Amino acid dipepetide frequency for Muribaculaceae bacterium Isolate-080 (Janvier)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.394AlaAla: 6.394 ± 0.093	0.895AlaCys: 0.895 ± 0.028	5.171AlaAsp: 5.171 ± 0.07	5.089AlaGlu: 5.089 ± 0.074	2.966AlaPhe: 2.966 ± 0.051	5.379AlaGly: 5.379 ± 0.078	1.231AlaHis: 1.231 ± 0.037	5.523AlaIle: 5.523 ± 0.087	4.268AlaLys: 4.268 ± 0.066	6.949AlaLeu: 6.949 ± 0.081	2.354AlaMet: 2.354 ± 0.051	3.175AlaAsn: 3.175 ± 0.054	2.769AlaPro: 2.769 ± 0.051	2.515AlaGln: 2.515 ± 0.055	3.747AlaArg: 3.747 ± 0.065	4.88AlaSer: 4.88 ± 0.071	4.513AlaThr: 4.513 ± 0.073	5.524AlaVal: 5.524 ± 0.082	0.849AlaTrp: 0.849 ± 0.025	2.841AlaTyr: 2.841 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.852CysAla: 0.852 ± 0.031	0.211CysCys: 0.211 ± 0.013	0.761CysAsp: 0.761 ± 0.029	0.704CysGlu: 0.704 ± 0.026	0.502CysPhe: 0.502 ± 0.02	1.178CysGly: 1.178 ± 0.035	0.333CysHis: 0.333 ± 0.016	0.828CysIle: 0.828 ± 0.029	0.592CysLys: 0.592 ± 0.024	1.001CysLeu: 1.001 ± 0.03	0.276CysMet: 0.276 ± 0.016	0.571CysAsn: 0.571 ± 0.024	0.557CysPro: 0.557 ± 0.025	0.322CysGln: 0.322 ± 0.018	0.776CysArg: 0.776 ± 0.028	0.792CysSer: 0.792 ± 0.024	0.566CysThr: 0.566 ± 0.024	0.861CysVal: 0.861 ± 0.027	0.138CysTrp: 0.138 ± 0.011	0.52CysTyr: 0.52 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.508AspAla: 4.508 ± 0.071	0.794AspCys: 0.794 ± 0.029	3.434AspAsp: 3.434 ± 0.052	4.189AspGlu: 4.189 ± 0.074	3.172AspPhe: 3.172 ± 0.059	4.962AspGly: 4.962 ± 0.088	0.892AspHis: 0.892 ± 0.029	4.7AspIle: 4.7 ± 0.061	3.501AspLys: 3.501 ± 0.066	4.385AspLeu: 4.385 ± 0.057	1.805AspMet: 1.805 ± 0.041	3.194AspAsn: 3.194 ± 0.059	2.201AspPro: 2.201 ± 0.039	1.08AspGln: 1.08 ± 0.032	3.346AspArg: 3.346 ± 0.055	4.147AspSer: 4.147 ± 0.062	3.173AspThr: 3.173 ± 0.058	3.737AspVal: 3.737 ± 0.058	0.81AspTrp: 0.81 ± 0.028	2.929AspTyr: 2.929 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.093GluAla: 5.093 ± 0.09	0.708GluCys: 0.708 ± 0.028	3.108GluAsp: 3.108 ± 0.053	4.147GluGlu: 4.147 ± 0.076	2.499GluPhe: 2.499 ± 0.051	3.833GluGly: 3.833 ± 0.058	1.088GluHis: 1.088 ± 0.032	4.9GluIle: 4.9 ± 0.07	4.465GluLys: 4.465 ± 0.067	5.766GluLeu: 5.766 ± 0.087	1.921GluMet: 1.921 ± 0.042	3.335GluAsn: 3.335 ± 0.054	1.929GluPro: 1.929 ± 0.047	2.126GluGln: 2.126 ± 0.053	3.632GluArg: 3.632 ± 0.065	3.56GluSer: 3.56 ± 0.058	3.35GluThr: 3.35 ± 0.057	3.826GluVal: 3.826 ± 0.055	0.871GluTrp: 0.871 ± 0.029	2.564GluTyr: 2.564 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.116PheAla: 3.116 ± 0.048	0.603PheCys: 0.603 ± 0.025	2.933PheAsp: 2.933 ± 0.054	2.254PheGlu: 2.254 ± 0.045	1.906PhePhe: 1.906 ± 0.039	3.222PheGly: 3.222 ± 0.05	0.818PheHis: 0.818 ± 0.027	3.15PheIle: 3.15 ± 0.061	2.186PheLys: 2.186 ± 0.049	3.418PheLeu: 3.418 ± 0.064	1.236PheMet: 1.236 ± 0.037	2.507PheAsn: 2.507 ± 0.05	1.693PhePro: 1.693 ± 0.04	1.005PheGln: 1.005 ± 0.031	2.209PheArg: 2.209 ± 0.054	3.229PheSer: 3.229 ± 0.061	2.691PheThr: 2.691 ± 0.05	2.541PheVal: 2.541 ± 0.049	0.51PheTrp: 0.51 ± 0.022	1.73PheTyr: 1.73 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.87GlyAla: 4.87 ± 0.074	1.087GlyCys: 1.087 ± 0.039	3.846GlyAsp: 3.846 ± 0.071	4.213GlyGlu: 4.213 ± 0.062	3.074GlyPhe: 3.074 ± 0.052	4.818GlyGly: 4.818 ± 0.071	1.505GlyHis: 1.505 ± 0.035	5.271GlyIle: 5.271 ± 0.072	4.692GlyLys: 4.692 ± 0.08	5.862GlyLeu: 5.862 ± 0.07	2.025GlyMet: 2.025 ± 0.044	3.634GlyAsn: 3.634 ± 0.077	1.455GlyPro: 1.455 ± 0.036	1.933GlyGln: 1.933 ± 0.048	3.613GlyArg: 3.613 ± 0.063	4.29GlySer: 4.29 ± 0.061	3.855GlyThr: 3.855 ± 0.062	4.821GlyVal: 4.821 ± 0.068	1.0GlyTrp: 1.0 ± 0.041	3.176GlyTyr: 3.176 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.221HisAla: 1.221 ± 0.031	0.283HisCys: 0.283 ± 0.018	1.157HisAsp: 1.157 ± 0.032	1.057HisGlu: 1.057 ± 0.034	0.909HisPhe: 0.909 ± 0.028	1.345HisGly: 1.345 ± 0.034	0.532HisHis: 0.532 ± 0.028	1.522HisIle: 1.522 ± 0.038	0.958HisLys: 0.958 ± 0.031	1.699HisLeu: 1.699 ± 0.043	0.331HisMet: 0.331 ± 0.018	0.968HisAsn: 0.968 ± 0.03	1.037HisPro: 1.037 ± 0.033	0.509HisGln: 0.509 ± 0.021	1.125HisArg: 1.125 ± 0.029	1.218HisSer: 1.218 ± 0.031	1.048HisThr: 1.048 ± 0.036	1.005HisVal: 1.005 ± 0.032	0.241HisTrp: 0.241 ± 0.014	0.794HisTyr: 0.794 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.937IleAla: 5.937 ± 0.091	0.947IleCys: 0.947 ± 0.028	4.925IleAsp: 4.925 ± 0.068	4.607IleGlu: 4.607 ± 0.073	2.766IlePhe: 2.766 ± 0.057	4.673IleGly: 4.673 ± 0.065	1.284IleHis: 1.284 ± 0.034	4.868IleIle: 4.868 ± 0.089	3.806IleLys: 3.806 ± 0.06	5.486IleLeu: 5.486 ± 0.075	1.621IleMet: 1.621 ± 0.039	3.588IleAsn: 3.588 ± 0.058	3.303IlePro: 3.303 ± 0.058	1.662IleGln: 1.662 ± 0.038	3.548IleArg: 3.548 ± 0.056	5.147IleSer: 5.147 ± 0.078	3.835IleThr: 3.835 ± 0.059	4.59IleVal: 4.59 ± 0.071	0.617IleTrp: 0.617 ± 0.026	2.631IleTyr: 2.631 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.726LysAla: 4.726 ± 0.069	0.533LysCys: 0.533 ± 0.018	3.411LysAsp: 3.411 ± 0.054	4.237LysGlu: 4.237 ± 0.078	2.212LysPhe: 2.212 ± 0.045	3.853LysGly: 3.853 ± 0.064	0.982LysHis: 0.982 ± 0.027	3.994LysIle: 3.994 ± 0.068	3.732LysLys: 3.732 ± 0.072	4.601LysLeu: 4.601 ± 0.074	1.782LysMet: 1.782 ± 0.039	2.897LysAsn: 2.897 ± 0.057	2.184LysPro: 2.184 ± 0.048	1.709LysGln: 1.709 ± 0.047	3.093LysArg: 3.093 ± 0.069	3.635LysSer: 3.635 ± 0.069	3.23LysThr: 3.23 ± 0.055	3.805LysVal: 3.805 ± 0.061	0.809LysTrp: 0.809 ± 0.031	2.393LysTyr: 2.393 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	6.71LeuAla: 6.71 ± 0.098	1.196LeuCys: 1.196 ± 0.033	5.137LeuAsp: 5.137 ± 0.06	4.672LeuGlu: 4.672 ± 0.072	3.568LeuPhe: 3.568 ± 0.062	5.614LeuGly: 5.614 ± 0.082	1.69LeuHis: 1.69 ± 0.042	5.357LeuIle: 5.357 ± 0.082	5.16LeuLys: 5.16 ± 0.071	7.682LeuLeu: 7.682 ± 0.121	2.339LeuMet: 2.339 ± 0.052	4.205LeuAsn: 4.205 ± 0.064	4.148LeuPro: 4.148 ± 0.065	2.501LeuGln: 2.501 ± 0.046	5.22LeuArg: 5.22 ± 0.067	6.757LeuSer: 6.757 ± 0.083	5.639LeuThr: 5.639 ± 0.08	4.825LeuVal: 4.825 ± 0.066	0.999LeuTrp: 0.999 ± 0.029	3.334LeuTyr: 3.334 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.441MetAla: 2.441 ± 0.045	0.242MetCys: 0.242 ± 0.016	1.374MetAsp: 1.374 ± 0.037	1.756MetGlu: 1.756 ± 0.04	1.011MetPhe: 1.011 ± 0.034	1.75MetGly: 1.75 ± 0.039	0.38MetHis: 0.38 ± 0.018	1.64MetIle: 1.64 ± 0.033	2.123MetLys: 2.123 ± 0.043	2.599MetLeu: 2.599 ± 0.056	0.793MetMet: 0.793 ± 0.028	1.299MetAsn: 1.299 ± 0.03	1.276MetPro: 1.276 ± 0.037	0.936MetGln: 0.936 ± 0.026	1.621MetArg: 1.621 ± 0.039	1.856MetSer: 1.856 ± 0.039	1.832MetThr: 1.832 ± 0.042	1.6MetVal: 1.6 ± 0.045	0.28MetTrp: 0.28 ± 0.017	0.723MetTyr: 0.723 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.611AsnAla: 3.611 ± 0.057	0.522AsnCys: 0.522 ± 0.023	2.857AsnAsp: 2.857 ± 0.052	2.742AsnGlu: 2.742 ± 0.06	2.101AsnPhe: 2.101 ± 0.047	3.943AsnGly: 3.943 ± 0.067	1.032AsnHis: 1.032 ± 0.033	3.654AsnIle: 3.654 ± 0.063	2.431AsnLys: 2.431 ± 0.055	4.24AsnLeu: 4.24 ± 0.073	1.189AsnMet: 1.189 ± 0.031	2.464AsnAsn: 2.464 ± 0.063	2.92AsnPro: 2.92 ± 0.054	1.33AsnGln: 1.33 ± 0.041	2.811AsnArg: 2.811 ± 0.05	2.983AsnSer: 2.983 ± 0.055	2.574AsnThr: 2.574 ± 0.05	3.134AsnVal: 3.134 ± 0.056	0.563AsnTrp: 0.563 ± 0.026	2.04AsnTyr: 2.04 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	3.467ProAla: 3.467 ± 0.064	0.386ProCys: 0.386 ± 0.02	3.225ProAsp: 3.225 ± 0.059	3.58ProGlu: 3.58 ± 0.071	1.761ProPhe: 1.761 ± 0.039	2.744ProGly: 2.744 ± 0.05	0.782ProHis: 0.782 ± 0.03	2.218ProIle: 2.218 ± 0.045	2.136ProLys: 2.136 ± 0.05	3.292ProLeu: 3.292 ± 0.053	1.086ProMet: 1.086 ± 0.029	1.503ProAsn: 1.503 ± 0.037	0.989ProPro: 0.989 ± 0.028	1.371ProGln: 1.371 ± 0.039	1.747ProArg: 1.747 ± 0.038	2.795ProSer: 2.795 ± 0.057	2.231ProThr: 2.231 ± 0.047	3.243ProVal: 3.243 ± 0.058	0.477ProTrp: 0.477 ± 0.022	1.597ProTyr: 1.597 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.136GlnAla: 2.136 ± 0.045	0.293GlnCys: 0.293 ± 0.015	1.286GlnAsp: 1.286 ± 0.034	1.76GlnGlu: 1.76 ± 0.042	1.209GlnPhe: 1.209 ± 0.034	1.73GlnGly: 1.73 ± 0.041	0.539GlnHis: 0.539 ± 0.021	1.907GlnIle: 1.907 ± 0.041	1.821GlnLys: 1.821 ± 0.04	2.904GlnLeu: 2.904 ± 0.057	0.902GlnMet: 0.902 ± 0.026	1.419GlnAsn: 1.419 ± 0.034	1.267GlnPro: 1.267 ± 0.044	1.282GlnGln: 1.282 ± 0.048	1.72GlnArg: 1.72 ± 0.046	1.927GlnSer: 1.927 ± 0.037	1.745GlnThr: 1.745 ± 0.039	1.594GlnVal: 1.594 ± 0.033	0.444GlnTrp: 0.444 ± 0.021	1.218GlnTyr: 1.218 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.287ArgAla: 3.287 ± 0.055	0.632ArgCys: 0.632 ± 0.024	2.92ArgAsp: 2.92 ± 0.056	3.534ArgGlu: 3.534 ± 0.061	2.591ArgPhe: 2.591 ± 0.05	2.959ArgGly: 2.959 ± 0.052	1.427ArgHis: 1.427 ± 0.037	4.056ArgIle: 4.056 ± 0.06	3.383ArgLys: 3.383 ± 0.061	5.403ArgLeu: 5.403 ± 0.075	1.619ArgMet: 1.619 ± 0.041	2.833ArgAsn: 2.833 ± 0.047	2.131ArgPro: 2.131 ± 0.058	2.148ArgGln: 2.148 ± 0.044	3.468ArgArg: 3.468 ± 0.059	2.921ArgSer: 2.921 ± 0.052	2.719ArgThr: 2.719 ± 0.044	2.922ArgVal: 2.922 ± 0.054	0.682ArgTrp: 0.682 ± 0.022	2.533ArgTyr: 2.533 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.025SerAla: 5.025 ± 0.068	0.794SerCys: 0.794 ± 0.027	4.263SerAsp: 4.263 ± 0.068	3.938SerGlu: 3.938 ± 0.062	3.116SerPhe: 3.116 ± 0.053	4.815SerGly: 4.815 ± 0.069	1.312SerHis: 1.312 ± 0.033	4.344SerIle: 4.344 ± 0.065	3.347SerLys: 3.347 ± 0.064	6.212SerLeu: 6.212 ± 0.094	1.712SerMet: 1.712 ± 0.039	2.763SerAsn: 2.763 ± 0.055	2.876SerPro: 2.876 ± 0.058	2.02SerGln: 2.02 ± 0.04	3.575SerArg: 3.575 ± 0.058	4.309SerSer: 4.309 ± 0.071	3.626SerThr: 3.626 ± 0.062	4.612SerVal: 4.612 ± 0.078	0.792SerTrp: 0.792 ± 0.025	2.701SerTyr: 2.701 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.689ThrAla: 4.689 ± 0.071	0.537ThrCys: 0.537 ± 0.023	3.837ThrAsp: 3.837 ± 0.059	3.208ThrGlu: 3.208 ± 0.046	2.65ThrPhe: 2.65 ± 0.053	4.235ThrGly: 4.235 ± 0.074	1.018ThrHis: 1.018 ± 0.032	3.99ThrIle: 3.99 ± 0.057	2.504ThrLys: 2.504 ± 0.05	5.485ThrLeu: 5.485 ± 0.075	1.247ThrMet: 1.247 ± 0.035	2.258ThrAsn: 2.258 ± 0.047	3.314ThrPro: 3.314 ± 0.058	1.565ThrGln: 1.565 ± 0.04	2.623ThrArg: 2.623 ± 0.049	3.537ThrSer: 3.537 ± 0.064	3.293ThrThr: 3.293 ± 0.061	4.463ThrVal: 4.463 ± 0.068	0.603ThrTrp: 0.603 ± 0.024	2.274ThrTyr: 2.274 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.374ValAla: 5.374 ± 0.084	0.938ValCys: 0.938 ± 0.027	4.013ValAsp: 4.013 ± 0.071	4.004ValGlu: 4.004 ± 0.063	2.521ValPhe: 2.521 ± 0.048	4.151ValGly: 4.151 ± 0.065	0.991ValHis: 0.991 ± 0.032	4.543ValIle: 4.543 ± 0.07	3.951ValLys: 3.951 ± 0.064	5.005ValLeu: 5.005 ± 0.074	1.857ValMet: 1.857 ± 0.043	3.449ValAsn: 3.449 ± 0.066	2.506ValPro: 2.506 ± 0.048	1.506ValGln: 1.506 ± 0.035	3.273ValArg: 3.273 ± 0.063	4.669ValSer: 4.669 ± 0.08	4.261ValThr: 4.261 ± 0.084	4.508ValVal: 4.508 ± 0.067	0.72ValTrp: 0.72 ± 0.026	2.433ValTyr: 2.433 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.774TrpAla: 0.774 ± 0.03	0.188TrpCys: 0.188 ± 0.012	0.727TrpAsp: 0.727 ± 0.028	0.75TrpGlu: 0.75 ± 0.03	0.511TrpPhe: 0.511 ± 0.021	0.918TrpGly: 0.918 ± 0.03	0.296TrpHis: 0.296 ± 0.016	0.762TrpIle: 0.762 ± 0.026	0.724TrpLys: 0.724 ± 0.024	1.19TrpLeu: 1.19 ± 0.031	0.399TrpMet: 0.399 ± 0.018	0.723TrpAsn: 0.723 ± 0.027	0.288TrpPro: 0.288 ± 0.017	0.436TrpGln: 0.436 ± 0.02	0.655TrpArg: 0.655 ± 0.024	0.749TrpSer: 0.749 ± 0.031	0.693TrpThr: 0.693 ± 0.026	0.657TrpVal: 0.657 ± 0.029	0.204TrpTrp: 0.204 ± 0.013	0.463TrpTyr: 0.463 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.803TyrAla: 2.803 ± 0.052	0.551TyrCys: 0.551 ± 0.022	2.576TyrAsp: 2.576 ± 0.052	2.282TyrGlu: 2.282 ± 0.04	1.913TyrPhe: 1.913 ± 0.038	2.917TyrGly: 2.917 ± 0.058	0.828TyrHis: 0.828 ± 0.027	2.617TyrIle: 2.617 ± 0.049	2.04TyrLys: 2.04 ± 0.052	3.573TyrLeu: 3.573 ± 0.058	1.038TyrMet: 1.038 ± 0.032	2.353TyrAsn: 2.353 ± 0.056	1.786TyrPro: 1.786 ± 0.042	1.146TyrGln: 1.146 ± 0.033	2.369TyrArg: 2.369 ± 0.045	2.749TyrSer: 2.749 ± 0.049	2.455TyrThr: 2.455 ± 0.055	2.403TyrVal: 2.403 ± 0.055	0.496TyrTrp: 0.496 ± 0.023	1.845TyrTyr: 1.845 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3287 proteins (1130632 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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