Amino acid dipepetide frequency for Propioniciclava tarda

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.83AlaAla: 19.83 ± 0.263
1.106AlaCys: 1.106 ± 0.035
8.777AlaAsp: 8.777 ± 0.094
7.534AlaGlu: 7.534 ± 0.12
3.783AlaPhe: 3.783 ± 0.064
11.631AlaGly: 11.631 ± 0.132
2.526AlaHis: 2.526 ± 0.054
5.346AlaIle: 5.346 ± 0.074
3.605AlaLys: 3.605 ± 0.085
14.35AlaLeu: 14.35 ± 0.179
2.972AlaMet: 2.972 ± 0.072
2.472AlaAsn: 2.472 ± 0.061
6.274AlaPro: 6.274 ± 0.105
3.991AlaGln: 3.991 ± 0.088
8.78AlaArg: 8.78 ± 0.123
10.102AlaSer: 10.102 ± 0.113
7.264AlaThr: 7.264 ± 0.106
10.975AlaVal: 10.975 ± 0.142
2.028AlaTrp: 2.028 ± 0.05
2.545AlaTyr: 2.545 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.945CysAla: 0.945 ± 0.036
0.125CysCys: 0.125 ± 0.013
0.486CysAsp: 0.486 ± 0.023
0.375CysGlu: 0.375 ± 0.02
0.238CysPhe: 0.238 ± 0.016
0.921CysGly: 0.921 ± 0.036
0.204CysHis: 0.204 ± 0.018
0.262CysIle: 0.262 ± 0.019
0.142CysLys: 0.142 ± 0.014
0.778CysLeu: 0.778 ± 0.032
0.119CysMet: 0.119 ± 0.012
0.145CysAsn: 0.145 ± 0.013
0.542CysPro: 0.542 ± 0.03
0.204CysGln: 0.204 ± 0.016
0.598CysArg: 0.598 ± 0.026
0.478CysSer: 0.478 ± 0.024
0.445CysThr: 0.445 ± 0.025
0.65CysVal: 0.65 ± 0.027
0.124CysTrp: 0.124 ± 0.013
0.164CysTyr: 0.164 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
10.913AspAla: 10.913 ± 0.124
0.432AspCys: 0.432 ± 0.024
3.65AspAsp: 3.65 ± 0.075
3.907AspGlu: 3.907 ± 0.079
1.702AspPhe: 1.702 ± 0.05
5.486AspGly: 5.486 ± 0.079
1.311AspHis: 1.311 ± 0.047
2.074AspIle: 2.074 ± 0.057
1.287AspLys: 1.287 ± 0.042
6.537AspLeu: 6.537 ± 0.108
0.829AspMet: 0.829 ± 0.036
0.971AspAsn: 0.971 ± 0.038
4.057AspPro: 4.057 ± 0.064
1.687AspGln: 1.687 ± 0.045
4.114AspArg: 4.114 ± 0.075
2.474AspSer: 2.474 ± 0.054
2.525AspThr: 2.525 ± 0.062
5.341AspVal: 5.341 ± 0.085
0.971AspTrp: 0.971 ± 0.041
1.33AspTyr: 1.33 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
7.033GluAla: 7.033 ± 0.108
0.351GluCys: 0.351 ± 0.023
2.25GluAsp: 2.25 ± 0.051
2.142GluGlu: 2.142 ± 0.061
1.65GluPhe: 1.65 ± 0.045
3.729GluGly: 3.729 ± 0.075
1.219GluHis: 1.219 ± 0.04
2.329GluIle: 2.329 ± 0.056
1.327GluLys: 1.327 ± 0.045
6.01GluLeu: 6.01 ± 0.1
0.872GluMet: 0.872 ± 0.031
0.974GluAsn: 0.974 ± 0.038
2.868GluPro: 2.868 ± 0.062
1.81GluGln: 1.81 ± 0.049
4.478GluArg: 4.478 ± 0.072
2.468GluSer: 2.468 ± 0.06
2.624GluThr: 2.624 ± 0.058
4.633GluVal: 4.633 ± 0.084
0.708GluTrp: 0.708 ± 0.025
0.935GluTyr: 0.935 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.034PheAla: 4.034 ± 0.065
0.31PheCys: 0.31 ± 0.019
2.286PheAsp: 2.286 ± 0.056
1.489PheGlu: 1.489 ± 0.042
1.022PhePhe: 1.022 ± 0.045
3.372PheGly: 3.372 ± 0.064
0.533PheHis: 0.533 ± 0.023
1.054PheIle: 1.054 ± 0.041
0.75PheLys: 0.75 ± 0.03
2.584PheLeu: 2.584 ± 0.058
0.468PheMet: 0.468 ± 0.026
0.795PheAsn: 0.795 ± 0.031
1.372PhePro: 1.372 ± 0.039
0.611PheGln: 0.611 ± 0.028
1.611PheArg: 1.611 ± 0.043
1.654PheSer: 1.654 ± 0.05
1.909PheThr: 1.909 ± 0.051
2.946PheVal: 2.946 ± 0.066
0.426PheTrp: 0.426 ± 0.026
0.637PheTyr: 0.637 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
9.672GlyAla: 9.672 ± 0.129
0.874GlyCys: 0.874 ± 0.036
4.739GlyAsp: 4.739 ± 0.071
4.288GlyGlu: 4.288 ± 0.072
3.058GlyPhe: 3.058 ± 0.068
7.358GlyGly: 7.358 ± 0.122
1.979GlyHis: 1.979 ± 0.052
3.89GlyIle: 3.89 ± 0.075
2.439GlyLys: 2.439 ± 0.057
9.804GlyLeu: 9.804 ± 0.14
2.085GlyMet: 2.085 ± 0.055
1.71GlyAsn: 1.71 ± 0.045
4.116GlyPro: 4.116 ± 0.07
2.764GlyGln: 2.764 ± 0.062
7.494GlyArg: 7.494 ± 0.118
5.023GlySer: 5.023 ± 0.079
5.279GlyThr: 5.279 ± 0.091
8.626GlyVal: 8.626 ± 0.111
1.719GlyTrp: 1.719 ± 0.051
2.169GlyTyr: 2.169 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.361HisAla: 2.361 ± 0.051
0.191HisCys: 0.191 ± 0.018
1.248HisAsp: 1.248 ± 0.037
1.049HisGlu: 1.049 ± 0.034
0.553HisPhe: 0.553 ± 0.025
1.986HisGly: 1.986 ± 0.057
0.565HisHis: 0.565 ± 0.03
0.642HisIle: 0.642 ± 0.027
0.365HisLys: 0.365 ± 0.018
2.287HisLeu: 2.287 ± 0.06
0.341HisMet: 0.341 ± 0.019
0.396HisAsn: 0.396 ± 0.021
1.542HisPro: 1.542 ± 0.045
0.601HisGln: 0.601 ± 0.024
1.528HisArg: 1.528 ± 0.047
0.869HisSer: 0.869 ± 0.035
1.014HisThr: 1.014 ± 0.034
1.73HisVal: 1.73 ± 0.047
0.285HisTrp: 0.285 ± 0.019
0.463HisTyr: 0.463 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.091IleAla: 6.091 ± 0.094
0.345IleCys: 0.345 ± 0.022
3.012IleAsp: 3.012 ± 0.062
2.565IleGlu: 2.565 ± 0.06
1.031IlePhe: 1.031 ± 0.032
4.154IleGly: 4.154 ± 0.087
0.698IleHis: 0.698 ± 0.031
1.591IleIle: 1.591 ± 0.047
1.185IleLys: 1.185 ± 0.043
3.385IleLeu: 3.385 ± 0.067
0.697IleMet: 0.697 ± 0.025
0.992IleAsn: 0.992 ± 0.035
2.097IlePro: 2.097 ± 0.048
0.93IleGln: 0.93 ± 0.031
2.283IleArg: 2.283 ± 0.059
2.051IleSer: 2.051 ± 0.044
2.665IleThr: 2.665 ± 0.054
4.143IleVal: 4.143 ± 0.074
0.438IleTrp: 0.438 ± 0.023
0.779IleTyr: 0.779 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.641LysAla: 3.641 ± 0.08
0.129LysCys: 0.129 ± 0.011
1.294LysAsp: 1.294 ± 0.042
1.02LysGlu: 1.02 ± 0.039
0.581LysPhe: 0.581 ± 0.027
2.008LysGly: 2.008 ± 0.055
0.491LysHis: 0.491 ± 0.025
1.194LysIle: 1.194 ± 0.039
0.99LysLys: 0.99 ± 0.044
2.461LysLeu: 2.461 ± 0.06
0.53LysMet: 0.53 ± 0.025
0.621LysAsn: 0.621 ± 0.027
1.47LysPro: 1.47 ± 0.038
0.78LysGln: 0.78 ± 0.035
1.723LysArg: 1.723 ± 0.049
1.342LysSer: 1.342 ± 0.041
1.629LysThr: 1.629 ± 0.051
2.285LysVal: 2.285 ± 0.058
0.24LysTrp: 0.24 ± 0.018
0.542LysTyr: 0.542 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
15.788LeuAla: 15.788 ± 0.185
0.73LeuCys: 0.73 ± 0.031
7.152LeuAsp: 7.152 ± 0.101
4.361LeuGlu: 4.361 ± 0.079
2.813LeuPhe: 2.813 ± 0.056
9.607LeuGly: 9.607 ± 0.126
1.893LeuHis: 1.893 ± 0.049
4.298LeuIle: 4.298 ± 0.082
2.402LeuLys: 2.402 ± 0.06
10.002LeuLeu: 10.002 ± 0.168
1.931LeuMet: 1.931 ± 0.051
2.115LeuAsn: 2.115 ± 0.05
5.774LeuPro: 5.774 ± 0.089
2.37LeuGln: 2.37 ± 0.05
7.246LeuArg: 7.246 ± 0.112
5.511LeuSer: 5.511 ± 0.084
6.539LeuThr: 6.539 ± 0.094
9.556LeuVal: 9.556 ± 0.127
1.257LeuTrp: 1.257 ± 0.038
1.778LeuTyr: 1.778 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.495MetAla: 2.495 ± 0.057
0.146MetCys: 0.146 ± 0.013
0.972MetAsp: 0.972 ± 0.037
0.693MetGlu: 0.693 ± 0.031
0.573MetPhe: 0.573 ± 0.027
1.653MetGly: 1.653 ± 0.053
0.316MetHis: 0.316 ± 0.017
0.944MetIle: 0.944 ± 0.037
0.609MetLys: 0.609 ± 0.031
1.961MetLeu: 1.961 ± 0.052
0.406MetMet: 0.406 ± 0.023
0.543MetAsn: 0.543 ± 0.027
1.115MetPro: 1.115 ± 0.037
0.471MetGln: 0.471 ± 0.022
1.366MetArg: 1.366 ± 0.04
1.378MetSer: 1.378 ± 0.038
1.742MetThr: 1.742 ± 0.043
1.543MetVal: 1.543 ± 0.044
0.228MetTrp: 0.228 ± 0.017
0.279MetTyr: 0.279 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.609AsnAla: 2.609 ± 0.06
0.178AsnCys: 0.178 ± 0.011
1.144AsnAsp: 1.144 ± 0.04
0.928AsnGlu: 0.928 ± 0.035
0.561AsnPhe: 0.561 ± 0.026
1.817AsnGly: 1.817 ± 0.051
0.438AsnHis: 0.438 ± 0.022
0.836AsnIle: 0.836 ± 0.033
0.562AsnLys: 0.562 ± 0.028
2.106AsnLeu: 2.106 ± 0.047
0.391AsnMet: 0.391 ± 0.022
0.491AsnAsn: 0.491 ± 0.027
1.683AsnPro: 1.683 ± 0.045
0.549AsnGln: 0.549 ± 0.026
1.314AsnArg: 1.314 ± 0.046
0.996AsnSer: 0.996 ± 0.032
1.171AsnThr: 1.171 ± 0.039
1.782AsnVal: 1.782 ± 0.051
0.34AsnTrp: 0.34 ± 0.023
0.492AsnTyr: 0.492 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.28ProAla: 7.28 ± 0.114
0.379ProCys: 0.379 ± 0.021
4.403ProAsp: 4.403 ± 0.073
3.474ProGlu: 3.474 ± 0.056
1.64ProPhe: 1.64 ± 0.048
5.53ProGly: 5.53 ± 0.092
1.097ProHis: 1.097 ± 0.036
2.204ProIle: 2.204 ± 0.058
1.353ProLys: 1.353 ± 0.039
4.92ProLeu: 4.92 ± 0.087
1.049ProMet: 1.049 ± 0.034
1.158ProAsn: 1.158 ± 0.037
2.615ProPro: 2.615 ± 0.078
1.59ProGln: 1.59 ± 0.047
3.346ProArg: 3.346 ± 0.069
3.295ProSer: 3.295 ± 0.063
3.777ProThr: 3.777 ± 0.067
4.754ProVal: 4.754 ± 0.073
0.891ProTrp: 0.891 ± 0.036
1.144ProTyr: 1.144 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.067GlnAla: 4.067 ± 0.089
0.176GlnCys: 0.176 ± 0.014
1.162GlnAsp: 1.162 ± 0.036
0.967GlnGlu: 0.967 ± 0.035
0.85GlnPhe: 0.85 ± 0.029
2.24GlnGly: 2.24 ± 0.053
0.599GlnHis: 0.599 ± 0.025
1.358GlnIle: 1.358 ± 0.042
0.611GlnLys: 0.611 ± 0.024
3.328GlnLeu: 3.328 ± 0.071
0.467GlnMet: 0.467 ± 0.019
0.519GlnAsn: 0.519 ± 0.024
1.74GlnPro: 1.74 ± 0.049
1.139GlnGln: 1.139 ± 0.044
2.422GlnArg: 2.422 ± 0.05
1.373GlnSer: 1.373 ± 0.043
1.565GlnThr: 1.565 ± 0.048
2.55GlnVal: 2.55 ± 0.053
0.436GlnTrp: 0.436 ± 0.024
0.541GlnTyr: 0.541 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.378ArgAla: 8.378 ± 0.119
0.529ArgCys: 0.529 ± 0.028
3.98ArgAsp: 3.98 ± 0.079
3.811ArgGlu: 3.811 ± 0.071
2.233ArgPhe: 2.233 ± 0.049
5.366ArgGly: 5.366 ± 0.094
1.596ArgHis: 1.596 ± 0.044
2.927ArgIle: 2.927 ± 0.05
1.5ArgLys: 1.5 ± 0.047
8.032ArgLeu: 8.032 ± 0.12
1.57ArgMet: 1.57 ± 0.04
1.411ArgAsn: 1.411 ± 0.039
4.607ArgPro: 4.607 ± 0.097
2.17ArgGln: 2.17 ± 0.054
6.874ArgArg: 6.874 ± 0.12
3.701ArgSer: 3.701 ± 0.06
4.244ArgThr: 4.244 ± 0.076
5.877ArgVal: 5.877 ± 0.083
1.232ArgTrp: 1.232 ± 0.043
1.543ArgTyr: 1.543 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.881SerAla: 6.881 ± 0.099
0.415SerCys: 0.415 ± 0.022
3.696SerAsp: 3.696 ± 0.071
2.84SerGlu: 2.84 ± 0.059
1.773SerPhe: 1.773 ± 0.045
6.29SerGly: 6.29 ± 0.082
0.955SerHis: 0.955 ± 0.035
2.301SerIle: 2.301 ± 0.049
1.352SerLys: 1.352 ± 0.042
5.259SerLeu: 5.259 ± 0.084
1.351SerMet: 1.351 ± 0.035
1.076SerAsn: 1.076 ± 0.038
3.093SerPro: 3.093 ± 0.064
1.473SerGln: 1.473 ± 0.043
3.559SerArg: 3.559 ± 0.073
3.303SerSer: 3.303 ± 0.072
3.496SerThr: 3.496 ± 0.069
4.816SerVal: 4.816 ± 0.075
0.982SerTrp: 0.982 ± 0.035
1.177SerTyr: 1.177 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
7.286ThrAla: 7.286 ± 0.103
0.478ThrCys: 0.478 ± 0.024
3.485ThrAsp: 3.485 ± 0.063
2.596ThrGlu: 2.596 ± 0.053
2.019ThrPhe: 2.019 ± 0.052
5.37ThrGly: 5.37 ± 0.087
1.243ThrHis: 1.243 ± 0.038
2.819ThrIle: 2.819 ± 0.064
1.591ThrLys: 1.591 ± 0.043
5.845ThrLeu: 5.845 ± 0.085
1.194ThrMet: 1.194 ± 0.04
1.319ThrAsn: 1.319 ± 0.046
4.336ThrPro: 4.336 ± 0.081
1.526ThrGln: 1.526 ± 0.045
3.701ThrArg: 3.701 ± 0.067
3.482ThrSer: 3.482 ± 0.074
3.989ThrThr: 3.989 ± 0.098
5.286ThrVal: 5.286 ± 0.081
1.028ThrTrp: 1.028 ± 0.035
1.309ThrTyr: 1.309 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
12.222ValAla: 12.222 ± 0.141
0.726ValCys: 0.726 ± 0.026
5.761ValAsp: 5.761 ± 0.082
4.744ValGlu: 4.744 ± 0.092
2.552ValPhe: 2.552 ± 0.056
7.54ValGly: 7.54 ± 0.105
1.679ValHis: 1.679 ± 0.043
3.872ValIle: 3.872 ± 0.081
2.162ValLys: 2.162 ± 0.054
9.254ValLeu: 9.254 ± 0.116
1.627ValMet: 1.627 ± 0.046
1.861ValAsn: 1.861 ± 0.049
4.705ValPro: 4.705 ± 0.064
2.35ValGln: 2.35 ± 0.065
6.388ValArg: 6.388 ± 0.083
4.61ValSer: 4.61 ± 0.077
5.84ValThr: 5.84 ± 0.089
8.707ValVal: 8.707 ± 0.114
1.227ValTrp: 1.227 ± 0.04
1.484ValTyr: 1.484 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.738TrpAla: 1.738 ± 0.053
0.152TrpCys: 0.152 ± 0.013
0.801TrpAsp: 0.801 ± 0.032
0.579TrpGlu: 0.579 ± 0.031
0.561TrpPhe: 0.561 ± 0.028
1.08TrpGly: 1.08 ± 0.035
0.315TrpHis: 0.315 ± 0.017
0.639TrpIle: 0.639 ± 0.031
0.312TrpLys: 0.312 ± 0.021
1.929TrpLeu: 1.929 ± 0.062
0.278TrpMet: 0.278 ± 0.02
0.367TrpAsn: 0.367 ± 0.022
0.816TrpPro: 0.816 ± 0.029
0.515TrpGln: 0.515 ± 0.027
1.232TrpArg: 1.232 ± 0.036
0.903TrpSer: 0.903 ± 0.033
1.05TrpThr: 1.05 ± 0.039
1.319TrpVal: 1.319 ± 0.04
0.326TrpTrp: 0.326 ± 0.018
0.286TrpTyr: 0.286 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.627TyrAla: 2.627 ± 0.063
0.169TyrCys: 0.169 ± 0.013
1.302TyrAsp: 1.302 ± 0.045
1.048TyrGlu: 1.048 ± 0.034
0.67TyrPhe: 0.67 ± 0.03
1.949TyrGly: 1.949 ± 0.047
0.358TyrHis: 0.358 ± 0.02
0.553TyrIle: 0.553 ± 0.027
0.427TyrLys: 0.427 ± 0.02
2.293TyrLeu: 2.293 ± 0.058
0.257TyrMet: 0.257 ± 0.019
0.452TyrAsn: 0.452 ± 0.026
1.081TyrPro: 1.081 ± 0.035
0.578TyrGln: 0.578 ± 0.027
1.523TyrArg: 1.523 ± 0.045
1.075TyrSer: 1.075 ± 0.032
1.133TyrThr: 1.133 ± 0.041
1.794TyrVal: 1.794 ± 0.047
0.31TyrTrp: 0.31 ± 0.019
0.454TyrTyr: 0.454 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2684 proteins (874148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski