Amino acid dipepetide frequency for Candidatus Deianiraea vastatrix

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.255AlaAla: 3.255 ± 0.142
0.889AlaCys: 0.889 ± 0.055
2.689AlaAsp: 2.689 ± 0.088
3.036AlaGlu: 3.036 ± 0.096
2.88AlaPhe: 2.88 ± 0.087
3.493AlaGly: 3.493 ± 0.137
0.851AlaHis: 0.851 ± 0.051
6.431AlaIle: 6.431 ± 0.157
6.669AlaLys: 6.669 ± 0.172
4.617AlaLeu: 4.617 ± 0.117
1.833AlaMet: 1.833 ± 0.076
3.698AlaAsn: 3.698 ± 0.117
1.384AlaPro: 1.384 ± 0.084
2.344AlaGln: 2.344 ± 0.103
2.276AlaArg: 2.276 ± 0.084
4.366AlaSer: 4.366 ± 0.114
2.806AlaThr: 2.806 ± 0.106
3.288AlaVal: 3.288 ± 0.108
0.372AlaTrp: 0.372 ± 0.036
1.696AlaTyr: 1.696 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.856CysAla: 0.856 ± 0.047
0.263CysCys: 0.263 ± 0.036
1.097CysAsp: 1.097 ± 0.057
0.916CysGlu: 0.916 ± 0.052
0.785CysPhe: 0.785 ± 0.048
1.204CysGly: 1.204 ± 0.063
0.309CysHis: 0.309 ± 0.028
1.387CysIle: 1.387 ± 0.065
1.327CysLys: 1.327 ± 0.069
1.143CysLeu: 1.143 ± 0.061
0.356CysMet: 0.356 ± 0.035
0.914CysAsn: 0.914 ± 0.053
0.46CysPro: 0.46 ± 0.035
0.438CysGln: 0.438 ± 0.031
0.408CysArg: 0.408 ± 0.037
0.998CysSer: 0.998 ± 0.063
0.673CysThr: 0.673 ± 0.053
1.067CysVal: 1.067 ± 0.055
0.055CysTrp: 0.055 ± 0.018
0.536CysTyr: 0.536 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
3.633AspAla: 3.633 ± 0.11
0.807AspCys: 0.807 ± 0.045
3.384AspAsp: 3.384 ± 0.118
4.694AspGlu: 4.694 ± 0.137
3.663AspPhe: 3.663 ± 0.128
3.737AspGly: 3.737 ± 0.122
0.591AspHis: 0.591 ± 0.037
6.412AspIle: 6.412 ± 0.133
5.49AspLys: 5.49 ± 0.125
4.915AspLeu: 4.915 ± 0.125
1.316AspMet: 1.316 ± 0.057
3.157AspAsn: 3.157 ± 0.107
1.275AspPro: 1.275 ± 0.074
1.313AspGln: 1.313 ± 0.07
1.707AspArg: 1.707 ± 0.08
3.165AspSer: 3.165 ± 0.099
2.131AspThr: 2.131 ± 0.088
3.819AspVal: 3.819 ± 0.128
0.353AspTrp: 0.353 ± 0.033
2.232AspTyr: 2.232 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
2.867GluAla: 2.867 ± 0.107
0.758GluCys: 0.758 ± 0.044
2.921GluAsp: 2.921 ± 0.113
3.572GluGlu: 3.572 ± 0.136
2.99GluPhe: 2.99 ± 0.094
2.262GluGly: 2.262 ± 0.101
0.785GluHis: 0.785 ± 0.049
7.815GluIle: 7.815 ± 0.17
7.396GluLys: 7.396 ± 0.176
4.204GluLeu: 4.204 ± 0.119
1.704GluMet: 1.704 ± 0.07
5.337GluAsn: 5.337 ± 0.134
0.946GluPro: 0.946 ± 0.053
1.923GluGln: 1.923 ± 0.109
2.128GluArg: 2.128 ± 0.082
3.255GluSer: 3.255 ± 0.098
2.407GluThr: 2.407 ± 0.084
3.329GluVal: 3.329 ± 0.103
0.276GluTrp: 0.276 ± 0.031
2.506GluTyr: 2.506 ± 0.086
0.0GluXaa: 0.0 ± 0.0
Phe
3.931PheAla: 3.931 ± 0.119
0.993PheCys: 0.993 ± 0.06
3.203PheAsp: 3.203 ± 0.09
3.159PheGlu: 3.159 ± 0.098
2.932PhePhe: 2.932 ± 0.117
3.427PheGly: 3.427 ± 0.119
0.894PheHis: 0.894 ± 0.051
4.76PheIle: 4.76 ± 0.146
3.14PheLys: 3.14 ± 0.106
4.781PheLeu: 4.781 ± 0.135
1.119PheMet: 1.119 ± 0.062
2.992PheAsn: 2.992 ± 0.1
1.275PhePro: 1.275 ± 0.067
1.299PheGln: 1.299 ± 0.065
1.526PheArg: 1.526 ± 0.069
4.196PheSer: 4.196 ± 0.111
2.782PheThr: 2.782 ± 0.102
2.943PheVal: 2.943 ± 0.1
0.38PheTrp: 0.38 ± 0.038
2.043PheTyr: 2.043 ± 0.092
0.0PheXaa: 0.0 ± 0.0
Gly
3.094GlyAla: 3.094 ± 0.108
1.023GlyCys: 1.023 ± 0.058
3.198GlyAsp: 3.198 ± 0.103
2.962GlyGlu: 2.962 ± 0.101
3.441GlyPhe: 3.441 ± 0.116
4.147GlyGly: 4.147 ± 0.155
1.026GlyHis: 1.026 ± 0.058
5.999GlyIle: 5.999 ± 0.149
5.498GlyLys: 5.498 ± 0.125
4.382GlyLeu: 4.382 ± 0.105
1.74GlyMet: 1.74 ± 0.068
3.419GlyAsn: 3.419 ± 0.141
0.916GlyPro: 0.916 ± 0.055
1.794GlyGln: 1.794 ± 0.069
2.019GlyArg: 2.019 ± 0.082
4.095GlySer: 4.095 ± 0.148
2.634GlyThr: 2.634 ± 0.085
4.092GlyVal: 4.092 ± 0.116
0.388GlyTrp: 0.388 ± 0.036
2.448GlyTyr: 2.448 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
0.974HisAla: 0.974 ± 0.053
0.301HisCys: 0.301 ± 0.031
0.946HisAsp: 0.946 ± 0.053
1.075HisGlu: 1.075 ± 0.061
0.867HisPhe: 0.867 ± 0.047
1.288HisGly: 1.288 ± 0.059
0.375HisHis: 0.375 ± 0.03
1.669HisIle: 1.669 ± 0.078
1.264HisLys: 1.264 ± 0.063
1.351HisLeu: 1.351 ± 0.058
0.309HisMet: 0.309 ± 0.025
1.168HisAsn: 1.168 ± 0.061
0.583HisPro: 0.583 ± 0.038
0.566HisGln: 0.566 ± 0.045
0.591HisArg: 0.591 ± 0.039
1.094HisSer: 1.094 ± 0.053
0.7HisThr: 0.7 ± 0.037
0.821HisVal: 0.821 ± 0.045
0.104HisTrp: 0.104 ± 0.017
0.708HisTyr: 0.708 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
7.67IleAla: 7.67 ± 0.185
1.855IleCys: 1.855 ± 0.083
6.496IleAsp: 6.496 ± 0.146
6.081IleGlu: 6.081 ± 0.169
5.618IlePhe: 5.618 ± 0.174
5.744IleGly: 5.744 ± 0.146
1.554IleHis: 1.554 ± 0.063
8.534IleIle: 8.534 ± 0.212
7.995IleLys: 7.995 ± 0.154
8.931IleLeu: 8.931 ± 0.211
2.292IleMet: 2.292 ± 0.093
6.097IleAsn: 6.097 ± 0.165
3.162IlePro: 3.162 ± 0.089
2.951IleGln: 2.951 ± 0.137
2.946IleArg: 2.946 ± 0.102
8.824IleSer: 8.824 ± 0.201
5.216IleThr: 5.216 ± 0.133
5.348IleVal: 5.348 ± 0.149
0.555IleTrp: 0.555 ± 0.043
3.323IleTyr: 3.323 ± 0.11
0.0IleXaa: 0.0 ± 0.0
Lys
4.281LysAla: 4.281 ± 0.127
1.13LysCys: 1.13 ± 0.058
5.772LysAsp: 5.772 ± 0.137
5.134LysGlu: 5.134 ± 0.154
3.958LysPhe: 3.958 ± 0.12
3.348LysGly: 3.348 ± 0.104
1.556LysHis: 1.556 ± 0.059
11.144LysIle: 11.144 ± 0.204
8.244LysLys: 8.244 ± 0.183
6.57LysLeu: 6.57 ± 0.159
2.91LysMet: 2.91 ± 0.083
7.648LysAsn: 7.648 ± 0.181
2.292LysPro: 2.292 ± 0.086
2.938LysGln: 2.938 ± 0.13
2.716LysArg: 2.716 ± 0.086
6.324LysSer: 6.324 ± 0.137
5.028LysThr: 5.028 ± 0.114
4.374LysVal: 4.374 ± 0.114
0.583LysTrp: 0.583 ± 0.035
4.15LysTyr: 4.15 ± 0.136
0.0LysXaa: 0.0 ± 0.0
Leu
5.186LeuAla: 5.186 ± 0.126
1.428LeuCys: 1.428 ± 0.063
4.781LeuAsp: 4.781 ± 0.125
5.266LeuGlu: 5.266 ± 0.126
4.286LeuPhe: 4.286 ± 0.129
4.784LeuGly: 4.784 ± 0.136
1.704LeuHis: 1.704 ± 0.074
6.964LeuIle: 6.964 ± 0.193
6.899LeuLys: 6.899 ± 0.144
6.967LeuLeu: 6.967 ± 0.172
2.12LeuMet: 2.12 ± 0.085
4.97LeuAsn: 4.97 ± 0.108
2.834LeuPro: 2.834 ± 0.095
3.28LeuGln: 3.28 ± 0.134
2.798LeuArg: 2.798 ± 0.094
6.975LeuSer: 6.975 ± 0.164
3.966LeuThr: 3.966 ± 0.127
4.007LeuVal: 4.007 ± 0.108
0.449LeuTrp: 0.449 ± 0.038
2.815LeuTyr: 2.815 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
1.452MetAla: 1.452 ± 0.074
0.301MetCys: 0.301 ± 0.028
1.176MetAsp: 1.176 ± 0.06
1.368MetGlu: 1.368 ± 0.064
1.089MetPhe: 1.089 ± 0.056
1.19MetGly: 1.19 ± 0.06
0.503MetHis: 0.503 ± 0.033
2.35MetIle: 2.35 ± 0.085
2.372MetLys: 2.372 ± 0.084
2.481MetLeu: 2.481 ± 0.086
0.695MetMet: 0.695 ± 0.039
1.422MetAsn: 1.422 ± 0.069
1.247MetPro: 1.247 ± 0.076
1.455MetGln: 1.455 ± 0.06
1.045MetArg: 1.045 ± 0.059
2.246MetSer: 2.246 ± 0.089
1.34MetThr: 1.34 ± 0.072
1.05MetVal: 1.05 ± 0.054
0.107MetTrp: 0.107 ± 0.019
0.815MetTyr: 0.815 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
4.098AsnAla: 4.098 ± 0.113
0.894AsnCys: 0.894 ± 0.06
3.425AsnAsp: 3.425 ± 0.112
3.966AsnGlu: 3.966 ± 0.125
3.479AsnPhe: 3.479 ± 0.114
4.325AsnGly: 4.325 ± 0.134
1.07AsnHis: 1.07 ± 0.056
7.41AsnIle: 7.41 ± 0.188
5.071AsnLys: 5.071 ± 0.155
6.138AsnLeu: 6.138 ± 0.182
1.398AsnMet: 1.398 ± 0.055
4.612AsnAsn: 4.612 ± 0.198
2.541AsnPro: 2.541 ± 0.092
2.514AsnGln: 2.514 ± 0.125
1.953AsnArg: 1.953 ± 0.081
4.316AsnSer: 4.316 ± 0.145
3.296AsnThr: 3.296 ± 0.149
3.611AsnVal: 3.611 ± 0.109
0.408AsnTrp: 0.408 ± 0.032
2.328AsnTyr: 2.328 ± 0.081
0.0AsnXaa: 0.0 ± 0.0
Pro
1.308ProAla: 1.308 ± 0.066
0.432ProCys: 0.432 ± 0.037
1.721ProAsp: 1.721 ± 0.07
1.701ProGlu: 1.701 ± 0.079
1.45ProPhe: 1.45 ± 0.069
1.288ProGly: 1.288 ± 0.082
0.533ProHis: 0.533 ± 0.042
2.47ProIle: 2.47 ± 0.091
2.336ProLys: 2.336 ± 0.086
2.062ProLeu: 2.062 ± 0.075
0.637ProMet: 0.637 ± 0.047
1.773ProAsn: 1.773 ± 0.077
0.667ProPro: 0.667 ± 0.064
1.193ProGln: 1.193 ± 0.074
0.949ProArg: 0.949 ± 0.062
2.476ProSer: 2.476 ± 0.09
1.269ProThr: 1.269 ± 0.06
1.783ProVal: 1.783 ± 0.077
0.227ProTrp: 0.227 ± 0.022
1.034ProTyr: 1.034 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.729GlnAla: 1.729 ± 0.091
0.339GlnCys: 0.339 ± 0.035
2.29GlnAsp: 2.29 ± 0.104
2.391GlnGlu: 2.391 ± 0.122
1.409GlnPhe: 1.409 ± 0.072
1.756GlnGly: 1.756 ± 0.094
0.503GlnHis: 0.503 ± 0.04
3.589GlnIle: 3.589 ± 0.118
3.69GlnLys: 3.69 ± 0.11
2.032GlnLeu: 2.032 ± 0.09
1.031GlnMet: 1.031 ± 0.055
3.529GlnAsn: 3.529 ± 0.143
0.796GlnPro: 0.796 ± 0.058
2.139GlnGln: 2.139 ± 0.241
1.256GlnArg: 1.256 ± 0.063
2.44GlnSer: 2.44 ± 0.091
1.619GlnThr: 1.619 ± 0.083
1.554GlnVal: 1.554 ± 0.074
0.142GlnTrp: 0.142 ± 0.024
1.338GlnTyr: 1.338 ± 0.079
0.0GlnXaa: 0.0 ± 0.0
Arg
1.756ArgAla: 1.756 ± 0.087
0.427ArgCys: 0.427 ± 0.04
1.98ArgAsp: 1.98 ± 0.082
2.03ArgGlu: 2.03 ± 0.089
1.846ArgPhe: 1.846 ± 0.072
1.978ArgGly: 1.978 ± 0.084
0.651ArgHis: 0.651 ± 0.04
3.001ArgIle: 3.001 ± 0.097
3.11ArgLys: 3.11 ± 0.082
3.028ArgLeu: 3.028 ± 0.088
0.93ArgMet: 0.93 ± 0.051
2.166ArgAsn: 2.166 ± 0.078
0.925ArgPro: 0.925 ± 0.062
1.269ArgGln: 1.269 ± 0.057
1.318ArgArg: 1.318 ± 0.069
2.106ArgSer: 2.106 ± 0.082
1.198ArgThr: 1.198 ± 0.06
1.898ArgVal: 1.898 ± 0.072
0.189ArgTrp: 0.189 ± 0.023
1.433ArgTyr: 1.433 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
4.139SerAla: 4.139 ± 0.154
1.179SerCys: 1.179 ± 0.066
4.557SerAsp: 4.557 ± 0.133
4.215SerGlu: 4.215 ± 0.104
3.674SerPhe: 3.674 ± 0.107
5.564SerGly: 5.564 ± 0.135
1.359SerHis: 1.359 ± 0.062
7.197SerIle: 7.197 ± 0.154
6.108SerLys: 6.108 ± 0.12
6.001SerLeu: 6.001 ± 0.148
1.737SerMet: 1.737 ± 0.073
4.5SerAsn: 4.5 ± 0.137
1.751SerPro: 1.751 ± 0.079
2.724SerGln: 2.724 ± 0.1
2.7SerArg: 2.7 ± 0.099
6.146SerSer: 6.146 ± 0.203
3.053SerThr: 3.053 ± 0.114
4.382SerVal: 4.382 ± 0.137
0.476SerTrp: 0.476 ± 0.032
2.741SerTyr: 2.741 ± 0.104
0.0SerXaa: 0.0 ± 0.0
Thr
2.744ThrAla: 2.744 ± 0.086
0.574ThrCys: 0.574 ± 0.045
2.538ThrAsp: 2.538 ± 0.08
2.361ThrGlu: 2.361 ± 0.096
2.06ThrPhe: 2.06 ± 0.074
3.195ThrGly: 3.195 ± 0.13
0.894ThrHis: 0.894 ± 0.051
4.568ThrIle: 4.568 ± 0.112
4.221ThrLys: 4.221 ± 0.107
4.273ThrLeu: 4.273 ± 0.128
1.05ThrMet: 1.05 ± 0.057
2.987ThrAsn: 2.987 ± 0.177
1.704ThrPro: 1.704 ± 0.072
1.956ThrGln: 1.956 ± 0.097
1.576ThrArg: 1.576 ± 0.074
3.808ThrSer: 3.808 ± 0.135
2.497ThrThr: 2.497 ± 0.113
2.262ThrVal: 2.262 ± 0.091
0.274ThrTrp: 0.274 ± 0.027
1.444ThrTyr: 1.444 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
3.512ValAla: 3.512 ± 0.093
0.886ValCys: 0.886 ± 0.049
3.113ValAsp: 3.113 ± 0.107
3.135ValGlu: 3.135 ± 0.106
2.927ValPhe: 2.927 ± 0.103
2.927ValGly: 2.927 ± 0.109
0.711ValHis: 0.711 ± 0.047
5.301ValIle: 5.301 ± 0.122
5.498ValLys: 5.498 ± 0.123
4.842ValLeu: 4.842 ± 0.137
1.556ValMet: 1.556 ± 0.071
3.373ValAsn: 3.373 ± 0.107
1.469ValPro: 1.469 ± 0.067
1.666ValGln: 1.666 ± 0.073
1.764ValArg: 1.764 ± 0.073
4.311ValSer: 4.311 ± 0.139
2.328ValThr: 2.328 ± 0.091
3.561ValVal: 3.561 ± 0.128
0.323ValTrp: 0.323 ± 0.033
1.909ValTyr: 1.909 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.364TrpAla: 0.364 ± 0.033
0.098TrpCys: 0.098 ± 0.018
0.254TrpAsp: 0.254 ± 0.024
0.238TrpGlu: 0.238 ± 0.025
0.326TrpPhe: 0.326 ± 0.028
0.268TrpGly: 0.268 ± 0.029
0.202TrpHis: 0.202 ± 0.02
0.583TrpIle: 0.583 ± 0.039
0.492TrpLys: 0.492 ± 0.039
0.591TrpLeu: 0.591 ± 0.045
0.2TrpMet: 0.2 ± 0.022
0.413TrpAsn: 0.413 ± 0.032
0.12TrpPro: 0.12 ± 0.017
0.342TrpGln: 0.342 ± 0.03
0.29TrpArg: 0.29 ± 0.03
0.405TrpSer: 0.405 ± 0.035
0.235TrpThr: 0.235 ± 0.026
0.263TrpVal: 0.263 ± 0.03
0.063TrpTrp: 0.063 ± 0.013
0.241TrpTyr: 0.241 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.027TyrAla: 2.027 ± 0.075
0.613TyrCys: 0.613 ± 0.046
2.248TyrAsp: 2.248 ± 0.095
2.082TyrGlu: 2.082 ± 0.077
2.098TyrPhe: 2.098 ± 0.081
2.391TyrGly: 2.391 ± 0.091
0.681TyrHis: 0.681 ± 0.039
3.613TyrIle: 3.613 ± 0.123
3.28TyrLys: 3.28 ± 0.102
3.17TyrLeu: 3.17 ± 0.087
0.769TyrMet: 0.769 ± 0.049
2.678TyrAsn: 2.678 ± 0.119
0.963TyrPro: 0.963 ± 0.059
1.466TyrGln: 1.466 ± 0.073
1.275TyrArg: 1.275 ± 0.058
2.656TyrSer: 2.656 ± 0.091
1.805TyrThr: 1.805 ± 0.074
1.66TyrVal: 1.66 ± 0.075
0.265TyrTrp: 0.265 ± 0.026
1.439TyrTyr: 1.439 ± 0.072
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1126 proteins (365583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski