Amino acid dipepetide frequency for Streptococcus satellite phage Javan729

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.24AlaAla: 1.24 ± 0.699
0.744AlaCys: 0.744 ± 0.493
2.481AlaAsp: 2.481 ± 1.097
5.21AlaGlu: 5.21 ± 1.294
3.473AlaPhe: 3.473 ± 0.873
2.977AlaGly: 2.977 ± 0.861
0.744AlaHis: 0.744 ± 0.386
4.962AlaIle: 4.962 ± 0.939
4.465AlaLys: 4.465 ± 1.062
5.21AlaLeu: 5.21 ± 1.016
1.24AlaMet: 1.24 ± 0.566
2.233AlaAsn: 2.233 ± 0.954
1.737AlaPro: 1.737 ± 0.602
1.985AlaGln: 1.985 ± 0.483
3.225AlaArg: 3.225 ± 0.729
2.977AlaSer: 2.977 ± 0.779
4.465AlaThr: 4.465 ± 0.96
3.225AlaVal: 3.225 ± 0.671
0.248AlaTrp: 0.248 ± 0.306
1.737AlaTyr: 1.737 ± 0.633
0.0AlaXaa: 0.0 ± 0.0
Cys
0.496CysAla: 0.496 ± 0.366
0.0CysCys: 0.0 ± 0.0
0.992CysAsp: 0.992 ± 0.5
0.496CysGlu: 0.496 ± 0.329
0.248CysPhe: 0.248 ± 0.247
1.488CysGly: 1.488 ± 0.742
0.248CysHis: 0.248 ± 0.227
0.496CysIle: 0.496 ± 0.331
0.496CysLys: 0.496 ± 0.296
0.496CysLeu: 0.496 ± 0.324
0.744CysMet: 0.744 ± 0.44
0.496CysAsn: 0.496 ± 0.312
0.992CysPro: 0.992 ± 0.549
0.248CysGln: 0.248 ± 0.264
0.496CysArg: 0.496 ± 0.31
0.248CysSer: 0.248 ± 0.239
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.248CysTyr: 0.248 ± 0.235
0.0CysXaa: 0.0 ± 0.0
Asp
1.488AspAla: 1.488 ± 0.416
0.992AspCys: 0.992 ± 0.571
2.481AspAsp: 2.481 ± 0.846
3.969AspGlu: 3.969 ± 1.156
3.721AspPhe: 3.721 ± 0.519
1.985AspGly: 1.985 ± 0.667
0.0AspHis: 0.0 ± 0.0
4.465AspIle: 4.465 ± 0.778
4.962AspLys: 4.962 ± 1.112
7.442AspLeu: 7.442 ± 1.233
0.496AspMet: 0.496 ± 0.343
3.225AspAsn: 3.225 ± 0.55
0.744AspPro: 0.744 ± 0.349
0.992AspGln: 0.992 ± 0.513
2.729AspArg: 2.729 ± 0.832
2.233AspSer: 2.233 ± 0.672
2.729AspThr: 2.729 ± 0.692
1.737AspVal: 1.737 ± 0.513
0.248AspTrp: 0.248 ± 0.236
3.969AspTyr: 3.969 ± 1.351
0.0AspXaa: 0.0 ± 0.0
Glu
3.721GluAla: 3.721 ± 1.285
1.24GluCys: 1.24 ± 0.424
4.217GluAsp: 4.217 ± 1.283
4.713GluGlu: 4.713 ± 1.143
2.233GluPhe: 2.233 ± 0.575
2.233GluGly: 2.233 ± 0.74
1.488GluHis: 1.488 ± 0.58
6.698GluIle: 6.698 ± 1.267
7.194GluLys: 7.194 ± 1.511
9.923GluLeu: 9.923 ± 1.918
2.977GluMet: 2.977 ± 0.919
5.706GluAsn: 5.706 ± 1.178
2.729GluPro: 2.729 ± 0.767
4.465GluGln: 4.465 ± 1.104
4.713GluArg: 4.713 ± 1.482
6.45GluSer: 6.45 ± 1.155
3.721GluThr: 3.721 ± 0.913
4.217GluVal: 4.217 ± 0.991
0.248GluTrp: 0.248 ± 0.235
4.217GluTyr: 4.217 ± 0.979
0.0GluXaa: 0.0 ± 0.0
Phe
0.496PheAla: 0.496 ± 0.306
0.744PheCys: 0.744 ± 0.515
2.729PheAsp: 2.729 ± 0.683
2.729PheGlu: 2.729 ± 0.826
1.24PhePhe: 1.24 ± 0.453
2.729PheGly: 2.729 ± 0.597
1.24PheHis: 1.24 ± 0.35
1.488PheIle: 1.488 ± 0.457
3.969PheLys: 3.969 ± 1.297
4.713PheLeu: 4.713 ± 0.96
0.496PheMet: 0.496 ± 0.282
1.737PheAsn: 1.737 ± 0.602
0.248PhePro: 0.248 ± 0.264
1.24PheGln: 1.24 ± 0.476
0.992PheArg: 0.992 ± 0.431
3.969PheSer: 3.969 ± 0.802
1.985PheThr: 1.985 ± 0.604
1.737PheVal: 1.737 ± 0.738
0.744PheTrp: 0.744 ± 0.355
2.481PheTyr: 2.481 ± 0.596
0.0PheXaa: 0.0 ± 0.0
Gly
2.977GlyAla: 2.977 ± 1.042
0.496GlyCys: 0.496 ± 0.392
1.985GlyAsp: 1.985 ± 0.572
3.969GlyGlu: 3.969 ± 0.724
1.985GlyPhe: 1.985 ± 0.615
3.473GlyGly: 3.473 ± 1.236
0.248GlyHis: 0.248 ± 0.227
4.962GlyIle: 4.962 ± 1.063
4.465GlyLys: 4.465 ± 0.966
5.706GlyLeu: 5.706 ± 1.184
0.992GlyMet: 0.992 ± 0.577
2.481GlyAsn: 2.481 ± 0.837
0.248GlyPro: 0.248 ± 0.236
3.721GlyGln: 3.721 ± 0.674
4.713GlyArg: 4.713 ± 0.727
1.737GlySer: 1.737 ± 0.625
3.225GlyThr: 3.225 ± 0.923
4.465GlyVal: 4.465 ± 0.852
0.992GlyTrp: 0.992 ± 0.516
3.721GlyTyr: 3.721 ± 0.724
0.0GlyXaa: 0.0 ± 0.0
His
1.737HisAla: 1.737 ± 0.642
0.0HisCys: 0.0 ± 0.0
0.496HisAsp: 0.496 ± 0.276
1.488HisGlu: 1.488 ± 0.725
0.496HisPhe: 0.496 ± 0.471
1.737HisGly: 1.737 ± 0.541
0.496HisHis: 0.496 ± 0.352
0.744HisIle: 0.744 ± 0.47
1.488HisLys: 1.488 ± 0.63
0.992HisLeu: 0.992 ± 0.553
0.0HisMet: 0.0 ± 0.0
1.737HisAsn: 1.737 ± 0.751
0.744HisPro: 0.744 ± 0.453
0.248HisGln: 0.248 ± 0.212
1.24HisArg: 1.24 ± 0.574
0.992HisSer: 0.992 ± 0.505
0.496HisThr: 0.496 ± 0.455
0.496HisVal: 0.496 ± 0.261
0.0HisTrp: 0.0 ± 0.0
1.24HisTyr: 1.24 ± 0.562
0.0HisXaa: 0.0 ± 0.0
Ile
3.969IleAla: 3.969 ± 1.126
0.496IleCys: 0.496 ± 0.302
4.713IleAsp: 4.713 ± 1.038
7.194IleGlu: 7.194 ± 1.687
2.729IlePhe: 2.729 ± 0.664
4.217IleGly: 4.217 ± 0.961
1.24IleHis: 1.24 ± 0.436
5.706IleIle: 5.706 ± 1.143
6.698IleLys: 6.698 ± 1.258
6.698IleLeu: 6.698 ± 1.196
0.744IleMet: 0.744 ± 0.36
2.481IleAsn: 2.481 ± 0.83
3.225IlePro: 3.225 ± 0.773
2.977IleGln: 2.977 ± 0.933
3.721IleArg: 3.721 ± 0.656
3.969IleSer: 3.969 ± 0.818
5.706IleThr: 5.706 ± 1.157
3.225IleVal: 3.225 ± 0.677
0.744IleTrp: 0.744 ± 0.345
2.481IleTyr: 2.481 ± 0.862
0.0IleXaa: 0.0 ± 0.0
Lys
7.442LysAla: 7.442 ± 1.231
0.496LysCys: 0.496 ± 0.319
4.465LysAsp: 4.465 ± 0.835
9.675LysGlu: 9.675 ± 1.368
1.985LysPhe: 1.985 ± 0.634
6.698LysGly: 6.698 ± 1.025
2.729LysHis: 2.729 ± 1.114
6.202LysIle: 6.202 ± 1.149
7.938LysLys: 7.938 ± 1.644
7.442LysLeu: 7.442 ± 1.566
1.985LysMet: 1.985 ± 0.638
7.194LysAsn: 7.194 ± 1.339
2.729LysPro: 2.729 ± 1.019
3.473LysGln: 3.473 ± 0.739
5.706LysArg: 5.706 ± 1.162
6.45LysSer: 6.45 ± 0.957
6.698LysThr: 6.698 ± 1.525
3.969LysVal: 3.969 ± 0.988
0.992LysTrp: 0.992 ± 0.389
1.985LysTyr: 1.985 ± 0.67
0.0LysXaa: 0.0 ± 0.0
Leu
8.187LeuAla: 8.187 ± 1.387
0.496LeuCys: 0.496 ± 0.349
6.946LeuAsp: 6.946 ± 1.702
9.179LeuGlu: 9.179 ± 1.602
3.225LeuPhe: 3.225 ± 1.01
4.713LeuGly: 4.713 ± 0.974
1.488LeuHis: 1.488 ± 0.644
4.962LeuIle: 4.962 ± 1.063
9.923LeuLys: 9.923 ± 1.334
7.442LeuLeu: 7.442 ± 1.261
1.985LeuMet: 1.985 ± 0.658
6.698LeuAsn: 6.698 ± 1.275
4.217LeuPro: 4.217 ± 0.881
4.962LeuGln: 4.962 ± 0.908
4.713LeuArg: 4.713 ± 0.844
4.713LeuSer: 4.713 ± 1.017
9.427LeuThr: 9.427 ± 1.751
4.713LeuVal: 4.713 ± 0.951
0.0LeuTrp: 0.0 ± 0.0
4.465LeuTyr: 4.465 ± 0.793
0.0LeuXaa: 0.0 ± 0.0
Met
0.992MetAla: 0.992 ± 0.649
0.0MetCys: 0.0 ± 0.0
1.24MetAsp: 1.24 ± 0.543
2.481MetGlu: 2.481 ± 0.672
0.992MetPhe: 0.992 ± 0.489
1.488MetGly: 1.488 ± 0.5
0.0MetHis: 0.0 ± 0.0
1.24MetIle: 1.24 ± 0.486
1.985MetLys: 1.985 ± 0.907
0.496MetLeu: 0.496 ± 0.31
0.0MetMet: 0.0 ± 0.0
1.737MetAsn: 1.737 ± 0.625
0.496MetPro: 0.496 ± 0.352
0.744MetGln: 0.744 ± 0.431
1.737MetArg: 1.737 ± 0.689
0.992MetSer: 0.992 ± 0.525
2.729MetThr: 2.729 ± 0.85
0.248MetVal: 0.248 ± 0.23
0.248MetTrp: 0.248 ± 0.233
0.248MetTyr: 0.248 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
2.977AsnAla: 2.977 ± 0.712
0.744AsnCys: 0.744 ± 0.376
3.473AsnAsp: 3.473 ± 1.098
3.473AsnGlu: 3.473 ± 0.727
1.24AsnPhe: 1.24 ± 0.721
5.21AsnGly: 5.21 ± 1.113
1.24AsnHis: 1.24 ± 0.536
3.225AsnIle: 3.225 ± 0.984
5.458AsnLys: 5.458 ± 0.99
5.21AsnLeu: 5.21 ± 1.32
1.737AsnMet: 1.737 ± 0.599
1.24AsnAsn: 1.24 ± 0.542
1.985AsnPro: 1.985 ± 0.743
1.985AsnGln: 1.985 ± 0.608
2.481AsnArg: 2.481 ± 0.727
3.473AsnSer: 3.473 ± 0.991
3.969AsnThr: 3.969 ± 1.007
2.233AsnVal: 2.233 ± 0.829
0.744AsnTrp: 0.744 ± 0.327
1.737AsnTyr: 1.737 ± 0.544
0.0AsnXaa: 0.0 ± 0.0
Pro
1.985ProAla: 1.985 ± 0.651
0.0ProCys: 0.0 ± 0.0
1.985ProAsp: 1.985 ± 0.647
2.729ProGlu: 2.729 ± 0.928
1.488ProPhe: 1.488 ± 0.506
0.496ProGly: 0.496 ± 0.528
0.496ProHis: 0.496 ± 0.286
2.729ProIle: 2.729 ± 0.704
2.481ProLys: 2.481 ± 0.849
1.985ProLeu: 1.985 ± 0.687
0.248ProMet: 0.248 ± 0.264
1.24ProAsn: 1.24 ± 0.429
0.992ProPro: 0.992 ± 0.528
1.488ProGln: 1.488 ± 0.641
2.729ProArg: 2.729 ± 0.591
2.729ProSer: 2.729 ± 0.964
1.737ProThr: 1.737 ± 0.586
2.233ProVal: 2.233 ± 0.622
0.0ProTrp: 0.0 ± 0.0
1.488ProTyr: 1.488 ± 0.564
0.0ProXaa: 0.0 ± 0.0
Gln
2.481GlnAla: 2.481 ± 0.619
0.248GlnCys: 0.248 ± 0.239
2.481GlnAsp: 2.481 ± 0.668
4.465GlnGlu: 4.465 ± 1.069
0.992GlnPhe: 0.992 ± 0.53
2.233GlnGly: 2.233 ± 0.631
0.744GlnHis: 0.744 ± 0.381
2.233GlnIle: 2.233 ± 0.639
5.21GlnLys: 5.21 ± 0.919
4.465GlnLeu: 4.465 ± 0.983
0.248GlnMet: 0.248 ± 0.216
2.233GlnAsn: 2.233 ± 0.893
0.744GlnPro: 0.744 ± 0.372
2.481GlnGln: 2.481 ± 0.826
1.488GlnArg: 1.488 ± 0.638
0.992GlnSer: 0.992 ± 0.378
2.481GlnThr: 2.481 ± 0.919
3.225GlnVal: 3.225 ± 0.945
0.496GlnTrp: 0.496 ± 0.283
0.992GlnTyr: 0.992 ± 0.504
0.0GlnXaa: 0.0 ± 0.0
Arg
2.233ArgAla: 2.233 ± 0.61
0.496ArgCys: 0.496 ± 0.331
2.977ArgAsp: 2.977 ± 0.975
4.962ArgGlu: 4.962 ± 1.051
1.737ArgPhe: 1.737 ± 0.633
1.985ArgGly: 1.985 ± 0.755
0.496ArgHis: 0.496 ± 0.337
3.721ArgIle: 3.721 ± 0.785
5.21ArgLys: 5.21 ± 0.926
7.69ArgLeu: 7.69 ± 1.502
1.488ArgMet: 1.488 ± 0.568
2.233ArgAsn: 2.233 ± 0.835
1.488ArgPro: 1.488 ± 0.665
3.473ArgGln: 3.473 ± 0.852
2.481ArgArg: 2.481 ± 0.746
2.729ArgSer: 2.729 ± 0.599
2.233ArgThr: 2.233 ± 0.597
2.977ArgVal: 2.977 ± 0.909
0.0ArgTrp: 0.0 ± 0.0
3.473ArgTyr: 3.473 ± 1.171
0.0ArgXaa: 0.0 ± 0.0
Ser
3.721SerAla: 3.721 ± 0.973
0.248SerCys: 0.248 ± 0.264
1.737SerAsp: 1.737 ± 0.558
4.465SerGlu: 4.465 ± 1.184
2.729SerPhe: 2.729 ± 0.633
2.481SerGly: 2.481 ± 0.638
0.744SerHis: 0.744 ± 0.577
5.21SerIle: 5.21 ± 1.101
5.954SerLys: 5.954 ± 1.062
6.45SerLeu: 6.45 ± 1.235
1.488SerMet: 1.488 ± 0.647
4.217SerAsn: 4.217 ± 0.958
2.729SerPro: 2.729 ± 0.659
1.24SerGln: 1.24 ± 0.449
2.729SerArg: 2.729 ± 0.831
2.977SerSer: 2.977 ± 0.888
3.969SerThr: 3.969 ± 0.895
1.985SerVal: 1.985 ± 0.874
0.992SerTrp: 0.992 ± 0.402
1.24SerTyr: 1.24 ± 0.45
0.0SerXaa: 0.0 ± 0.0
Thr
3.225ThrAla: 3.225 ± 0.919
0.496ThrCys: 0.496 ± 0.405
2.233ThrAsp: 2.233 ± 0.73
3.473ThrGlu: 3.473 ± 0.836
1.488ThrPhe: 1.488 ± 0.509
3.969ThrGly: 3.969 ± 0.668
1.737ThrHis: 1.737 ± 0.639
5.458ThrIle: 5.458 ± 0.977
6.946ThrLys: 6.946 ± 1.516
7.938ThrLeu: 7.938 ± 1.264
1.24ThrMet: 1.24 ± 0.75
1.985ThrAsn: 1.985 ± 0.716
3.473ThrPro: 3.473 ± 0.816
1.985ThrGln: 1.985 ± 0.616
3.225ThrArg: 3.225 ± 0.878
3.473ThrSer: 3.473 ± 0.702
2.977ThrThr: 2.977 ± 0.95
4.217ThrVal: 4.217 ± 1.454
0.248ThrTrp: 0.248 ± 0.246
3.473ThrTyr: 3.473 ± 1.351
0.0ThrXaa: 0.0 ± 0.0
Val
3.225ValAla: 3.225 ± 1.159
0.496ValCys: 0.496 ± 0.239
1.737ValAsp: 1.737 ± 0.644
3.969ValGlu: 3.969 ± 1.18
2.233ValPhe: 2.233 ± 0.671
4.713ValGly: 4.713 ± 1.264
0.0ValHis: 0.0 ± 0.0
3.969ValIle: 3.969 ± 0.981
5.458ValLys: 5.458 ± 0.993
4.465ValLeu: 4.465 ± 1.173
0.744ValMet: 0.744 ± 0.433
2.977ValAsn: 2.977 ± 0.876
1.24ValPro: 1.24 ± 0.451
1.985ValGln: 1.985 ± 0.605
2.233ValArg: 2.233 ± 0.718
2.977ValSer: 2.977 ± 0.718
2.729ValThr: 2.729 ± 0.655
2.233ValVal: 2.233 ± 1.147
0.496ValTrp: 0.496 ± 0.392
1.24ValTyr: 1.24 ± 0.769
0.0ValXaa: 0.0 ± 0.0
Trp
0.496TrpAla: 0.496 ± 0.283
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.24TrpGlu: 1.24 ± 0.547
0.248TrpPhe: 0.248 ± 0.233
0.248TrpGly: 0.248 ± 0.328
0.0TrpHis: 0.0 ± 0.0
0.992TrpIle: 0.992 ± 0.467
0.992TrpLys: 0.992 ± 0.532
0.992TrpLeu: 0.992 ± 0.427
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.248TrpGln: 0.248 ± 0.306
0.496TrpArg: 0.496 ± 0.338
0.744TrpSer: 0.744 ± 0.409
0.0TrpThr: 0.0 ± 0.0
0.496TrpVal: 0.496 ± 0.327
0.0TrpTrp: 0.0 ± 0.0
0.496TrpTyr: 0.496 ± 0.338
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.488TyrAla: 1.488 ± 0.592
0.496TyrCys: 0.496 ± 0.313
1.24TyrAsp: 1.24 ± 0.363
3.225TyrGlu: 3.225 ± 0.737
3.225TyrPhe: 3.225 ± 0.84
1.488TyrGly: 1.488 ± 0.64
1.488TyrHis: 1.488 ± 0.572
3.473TyrIle: 3.473 ± 0.909
4.962TyrLys: 4.962 ± 1.363
6.698TyrLeu: 6.698 ± 1.571
0.992TyrMet: 0.992 ± 0.622
1.985TyrAsn: 1.985 ± 0.573
0.496TyrPro: 0.496 ± 0.254
0.992TyrGln: 0.992 ± 0.444
2.233TyrArg: 2.233 ± 0.766
2.729TyrSer: 2.729 ± 0.694
1.985TyrThr: 1.985 ± 0.531
1.488TyrVal: 1.488 ± 0.787
0.248TyrTrp: 0.248 ± 0.264
1.488TyrTyr: 1.488 ± 0.544
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 26 proteins (4032 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski