Amino acid dipepetide frequency for Streptococcus satellite phage Javan321

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.901AlaAla: 1.901 ± 1.114
0.238AlaCys: 0.238 ± 0.243
4.039AlaAsp: 4.039 ± 1.023
5.702AlaGlu: 5.702 ± 1.392
1.901AlaPhe: 1.901 ± 0.663
1.188AlaGly: 1.188 ± 0.482
0.95AlaHis: 0.95 ± 0.476
3.564AlaIle: 3.564 ± 0.882
5.94AlaLys: 5.94 ± 0.967
3.326AlaLeu: 3.326 ± 0.892
1.188AlaMet: 1.188 ± 0.501
4.039AlaAsn: 4.039 ± 1.058
0.475AlaPro: 0.475 ± 0.344
3.089AlaGln: 3.089 ± 1.175
2.851AlaArg: 2.851 ± 0.526
2.376AlaSer: 2.376 ± 0.804
3.801AlaThr: 3.801 ± 0.592
3.089AlaVal: 3.089 ± 0.606
0.475AlaTrp: 0.475 ± 0.264
2.613AlaTyr: 2.613 ± 0.724
0.0AlaXaa: 0.0 ± 0.0
Cys
0.238CysAla: 0.238 ± 0.225
0.0CysCys: 0.0 ± 0.0
0.713CysAsp: 0.713 ± 0.387
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.188CysGly: 1.188 ± 0.603
0.0CysHis: 0.0 ± 0.0
0.713CysIle: 0.713 ± 0.361
0.238CysLys: 0.238 ± 0.269
0.238CysLeu: 0.238 ± 0.243
0.238CysMet: 0.238 ± 0.256
0.0CysAsn: 0.0 ± 0.0
0.95CysPro: 0.95 ± 0.458
0.475CysGln: 0.475 ± 0.306
0.475CysArg: 0.475 ± 0.344
0.238CysSer: 0.238 ± 0.219
0.0CysThr: 0.0 ± 0.0
0.713CysVal: 0.713 ± 0.379
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.95AspAla: 0.95 ± 0.441
0.475AspCys: 0.475 ± 0.314
4.752AspAsp: 4.752 ± 1.119
3.089AspGlu: 3.089 ± 0.662
5.464AspPhe: 5.464 ± 0.996
4.039AspGly: 4.039 ± 1.005
0.238AspHis: 0.238 ± 0.243
7.128AspIle: 7.128 ± 1.235
8.316AspLys: 8.316 ± 1.225
5.94AspLeu: 5.94 ± 1.127
1.426AspMet: 1.426 ± 0.471
3.089AspAsn: 3.089 ± 0.759
1.188AspPro: 1.188 ± 0.536
1.901AspGln: 1.901 ± 0.676
3.801AspArg: 3.801 ± 1.41
3.801AspSer: 3.801 ± 0.851
3.089AspThr: 3.089 ± 1.063
3.564AspVal: 3.564 ± 0.65
0.713AspTrp: 0.713 ± 0.372
2.138AspTyr: 2.138 ± 0.73
0.0AspXaa: 0.0 ± 0.0
Glu
4.752GluAla: 4.752 ± 0.963
0.475GluCys: 0.475 ± 0.31
6.177GluAsp: 6.177 ± 1.099
5.702GluGlu: 5.702 ± 1.387
2.851GluPhe: 2.851 ± 0.778
3.089GluGly: 3.089 ± 0.866
1.901GluHis: 1.901 ± 0.873
8.316GluIle: 8.316 ± 1.399
9.979GluLys: 9.979 ± 2.069
8.553GluLeu: 8.553 ± 1.823
1.663GluMet: 1.663 ± 0.679
5.94GluAsn: 5.94 ± 1.228
1.663GluPro: 1.663 ± 0.837
3.801GluGln: 3.801 ± 0.981
3.801GluArg: 3.801 ± 0.986
4.039GluSer: 4.039 ± 0.802
4.752GluThr: 4.752 ± 0.96
4.752GluVal: 4.752 ± 0.903
0.238GluTrp: 0.238 ± 0.231
3.564GluTyr: 3.564 ± 0.932
0.0GluXaa: 0.0 ± 0.0
Phe
0.95PheAla: 0.95 ± 0.501
0.238PheCys: 0.238 ± 0.21
4.989PheAsp: 4.989 ± 0.731
3.564PheGlu: 3.564 ± 1.141
1.901PhePhe: 1.901 ± 0.62
2.851PheGly: 2.851 ± 0.937
0.238PheHis: 0.238 ± 0.242
1.901PheIle: 1.901 ± 0.576
4.277PheLys: 4.277 ± 0.871
5.702PheLeu: 5.702 ± 0.98
0.95PheMet: 0.95 ± 0.44
1.901PheAsn: 1.901 ± 0.613
0.95PhePro: 0.95 ± 0.535
1.663PheGln: 1.663 ± 0.646
1.188PheArg: 1.188 ± 0.536
3.801PheSer: 3.801 ± 0.987
1.663PheThr: 1.663 ± 0.741
3.089PheVal: 3.089 ± 0.951
0.713PheTrp: 0.713 ± 0.528
0.95PheTyr: 0.95 ± 0.451
0.0PheXaa: 0.0 ± 0.0
Gly
1.663GlyAla: 1.663 ± 0.632
0.475GlyCys: 0.475 ± 0.307
1.663GlyAsp: 1.663 ± 0.676
1.663GlyGlu: 1.663 ± 0.613
2.851GlyPhe: 2.851 ± 0.783
3.326GlyGly: 3.326 ± 1.129
0.95GlyHis: 0.95 ± 0.522
4.514GlyIle: 4.514 ± 0.979
5.227GlyLys: 5.227 ± 1.397
2.851GlyLeu: 2.851 ± 0.867
1.188GlyMet: 1.188 ± 0.511
2.613GlyAsn: 2.613 ± 0.728
0.713GlyPro: 0.713 ± 0.421
1.426GlyGln: 1.426 ± 0.468
1.901GlyArg: 1.901 ± 0.655
4.039GlySer: 4.039 ± 1.03
2.376GlyThr: 2.376 ± 0.67
3.564GlyVal: 3.564 ± 0.708
0.475GlyTrp: 0.475 ± 0.296
3.564GlyTyr: 3.564 ± 1.181
0.0GlyXaa: 0.0 ± 0.0
His
1.426HisAla: 1.426 ± 0.595
0.475HisCys: 0.475 ± 0.356
0.713HisAsp: 0.713 ± 0.373
0.238HisGlu: 0.238 ± 0.242
0.475HisPhe: 0.475 ± 0.485
1.188HisGly: 1.188 ± 0.458
0.238HisHis: 0.238 ± 0.225
1.426HisIle: 1.426 ± 0.697
1.188HisLys: 1.188 ± 0.555
1.426HisLeu: 1.426 ± 0.617
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.238HisPro: 0.238 ± 0.231
0.95HisGln: 0.95 ± 0.487
0.713HisArg: 0.713 ± 0.504
1.426HisSer: 1.426 ± 0.492
2.376HisThr: 2.376 ± 0.702
0.713HisVal: 0.713 ± 0.401
0.0HisTrp: 0.0 ± 0.0
0.475HisTyr: 0.475 ± 0.298
0.0HisXaa: 0.0 ± 0.0
Ile
5.464IleAla: 5.464 ± 1.136
0.713IleCys: 0.713 ± 0.398
5.94IleAsp: 5.94 ± 1.149
7.128IleGlu: 7.128 ± 1.485
2.138IlePhe: 2.138 ± 0.846
2.138IleGly: 2.138 ± 0.592
1.663IleHis: 1.663 ± 0.611
5.464IleIle: 5.464 ± 1.363
6.415IleLys: 6.415 ± 1.221
6.652IleLeu: 6.652 ± 0.897
0.95IleMet: 0.95 ± 0.5
5.94IleAsn: 5.94 ± 1.361
3.564IlePro: 3.564 ± 0.874
2.376IleGln: 2.376 ± 0.563
2.376IleArg: 2.376 ± 0.838
3.564IleSer: 3.564 ± 0.973
4.514IleThr: 4.514 ± 1.191
4.039IleVal: 4.039 ± 1.131
0.0IleTrp: 0.0 ± 0.0
3.089IleTyr: 3.089 ± 0.808
0.0IleXaa: 0.0 ± 0.0
Lys
6.89LysAla: 6.89 ± 1.483
0.475LysCys: 0.475 ± 0.379
5.94LysAsp: 5.94 ± 1.238
10.216LysGlu: 10.216 ± 1.303
3.089LysPhe: 3.089 ± 0.872
6.415LysGly: 6.415 ± 1.033
1.663LysHis: 1.663 ± 0.822
5.702LysIle: 5.702 ± 0.945
8.316LysLys: 8.316 ± 1.486
7.603LysLeu: 7.603 ± 1.322
4.039LysMet: 4.039 ± 1.081
5.94LysAsn: 5.94 ± 1.406
3.326LysPro: 3.326 ± 0.764
4.514LysGln: 4.514 ± 1.152
4.989LysArg: 4.989 ± 0.957
5.464LysSer: 5.464 ± 1.023
5.94LysThr: 5.94 ± 1.034
4.514LysVal: 4.514 ± 1.007
0.475LysTrp: 0.475 ± 0.339
3.801LysTyr: 3.801 ± 0.966
0.0LysXaa: 0.0 ± 0.0
Leu
6.415LeuAla: 6.415 ± 1.181
0.238LeuCys: 0.238 ± 0.256
9.503LeuAsp: 9.503 ± 1.408
10.454LeuGlu: 10.454 ± 1.957
4.514LeuPhe: 4.514 ± 0.908
4.989LeuGly: 4.989 ± 0.885
1.426LeuHis: 1.426 ± 0.627
5.94LeuIle: 5.94 ± 1.018
7.84LeuLys: 7.84 ± 0.881
6.89LeuLeu: 6.89 ± 1.248
1.426LeuMet: 1.426 ± 0.523
4.039LeuAsn: 4.039 ± 1.3
1.426LeuPro: 1.426 ± 0.539
4.989LeuGln: 4.989 ± 1.116
3.801LeuArg: 3.801 ± 0.888
6.415LeuSer: 6.415 ± 1.024
5.227LeuThr: 5.227 ± 1.117
5.702LeuVal: 5.702 ± 0.998
0.475LeuTrp: 0.475 ± 0.344
2.376LeuTyr: 2.376 ± 0.735
0.0LeuXaa: 0.0 ± 0.0
Met
1.901MetAla: 1.901 ± 0.529
0.0MetCys: 0.0 ± 0.0
2.138MetAsp: 2.138 ± 0.778
2.851MetGlu: 2.851 ± 0.932
0.713MetPhe: 0.713 ± 0.345
0.238MetGly: 0.238 ± 0.251
0.0MetHis: 0.0 ± 0.0
0.95MetIle: 0.95 ± 0.409
2.138MetLys: 2.138 ± 0.643
2.376MetLeu: 2.376 ± 0.69
0.238MetMet: 0.238 ± 0.22
1.663MetAsn: 1.663 ± 0.634
0.238MetPro: 0.238 ± 0.231
0.95MetGln: 0.95 ± 0.52
2.138MetArg: 2.138 ± 0.703
0.475MetSer: 0.475 ± 0.338
2.851MetThr: 2.851 ± 0.913
0.95MetVal: 0.95 ± 0.446
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.326AsnAla: 3.326 ± 0.84
0.238AsnCys: 0.238 ± 0.219
1.901AsnAsp: 1.901 ± 0.627
4.039AsnGlu: 4.039 ± 1.276
2.851AsnPhe: 2.851 ± 0.895
2.851AsnGly: 2.851 ± 0.731
1.188AsnHis: 1.188 ± 0.438
3.326AsnIle: 3.326 ± 0.771
4.752AsnLys: 4.752 ± 1.013
6.652AsnLeu: 6.652 ± 1.261
1.663AsnMet: 1.663 ± 0.72
3.326AsnAsn: 3.326 ± 0.942
1.663AsnPro: 1.663 ± 0.522
2.376AsnGln: 2.376 ± 0.689
2.851AsnArg: 2.851 ± 0.626
3.801AsnSer: 3.801 ± 0.761
5.227AsnThr: 5.227 ± 1.619
2.613AsnVal: 2.613 ± 0.882
1.188AsnTrp: 1.188 ± 0.528
3.089AsnTyr: 3.089 ± 0.777
0.0AsnXaa: 0.0 ± 0.0
Pro
0.475ProAla: 0.475 ± 0.333
0.238ProCys: 0.238 ± 0.207
0.95ProAsp: 0.95 ± 0.53
3.089ProGlu: 3.089 ± 0.813
1.188ProPhe: 1.188 ± 0.461
0.713ProGly: 0.713 ± 0.378
0.713ProHis: 0.713 ± 0.417
1.426ProIle: 1.426 ± 0.537
3.089ProLys: 3.089 ± 0.888
2.138ProLeu: 2.138 ± 0.713
0.238ProMet: 0.238 ± 0.225
2.138ProAsn: 2.138 ± 0.582
0.713ProPro: 0.713 ± 0.378
1.188ProGln: 1.188 ± 0.718
0.95ProArg: 0.95 ± 0.43
0.475ProSer: 0.475 ± 0.359
0.95ProThr: 0.95 ± 0.477
1.426ProVal: 1.426 ± 0.544
0.238ProTrp: 0.238 ± 0.207
0.713ProTyr: 0.713 ± 0.402
0.0ProXaa: 0.0 ± 0.0
Gln
4.514GlnAla: 4.514 ± 1.013
0.238GlnCys: 0.238 ± 0.269
1.663GlnAsp: 1.663 ± 0.493
4.277GlnGlu: 4.277 ± 0.849
1.663GlnPhe: 1.663 ± 0.574
1.188GlnGly: 1.188 ± 0.606
0.95GlnHis: 0.95 ± 0.358
2.613GlnIle: 2.613 ± 0.712
3.801GlnLys: 3.801 ± 0.913
3.801GlnLeu: 3.801 ± 0.889
1.188GlnMet: 1.188 ± 0.708
2.613GlnAsn: 2.613 ± 0.627
0.475GlnPro: 0.475 ± 0.521
1.901GlnGln: 1.901 ± 0.706
2.376GlnArg: 2.376 ± 0.691
1.901GlnSer: 1.901 ± 0.706
2.138GlnThr: 2.138 ± 0.681
3.326GlnVal: 3.326 ± 0.791
0.713GlnTrp: 0.713 ± 0.444
1.901GlnTyr: 1.901 ± 0.761
0.0GlnXaa: 0.0 ± 0.0
Arg
2.138ArgAla: 2.138 ± 0.669
0.238ArgCys: 0.238 ± 0.249
2.613ArgAsp: 2.613 ± 0.503
4.277ArgGlu: 4.277 ± 0.927
2.613ArgPhe: 2.613 ± 0.872
1.663ArgGly: 1.663 ± 0.587
0.713ArgHis: 0.713 ± 0.375
4.989ArgIle: 4.989 ± 1.111
4.989ArgLys: 4.989 ± 1.285
4.989ArgLeu: 4.989 ± 1.209
0.95ArgMet: 0.95 ± 0.383
3.801ArgAsn: 3.801 ± 0.844
0.475ArgPro: 0.475 ± 0.331
2.613ArgGln: 2.613 ± 0.783
2.138ArgArg: 2.138 ± 0.667
1.901ArgSer: 1.901 ± 0.538
2.851ArgThr: 2.851 ± 0.885
0.475ArgVal: 0.475 ± 0.34
0.475ArgTrp: 0.475 ± 0.387
2.376ArgTyr: 2.376 ± 0.858
0.0ArgXaa: 0.0 ± 0.0
Ser
2.138SerAla: 2.138 ± 0.668
0.238SerCys: 0.238 ± 0.231
3.326SerAsp: 3.326 ± 0.702
6.177SerGlu: 6.177 ± 0.923
2.613SerPhe: 2.613 ± 0.848
3.801SerGly: 3.801 ± 0.744
0.713SerHis: 0.713 ± 0.402
2.851SerIle: 2.851 ± 1.016
5.702SerLys: 5.702 ± 1.161
7.603SerLeu: 7.603 ± 1.041
2.138SerMet: 2.138 ± 0.696
1.663SerAsn: 1.663 ± 0.556
2.376SerPro: 2.376 ± 0.613
3.089SerGln: 3.089 ± 0.599
0.95SerArg: 0.95 ± 0.355
1.426SerSer: 1.426 ± 0.524
2.376SerThr: 2.376 ± 0.627
2.613SerVal: 2.613 ± 0.95
0.95SerTrp: 0.95 ± 0.401
2.851SerTyr: 2.851 ± 0.906
0.0SerXaa: 0.0 ± 0.0
Thr
3.089ThrAla: 3.089 ± 0.852
0.238ThrCys: 0.238 ± 0.219
1.426ThrAsp: 1.426 ± 0.714
4.989ThrGlu: 4.989 ± 1.008
1.663ThrPhe: 1.663 ± 0.533
3.801ThrGly: 3.801 ± 0.932
1.188ThrHis: 1.188 ± 0.64
5.227ThrIle: 5.227 ± 1.305
4.752ThrLys: 4.752 ± 1.201
6.415ThrLeu: 6.415 ± 1.015
1.188ThrMet: 1.188 ± 0.341
4.039ThrAsn: 4.039 ± 0.796
1.188ThrPro: 1.188 ± 0.383
1.663ThrGln: 1.663 ± 0.736
2.851ThrArg: 2.851 ± 1.343
3.801ThrSer: 3.801 ± 0.843
3.564ThrThr: 3.564 ± 0.861
5.702ThrVal: 5.702 ± 1.253
0.475ThrTrp: 0.475 ± 0.409
2.138ThrTyr: 2.138 ± 0.57
0.0ThrXaa: 0.0 ± 0.0
Val
2.851ValAla: 2.851 ± 1.081
1.188ValCys: 1.188 ± 0.713
3.564ValAsp: 3.564 ± 1.295
4.277ValGlu: 4.277 ± 1.236
2.138ValPhe: 2.138 ± 0.747
0.713ValGly: 0.713 ± 0.385
0.475ValHis: 0.475 ± 0.338
3.801ValIle: 3.801 ± 0.847
5.94ValLys: 5.94 ± 1.378
4.752ValLeu: 4.752 ± 1.186
0.713ValMet: 0.713 ± 0.395
4.277ValAsn: 4.277 ± 0.919
0.713ValPro: 0.713 ± 0.4
2.138ValGln: 2.138 ± 0.759
2.613ValArg: 2.613 ± 0.734
4.514ValSer: 4.514 ± 1.022
4.277ValThr: 4.277 ± 0.789
3.326ValVal: 3.326 ± 0.877
0.0ValTrp: 0.0 ± 0.0
3.801ValTyr: 3.801 ± 1.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.713TrpAla: 0.713 ± 0.343
0.0TrpCys: 0.0 ± 0.0
0.238TrpAsp: 0.238 ± 0.269
1.901TrpGlu: 1.901 ± 0.629
0.0TrpPhe: 0.0 ± 0.0
0.238TrpGly: 0.238 ± 0.243
0.0TrpHis: 0.0 ± 0.0
0.713TrpIle: 0.713 ± 0.432
0.475TrpLys: 0.475 ± 0.327
0.95TrpLeu: 0.95 ± 0.598
0.238TrpMet: 0.238 ± 0.233
0.238TrpAsn: 0.238 ± 0.241
0.0TrpPro: 0.0 ± 0.0
0.713TrpGln: 0.713 ± 0.408
0.475TrpArg: 0.475 ± 0.368
0.238TrpSer: 0.238 ± 0.242
0.0TrpThr: 0.0 ± 0.0
0.713TrpVal: 0.713 ± 0.352
0.238TrpTrp: 0.238 ± 0.242
0.238TrpTyr: 0.238 ± 0.207
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.95TyrAla: 0.95 ± 0.617
0.0TyrCys: 0.0 ± 0.0
2.851TyrAsp: 2.851 ± 0.851
2.613TyrGlu: 2.613 ± 0.706
2.851TyrPhe: 2.851 ± 0.829
1.426TyrGly: 1.426 ± 0.478
0.475TyrHis: 0.475 ± 0.286
3.564TyrIle: 3.564 ± 0.932
5.94TyrLys: 5.94 ± 1.58
5.227TyrLeu: 5.227 ± 1.379
0.95TyrMet: 0.95 ± 0.442
1.663TyrAsn: 1.663 ± 0.598
0.713TyrPro: 0.713 ± 0.411
1.426TyrGln: 1.426 ± 0.476
4.039TyrArg: 4.039 ± 1.128
1.901TyrSer: 1.901 ± 0.686
1.426TyrThr: 1.426 ± 0.658
1.188TyrVal: 1.188 ± 0.684
0.475TyrTrp: 0.475 ± 0.316
1.663TyrTyr: 1.663 ± 0.805
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 27 proteins (4210 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski