Amino acid dipepetide frequency for Anaeromyxobacter dehalogenans (strain 2CP-C)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	28.435AlaAla: 28.435 ± 0.334	1.607AlaCys: 1.607 ± 0.048	6.892AlaAsp: 6.892 ± 0.094	9.551AlaGlu: 9.551 ± 0.144	4.592AlaPhe: 4.592 ± 0.061	15.024AlaGly: 15.024 ± 0.144	2.685AlaHis: 2.685 ± 0.049	4.51AlaIle: 4.51 ± 0.058	3.041AlaLys: 3.041 ± 0.064	19.483AlaLeu: 19.483 ± 0.192	2.669AlaMet: 2.669 ± 0.05	1.848AlaAsn: 1.848 ± 0.042	10.232AlaPro: 10.232 ± 0.136	3.78AlaGln: 3.78 ± 0.052	16.282AlaArg: 16.282 ± 0.212	6.425AlaSer: 6.425 ± 0.085	6.086AlaThr: 6.086 ± 0.086	11.874AlaVal: 11.874 ± 0.112	2.144AlaTrp: 2.144 ± 0.045	2.508AlaTyr: 2.508 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.312CysAla: 1.312 ± 0.034	0.109CysCys: 0.109 ± 0.014	0.471CysAsp: 0.471 ± 0.019	0.494CysGlu: 0.494 ± 0.019	0.237CysPhe: 0.237 ± 0.014	1.043CysGly: 1.043 ± 0.034	0.484CysHis: 0.484 ± 0.049	0.226CysIle: 0.226 ± 0.015	0.158CysLys: 0.158 ± 0.013	0.681CysLeu: 0.681 ± 0.02	0.115CysMet: 0.115 ± 0.01	0.143CysAsn: 0.143 ± 0.012	0.609CysPro: 0.609 ± 0.027	0.217CysGln: 0.217 ± 0.014	0.692CysArg: 0.692 ± 0.023	0.449CysSer: 0.449 ± 0.02	0.475CysThr: 0.475 ± 0.023	0.662CysVal: 0.662 ± 0.021	0.094CysTrp: 0.094 ± 0.009	0.167CysTyr: 0.167 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.645AspAla: 8.645 ± 0.101	0.407AspCys: 0.407 ± 0.02	2.563AspAsp: 2.563 ± 0.048	3.349AspGlu: 3.349 ± 0.054	1.447AspPhe: 1.447 ± 0.031	5.354AspGly: 5.354 ± 0.081	1.004AspHis: 1.004 ± 0.028	1.068AspIle: 1.068 ± 0.034	0.851AspLys: 0.851 ± 0.027	6.299AspLeu: 6.299 ± 0.068	0.532AspMet: 0.532 ± 0.019	0.532AspAsn: 0.532 ± 0.022	4.242AspPro: 4.242 ± 0.068	1.114AspGln: 1.114 ± 0.028	4.776AspArg: 4.776 ± 0.064	1.267AspSer: 1.267 ± 0.032	1.653AspThr: 1.653 ± 0.036	4.585AspVal: 4.585 ± 0.056	0.641AspTrp: 0.641 ± 0.02	0.944AspTyr: 0.944 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	10.02GluAla: 10.02 ± 0.14	0.353GluCys: 0.353 ± 0.016	2.729GluAsp: 2.729 ± 0.048	3.59GluGlu: 3.59 ± 0.062	1.188GluPhe: 1.188 ± 0.034	4.956GluGly: 4.956 ± 0.062	1.3GluHis: 1.3 ± 0.032	2.402GluIle: 2.402 ± 0.039	1.935GluLys: 1.935 ± 0.047	7.095GluLeu: 7.095 ± 0.088	0.944GluMet: 0.944 ± 0.027	0.948GluAsn: 0.948 ± 0.03	3.55GluPro: 3.55 ± 0.051	1.975GluGln: 1.975 ± 0.043	7.154GluArg: 7.154 ± 0.085	1.926GluSer: 1.926 ± 0.036	2.315GluThr: 2.315 ± 0.039	5.564GluVal: 5.564 ± 0.064	0.681GluTrp: 0.681 ± 0.023	0.965GluTyr: 0.965 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.008PheAla: 4.008 ± 0.053	0.293PheCys: 0.293 ± 0.016	1.931PheAsp: 1.931 ± 0.037	1.928PheGlu: 1.928 ± 0.04	1.043PhePhe: 1.043 ± 0.032	2.851PheGly: 2.851 ± 0.054	0.696PheHis: 0.696 ± 0.019	0.704PheIle: 0.704 ± 0.025	0.651PheLys: 0.651 ± 0.025	3.083PheLeu: 3.083 ± 0.056	0.472PheMet: 0.472 ± 0.017	0.524PheAsn: 0.524 ± 0.02	1.556PhePro: 1.556 ± 0.033	0.819PheGln: 0.819 ± 0.021	2.393PheArg: 2.393 ± 0.044	1.398PheSer: 1.398 ± 0.033	1.681PheThr: 1.681 ± 0.042	2.512PheVal: 2.512 ± 0.042	0.408PheTrp: 0.408 ± 0.017	0.665PheTyr: 0.665 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	14.211GlyAla: 14.211 ± 0.149	0.973GlyCys: 0.973 ± 0.028	4.659GlyAsp: 4.659 ± 0.067	5.828GlyGlu: 5.828 ± 0.073	3.002GlyPhe: 3.002 ± 0.051	9.374GlyGly: 9.374 ± 0.149	1.813GlyHis: 1.813 ± 0.034	3.181GlyIle: 3.181 ± 0.05	2.803GlyLys: 2.803 ± 0.059	9.088GlyLeu: 9.088 ± 0.094	1.879GlyMet: 1.879 ± 0.04	1.46GlyAsn: 1.46 ± 0.039	5.081GlyPro: 5.081 ± 0.071	2.291GlyGln: 2.291 ± 0.045	8.477GlyArg: 8.477 ± 0.108	4.051GlySer: 4.051 ± 0.059	4.724GlyThr: 4.724 ± 0.08	7.167GlyVal: 7.167 ± 0.085	1.481GlyTrp: 1.481 ± 0.037	1.935GlyTyr: 1.935 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.932HisAla: 2.932 ± 0.048	0.182HisCys: 0.182 ± 0.011	1.089HisAsp: 1.089 ± 0.031	1.156HisGlu: 1.156 ± 0.03	0.59HisPhe: 0.59 ± 0.024	2.162HisGly: 2.162 ± 0.047	0.548HisHis: 0.548 ± 0.021	0.338HisIle: 0.338 ± 0.016	0.309HisLys: 0.309 ± 0.015	2.291HisLeu: 2.291 ± 0.046	0.274HisMet: 0.274 ± 0.012	0.278HisAsn: 0.278 ± 0.013	1.508HisPro: 1.508 ± 0.034	0.495HisGln: 0.495 ± 0.023	1.815HisArg: 1.815 ± 0.048	0.619HisSer: 0.619 ± 0.021	0.651HisThr: 0.651 ± 0.023	1.752HisVal: 1.752 ± 0.033	0.255HisTrp: 0.255 ± 0.012	0.384HisTyr: 0.384 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.583IleAla: 4.583 ± 0.066	0.264IleCys: 0.264 ± 0.014	1.902IleAsp: 1.902 ± 0.04	2.105IleGlu: 2.105 ± 0.04	0.808IlePhe: 0.808 ± 0.027	2.792IleGly: 2.792 ± 0.048	0.636IleHis: 0.636 ± 0.022	0.737IleIle: 0.737 ± 0.029	0.533IleLys: 0.533 ± 0.023	2.771IleLeu: 2.771 ± 0.048	0.36IleMet: 0.36 ± 0.016	0.433IleAsn: 0.433 ± 0.021	1.831IlePro: 1.831 ± 0.042	0.831IleGln: 0.831 ± 0.027	2.372IleArg: 2.372 ± 0.04	1.409IleSer: 1.409 ± 0.035	1.49IleThr: 1.49 ± 0.038	2.618IleVal: 2.618 ± 0.054	0.311IleTrp: 0.311 ± 0.016	0.547IleTyr: 0.547 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.169LysAla: 3.169 ± 0.054	0.151LysCys: 0.151 ± 0.011	1.37LysAsp: 1.37 ± 0.035	1.401LysGlu: 1.401 ± 0.037	0.524LysPhe: 0.524 ± 0.019	2.044LysGly: 2.044 ± 0.045	0.442LysHis: 0.442 ± 0.021	0.898LysIle: 0.898 ± 0.032	1.103LysLys: 1.103 ± 0.038	2.549LysLeu: 2.549 ± 0.049	0.496LysMet: 0.496 ± 0.02	0.459LysAsn: 0.459 ± 0.021	1.461LysPro: 1.461 ± 0.037	0.681LysGln: 0.681 ± 0.026	1.848LysArg: 1.848 ± 0.04	0.841LysSer: 0.841 ± 0.028	1.118LysThr: 1.118 ± 0.032	2.181LysVal: 2.181 ± 0.052	0.2LysTrp: 0.2 ± 0.011	0.448LysTyr: 0.448 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	19.738LeuAla: 19.738 ± 0.188	0.85LeuCys: 0.85 ± 0.027	6.358LeuAsp: 6.358 ± 0.078	7.174LeuGlu: 7.174 ± 0.083	3.057LeuPhe: 3.057 ± 0.054	10.144LeuGly: 10.144 ± 0.097	2.072LeuHis: 2.072 ± 0.039	1.92LeuIle: 1.92 ± 0.042	2.284LeuLys: 2.284 ± 0.05	11.138LeuLeu: 11.138 ± 0.124	1.352LeuMet: 1.352 ± 0.032	1.437LeuAsn: 1.437 ± 0.028	6.307LeuPro: 6.307 ± 0.072	2.52LeuGln: 2.52 ± 0.043	9.933LeuArg: 9.933 ± 0.11	5.237LeuSer: 5.237 ± 0.062	4.45LeuThr: 4.45 ± 0.066	9.697LeuVal: 9.697 ± 0.096	1.141LeuTrp: 1.141 ± 0.03	1.737LeuTyr: 1.737 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.168MetAla: 2.168 ± 0.044	0.12MetCys: 0.12 ± 0.009	0.801MetAsp: 0.801 ± 0.024	0.833MetGlu: 0.833 ± 0.026	0.394MetPhe: 0.394 ± 0.017	1.424MetGly: 1.424 ± 0.032	0.299MetHis: 0.299 ± 0.013	0.603MetIle: 0.603 ± 0.022	0.615MetLys: 0.615 ± 0.02	1.548MetLeu: 1.548 ± 0.037	0.307MetMet: 0.307 ± 0.017	0.444MetAsn: 0.444 ± 0.017	1.174MetPro: 1.174 ± 0.029	0.455MetGln: 0.455 ± 0.018	1.529MetArg: 1.529 ± 0.031	1.008MetSer: 1.008 ± 0.028	1.041MetThr: 1.041 ± 0.03	1.227MetVal: 1.227 ± 0.029	0.12MetTrp: 0.12 ± 0.009	0.242MetTyr: 0.242 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.133AsnAla: 2.133 ± 0.046	0.179AsnCys: 0.179 ± 0.014	0.735AsnAsp: 0.735 ± 0.024	0.763AsnGlu: 0.763 ± 0.023	0.468AsnPhe: 0.468 ± 0.02	1.514AsnGly: 1.514 ± 0.046	0.307AsnHis: 0.307 ± 0.014	0.482AsnIle: 0.482 ± 0.021	0.332AsnLys: 0.332 ± 0.017	1.741AsnLeu: 1.741 ± 0.038	0.259AsnMet: 0.259 ± 0.016	0.277AsnAsn: 0.277 ± 0.017	1.225AsnPro: 1.225 ± 0.033	0.405AsnGln: 0.405 ± 0.02	1.156AsnArg: 1.156 ± 0.025	0.471AsnSer: 0.471 ± 0.021	0.639AsnThr: 0.639 ± 0.023	1.656AsnVal: 1.656 ± 0.037	0.206AsnTrp: 0.206 ± 0.011	0.315AsnTyr: 0.315 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	11.173ProAla: 11.173 ± 0.137	0.402ProCys: 0.402 ± 0.019	3.662ProAsp: 3.662 ± 0.049	4.554ProGlu: 4.554 ± 0.059	1.912ProPhe: 1.912 ± 0.037	7.033ProGly: 7.033 ± 0.081	1.002ProHis: 1.002 ± 0.027	1.604ProIle: 1.604 ± 0.032	1.151ProLys: 1.151 ± 0.033	5.559ProLeu: 5.559 ± 0.06	1.079ProMet: 1.079 ± 0.029	0.773ProAsn: 0.773 ± 0.026	5.069ProPro: 5.069 ± 0.102	1.28ProGln: 1.28 ± 0.034	5.325ProArg: 5.325 ± 0.076	2.961ProSer: 2.961 ± 0.049	2.288ProThr: 2.288 ± 0.043	4.944ProVal: 4.944 ± 0.068	0.818ProTrp: 0.818 ± 0.024	1.056ProTyr: 1.056 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.955GlnAla: 3.955 ± 0.057	0.154GlnCys: 0.154 ± 0.011	1.128GlnAsp: 1.128 ± 0.026	1.349GlnGlu: 1.349 ± 0.026	0.607GlnPhe: 0.607 ± 0.018	2.15GlnGly: 2.15 ± 0.036	0.497GlnHis: 0.497 ± 0.018	0.863GlnIle: 0.863 ± 0.026	0.749GlnLys: 0.749 ± 0.03	2.77GlnLeu: 2.77 ± 0.048	0.377GlnMet: 0.377 ± 0.016	0.473GlnAsn: 0.473 ± 0.02	1.412GlnPro: 1.412 ± 0.03	0.814GlnGln: 0.814 ± 0.027	2.392GlnArg: 2.392 ± 0.043	0.916GlnSer: 0.916 ± 0.029	0.944GlnThr: 0.944 ± 0.026	2.478GlnVal: 2.478 ± 0.045	0.278GlnTrp: 0.278 ± 0.014	0.453GlnTyr: 0.453 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	14.973ArgAla: 14.973 ± 0.189	0.82ArgCys: 0.82 ± 0.031	4.604ArgAsp: 4.604 ± 0.063	5.99ArgGlu: 5.99 ± 0.087	3.091ArgPhe: 3.091 ± 0.046	7.538ArgGly: 7.538 ± 0.114	1.894ArgHis: 1.894 ± 0.043	3.358ArgIle: 3.358 ± 0.051	1.995ArgLys: 1.995 ± 0.037	10.35ArgLeu: 10.35 ± 0.111	1.91ArgMet: 1.91 ± 0.033	1.376ArgAsn: 1.376 ± 0.03	5.607ArgPro: 5.607 ± 0.078	2.074ArgGln: 2.074 ± 0.037	9.93ArgArg: 9.93 ± 0.166	3.703ArgSer: 3.703 ± 0.046	4.24ArgThr: 4.24 ± 0.055	7.127ArgVal: 7.127 ± 0.076	1.466ArgTrp: 1.466 ± 0.032	1.815ArgTyr: 1.815 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.119SerAla: 6.119 ± 0.069	0.458SerCys: 0.458 ± 0.022	1.995SerAsp: 1.995 ± 0.039	2.11SerGlu: 2.11 ± 0.037	1.47SerPhe: 1.47 ± 0.036	4.577SerGly: 4.577 ± 0.062	0.76SerHis: 0.76 ± 0.021	1.553SerIle: 1.553 ± 0.037	0.901SerLys: 0.901 ± 0.031	4.1SerLeu: 4.1 ± 0.056	0.822SerMet: 0.822 ± 0.022	0.735SerAsn: 0.735 ± 0.025	2.911SerPro: 2.911 ± 0.042	0.977SerGln: 0.977 ± 0.027	3.551SerArg: 3.551 ± 0.051	2.112SerSer: 2.112 ± 0.049	2.144SerThr: 2.144 ± 0.048	3.262SerVal: 3.262 ± 0.05	0.651SerTrp: 0.651 ± 0.023	0.896SerTyr: 0.896 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.947ThrAla: 5.947 ± 0.082	0.511ThrCys: 0.511 ± 0.022	2.004ThrAsp: 2.004 ± 0.042	2.041ThrGlu: 2.041 ± 0.038	1.674ThrPhe: 1.674 ± 0.037	4.5ThrGly: 4.5 ± 0.072	0.837ThrHis: 0.837 ± 0.029	1.407ThrIle: 1.407 ± 0.033	0.872ThrLys: 0.872 ± 0.028	5.066ThrLeu: 5.066 ± 0.069	0.641ThrMet: 0.641 ± 0.021	0.779ThrAsn: 0.779 ± 0.031	3.155ThrPro: 3.155 ± 0.045	0.99ThrGln: 0.99 ± 0.026	3.424ThrArg: 3.424 ± 0.054	2.072ThrSer: 2.072 ± 0.042	2.164ThrThr: 2.164 ± 0.054	4.173ThrVal: 4.173 ± 0.074	0.646ThrTrp: 0.646 ± 0.024	0.971ThrTyr: 0.971 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	12.172ValAla: 12.172 ± 0.119	0.673ValCys: 0.673 ± 0.024	4.592ValAsp: 4.592 ± 0.053	5.723ValGlu: 5.723 ± 0.074	2.417ValPhe: 2.417 ± 0.047	6.337ValGly: 6.337 ± 0.074	1.702ValHis: 1.702 ± 0.04	2.634ValIle: 2.634 ± 0.051	2.336ValLys: 2.336 ± 0.047	9.207ValLeu: 9.207 ± 0.092	1.317ValMet: 1.317 ± 0.032	1.701ValAsn: 1.701 ± 0.037	5.069ValPro: 5.069 ± 0.058	2.062ValGln: 2.062 ± 0.042	7.637ValArg: 7.637 ± 0.074	3.788ValSer: 3.788 ± 0.057	4.278ValThr: 4.278 ± 0.073	7.786ValVal: 7.786 ± 0.084	0.821ValTrp: 0.821 ± 0.026	1.456ValTyr: 1.456 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.52TrpAla: 1.52 ± 0.035	0.136TrpCys: 0.136 ± 0.01	0.663TrpAsp: 0.663 ± 0.022	0.6TrpGlu: 0.6 ± 0.023	0.445TrpPhe: 0.445 ± 0.018	0.859TrpGly: 0.859 ± 0.027	0.262TrpHis: 0.262 ± 0.014	0.511TrpIle: 0.511 ± 0.02	0.408TrpLys: 0.408 ± 0.019	1.608TrpLeu: 1.608 ± 0.038	0.284TrpMet: 0.284 ± 0.015	0.351TrpAsn: 0.351 ± 0.017	0.673TrpPro: 0.673 ± 0.023	0.379TrpGln: 0.379 ± 0.015	1.352TrpArg: 1.352 ± 0.034	0.734TrpSer: 0.734 ± 0.026	0.707TrpThr: 0.707 ± 0.026	0.872TrpVal: 0.872 ± 0.026	0.214TrpTrp: 0.214 ± 0.012	0.263TrpTyr: 0.263 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.455TyrAla: 2.455 ± 0.043	0.196TyrCys: 0.196 ± 0.013	1.124TyrAsp: 1.124 ± 0.032	1.051TyrGlu: 1.051 ± 0.03	0.649TyrPhe: 0.649 ± 0.023	1.804TyrGly: 1.804 ± 0.042	0.386TyrHis: 0.386 ± 0.018	0.33TyrIle: 0.33 ± 0.015	0.357TyrLys: 0.357 ± 0.018	2.117TyrLeu: 2.117 ± 0.039	0.265TyrMet: 0.265 ± 0.016	0.294TyrAsn: 0.294 ± 0.017	0.973TyrPro: 0.973 ± 0.026	0.601TyrGln: 0.601 ± 0.021	1.824TyrArg: 1.824 ± 0.038	0.715TyrSer: 0.715 ± 0.022	0.785TyrThr: 0.785 ± 0.025	1.571TyrVal: 1.571 ± 0.033	0.268TyrTrp: 0.268 ± 0.016	0.473TyrTyr: 0.473 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4345 proteins (1516487 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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