Amino acid dipepetide frequency for Elizabethkingia anophelis NUHP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.331AlaAla: 4.331 ± 0.071	0.488AlaCys: 0.488 ± 0.02	3.418AlaAsp: 3.418 ± 0.048	4.276AlaGlu: 4.276 ± 0.067	3.148AlaPhe: 3.148 ± 0.057	4.362AlaGly: 4.362 ± 0.071	0.993AlaHis: 0.993 ± 0.031	4.927AlaIle: 4.927 ± 0.074	4.949AlaLys: 4.949 ± 0.074	6.02AlaLeu: 6.02 ± 0.073	1.508AlaMet: 1.508 ± 0.039	3.292AlaAsn: 3.292 ± 0.057	1.901AlaPro: 1.901 ± 0.041	2.582AlaGln: 2.582 ± 0.038	2.0AlaArg: 2.0 ± 0.051	3.996AlaSer: 3.996 ± 0.07	3.39AlaThr: 3.39 ± 0.052	4.12AlaVal: 4.12 ± 0.056	0.626AlaTrp: 0.626 ± 0.027	2.729AlaTyr: 2.729 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.386CysAla: 0.386 ± 0.019	0.107CysCys: 0.107 ± 0.01	0.36CysAsp: 0.36 ± 0.017	0.36CysGlu: 0.36 ± 0.017	0.414CysPhe: 0.414 ± 0.018	0.572CysGly: 0.572 ± 0.024	0.154CysHis: 0.154 ± 0.013	0.666CysIle: 0.666 ± 0.028	0.431CysLys: 0.431 ± 0.019	0.628CysLeu: 0.628 ± 0.023	0.155CysMet: 0.155 ± 0.011	0.397CysAsn: 0.397 ± 0.017	0.301CysPro: 0.301 ± 0.019	0.2CysGln: 0.2 ± 0.014	0.265CysArg: 0.265 ± 0.015	0.509CysSer: 0.509 ± 0.02	0.357CysThr: 0.357 ± 0.017	0.382CysVal: 0.382 ± 0.017	0.053CysTrp: 0.053 ± 0.006	0.287CysTyr: 0.287 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.395AspAla: 3.395 ± 0.052	0.343AspCys: 0.343 ± 0.017	2.477AspAsp: 2.477 ± 0.059	3.603AspGlu: 3.603 ± 0.068	3.565AspPhe: 3.565 ± 0.053	3.303AspGly: 3.303 ± 0.052	0.904AspHis: 0.904 ± 0.027	4.536AspIle: 4.536 ± 0.059	4.704AspLys: 4.704 ± 0.07	5.006AspLeu: 5.006 ± 0.062	1.169AspMet: 1.169 ± 0.032	3.122AspAsn: 3.122 ± 0.042	1.811AspPro: 1.811 ± 0.039	1.783AspGln: 1.783 ± 0.037	1.903AspArg: 1.903 ± 0.039	2.881AspSer: 2.881 ± 0.054	2.372AspThr: 2.372 ± 0.043	3.124AspVal: 3.124 ± 0.047	0.774AspTrp: 0.774 ± 0.024	2.864AspTyr: 2.864 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.132GluAla: 4.132 ± 0.067	0.356GluCys: 0.356 ± 0.018	3.304GluAsp: 3.304 ± 0.061	4.859GluGlu: 4.859 ± 0.093	2.863GluPhe: 2.863 ± 0.049	3.52GluGly: 3.52 ± 0.059	1.064GluHis: 1.064 ± 0.031	5.526GluIle: 5.526 ± 0.079	6.663GluLys: 6.663 ± 0.085	5.807GluLeu: 5.807 ± 0.067	1.604GluMet: 1.604 ± 0.043	4.81GluAsn: 4.81 ± 0.063	1.422GluPro: 1.422 ± 0.035	2.49GluGln: 2.49 ± 0.048	2.487GluArg: 2.487 ± 0.047	3.265GluSer: 3.265 ± 0.05	3.333GluThr: 3.333 ± 0.048	4.039GluVal: 4.039 ± 0.067	0.707GluTrp: 0.707 ± 0.021	2.738GluTyr: 2.738 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.091PheAla: 3.091 ± 0.051	0.445PheCys: 0.445 ± 0.017	2.939PheAsp: 2.939 ± 0.048	2.894PheGlu: 2.894 ± 0.054	2.861PhePhe: 2.861 ± 0.057	3.567PheGly: 3.567 ± 0.055	0.898PheHis: 0.898 ± 0.032	4.177PheIle: 4.177 ± 0.073	3.383PheLys: 3.383 ± 0.055	4.751PheLeu: 4.751 ± 0.076	1.266PheMet: 1.266 ± 0.03	3.269PheAsn: 3.269 ± 0.057	1.852PhePro: 1.852 ± 0.038	1.665PheGln: 1.665 ± 0.037	2.027PheArg: 2.027 ± 0.041	4.154PheSer: 4.154 ± 0.068	2.949PheThr: 2.949 ± 0.047	2.941PheVal: 2.941 ± 0.051	0.608PheTrp: 0.608 ± 0.023	2.37PheTyr: 2.37 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.051GlyAla: 4.051 ± 0.074	0.463GlyCys: 0.463 ± 0.023	3.037GlyAsp: 3.037 ± 0.052	3.512GlyGlu: 3.512 ± 0.051	3.539GlyPhe: 3.539 ± 0.051	4.556GlyGly: 4.556 ± 0.069	1.009GlyHis: 1.009 ± 0.029	5.538GlyIle: 5.538 ± 0.072	5.63GlyLys: 5.63 ± 0.069	5.552GlyLeu: 5.552 ± 0.074	1.658GlyMet: 1.658 ± 0.038	3.954GlyAsn: 3.954 ± 0.064	1.174GlyPro: 1.174 ± 0.028	2.08GlyGln: 2.08 ± 0.046	2.194GlyArg: 2.194 ± 0.036	4.006GlySer: 4.006 ± 0.056	3.701GlyThr: 3.701 ± 0.059	4.129GlyVal: 4.129 ± 0.065	0.853GlyTrp: 0.853 ± 0.027	3.06GlyTyr: 3.06 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	0.879HisAla: 0.879 ± 0.029	0.16HisCys: 0.16 ± 0.013	0.77HisAsp: 0.77 ± 0.026	0.907HisGlu: 0.907 ± 0.027	1.03HisPhe: 1.03 ± 0.03	0.97HisGly: 0.97 ± 0.031	0.486HisHis: 0.486 ± 0.023	1.358HisIle: 1.358 ± 0.035	1.166HisLys: 1.166 ± 0.026	1.625HisLeu: 1.625 ± 0.042	0.311HisMet: 0.311 ± 0.017	0.964HisAsn: 0.964 ± 0.029	0.839HisPro: 0.839 ± 0.027	0.746HisGln: 0.746 ± 0.026	0.676HisArg: 0.676 ± 0.022	1.057HisSer: 1.057 ± 0.027	0.889HisThr: 0.889 ± 0.027	0.723HisVal: 0.723 ± 0.025	0.237HisTrp: 0.237 ± 0.015	0.867HisTyr: 0.867 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.447IleAla: 5.447 ± 0.077	0.623IleCys: 0.623 ± 0.022	4.364IleAsp: 4.364 ± 0.063	5.059IleGlu: 5.059 ± 0.068	3.849IlePhe: 3.849 ± 0.064	4.911IleGly: 4.911 ± 0.075	1.375IleHis: 1.375 ± 0.034	6.297IleIle: 6.297 ± 0.094	6.07IleLys: 6.07 ± 0.08	7.21IleLeu: 7.21 ± 0.092	1.508IleMet: 1.508 ± 0.035	4.881IleAsn: 4.881 ± 0.068	3.396IlePro: 3.396 ± 0.056	2.769IleGln: 2.769 ± 0.051	2.764IleArg: 2.764 ± 0.05	5.992IleSer: 5.992 ± 0.077	4.565IleThr: 4.565 ± 0.08	4.394IleVal: 4.394 ± 0.068	0.721IleTrp: 0.721 ± 0.023	2.977IleTyr: 2.977 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.247LysAla: 5.247 ± 0.073	0.34LysCys: 0.34 ± 0.016	5.209LysAsp: 5.209 ± 0.067	6.578LysGlu: 6.578 ± 0.085	3.348LysPhe: 3.348 ± 0.055	4.764LysGly: 4.764 ± 0.06	1.325LysHis: 1.325 ± 0.032	6.805LysIle: 6.805 ± 0.079	7.466LysLys: 7.466 ± 0.099	6.817LysLeu: 6.817 ± 0.073	2.303LysMet: 2.303 ± 0.044	6.027LysAsn: 6.027 ± 0.069	2.683LysPro: 2.683 ± 0.055	2.917LysGln: 2.917 ± 0.05	2.739LysArg: 2.739 ± 0.049	4.746LysSer: 4.746 ± 0.059	4.81LysThr: 4.81 ± 0.068	4.704LysVal: 4.704 ± 0.067	0.838LysTrp: 0.838 ± 0.027	3.594LysTyr: 3.594 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.65LeuAla: 5.65 ± 0.072	0.704LeuCys: 0.704 ± 0.024	4.653LeuAsp: 4.653 ± 0.066	5.502LeuGlu: 5.502 ± 0.077	4.798LeuPhe: 4.798 ± 0.069	5.8LeuGly: 5.8 ± 0.072	1.541LeuHis: 1.541 ± 0.036	6.613LeuIle: 6.613 ± 0.088	7.841LeuLys: 7.841 ± 0.077	8.516LeuLeu: 8.516 ± 0.108	2.233LeuMet: 2.233 ± 0.049	5.58LeuAsn: 5.58 ± 0.08	3.643LeuPro: 3.643 ± 0.059	3.592LeuGln: 3.592 ± 0.061	3.229LeuArg: 3.229 ± 0.054	6.813LeuSer: 6.813 ± 0.067	4.849LeuThr: 4.849 ± 0.066	4.874LeuVal: 4.874 ± 0.075	0.868LeuTrp: 0.868 ± 0.028	3.432LeuTyr: 3.432 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.615MetAla: 1.615 ± 0.038	0.126MetCys: 0.126 ± 0.011	1.226MetAsp: 1.226 ± 0.037	1.522MetGlu: 1.522 ± 0.034	0.865MetPhe: 0.865 ± 0.027	1.478MetGly: 1.478 ± 0.034	0.363MetHis: 0.363 ± 0.018	1.627MetIle: 1.627 ± 0.035	2.614MetLys: 2.614 ± 0.047	2.163MetLeu: 2.163 ± 0.037	0.715MetMet: 0.715 ± 0.025	1.492MetAsn: 1.492 ± 0.039	0.922MetPro: 0.922 ± 0.025	0.863MetGln: 0.863 ± 0.026	0.865MetArg: 0.865 ± 0.029	1.38MetSer: 1.38 ± 0.029	1.158MetThr: 1.158 ± 0.031	1.375MetVal: 1.375 ± 0.038	0.184MetTrp: 0.184 ± 0.013	0.769MetTyr: 0.769 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.854AsnAla: 3.854 ± 0.062	0.385AsnCys: 0.385 ± 0.016	3.084AsnAsp: 3.084 ± 0.051	3.532AsnGlu: 3.532 ± 0.058	3.378AsnPhe: 3.378 ± 0.056	4.075AsnGly: 4.075 ± 0.058	0.971AsnHis: 0.971 ± 0.028	5.555AsnIle: 5.555 ± 0.069	4.748AsnLys: 4.748 ± 0.068	5.543AsnLeu: 5.543 ± 0.08	1.339AsnMet: 1.339 ± 0.033	4.256AsnAsn: 4.256 ± 0.069	2.945AsnPro: 2.945 ± 0.044	2.292AsnGln: 2.292 ± 0.043	2.248AsnArg: 2.248 ± 0.042	3.897AsnSer: 3.897 ± 0.064	3.676AsnThr: 3.676 ± 0.059	3.274AsnVal: 3.274 ± 0.054	0.781AsnTrp: 0.781 ± 0.027	3.108AsnTyr: 3.108 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.185ProAla: 2.185 ± 0.035	0.201ProCys: 0.201 ± 0.013	2.191ProAsp: 2.191 ± 0.036	3.189ProGlu: 3.189 ± 0.056	1.875ProPhe: 1.875 ± 0.039	2.079ProGly: 2.079 ± 0.039	0.56ProHis: 0.56 ± 0.02	2.281ProIle: 2.281 ± 0.044	2.716ProLys: 2.716 ± 0.061	2.914ProLeu: 2.914 ± 0.055	0.762ProMet: 0.762 ± 0.025	1.956ProAsn: 1.956 ± 0.041	0.84ProPro: 0.84 ± 0.033	1.38ProGln: 1.38 ± 0.032	0.957ProArg: 0.957 ± 0.028	2.065ProSer: 2.065 ± 0.037	1.78ProThr: 1.78 ± 0.038	2.77ProVal: 2.77 ± 0.044	0.332ProTrp: 0.332 ± 0.014	1.522ProTyr: 1.522 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.177GlnAla: 2.177 ± 0.041	0.172GlnCys: 0.172 ± 0.012	1.829GlnAsp: 1.829 ± 0.035	2.457GlnGlu: 2.457 ± 0.049	1.625GlnPhe: 1.625 ± 0.036	1.862GlnGly: 1.862 ± 0.041	0.671GlnHis: 0.671 ± 0.022	2.752GlnIle: 2.752 ± 0.044	3.666GlnLys: 3.666 ± 0.056	3.446GlnLeu: 3.446 ± 0.055	0.939GlnMet: 0.939 ± 0.027	2.747GlnAsn: 2.747 ± 0.049	1.12GlnPro: 1.12 ± 0.029	1.886GlnGln: 1.886 ± 0.047	1.326GlnArg: 1.326 ± 0.03	2.136GlnSer: 2.136 ± 0.044	1.934GlnThr: 1.934 ± 0.039	1.936GlnVal: 1.936 ± 0.039	0.433GlnTrp: 0.433 ± 0.018	1.792GlnTyr: 1.792 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.951ArgAla: 1.951 ± 0.041	0.201ArgCys: 0.201 ± 0.013	1.765ArgAsp: 1.765 ± 0.038	2.228ArgGlu: 2.228 ± 0.044	1.924ArgPhe: 1.924 ± 0.035	1.828ArgGly: 1.828 ± 0.044	0.597ArgHis: 0.597 ± 0.021	3.037ArgIle: 3.037 ± 0.051	3.138ArgLys: 3.138 ± 0.053	3.197ArgLeu: 3.197 ± 0.054	0.977ArgMet: 0.977 ± 0.026	2.453ArgAsn: 2.453 ± 0.051	1.133ArgPro: 1.133 ± 0.032	1.232ArgGln: 1.232 ± 0.034	1.324ArgArg: 1.324 ± 0.029	1.994ArgSer: 1.994 ± 0.039	1.877ArgThr: 1.877 ± 0.039	1.957ArgVal: 1.957 ± 0.04	0.393ArgTrp: 0.393 ± 0.017	1.685ArgTyr: 1.685 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.082SerAla: 4.082 ± 0.058	0.662SerCys: 0.662 ± 0.028	3.555SerAsp: 3.555 ± 0.047	3.954SerGlu: 3.954 ± 0.059	3.826SerPhe: 3.826 ± 0.061	4.856SerGly: 4.856 ± 0.067	1.018SerHis: 1.018 ± 0.028	4.964SerIle: 4.964 ± 0.079	4.81SerLys: 4.81 ± 0.066	6.049SerLeu: 6.049 ± 0.074	1.343SerMet: 1.343 ± 0.034	3.392SerAsn: 3.392 ± 0.058	2.146SerPro: 2.146 ± 0.037	2.267SerGln: 2.267 ± 0.041	2.232SerArg: 2.232 ± 0.039	4.119SerSer: 4.119 ± 0.075	3.311SerThr: 3.311 ± 0.046	4.259SerVal: 4.259 ± 0.064	0.724SerTrp: 0.724 ± 0.026	3.047SerTyr: 3.047 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.62ThrAla: 3.62 ± 0.059	0.337ThrCys: 0.337 ± 0.016	3.295ThrAsp: 3.295 ± 0.059	3.797ThrGlu: 3.797 ± 0.053	2.708ThrPhe: 2.708 ± 0.046	4.117ThrGly: 4.117 ± 0.059	0.872ThrHis: 0.872 ± 0.027	4.036ThrIle: 4.036 ± 0.061	3.957ThrLys: 3.957 ± 0.058	4.967ThrLeu: 4.967 ± 0.065	0.946ThrMet: 0.946 ± 0.028	2.991ThrAsn: 2.991 ± 0.061	2.423ThrPro: 2.423 ± 0.042	1.929ThrGln: 1.929 ± 0.045	1.611ThrArg: 1.611 ± 0.035	3.648ThrSer: 3.648 ± 0.059	3.237ThrThr: 3.237 ± 0.068	3.289ThrVal: 3.289 ± 0.054	0.517ThrTrp: 0.517 ± 0.021	2.228ThrTyr: 2.228 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	3.769ValAla: 3.769 ± 0.068	0.446ValCys: 0.446 ± 0.022	3.112ValAsp: 3.112 ± 0.052	3.569ValGlu: 3.569 ± 0.061	3.287ValPhe: 3.287 ± 0.05	3.538ValGly: 3.538 ± 0.056	0.907ValHis: 0.907 ± 0.026	4.543ValIle: 4.543 ± 0.073	4.746ValLys: 4.746 ± 0.064	5.454ValLeu: 5.454 ± 0.072	1.408ValMet: 1.408 ± 0.033	3.564ValAsn: 3.564 ± 0.049	2.165ValPro: 2.165 ± 0.039	1.943ValGln: 1.943 ± 0.035	1.948ValArg: 1.948 ± 0.038	4.259ValSer: 4.259 ± 0.054	3.227ValThr: 3.227 ± 0.053	3.744ValVal: 3.744 ± 0.06	0.562ValTrp: 0.562 ± 0.022	2.509ValTyr: 2.509 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.648TrpAla: 0.648 ± 0.023	0.097TrpCys: 0.097 ± 0.009	0.626TrpAsp: 0.626 ± 0.023	0.679TrpGlu: 0.679 ± 0.022	0.555TrpPhe: 0.555 ± 0.02	0.78TrpGly: 0.78 ± 0.028	0.186TrpHis: 0.186 ± 0.012	0.801TrpIle: 0.801 ± 0.025	0.978TrpLys: 0.978 ± 0.028	0.998TrpLeu: 0.998 ± 0.031	0.306TrpMet: 0.306 ± 0.015	0.78TrpAsn: 0.78 ± 0.028	0.22TrpPro: 0.22 ± 0.014	0.459TrpGln: 0.459 ± 0.021	0.393TrpArg: 0.393 ± 0.017	0.627TrpSer: 0.627 ± 0.023	0.603TrpThr: 0.603 ± 0.026	0.586TrpVal: 0.586 ± 0.022	0.162TrpTrp: 0.162 ± 0.011	0.45TrpTyr: 0.45 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.547TyrAla: 2.547 ± 0.046	0.327TyrCys: 0.327 ± 0.016	2.427TyrAsp: 2.427 ± 0.047	2.514TyrGlu: 2.514 ± 0.043	2.648TyrPhe: 2.648 ± 0.046	2.757TyrGly: 2.757 ± 0.055	0.766TyrHis: 0.766 ± 0.023	3.135TyrIle: 3.135 ± 0.057	3.581TyrLys: 3.581 ± 0.054	4.068TyrLeu: 4.068 ± 0.06	0.872TyrMet: 0.872 ± 0.026	3.012TyrAsn: 3.012 ± 0.056	1.617TyrPro: 1.617 ± 0.043	1.834TyrGln: 1.834 ± 0.04	1.702TyrArg: 1.702 ± 0.034	3.071TyrSer: 3.071 ± 0.053	2.509TyrThr: 2.509 ± 0.052	2.08TyrVal: 2.08 ± 0.043	0.563TyrTrp: 0.563 ± 0.02	2.285TyrTyr: 2.285 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4061 proteins (1281627 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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