Amino acid dipepetide frequency for Pontivivens insulae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.543AlaAla: 16.543 ± 0.171	1.097AlaCys: 1.097 ± 0.032	7.796AlaAsp: 7.796 ± 0.107	8.549AlaGlu: 8.549 ± 0.133	4.437AlaPhe: 4.437 ± 0.074	10.378AlaGly: 10.378 ± 0.138	2.462AlaHis: 2.462 ± 0.062	6.198AlaIle: 6.198 ± 0.079	3.447AlaLys: 3.447 ± 0.061	13.941AlaLeu: 13.941 ± 0.144	3.835AlaMet: 3.835 ± 0.058	2.941AlaAsn: 2.941 ± 0.057	5.633AlaPro: 5.633 ± 0.092	4.771AlaGln: 4.771 ± 0.068	8.783AlaArg: 8.783 ± 0.121	5.741AlaSer: 5.741 ± 0.078	6.179AlaThr: 6.179 ± 0.109	8.312AlaVal: 8.312 ± 0.098	1.445AlaTrp: 1.445 ± 0.036	2.478AlaTyr: 2.478 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.12CysAla: 1.12 ± 0.039	0.115CysCys: 0.115 ± 0.01	0.625CysAsp: 0.625 ± 0.027	0.496CysGlu: 0.496 ± 0.024	0.385CysPhe: 0.385 ± 0.019	0.953CysGly: 0.953 ± 0.035	0.257CysHis: 0.257 ± 0.018	0.42CysIle: 0.42 ± 0.021	0.187CysLys: 0.187 ± 0.013	0.828CysLeu: 0.828 ± 0.028	0.17CysMet: 0.17 ± 0.012	0.225CysAsn: 0.225 ± 0.016	0.497CysPro: 0.497 ± 0.025	0.224CysGln: 0.224 ± 0.015	0.514CysArg: 0.514 ± 0.021	0.484CysSer: 0.484 ± 0.024	0.467CysThr: 0.467 ± 0.023	0.653CysVal: 0.653 ± 0.028	0.123CysTrp: 0.123 ± 0.011	0.208CysTyr: 0.208 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.017AspAla: 8.017 ± 0.102	0.476AspCys: 0.476 ± 0.023	3.525AspAsp: 3.525 ± 0.091	3.684AspGlu: 3.684 ± 0.065	2.218AspPhe: 2.218 ± 0.047	6.017AspGly: 6.017 ± 0.116	1.412AspHis: 1.412 ± 0.035	3.19AspIle: 3.19 ± 0.056	1.361AspLys: 1.361 ± 0.04	6.678AspLeu: 6.678 ± 0.101	1.768AspMet: 1.768 ± 0.042	1.315AspAsn: 1.315 ± 0.043	3.647AspPro: 3.647 ± 0.056	2.046AspGln: 2.046 ± 0.041	4.33AspArg: 4.33 ± 0.058	2.113AspSer: 2.113 ± 0.044	2.967AspThr: 2.967 ± 0.079	4.767AspVal: 4.767 ± 0.074	1.23AspTrp: 1.23 ± 0.043	1.585AspTyr: 1.585 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.278GluAla: 8.278 ± 0.123	0.364GluCys: 0.364 ± 0.016	3.416GluAsp: 3.416 ± 0.056	3.697GluGlu: 3.697 ± 0.079	1.796GluPhe: 1.796 ± 0.042	4.981GluGly: 4.981 ± 0.081	1.217GluHis: 1.217 ± 0.033	3.616GluIle: 3.616 ± 0.061	1.904GluLys: 1.904 ± 0.05	5.551GluLeu: 5.551 ± 0.077	1.905GluMet: 1.905 ± 0.044	1.683GluAsn: 1.683 ± 0.044	2.658GluPro: 2.658 ± 0.072	2.363GluGln: 2.363 ± 0.053	4.713GluArg: 4.713 ± 0.084	2.22GluSer: 2.22 ± 0.052	3.769GluThr: 3.769 ± 0.061	4.422GluVal: 4.422 ± 0.066	0.787GluTrp: 0.787 ± 0.03	1.034GluTyr: 1.034 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.804PheAla: 4.804 ± 0.081	0.446PheCys: 0.446 ± 0.02	2.87PheAsp: 2.87 ± 0.05	2.48PheGlu: 2.48 ± 0.045	1.422PhePhe: 1.422 ± 0.041	3.681PheGly: 3.681 ± 0.063	0.721PheHis: 0.721 ± 0.025	1.682PheIle: 1.682 ± 0.044	0.816PheLys: 0.816 ± 0.03	3.313PheLeu: 3.313 ± 0.07	0.829PheMet: 0.829 ± 0.025	1.012PheAsn: 1.012 ± 0.034	1.516PhePro: 1.516 ± 0.037	1.01PheGln: 1.01 ± 0.03	2.056PheArg: 2.056 ± 0.045	2.126PheSer: 2.126 ± 0.047	2.183PheThr: 2.183 ± 0.056	2.727PheVal: 2.727 ± 0.05	0.597PheTrp: 0.597 ± 0.025	0.886PheTyr: 0.886 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.992GlyAla: 9.992 ± 0.108	0.881GlyCys: 0.881 ± 0.03	4.741GlyAsp: 4.741 ± 0.12	4.992GlyGlu: 4.992 ± 0.073	3.61GlyPhe: 3.61 ± 0.057	7.465GlyGly: 7.465 ± 0.133	1.907GlyHis: 1.907 ± 0.054	4.442GlyIle: 4.442 ± 0.061	2.735GlyLys: 2.735 ± 0.06	9.111GlyLeu: 9.111 ± 0.109	2.573GlyMet: 2.573 ± 0.053	2.08GlyAsn: 2.08 ± 0.065	3.752GlyPro: 3.752 ± 0.063	3.412GlyGln: 3.412 ± 0.056	5.599GlyArg: 5.599 ± 0.085	4.353GlySer: 4.353 ± 0.086	4.875GlyThr: 4.875 ± 0.104	6.425GlyVal: 6.425 ± 0.086	1.515GlyTrp: 1.515 ± 0.044	2.194GlyTyr: 2.194 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.358HisAla: 2.358 ± 0.053	0.245HisCys: 0.245 ± 0.015	1.292HisAsp: 1.292 ± 0.04	1.018HisGlu: 1.018 ± 0.033	0.824HisPhe: 0.824 ± 0.029	1.932HisGly: 1.932 ± 0.047	0.549HisHis: 0.549 ± 0.024	1.04HisIle: 1.04 ± 0.034	0.5HisLys: 0.5 ± 0.021	2.114HisLeu: 2.114 ± 0.047	0.582HisMet: 0.582 ± 0.024	0.448HisAsn: 0.448 ± 0.022	1.325HisPro: 1.325 ± 0.041	0.612HisGln: 0.612 ± 0.024	1.342HisArg: 1.342 ± 0.042	0.902HisSer: 0.902 ± 0.031	0.85HisThr: 0.85 ± 0.029	1.568HisVal: 1.568 ± 0.041	0.359HisTrp: 0.359 ± 0.019	0.543HisTyr: 0.543 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.661IleAla: 7.661 ± 0.101	0.647IleCys: 0.647 ± 0.023	3.425IleAsp: 3.425 ± 0.062	3.642IleGlu: 3.642 ± 0.054	1.818IlePhe: 1.818 ± 0.053	5.02IleGly: 5.02 ± 0.071	0.943IleHis: 0.943 ± 0.028	2.341IleIle: 2.341 ± 0.051	1.251IleLys: 1.251 ± 0.039	4.754IleLeu: 4.754 ± 0.075	1.118IleMet: 1.118 ± 0.036	1.387IleAsn: 1.387 ± 0.043	2.344IlePro: 2.344 ± 0.057	1.225IleGln: 1.225 ± 0.033	3.078IleArg: 3.078 ± 0.054	3.075IleSer: 3.075 ± 0.056	2.964IleThr: 2.964 ± 0.065	4.105IleVal: 4.105 ± 0.075	0.777IleTrp: 0.777 ± 0.031	1.152IleTyr: 1.152 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.419LysAla: 3.419 ± 0.069	0.174LysCys: 0.174 ± 0.013	1.469LysAsp: 1.469 ± 0.045	1.324LysGlu: 1.324 ± 0.043	0.87LysPhe: 0.87 ± 0.028	2.33LysGly: 2.33 ± 0.053	0.545LysHis: 0.545 ± 0.024	1.457LysIle: 1.457 ± 0.036	0.957LysLys: 0.957 ± 0.036	2.69LysLeu: 2.69 ± 0.057	0.768LysMet: 0.768 ± 0.03	0.646LysAsn: 0.646 ± 0.03	1.547LysPro: 1.547 ± 0.042	0.799LysGln: 0.799 ± 0.031	2.054LysArg: 2.054 ± 0.055	1.611LysSer: 1.611 ± 0.045	1.648LysThr: 1.648 ± 0.042	2.111LysVal: 2.111 ± 0.058	0.355LysTrp: 0.355 ± 0.018	0.565LysTyr: 0.565 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.743LeuAla: 12.743 ± 0.135	0.983LeuCys: 0.983 ± 0.034	6.616LeuAsp: 6.616 ± 0.1	5.588LeuGlu: 5.588 ± 0.073	3.603LeuPhe: 3.603 ± 0.055	8.247LeuGly: 8.247 ± 0.097	1.933LeuHis: 1.933 ± 0.045	5.67LeuIle: 5.67 ± 0.097	2.848LeuLys: 2.848 ± 0.055	8.716LeuLeu: 8.716 ± 0.124	2.731LeuMet: 2.731 ± 0.055	2.92LeuAsn: 2.92 ± 0.054	5.333LeuPro: 5.333 ± 0.075	2.653LeuGln: 2.653 ± 0.049	6.963LeuArg: 6.963 ± 0.096	6.69LeuSer: 6.69 ± 0.093	6.198LeuThr: 6.198 ± 0.097	6.533LeuVal: 6.533 ± 0.092	1.25LeuTrp: 1.25 ± 0.037	1.992LeuTyr: 1.992 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.386MetAla: 3.386 ± 0.057	0.19MetCys: 0.19 ± 0.015	1.433MetAsp: 1.433 ± 0.044	1.516MetGlu: 1.516 ± 0.041	0.85MetPhe: 0.85 ± 0.026	2.359MetGly: 2.359 ± 0.051	0.468MetHis: 0.468 ± 0.022	1.556MetIle: 1.556 ± 0.042	0.964MetLys: 0.964 ± 0.035	2.751MetLeu: 2.751 ± 0.049	0.782MetMet: 0.782 ± 0.032	0.799MetAsn: 0.799 ± 0.031	1.415MetPro: 1.415 ± 0.035	0.962MetGln: 0.962 ± 0.03	2.077MetArg: 2.077 ± 0.044	1.931MetSer: 1.931 ± 0.037	2.038MetThr: 2.038 ± 0.044	1.85MetVal: 1.85 ± 0.04	0.269MetTrp: 0.269 ± 0.017	0.321MetTyr: 0.321 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.352AsnAla: 3.352 ± 0.063	0.265AsnCys: 0.265 ± 0.017	1.504AsnAsp: 1.504 ± 0.055	1.238AsnGlu: 1.238 ± 0.041	0.953AsnPhe: 0.953 ± 0.033	2.505AsnGly: 2.505 ± 0.058	0.513AsnHis: 0.513 ± 0.022	1.4AsnIle: 1.4 ± 0.033	0.601AsnLys: 0.601 ± 0.026	2.501AsnLeu: 2.501 ± 0.055	0.696AsnMet: 0.696 ± 0.026	0.665AsnAsn: 0.665 ± 0.025	1.78AsnPro: 1.78 ± 0.042	0.696AsnGln: 0.696 ± 0.025	1.744AsnArg: 1.744 ± 0.043	1.221AsnSer: 1.221 ± 0.03	1.288AsnThr: 1.288 ± 0.034	1.935AsnVal: 1.935 ± 0.045	0.445AsnTrp: 0.445 ± 0.021	0.675AsnTyr: 0.675 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.422ProAla: 5.422 ± 0.078	0.336ProCys: 0.336 ± 0.019	3.977ProAsp: 3.977 ± 0.071	3.789ProGlu: 3.789 ± 0.064	1.971ProPhe: 1.971 ± 0.041	4.217ProGly: 4.217 ± 0.066	1.09ProHis: 1.09 ± 0.034	2.388ProIle: 2.388 ± 0.047	1.361ProLys: 1.361 ± 0.039	4.658ProLeu: 4.658 ± 0.067	1.301ProMet: 1.301 ± 0.042	1.411ProAsn: 1.411 ± 0.037	2.105ProPro: 2.105 ± 0.053	1.677ProGln: 1.677 ± 0.041	2.789ProArg: 2.789 ± 0.057	2.531ProSer: 2.531 ± 0.046	2.554ProThr: 2.554 ± 0.052	4.235ProVal: 4.235 ± 0.063	0.654ProTrp: 0.654 ± 0.026	1.114ProTyr: 1.114 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.009GlnAla: 4.009 ± 0.067	0.237GlnCys: 0.237 ± 0.017	1.855GlnAsp: 1.855 ± 0.045	1.626GlnGlu: 1.626 ± 0.043	1.166GlnPhe: 1.166 ± 0.032	2.586GlnGly: 2.586 ± 0.046	0.617GlnHis: 0.617 ± 0.027	2.129GlnIle: 2.129 ± 0.053	0.912GlnLys: 0.912 ± 0.033	2.948GlnLeu: 2.948 ± 0.062	1.17GlnMet: 1.17 ± 0.033	0.958GlnAsn: 0.958 ± 0.027	1.702GlnPro: 1.702 ± 0.04	1.135GlnGln: 1.135 ± 0.039	2.282GlnArg: 2.282 ± 0.051	1.947GlnSer: 1.947 ± 0.048	1.961GlnThr: 1.961 ± 0.039	2.436GlnVal: 2.436 ± 0.046	0.403GlnTrp: 0.403 ± 0.021	0.572GlnTyr: 0.572 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.343ArgAla: 8.343 ± 0.104	0.509ArgCys: 0.509 ± 0.026	4.433ArgAsp: 4.433 ± 0.068	3.855ArgGlu: 3.855 ± 0.079	2.692ArgPhe: 2.692 ± 0.051	4.623ArgGly: 4.623 ± 0.071	1.385ArgHis: 1.385 ± 0.039	3.825ArgIle: 3.825 ± 0.069	2.06ArgLys: 2.06 ± 0.049	7.027ArgLeu: 7.027 ± 0.107	2.069ArgMet: 2.069 ± 0.043	1.802ArgAsn: 1.802 ± 0.037	3.318ArgPro: 3.318 ± 0.078	2.292ArgGln: 2.292 ± 0.051	4.763ArgArg: 4.763 ± 0.088	3.276ArgSer: 3.276 ± 0.054	3.36ArgThr: 3.36 ± 0.061	4.753ArgVal: 4.753 ± 0.061	0.956ArgTrp: 0.956 ± 0.028	1.512ArgTyr: 1.512 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.127SerAla: 6.127 ± 0.081	0.471SerCys: 0.471 ± 0.021	3.438SerAsp: 3.438 ± 0.065	2.909SerGlu: 2.909 ± 0.055	2.26SerPhe: 2.26 ± 0.05	5.489SerGly: 5.489 ± 0.084	1.037SerHis: 1.037 ± 0.035	2.706SerIle: 2.706 ± 0.059	1.349SerLys: 1.349 ± 0.037	4.918SerLeu: 4.918 ± 0.085	1.329SerMet: 1.329 ± 0.041	1.363SerAsn: 1.363 ± 0.039	2.353SerPro: 2.353 ± 0.052	1.605SerGln: 1.605 ± 0.041	3.229SerArg: 3.229 ± 0.065	2.57SerSer: 2.57 ± 0.053	2.675SerThr: 2.675 ± 0.049	3.895SerVal: 3.895 ± 0.057	0.728SerTrp: 0.728 ± 0.031	1.282SerTyr: 1.282 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.478ThrAla: 6.478 ± 0.094	0.524ThrCys: 0.524 ± 0.024	3.335ThrAsp: 3.335 ± 0.075	2.977ThrGlu: 2.977 ± 0.053	2.149ThrPhe: 2.149 ± 0.053	5.347ThrGly: 5.347 ± 0.104	1.139ThrHis: 1.139 ± 0.028	2.843ThrIle: 2.843 ± 0.061	1.35ThrLys: 1.35 ± 0.033	6.268ThrLeu: 6.268 ± 0.1	1.289ThrMet: 1.289 ± 0.038	1.353ThrAsn: 1.353 ± 0.039	3.295ThrPro: 3.295 ± 0.058	1.631ThrGln: 1.631 ± 0.041	3.426ThrArg: 3.426 ± 0.055	2.761ThrSer: 2.761 ± 0.057	2.833ThrThr: 2.833 ± 0.075	4.471ThrVal: 4.471 ± 0.088	0.681ThrTrp: 0.681 ± 0.027	1.262ThrTyr: 1.262 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.012ValAla: 9.012 ± 0.1	0.606ValCys: 0.606 ± 0.025	4.211ValAsp: 4.211 ± 0.068	5.077ValGlu: 5.077 ± 0.076	2.659ValPhe: 2.659 ± 0.057	5.521ValGly: 5.521 ± 0.069	1.364ValHis: 1.364 ± 0.036	4.14ValIle: 4.14 ± 0.062	1.903ValLys: 1.903 ± 0.05	7.632ValLeu: 7.632 ± 0.083	2.116ValMet: 2.116 ± 0.045	1.964ValAsn: 1.964 ± 0.043	3.606ValPro: 3.606 ± 0.056	2.178ValGln: 2.178 ± 0.048	4.48ValArg: 4.48 ± 0.058	4.259ValSer: 4.259 ± 0.074	4.62ValThr: 4.62 ± 0.081	5.423ValVal: 5.423 ± 0.083	0.936ValTrp: 0.936 ± 0.032	1.35ValTyr: 1.35 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.43TrpAla: 1.43 ± 0.04	0.149TrpCys: 0.149 ± 0.012	0.776TrpAsp: 0.776 ± 0.026	0.65TrpGlu: 0.65 ± 0.026	0.59TrpPhe: 0.59 ± 0.027	0.973TrpGly: 0.973 ± 0.031	0.354TrpHis: 0.354 ± 0.019	0.733TrpIle: 0.733 ± 0.031	0.375TrpLys: 0.375 ± 0.02	1.674TrpLeu: 1.674 ± 0.049	0.437TrpMet: 0.437 ± 0.022	0.436TrpAsn: 0.436 ± 0.02	0.724TrpPro: 0.724 ± 0.029	0.658TrpGln: 0.658 ± 0.025	1.099TrpArg: 1.099 ± 0.034	0.823TrpSer: 0.823 ± 0.027	0.818TrpThr: 0.818 ± 0.028	0.907TrpVal: 0.907 ± 0.032	0.254TrpTrp: 0.254 ± 0.018	0.265TrpTyr: 0.265 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.476TyrAla: 2.476 ± 0.05	0.235TyrCys: 0.235 ± 0.015	1.611TyrAsp: 1.611 ± 0.04	1.265TyrGlu: 1.265 ± 0.038	0.904TyrPhe: 0.904 ± 0.031	2.029TyrGly: 2.029 ± 0.048	0.489TyrHis: 0.489 ± 0.02	0.951TyrIle: 0.951 ± 0.031	0.459TyrLys: 0.459 ± 0.022	2.134TyrLeu: 2.134 ± 0.051	0.447TyrMet: 0.447 ± 0.021	0.567TyrAsn: 0.567 ± 0.025	1.031TyrPro: 1.031 ± 0.029	0.704TyrGln: 0.704 ± 0.025	1.533TyrArg: 1.533 ± 0.04	1.096TyrSer: 1.096 ± 0.029	1.165TyrThr: 1.165 ± 0.032	1.529TyrVal: 1.529 ± 0.039	0.364TyrTrp: 0.364 ± 0.018	0.552TyrTyr: 0.552 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3498 proteins (1084088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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