Amino acid dipepetide frequency for Actinidia chlorotic ringspot-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.517AlaAla: 0.517 ± 0.704
0.517AlaCys: 0.517 ± 0.362
2.584AlaAsp: 2.584 ± 0.516
2.067AlaGlu: 2.067 ± 0.363
2.067AlaPhe: 2.067 ± 0.342
1.292AlaGly: 1.292 ± 1.0
0.775AlaHis: 0.775 ± 0.361
3.876AlaIle: 3.876 ± 0.771
2.067AlaLys: 2.067 ± 0.959
2.842AlaLeu: 2.842 ± 0.913
0.775AlaMet: 0.775 ± 0.62
2.584AlaAsn: 2.584 ± 0.601
0.517AlaPro: 0.517 ± 0.244
1.55AlaGln: 1.55 ± 0.925
0.775AlaArg: 0.775 ± 0.244
2.584AlaSer: 2.584 ± 0.612
2.842AlaThr: 2.842 ± 0.545
3.101AlaVal: 3.101 ± 2.294
0.0AlaTrp: 0.0 ± 0.0
2.584AlaTyr: 2.584 ± 0.291
0.0AlaXaa: 0.0 ± 0.0
Cys
1.034CysAla: 1.034 ± 0.853
0.258CysCys: 0.258 ± 0.511
1.292CysAsp: 1.292 ± 0.45
1.809CysGlu: 1.809 ± 1.035
0.775CysPhe: 0.775 ± 0.536
1.034CysGly: 1.034 ± 0.715
0.0CysHis: 0.0 ± 0.0
2.067CysIle: 2.067 ± 0.499
2.326CysLys: 2.326 ± 0.742
1.034CysLeu: 1.034 ± 0.617
0.517CysMet: 0.517 ± 0.244
1.034CysAsn: 1.034 ± 0.879
0.517CysPro: 0.517 ± 0.244
0.517CysGln: 0.517 ± 0.308
0.517CysArg: 0.517 ± 0.362
2.067CysSer: 2.067 ± 0.473
0.0CysThr: 0.0 ± 0.0
1.034CysVal: 1.034 ± 0.879
0.258CysTrp: 0.258 ± 0.154
1.292CysTyr: 1.292 ± 1.068
0.0CysXaa: 0.0 ± 0.0
Asp
1.55AspAla: 1.55 ± 0.459
1.55AspCys: 1.55 ± 0.732
5.943AspAsp: 5.943 ± 1.892
3.618AspGlu: 3.618 ± 1.3
4.393AspPhe: 4.393 ± 0.711
4.393AspGly: 4.393 ± 0.979
1.809AspHis: 1.809 ± 0.369
4.393AspIle: 4.393 ± 0.925
4.134AspLys: 4.134 ± 0.678
8.269AspLeu: 8.269 ± 0.421
2.067AspMet: 2.067 ± 1.242
3.618AspAsn: 3.618 ± 1.396
4.134AspPro: 4.134 ± 1.044
2.842AspGln: 2.842 ± 1.058
2.067AspArg: 2.067 ± 0.363
3.618AspSer: 3.618 ± 0.803
2.584AspThr: 2.584 ± 0.737
2.842AspVal: 2.842 ± 0.679
0.517AspTrp: 0.517 ± 0.362
3.101AspTyr: 3.101 ± 0.836
0.0AspXaa: 0.0 ± 0.0
Glu
2.067GluAla: 2.067 ± 1.234
1.809GluCys: 1.809 ± 0.46
3.101GluAsp: 3.101 ± 1.036
2.067GluGlu: 2.067 ± 0.677
3.876GluPhe: 3.876 ± 1.033
1.292GluGly: 1.292 ± 0.945
1.55GluHis: 1.55 ± 1.026
6.718GluIle: 6.718 ± 1.402
3.876GluLys: 3.876 ± 1.031
5.426GluLeu: 5.426 ± 1.409
2.067GluMet: 2.067 ± 0.497
2.584GluAsn: 2.584 ± 0.843
1.809GluPro: 1.809 ± 0.396
0.775GluGln: 0.775 ± 0.867
2.326GluArg: 2.326 ± 0.605
4.393GluSer: 4.393 ± 1.265
2.584GluThr: 2.584 ± 1.29
4.134GluVal: 4.134 ± 1.312
0.0GluTrp: 0.0 ± 0.0
1.55GluTyr: 1.55 ± 0.348
0.0GluXaa: 0.0 ± 0.0
Phe
1.034PheAla: 1.034 ± 0.255
1.034PheCys: 1.034 ± 0.488
4.134PheAsp: 4.134 ± 1.537
3.359PheGlu: 3.359 ± 1.825
1.809PhePhe: 1.809 ± 0.94
2.584PheGly: 2.584 ± 0.943
1.292PheHis: 1.292 ± 0.658
3.618PheIle: 3.618 ± 0.896
2.842PheLys: 2.842 ± 1.069
5.168PheLeu: 5.168 ± 1.514
1.809PheMet: 1.809 ± 0.835
2.326PheAsn: 2.326 ± 0.801
2.067PhePro: 2.067 ± 0.746
0.775PheGln: 0.775 ± 0.388
1.809PheArg: 1.809 ± 0.811
4.134PheSer: 4.134 ± 0.905
3.101PheThr: 3.101 ± 1.048
1.55PheVal: 1.55 ± 0.459
0.0PheTrp: 0.0 ± 0.0
3.618PheTyr: 3.618 ± 0.904
0.0PheXaa: 0.0 ± 0.0
Gly
0.517GlyAla: 0.517 ± 0.453
0.775GlyCys: 0.775 ± 0.556
2.842GlyAsp: 2.842 ± 0.282
1.292GlyGlu: 1.292 ± 0.359
2.842GlyPhe: 2.842 ± 0.88
1.55GlyGly: 1.55 ± 0.295
0.775GlyHis: 0.775 ± 0.536
1.55GlyIle: 1.55 ± 0.587
2.842GlyLys: 2.842 ± 0.88
3.101GlyLeu: 3.101 ± 1.096
0.517GlyMet: 0.517 ± 0.244
3.359GlyAsn: 3.359 ± 0.784
0.775GlyPro: 0.775 ± 0.91
1.292GlyGln: 1.292 ± 0.397
1.292GlyArg: 1.292 ± 0.522
4.651GlySer: 4.651 ± 0.948
1.55GlyThr: 1.55 ± 0.884
1.55GlyVal: 1.55 ± 0.606
0.0GlyTrp: 0.0 ± 0.0
2.584GlyTyr: 2.584 ± 0.291
0.0GlyXaa: 0.0 ± 0.0
His
0.775HisAla: 0.775 ± 0.463
1.034HisCys: 1.034 ± 0.327
1.55HisAsp: 1.55 ± 0.899
1.292HisGlu: 1.292 ± 0.558
1.55HisPhe: 1.55 ± 0.398
1.55HisGly: 1.55 ± 0.738
2.067HisHis: 2.067 ± 0.698
2.326HisIle: 2.326 ± 1.608
1.292HisLys: 1.292 ± 0.359
3.618HisLeu: 3.618 ± 0.573
0.0HisMet: 0.0 ± 0.0
0.775HisAsn: 0.775 ± 0.333
0.517HisPro: 0.517 ± 0.308
0.258HisGln: 0.258 ± 0.154
0.0HisArg: 0.0 ± 0.0
1.809HisSer: 1.809 ± 0.369
1.55HisThr: 1.55 ± 0.644
2.326HisVal: 2.326 ± 0.905
0.258HisTrp: 0.258 ± 0.154
0.775HisTyr: 0.775 ± 0.244
0.0HisXaa: 0.0 ± 0.0
Ile
3.618IleAla: 3.618 ± 0.624
2.326IleCys: 2.326 ± 0.732
6.46IleAsp: 6.46 ± 1.195
5.426IleGlu: 5.426 ± 1.484
2.584IlePhe: 2.584 ± 1.119
2.842IleGly: 2.842 ± 0.367
1.809IleHis: 1.809 ± 0.396
8.269IleIle: 8.269 ± 1.934
8.527IleLys: 8.527 ± 0.715
5.426IleLeu: 5.426 ± 1.308
3.876IleMet: 3.876 ± 0.253
6.202IleAsn: 6.202 ± 2.103
2.326IlePro: 2.326 ± 0.401
2.584IleGln: 2.584 ± 0.73
3.618IleArg: 3.618 ± 1.435
8.786IleSer: 8.786 ± 1.528
5.426IleThr: 5.426 ± 1.359
3.101IleVal: 3.101 ± 0.523
0.0IleTrp: 0.0 ± 0.0
5.168IleTyr: 5.168 ± 1.229
0.0IleXaa: 0.0 ± 0.0
Lys
3.876LysAla: 3.876 ± 0.965
0.517LysCys: 0.517 ± 0.244
5.685LysAsp: 5.685 ± 1.13
3.359LysGlu: 3.359 ± 0.424
3.359LysPhe: 3.359 ± 1.037
1.55LysGly: 1.55 ± 0.925
2.067LysHis: 2.067 ± 1.036
4.393LysIle: 4.393 ± 0.934
6.718LysLys: 6.718 ± 0.399
10.078LysLeu: 10.078 ± 1.09
1.292LysMet: 1.292 ± 1.151
4.91LysAsn: 4.91 ± 0.89
3.876LysPro: 3.876 ± 0.662
1.55LysGln: 1.55 ± 0.925
2.067LysArg: 2.067 ± 1.036
7.494LysSer: 7.494 ± 1.363
3.876LysThr: 3.876 ± 0.681
6.202LysVal: 6.202 ± 1.847
0.258LysTrp: 0.258 ± 0.154
7.494LysTyr: 7.494 ± 0.83
0.0LysXaa: 0.0 ± 0.0
Leu
4.134LeuAla: 4.134 ± 0.936
2.326LeuCys: 2.326 ± 0.737
5.426LeuAsp: 5.426 ± 1.101
4.91LeuGlu: 4.91 ± 0.578
5.168LeuPhe: 5.168 ± 0.957
1.809LeuGly: 1.809 ± 0.52
1.292LeuHis: 1.292 ± 0.463
9.044LeuIle: 9.044 ± 2.485
6.977LeuLys: 6.977 ± 2.666
10.594LeuLeu: 10.594 ± 1.528
2.842LeuMet: 2.842 ± 0.959
4.393LeuAsn: 4.393 ± 1.88
3.876LeuPro: 3.876 ± 1.221
2.326LeuGln: 2.326 ± 1.044
3.101LeuArg: 3.101 ± 1.381
9.302LeuSer: 9.302 ± 0.966
5.685LeuThr: 5.685 ± 1.049
5.168LeuVal: 5.168 ± 0.749
0.258LeuTrp: 0.258 ± 0.336
5.685LeuTyr: 5.685 ± 1.295
0.0LeuXaa: 0.0 ± 0.0
Met
1.292MetAla: 1.292 ± 0.468
0.517MetCys: 0.517 ± 0.308
1.034MetAsp: 1.034 ± 0.255
2.326MetGlu: 2.326 ± 1.473
1.55MetPhe: 1.55 ± 0.869
0.258MetGly: 0.258 ± 0.154
0.517MetHis: 0.517 ± 0.301
1.292MetIle: 1.292 ± 0.463
2.067MetLys: 2.067 ± 0.788
3.359MetLeu: 3.359 ± 0.794
0.775MetMet: 0.775 ± 0.333
2.067MetAsn: 2.067 ± 0.342
1.292MetPro: 1.292 ± 0.646
0.775MetGln: 0.775 ± 0.361
0.775MetArg: 0.775 ± 0.664
2.842MetSer: 2.842 ± 0.395
2.842MetThr: 2.842 ± 1.034
1.809MetVal: 1.809 ± 1.34
0.258MetTrp: 0.258 ± 0.154
1.034MetTyr: 1.034 ± 1.071
0.0MetXaa: 0.0 ± 0.0
Asn
2.842AsnAla: 2.842 ± 0.58
0.517AsnCys: 0.517 ± 0.427
3.876AsnAsp: 3.876 ± 0.681
2.842AsnGlu: 2.842 ± 0.923
2.326AsnPhe: 2.326 ± 0.411
1.809AsnGly: 1.809 ± 0.731
1.809AsnHis: 1.809 ± 0.556
6.718AsnIle: 6.718 ± 2.223
4.651AsnLys: 4.651 ± 0.957
5.685AsnLeu: 5.685 ± 1.857
1.292AsnMet: 1.292 ± 0.258
4.393AsnAsn: 4.393 ± 0.848
2.326AsnPro: 2.326 ± 0.801
1.292AsnGln: 1.292 ± 0.359
2.584AsnArg: 2.584 ± 1.062
6.718AsnSer: 6.718 ± 1.53
3.359AsnThr: 3.359 ± 1.041
1.55AsnVal: 1.55 ± 0.702
0.258AsnTrp: 0.258 ± 0.154
3.876AsnTyr: 3.876 ± 0.662
0.0AsnXaa: 0.0 ± 0.0
Pro
1.809ProAla: 1.809 ± 0.931
0.258ProCys: 0.258 ± 0.327
2.067ProAsp: 2.067 ± 0.879
2.067ProGlu: 2.067 ± 0.671
0.775ProPhe: 0.775 ± 0.463
0.775ProGly: 0.775 ± 0.456
0.517ProHis: 0.517 ± 0.427
3.101ProIle: 3.101 ± 0.695
2.326ProLys: 2.326 ± 0.292
2.842ProLeu: 2.842 ± 0.892
1.034ProMet: 1.034 ± 0.422
1.55ProAsn: 1.55 ± 0.295
0.517ProPro: 0.517 ± 0.308
0.775ProGln: 0.775 ± 0.361
1.809ProArg: 1.809 ± 0.832
4.393ProSer: 4.393 ± 0.723
1.55ProThr: 1.55 ± 0.667
1.55ProVal: 1.55 ± 0.732
0.0ProTrp: 0.0 ± 0.0
2.584ProTyr: 2.584 ± 0.794
0.0ProXaa: 0.0 ± 0.0
Gln
1.034GlnAla: 1.034 ± 0.759
0.258GlnCys: 0.258 ± 0.154
1.55GlnAsp: 1.55 ± 0.732
1.292GlnGlu: 1.292 ± 0.75
2.326GlnPhe: 2.326 ± 1.061
1.292GlnGly: 1.292 ± 0.596
0.258GlnHis: 0.258 ± 0.154
3.618GlnIle: 3.618 ± 1.081
1.292GlnLys: 1.292 ± 0.258
2.067GlnLeu: 2.067 ± 0.759
0.775GlnMet: 0.775 ± 0.361
1.034GlnAsn: 1.034 ± 0.617
0.0GlnPro: 0.0 ± 0.0
0.775GlnGln: 0.775 ± 0.62
1.034GlnArg: 1.034 ± 0.617
1.292GlnSer: 1.292 ± 0.403
2.584GlnThr: 2.584 ± 0.909
0.775GlnVal: 0.775 ± 0.244
0.258GlnTrp: 0.258 ± 0.336
1.809GlnTyr: 1.809 ± 0.401
0.0GlnXaa: 0.0 ± 0.0
Arg
0.775ArgAla: 0.775 ± 0.361
0.0ArgCys: 0.0 ± 0.0
2.326ArgAsp: 2.326 ± 0.411
1.809ArgGlu: 1.809 ± 0.46
2.067ArgPhe: 2.067 ± 0.959
0.517ArgGly: 0.517 ± 0.427
1.292ArgHis: 1.292 ± 0.513
3.101ArgIle: 3.101 ± 1.036
2.584ArgLys: 2.584 ± 1.05
5.685ArgLeu: 5.685 ± 1.159
0.517ArgMet: 0.517 ± 0.427
1.55ArgAsn: 1.55 ± 0.702
1.034ArgPro: 1.034 ± 0.488
0.775ArgGln: 0.775 ± 0.388
1.809ArgArg: 1.809 ± 0.554
2.584ArgSer: 2.584 ± 0.571
1.809ArgThr: 1.809 ± 0.801
2.842ArgVal: 2.842 ± 0.54
0.0ArgTrp: 0.0 ± 0.0
2.584ArgTyr: 2.584 ± 0.899
0.0ArgXaa: 0.0 ± 0.0
Ser
2.326SerAla: 2.326 ± 0.769
2.067SerCys: 2.067 ± 2.006
5.943SerAsp: 5.943 ± 0.912
4.91SerGlu: 4.91 ± 0.945
4.651SerPhe: 4.651 ± 1.049
3.618SerGly: 3.618 ± 1.18
3.618SerHis: 3.618 ± 0.742
8.269SerIle: 8.269 ± 0.989
7.235SerLys: 7.235 ± 1.217
8.01SerLeu: 8.01 ± 1.289
2.067SerMet: 2.067 ± 0.597
7.235SerAsn: 7.235 ± 1.312
3.101SerPro: 3.101 ± 0.721
2.326SerGln: 2.326 ± 0.52
3.618SerArg: 3.618 ± 1.104
8.269SerSer: 8.269 ± 1.159
4.651SerThr: 4.651 ± 0.964
5.426SerVal: 5.426 ± 1.288
1.034SerTrp: 1.034 ± 0.679
4.91SerTyr: 4.91 ± 1.574
0.0SerXaa: 0.0 ± 0.0
Thr
2.584ThrAla: 2.584 ± 1.165
1.809ThrCys: 1.809 ± 0.89
4.91ThrAsp: 4.91 ± 0.797
2.584ThrGlu: 2.584 ± 0.652
2.326ThrPhe: 2.326 ± 0.801
2.326ThrGly: 2.326 ± 0.643
1.292ThrHis: 1.292 ± 0.463
8.269ThrIle: 8.269 ± 0.219
6.977ThrLys: 6.977 ± 1.144
2.842ThrLeu: 2.842 ± 1.034
1.809ThrMet: 1.809 ± 0.622
1.55ThrAsn: 1.55 ± 0.606
1.809ThrPro: 1.809 ± 0.476
1.034ThrGln: 1.034 ± 0.617
1.55ThrArg: 1.55 ± 0.691
5.168ThrSer: 5.168 ± 0.636
4.393ThrThr: 4.393 ± 0.618
2.326ThrVal: 2.326 ± 0.697
0.258ThrTrp: 0.258 ± 0.327
1.809ThrTyr: 1.809 ± 0.707
0.0ThrXaa: 0.0 ± 0.0
Val
2.067ValAla: 2.067 ± 0.462
0.258ValCys: 0.258 ± 0.327
3.876ValAsp: 3.876 ± 0.755
3.359ValGlu: 3.359 ± 0.79
2.842ValPhe: 2.842 ± 1.58
2.067ValGly: 2.067 ± 1.046
1.55ValHis: 1.55 ± 0.398
2.326ValIle: 2.326 ± 0.411
5.943ValLys: 5.943 ± 3.133
2.842ValLeu: 2.842 ± 0.621
1.292ValMet: 1.292 ± 0.403
4.651ValAsn: 4.651 ± 1.191
1.034ValPro: 1.034 ± 1.155
1.034ValGln: 1.034 ± 0.95
2.067ValArg: 2.067 ± 0.807
6.46ValSer: 6.46 ± 1.406
3.359ValThr: 3.359 ± 1.234
2.842ValVal: 2.842 ± 0.545
0.775ValTrp: 0.775 ± 0.333
2.326ValTyr: 2.326 ± 1.012
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.258TrpCys: 0.258 ± 0.154
0.258TrpAsp: 0.258 ± 0.336
0.258TrpGlu: 0.258 ± 0.423
0.0TrpPhe: 0.0 ± 0.0
0.258TrpGly: 0.258 ± 0.336
0.0TrpHis: 0.0 ± 0.0
0.258TrpIle: 0.258 ± 0.154
0.258TrpLys: 0.258 ± 0.336
1.034TrpLeu: 1.034 ± 0.327
0.775TrpMet: 0.775 ± 0.879
0.258TrpAsn: 0.258 ± 0.154
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.034TrpSer: 1.034 ± 0.327
0.0TrpThr: 0.0 ± 0.0
0.258TrpVal: 0.258 ± 0.327
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.067TyrAla: 2.067 ± 0.499
1.292TyrCys: 1.292 ± 0.343
2.842TyrAsp: 2.842 ± 0.887
3.359TyrGlu: 3.359 ± 0.837
0.775TyrPhe: 0.775 ± 0.463
2.842TyrGly: 2.842 ± 0.395
1.034TyrHis: 1.034 ± 0.488
5.168TyrIle: 5.168 ± 1.284
5.685TyrLys: 5.685 ± 2.347
4.393TyrLeu: 4.393 ± 1.217
2.326TyrMet: 2.326 ± 0.438
4.651TyrAsn: 4.651 ± 1.172
0.775TyrPro: 0.775 ± 0.463
2.067TyrGln: 2.067 ± 0.462
2.842TyrArg: 2.842 ± 0.892
5.685TyrSer: 5.685 ± 0.741
3.876TyrThr: 3.876 ± 1.61
2.584TyrVal: 2.584 ± 1.218
0.517TyrTrp: 0.517 ± 0.362
4.651TyrTyr: 4.651 ± 0.929
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3871 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski