045TyrGly: 2.045 ± 0.038
0.347TyrHis: 0.347 ± 0.016
0.741TyrIle: 0.741 ± 0.027
0.538TyrLys: 0.538 ± 0.021
2.198TyrLeu: 2.198 ± 0.045
0.343TyrMet: 0.343 ± 0.016
0.579TyrAsn: 0.579 ± 0.023
1.103TyrPro: 1.103 ± 0.033
0.663TyrGln: 0.663 ± 0.023
1.505TyrArg: 1.505 ± 0.032
1.334TyrSer: 1.334 ± 0.033
1.139TyrThr: 1.139 ± 0.031
1.664TyrVal: 1.664 ± 0.035
0.317TyrTrp: 0.317 ± 0.016
0.527TyrTyr: 0.527 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3663 proteins (1169135 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski