Amino acid dipepetide frequency for Domibacillus aminovorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.713AlaAla: 7.713 ± 0.102	0.596AlaCys: 0.596 ± 0.025	4.18AlaAsp: 4.18 ± 0.06	5.298AlaGlu: 5.298 ± 0.086	3.439AlaPhe: 3.439 ± 0.068	6.214AlaGly: 6.214 ± 0.088	1.433AlaHis: 1.433 ± 0.032	5.98AlaIle: 5.98 ± 0.076	4.663AlaLys: 4.663 ± 0.073	7.56AlaLeu: 7.56 ± 0.087	2.21AlaMet: 2.21 ± 0.053	2.641AlaAsn: 2.641 ± 0.056	2.265AlaPro: 2.265 ± 0.054	2.242AlaGln: 2.242 ± 0.043	3.117AlaArg: 3.117 ± 0.059	4.458AlaSer: 4.458 ± 0.064	3.354AlaThr: 3.354 ± 0.068	6.302AlaVal: 6.302 ± 0.076	0.598AlaTrp: 0.598 ± 0.028	2.408AlaTyr: 2.408 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.475CysAla: 0.475 ± 0.025	0.107CysCys: 0.107 ± 0.01	0.399CysAsp: 0.399 ± 0.021	0.477CysGlu: 0.477 ± 0.024	0.322CysPhe: 0.322 ± 0.019	0.712CysGly: 0.712 ± 0.031	0.207CysHis: 0.207 ± 0.015	0.496CysIle: 0.496 ± 0.024	0.339CysLys: 0.339 ± 0.019	0.656CysLeu: 0.656 ± 0.026	0.168CysMet: 0.168 ± 0.014	0.287CysAsn: 0.287 ± 0.017	0.347CysPro: 0.347 ± 0.022	0.219CysGln: 0.219 ± 0.015	0.326CysArg: 0.326 ± 0.017	0.497CysSer: 0.497 ± 0.023	0.409CysThr: 0.409 ± 0.021	0.451CysVal: 0.451 ± 0.022	0.085CysTrp: 0.085 ± 0.007	0.241CysTyr: 0.241 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.585AspAla: 3.585 ± 0.067	0.406AspCys: 0.406 ± 0.025	2.644AspAsp: 2.644 ± 0.057	4.658AspGlu: 4.658 ± 0.082	2.308AspPhe: 2.308 ± 0.05	3.715AspGly: 3.715 ± 0.071	1.226AspHis: 1.226 ± 0.035	4.106AspIle: 4.106 ± 0.068	2.874AspLys: 2.874 ± 0.054	4.696AspLeu: 4.696 ± 0.067	1.53AspMet: 1.53 ± 0.043	1.645AspAsn: 1.645 ± 0.043	1.999AspPro: 1.999 ± 0.053	1.994AspGln: 1.994 ± 0.048	2.457AspArg: 2.457 ± 0.054	2.598AspSer: 2.598 ± 0.051	2.531AspThr: 2.531 ± 0.046	4.35AspVal: 4.35 ± 0.064	0.598AspTrp: 0.598 ± 0.025	2.118AspTyr: 2.118 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	6.001GluAla: 6.001 ± 0.09	0.423GluCys: 0.423 ± 0.023	3.574GluAsp: 3.574 ± 0.056	7.016GluGlu: 7.016 ± 0.118	2.49GluPhe: 2.49 ± 0.049	4.404GluGly: 4.404 ± 0.079	1.487GluHis: 1.487 ± 0.043	5.069GluIle: 5.069 ± 0.074	6.667GluLys: 6.667 ± 0.1	7.07GluLeu: 7.07 ± 0.083	2.487GluMet: 2.487 ± 0.053	3.436GluAsn: 3.436 ± 0.062	2.109GluPro: 2.109 ± 0.052	3.606GluGln: 3.606 ± 0.067	3.77GluArg: 3.77 ± 0.065	3.79GluSer: 3.79 ± 0.065	4.296GluThr: 4.296 ± 0.07	4.76GluVal: 4.76 ± 0.069	0.93GluTrp: 0.93 ± 0.034	2.179GluTyr: 2.179 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.127PheAla: 3.127 ± 0.059	0.379PheCys: 0.379 ± 0.019	2.466PheAsp: 2.466 ± 0.057	2.809PheGlu: 2.809 ± 0.057	2.438PhePhe: 2.438 ± 0.063	3.35PheGly: 3.35 ± 0.063	1.007PheHis: 1.007 ± 0.031	3.82PheIle: 3.82 ± 0.067	2.187PheLys: 2.187 ± 0.046	4.413PheLeu: 4.413 ± 0.088	1.261PheMet: 1.261 ± 0.035	1.66PheAsn: 1.66 ± 0.039	1.617PhePro: 1.617 ± 0.037	1.476PheGln: 1.476 ± 0.042	1.587PheArg: 1.587 ± 0.037	3.063PheSer: 3.063 ± 0.058	2.67PheThr: 2.67 ± 0.052	3.188PheVal: 3.188 ± 0.068	0.501PheTrp: 0.501 ± 0.025	1.648PheTyr: 1.648 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.332GlyAla: 5.332 ± 0.087	0.633GlyCys: 0.633 ± 0.027	3.324GlyAsp: 3.324 ± 0.058	4.612GlyGlu: 4.612 ± 0.073	3.323GlyPhe: 3.323 ± 0.069	4.968GlyGly: 4.968 ± 0.092	1.499GlyHis: 1.499 ± 0.038	5.947GlyIle: 5.947 ± 0.081	4.833GlyLys: 4.833 ± 0.07	6.698GlyLeu: 6.698 ± 0.088	2.156GlyMet: 2.156 ± 0.046	2.517GlyAsn: 2.517 ± 0.052	1.822GlyPro: 1.822 ± 0.051	2.26GlyGln: 2.26 ± 0.047	2.969GlyArg: 2.969 ± 0.056	4.068GlySer: 4.068 ± 0.073	4.337GlyThr: 4.337 ± 0.071	5.143GlyVal: 5.143 ± 0.086	0.803GlyTrp: 0.803 ± 0.034	2.586GlyTyr: 2.586 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.412HisAla: 1.412 ± 0.035	0.181HisCys: 0.181 ± 0.015	1.114HisAsp: 1.114 ± 0.033	1.486HisGlu: 1.486 ± 0.039	1.079HisPhe: 1.079 ± 0.032	1.455HisGly: 1.455 ± 0.036	0.705HisHis: 0.705 ± 0.029	1.644HisIle: 1.644 ± 0.04	0.986HisLys: 0.986 ± 0.032	2.126HisLeu: 2.126 ± 0.053	0.554HisMet: 0.554 ± 0.024	0.679HisAsn: 0.679 ± 0.029	1.118HisPro: 1.118 ± 0.039	0.714HisGln: 0.714 ± 0.028	0.931HisArg: 0.931 ± 0.031	1.226HisSer: 1.226 ± 0.039	1.16HisThr: 1.16 ± 0.035	1.615HisVal: 1.615 ± 0.038	0.207HisTrp: 0.207 ± 0.014	0.845HisTyr: 0.845 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.485IleAla: 6.485 ± 0.096	0.586IleCys: 0.586 ± 0.025	4.478IleAsp: 4.478 ± 0.067	5.965IleGlu: 5.965 ± 0.074	3.013IlePhe: 3.013 ± 0.061	6.076IleGly: 6.076 ± 0.079	1.755IleHis: 1.755 ± 0.037	5.611IleIle: 5.611 ± 0.077	4.114IleLys: 4.114 ± 0.072	6.556IleLeu: 6.556 ± 0.096	1.995IleMet: 1.995 ± 0.042	2.893IleAsn: 2.893 ± 0.054	3.183IlePro: 3.183 ± 0.053	2.893IleGln: 2.893 ± 0.055	3.373IleArg: 3.373 ± 0.058	4.553IleSer: 4.553 ± 0.079	4.094IleThr: 4.094 ± 0.075	5.772IleVal: 5.772 ± 0.074	0.662IleTrp: 0.662 ± 0.028	2.191IleTyr: 2.191 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.838LysAla: 4.838 ± 0.073	0.327LysCys: 0.327 ± 0.021	3.335LysAsp: 3.335 ± 0.062	6.966LysGlu: 6.966 ± 0.096	1.736LysPhe: 1.736 ± 0.041	4.223LysGly: 4.223 ± 0.075	1.198LysHis: 1.198 ± 0.035	4.191LysIle: 4.191 ± 0.073	5.886LysLys: 5.886 ± 0.097	5.299LysLeu: 5.299 ± 0.077	2.401LysMet: 2.401 ± 0.043	2.946LysAsn: 2.946 ± 0.063	2.191LysPro: 2.191 ± 0.049	3.021LysGln: 3.021 ± 0.069	3.4LysArg: 3.4 ± 0.059	3.393LysSer: 3.393 ± 0.064	3.879LysThr: 3.879 ± 0.056	4.308LysVal: 4.308 ± 0.061	0.841LysTrp: 0.841 ± 0.029	1.889LysTyr: 1.889 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.382LeuAla: 7.382 ± 0.094	0.681LeuCys: 0.681 ± 0.028	4.703LeuAsp: 4.703 ± 0.073	6.079LeuGlu: 6.079 ± 0.091	4.993LeuPhe: 4.993 ± 0.098	5.87LeuGly: 5.87 ± 0.082	2.003LeuHis: 2.003 ± 0.043	7.019LeuIle: 7.019 ± 0.105	6.358LeuLys: 6.358 ± 0.08	9.687LeuLeu: 9.687 ± 0.142	2.594LeuMet: 2.594 ± 0.051	4.105LeuAsn: 4.105 ± 0.062	3.817LeuPro: 3.817 ± 0.058	3.344LeuGln: 3.344 ± 0.06	3.595LeuArg: 3.595 ± 0.066	6.78LeuSer: 6.78 ± 0.09	5.901LeuThr: 5.901 ± 0.072	5.759LeuVal: 5.759 ± 0.075	0.729LeuTrp: 0.729 ± 0.024	3.186LeuTyr: 3.186 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.358MetAla: 2.358 ± 0.052	0.178MetCys: 0.178 ± 0.014	1.586MetAsp: 1.586 ± 0.038	2.067MetGlu: 2.067 ± 0.046	1.063MetPhe: 1.063 ± 0.033	1.737MetGly: 1.737 ± 0.043	0.451MetHis: 0.451 ± 0.021	2.355MetIle: 2.355 ± 0.058	2.737MetLys: 2.737 ± 0.051	2.6MetLeu: 2.6 ± 0.053	1.09MetMet: 1.09 ± 0.037	1.791MetAsn: 1.791 ± 0.042	1.12MetPro: 1.12 ± 0.045	0.966MetGln: 0.966 ± 0.032	1.233MetArg: 1.233 ± 0.035	1.788MetSer: 1.788 ± 0.042	2.052MetThr: 2.052 ± 0.048	1.634MetVal: 1.634 ± 0.04	0.199MetTrp: 0.199 ± 0.012	0.791MetTyr: 0.791 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.726AsnAla: 2.726 ± 0.051	0.264AsnCys: 0.264 ± 0.016	2.148AsnAsp: 2.148 ± 0.049	3.581AsnGlu: 3.581 ± 0.053	1.282AsnPhe: 1.282 ± 0.04	3.318AsnGly: 3.318 ± 0.059	0.883AsnHis: 0.883 ± 0.034	3.113AsnIle: 3.113 ± 0.055	2.554AsnLys: 2.554 ± 0.047	3.203AsnLeu: 3.203 ± 0.065	1.264AsnMet: 1.264 ± 0.037	1.675AsnAsn: 1.675 ± 0.048	1.941AsnPro: 1.941 ± 0.045	1.524AsnGln: 1.524 ± 0.043	1.998AsnArg: 1.998 ± 0.044	1.979AsnSer: 1.979 ± 0.043	2.026AsnThr: 2.026 ± 0.05	3.186AsnVal: 3.186 ± 0.059	0.477AsnTrp: 0.477 ± 0.022	1.324AsnTyr: 1.324 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.834ProAla: 2.834 ± 0.05	0.238ProCys: 0.238 ± 0.018	2.35ProAsp: 2.35 ± 0.051	3.005ProGlu: 3.005 ± 0.067	2.076ProPhe: 2.076 ± 0.049	2.478ProGly: 2.478 ± 0.057	0.833ProHis: 0.833 ± 0.031	2.675ProIle: 2.675 ± 0.053	1.967ProLys: 1.967 ± 0.053	3.586ProLeu: 3.586 ± 0.062	0.823ProMet: 0.823 ± 0.03	1.498ProAsn: 1.498 ± 0.043	1.056ProPro: 1.056 ± 0.037	1.015ProGln: 1.015 ± 0.031	1.08ProArg: 1.08 ± 0.033	2.258ProSer: 2.258 ± 0.052	1.739ProThr: 1.739 ± 0.042	3.18ProVal: 3.18 ± 0.05	0.364ProTrp: 0.364 ± 0.02	1.417ProTyr: 1.417 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.614GlnAla: 2.614 ± 0.048	0.206GlnCys: 0.206 ± 0.013	1.514GlnAsp: 1.514 ± 0.036	2.636GlnGlu: 2.636 ± 0.056	1.652GlnPhe: 1.652 ± 0.045	1.981GlnGly: 1.981 ± 0.043	0.74GlnHis: 0.74 ± 0.03	2.413GlnIle: 2.413 ± 0.054	2.726GlnLys: 2.726 ± 0.058	3.815GlnLeu: 3.815 ± 0.067	1.188GlnMet: 1.188 ± 0.032	1.563GlnAsn: 1.563 ± 0.043	1.296GlnPro: 1.296 ± 0.034	1.623GlnGln: 1.623 ± 0.046	1.469GlnArg: 1.469 ± 0.038	2.256GlnSer: 2.256 ± 0.046	2.184GlnThr: 2.184 ± 0.054	2.203GlnVal: 2.203 ± 0.05	0.373GlnTrp: 0.373 ± 0.022	1.317GlnTyr: 1.317 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.965ArgAla: 2.965 ± 0.062	0.28ArgCys: 0.28 ± 0.015	2.24ArgAsp: 2.24 ± 0.047	3.382ArgGlu: 3.382 ± 0.059	2.062ArgPhe: 2.062 ± 0.044	2.529ArgGly: 2.529 ± 0.048	0.966ArgHis: 0.966 ± 0.035	3.275ArgIle: 3.275 ± 0.059	3.125ArgLys: 3.125 ± 0.059	4.25ArgLeu: 4.25 ± 0.064	1.434ArgMet: 1.434 ± 0.036	1.746ArgAsn: 1.746 ± 0.035	1.539ArgPro: 1.539 ± 0.042	1.648ArgGln: 1.648 ± 0.046	2.143ArgArg: 2.143 ± 0.048	2.386ArgSer: 2.386 ± 0.053	2.304ArgThr: 2.304 ± 0.048	2.767ArgVal: 2.767 ± 0.057	0.409ArgTrp: 0.409 ± 0.021	1.51ArgTyr: 1.51 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.217SerAla: 4.217 ± 0.071	0.409SerCys: 0.409 ± 0.02	2.829SerAsp: 2.829 ± 0.051	3.726SerGlu: 3.726 ± 0.058	3.33SerPhe: 3.33 ± 0.067	4.756SerGly: 4.756 ± 0.079	1.226SerHis: 1.226 ± 0.029	5.07SerIle: 5.07 ± 0.08	3.429SerLys: 3.429 ± 0.061	5.935SerLeu: 5.935 ± 0.094	1.798SerMet: 1.798 ± 0.039	2.308SerAsn: 2.308 ± 0.046	2.143SerPro: 2.143 ± 0.047	1.745SerGln: 1.745 ± 0.041	2.379SerArg: 2.379 ± 0.048	3.8SerSer: 3.8 ± 0.072	3.093SerThr: 3.093 ± 0.061	4.387SerVal: 4.387 ± 0.058	0.617SerTrp: 0.617 ± 0.025	1.999SerTyr: 1.999 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.742ThrAla: 4.742 ± 0.071	0.384ThrCys: 0.384 ± 0.02	3.035ThrAsp: 3.035 ± 0.062	3.853ThrGlu: 3.853 ± 0.066	2.73ThrPhe: 2.73 ± 0.057	4.642ThrGly: 4.642 ± 0.064	1.126ThrHis: 1.126 ± 0.033	4.641ThrIle: 4.641 ± 0.072	3.277ThrLys: 3.277 ± 0.061	5.077ThrLeu: 5.077 ± 0.077	1.485ThrMet: 1.485 ± 0.042	2.267ThrAsn: 2.267 ± 0.047	2.35ThrPro: 2.35 ± 0.044	1.384ThrGln: 1.384 ± 0.042	2.024ThrArg: 2.024 ± 0.046	3.153ThrSer: 3.153 ± 0.055	2.984ThrThr: 2.984 ± 0.064	4.579ThrVal: 4.579 ± 0.074	0.508ThrTrp: 0.508 ± 0.022	1.899ThrTyr: 1.899 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.918ValAla: 4.918 ± 0.075	0.578ValCys: 0.578 ± 0.025	3.709ValAsp: 3.709 ± 0.058	4.799ValGlu: 4.799 ± 0.075	3.198ValPhe: 3.198 ± 0.059	4.357ValGly: 4.357 ± 0.075	1.564ValHis: 1.564 ± 0.041	5.69ValIle: 5.69 ± 0.08	4.837ValLys: 4.837 ± 0.07	7.12ValLeu: 7.12 ± 0.094	2.088ValMet: 2.088 ± 0.046	2.976ValAsn: 2.976 ± 0.055	2.925ValPro: 2.925 ± 0.057	2.621ValGln: 2.621 ± 0.059	3.007ValArg: 3.007 ± 0.056	4.549ValSer: 4.549 ± 0.063	4.594ValThr: 4.594 ± 0.07	4.896ValVal: 4.896 ± 0.088	0.674ValTrp: 0.674 ± 0.027	2.283ValTyr: 2.283 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.648TrpAla: 0.648 ± 0.025	0.083TrpCys: 0.083 ± 0.009	0.509TrpAsp: 0.509 ± 0.024	0.588TrpGlu: 0.588 ± 0.026	0.492TrpPhe: 0.492 ± 0.024	0.617TrpGly: 0.617 ± 0.024	0.222TrpHis: 0.222 ± 0.013	0.83TrpIle: 0.83 ± 0.03	0.703TrpLys: 0.703 ± 0.026	1.122TrpLeu: 1.122 ± 0.037	0.347TrpMet: 0.347 ± 0.019	0.506TrpAsn: 0.506 ± 0.025	0.282TrpPro: 0.282 ± 0.018	0.353TrpGln: 0.353 ± 0.018	0.461TrpArg: 0.461 ± 0.023	0.577TrpSer: 0.577 ± 0.022	0.621TrpThr: 0.621 ± 0.026	0.619TrpVal: 0.619 ± 0.023	0.124TrpTrp: 0.124 ± 0.012	0.332TrpTyr: 0.332 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.298TyrAla: 2.298 ± 0.04	0.281TyrCys: 0.281 ± 0.017	1.903TyrAsp: 1.903 ± 0.048	2.56TyrGlu: 2.56 ± 0.05	1.642TyrPhe: 1.642 ± 0.047	2.426TyrGly: 2.426 ± 0.048	0.706TyrHis: 0.706 ± 0.026	2.304TyrIle: 2.304 ± 0.045	2.005TyrLys: 2.005 ± 0.045	3.117TyrLeu: 3.117 ± 0.055	0.92TyrMet: 0.92 ± 0.035	1.332TyrAsn: 1.332 ± 0.039	1.351TyrPro: 1.351 ± 0.039	1.121TyrGln: 1.121 ± 0.03	1.64TyrArg: 1.64 ± 0.044	2.027TyrSer: 2.027 ± 0.048	1.913TyrThr: 1.913 ± 0.043	2.28TyrVal: 2.28 ± 0.05	0.337TyrTrp: 0.337 ± 0.019	1.282TyrTyr: 1.282 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3573 proteins (1010879 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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