Amino acid dipepetide frequency for Celeribacter ethanolicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.158AlaAla: 14.158 ± 0.16	1.007AlaCys: 1.007 ± 0.033	6.131AlaAsp: 6.131 ± 0.075	8.308AlaGlu: 8.308 ± 0.117	4.44AlaPhe: 4.44 ± 0.068	9.686AlaGly: 9.686 ± 0.111	2.271AlaHis: 2.271 ± 0.045	5.698AlaIle: 5.698 ± 0.065	4.263AlaLys: 4.263 ± 0.078	13.606AlaLeu: 13.606 ± 0.158	3.821AlaMet: 3.821 ± 0.06	2.52AlaAsn: 2.52 ± 0.043	5.582AlaPro: 5.582 ± 0.078	4.228AlaGln: 4.228 ± 0.065	8.119AlaArg: 8.119 ± 0.09	5.601AlaSer: 5.601 ± 0.067	5.994AlaThr: 5.994 ± 0.073	7.807AlaVal: 7.807 ± 0.092	1.381AlaTrp: 1.381 ± 0.035	2.585AlaTyr: 2.585 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.987CysAla: 0.987 ± 0.028	0.11CysCys: 0.11 ± 0.009	0.617CysAsp: 0.617 ± 0.024	0.502CysGlu: 0.502 ± 0.021	0.34CysPhe: 0.34 ± 0.017	0.908CysGly: 0.908 ± 0.033	0.289CysHis: 0.289 ± 0.014	0.376CysIle: 0.376 ± 0.019	0.234CysLys: 0.234 ± 0.014	0.848CysLeu: 0.848 ± 0.024	0.171CysMet: 0.171 ± 0.012	0.199CysAsn: 0.199 ± 0.013	0.487CysPro: 0.487 ± 0.019	0.22CysGln: 0.22 ± 0.012	0.516CysArg: 0.516 ± 0.02	0.425CysSer: 0.425 ± 0.019	0.419CysThr: 0.419 ± 0.021	0.638CysVal: 0.638 ± 0.026	0.089CysTrp: 0.089 ± 0.008	0.194CysTyr: 0.194 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.585AspAla: 6.585 ± 0.082	0.502AspCys: 0.502 ± 0.021	3.188AspAsp: 3.188 ± 0.082	3.718AspGlu: 3.718 ± 0.064	2.361AspPhe: 2.361 ± 0.044	5.224AspGly: 5.224 ± 0.079	1.354AspHis: 1.354 ± 0.039	3.14AspIle: 3.14 ± 0.055	1.943AspLys: 1.943 ± 0.046	6.615AspLeu: 6.615 ± 0.094	1.75AspMet: 1.75 ± 0.036	1.324AspAsn: 1.324 ± 0.037	3.435AspPro: 3.435 ± 0.058	1.835AspGln: 1.835 ± 0.043	3.94AspArg: 3.94 ± 0.068	2.136AspSer: 2.136 ± 0.043	3.064AspThr: 3.064 ± 0.069	4.195AspVal: 4.195 ± 0.059	1.11AspTrp: 1.11 ± 0.027	1.637AspTyr: 1.637 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.714GluAla: 8.714 ± 0.116	0.335GluCys: 0.335 ± 0.016	3.723GluAsp: 3.723 ± 0.057	4.351GluGlu: 4.351 ± 0.085	2.042GluPhe: 2.042 ± 0.046	5.28GluGly: 5.28 ± 0.071	1.265GluHis: 1.265 ± 0.035	4.201GluIle: 4.201 ± 0.067	2.591GluLys: 2.591 ± 0.062	5.587GluLeu: 5.587 ± 0.074	2.102GluMet: 2.102 ± 0.042	1.879GluAsn: 1.879 ± 0.039	2.531GluPro: 2.531 ± 0.049	1.921GluGln: 1.921 ± 0.042	4.379GluArg: 4.379 ± 0.068	2.335GluSer: 2.335 ± 0.044	4.236GluThr: 4.236 ± 0.065	4.616GluVal: 4.616 ± 0.075	0.694GluTrp: 0.694 ± 0.023	1.151GluTyr: 1.151 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.472PheAla: 4.472 ± 0.067	0.437PheCys: 0.437 ± 0.017	2.906PheAsp: 2.906 ± 0.052	2.52PheGlu: 2.52 ± 0.046	1.539PhePhe: 1.539 ± 0.044	3.864PheGly: 3.864 ± 0.064	0.769PheHis: 0.769 ± 0.026	1.671PheIle: 1.671 ± 0.038	1.136PheLys: 1.136 ± 0.034	3.6PheLeu: 3.6 ± 0.056	0.918PheMet: 0.918 ± 0.028	1.054PheAsn: 1.054 ± 0.031	1.633PhePro: 1.633 ± 0.038	0.984PheGln: 0.984 ± 0.027	2.08PheArg: 2.08 ± 0.04	2.353PheSer: 2.353 ± 0.054	2.194PheThr: 2.194 ± 0.046	2.717PheVal: 2.717 ± 0.06	0.627PheTrp: 0.627 ± 0.029	0.993PheTyr: 0.993 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.461GlyAla: 9.461 ± 0.097	0.826GlyCys: 0.826 ± 0.025	4.62GlyAsp: 4.62 ± 0.084	5.162GlyGlu: 5.162 ± 0.075	3.834GlyPhe: 3.834 ± 0.065	7.04GlyGly: 7.04 ± 0.131	1.873GlyHis: 1.873 ± 0.04	4.467GlyIle: 4.467 ± 0.07	3.464GlyLys: 3.464 ± 0.058	9.096GlyLeu: 9.096 ± 0.103	2.623GlyMet: 2.623 ± 0.05	2.065GlyAsn: 2.065 ± 0.053	3.481GlyPro: 3.481 ± 0.059	3.098GlyGln: 3.098 ± 0.043	5.324GlyArg: 5.324 ± 0.069	4.13GlySer: 4.13 ± 0.072	4.757GlyThr: 4.757 ± 0.103	6.362GlyVal: 6.362 ± 0.078	1.382GlyTrp: 1.382 ± 0.034	2.416GlyTyr: 2.416 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.258HisAla: 2.258 ± 0.047	0.237HisCys: 0.237 ± 0.015	1.286HisAsp: 1.286 ± 0.038	1.184HisGlu: 1.184 ± 0.033	0.873HisPhe: 0.873 ± 0.027	1.898HisGly: 1.898 ± 0.04	0.59HisHis: 0.59 ± 0.033	0.978HisIle: 0.978 ± 0.027	0.619HisLys: 0.619 ± 0.024	2.144HisLeu: 2.144 ± 0.048	0.597HisMet: 0.597 ± 0.023	0.49HisAsn: 0.49 ± 0.02	1.346HisPro: 1.346 ± 0.034	0.558HisGln: 0.558 ± 0.023	1.372HisArg: 1.372 ± 0.034	0.926HisSer: 0.926 ± 0.025	0.867HisThr: 0.867 ± 0.026	1.535HisVal: 1.535 ± 0.035	0.362HisTrp: 0.362 ± 0.019	0.545HisTyr: 0.545 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.076IleAla: 7.076 ± 0.079	0.593IleCys: 0.593 ± 0.021	3.38IleAsp: 3.38 ± 0.057	3.787IleGlu: 3.787 ± 0.063	1.887IlePhe: 1.887 ± 0.041	4.862IleGly: 4.862 ± 0.074	0.971IleHis: 0.971 ± 0.032	2.122IleIle: 2.122 ± 0.049	1.614IleLys: 1.614 ± 0.039	4.888IleLeu: 4.888 ± 0.068	1.117IleMet: 1.117 ± 0.035	1.263IleAsn: 1.263 ± 0.03	2.424IlePro: 2.424 ± 0.045	1.161IleGln: 1.161 ± 0.034	3.12IleArg: 3.12 ± 0.053	3.213IleSer: 3.213 ± 0.053	3.032IleThr: 3.032 ± 0.052	3.973IleVal: 3.973 ± 0.065	0.708IleTrp: 0.708 ± 0.023	1.256IleTyr: 1.256 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.361LysAla: 4.361 ± 0.068	0.201LysCys: 0.201 ± 0.012	2.081LysAsp: 2.081 ± 0.044	1.909LysGlu: 1.909 ± 0.05	1.101LysPhe: 1.101 ± 0.033	3.117LysGly: 3.117 ± 0.057	0.72LysHis: 0.72 ± 0.026	2.077LysIle: 2.077 ± 0.051	1.455LysLys: 1.455 ± 0.043	3.325LysLeu: 3.325 ± 0.068	1.014LysMet: 1.014 ± 0.032	0.923LysAsn: 0.923 ± 0.03	2.039LysPro: 2.039 ± 0.044	0.977LysGln: 0.977 ± 0.03	2.487LysArg: 2.487 ± 0.046	2.02LysSer: 2.02 ± 0.046	2.322LysThr: 2.322 ± 0.047	2.557LysVal: 2.557 ± 0.052	0.433LysTrp: 0.433 ± 0.021	0.733LysTyr: 0.733 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.147LeuAla: 12.147 ± 0.121	0.921LeuCys: 0.921 ± 0.028	6.013LeuAsp: 6.013 ± 0.073	5.561LeuGlu: 5.561 ± 0.081	3.769LeuPhe: 3.769 ± 0.071	8.437LeuGly: 8.437 ± 0.094	1.897LeuHis: 1.897 ± 0.047	5.49LeuIle: 5.49 ± 0.073	3.829LeuLys: 3.829 ± 0.064	8.933LeuLeu: 8.933 ± 0.135	2.877LeuMet: 2.877 ± 0.05	2.676LeuAsn: 2.676 ± 0.045	5.54LeuPro: 5.54 ± 0.076	2.489LeuGln: 2.489 ± 0.043	6.553LeuArg: 6.553 ± 0.1	7.337LeuSer: 7.337 ± 0.092	6.309LeuThr: 6.309 ± 0.077	6.754LeuVal: 6.754 ± 0.076	1.341LeuTrp: 1.341 ± 0.038	2.143LeuTyr: 2.143 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.453MetAla: 3.453 ± 0.056	0.187MetCys: 0.187 ± 0.013	1.475MetAsp: 1.475 ± 0.034	1.52MetGlu: 1.52 ± 0.039	0.895MetPhe: 0.895 ± 0.027	2.366MetGly: 2.366 ± 0.045	0.481MetHis: 0.481 ± 0.02	1.613MetIle: 1.613 ± 0.033	1.272MetLys: 1.272 ± 0.035	2.695MetLeu: 2.695 ± 0.045	0.843MetMet: 0.843 ± 0.03	0.882MetAsn: 0.882 ± 0.028	1.529MetPro: 1.529 ± 0.036	0.948MetGln: 0.948 ± 0.027	1.889MetArg: 1.889 ± 0.038	2.042MetSer: 2.042 ± 0.042	2.21MetThr: 2.21 ± 0.039	1.985MetVal: 1.985 ± 0.042	0.246MetTrp: 0.246 ± 0.015	0.377MetTyr: 0.377 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.176AsnAla: 3.176 ± 0.052	0.243AsnCys: 0.243 ± 0.015	1.428AsnAsp: 1.428 ± 0.039	1.244AsnGlu: 1.244 ± 0.031	0.934AsnPhe: 0.934 ± 0.027	2.413AsnGly: 2.413 ± 0.048	0.546AsnHis: 0.546 ± 0.02	1.409AsnIle: 1.409 ± 0.038	0.74AsnLys: 0.74 ± 0.026	2.517AsnLeu: 2.517 ± 0.041	0.738AsnMet: 0.738 ± 0.021	0.613AsnAsn: 0.613 ± 0.03	1.783AsnPro: 1.783 ± 0.039	0.647AsnGln: 0.647 ± 0.025	1.619AsnArg: 1.619 ± 0.037	1.192AsnSer: 1.192 ± 0.043	1.404AsnThr: 1.404 ± 0.038	1.771AsnVal: 1.771 ± 0.04	0.473AsnTrp: 0.473 ± 0.021	0.642AsnTyr: 0.642 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.19ProAla: 5.19 ± 0.084	0.342ProCys: 0.342 ± 0.018	3.513ProAsp: 3.513 ± 0.053	4.75ProGlu: 4.75 ± 0.074	1.986ProPhe: 1.986 ± 0.049	4.102ProGly: 4.102 ± 0.06	1.09ProHis: 1.09 ± 0.031	2.228ProIle: 2.228 ± 0.041	1.934ProLys: 1.934 ± 0.046	4.632ProLeu: 4.632 ± 0.075	1.352ProMet: 1.352 ± 0.034	1.334ProAsn: 1.334 ± 0.036	2.125ProPro: 2.125 ± 0.059	1.569ProGln: 1.569 ± 0.042	2.728ProArg: 2.728 ± 0.05	2.594ProSer: 2.594 ± 0.046	2.478ProThr: 2.478 ± 0.048	4.315ProVal: 4.315 ± 0.065	0.662ProTrp: 0.662 ± 0.022	1.187ProTyr: 1.187 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.649GlnAla: 3.649 ± 0.057	0.207GlnCys: 0.207 ± 0.013	1.617GlnAsp: 1.617 ± 0.038	1.59GlnGlu: 1.59 ± 0.046	1.051GlnPhe: 1.051 ± 0.032	2.601GlnGly: 2.601 ± 0.052	0.554GlnHis: 0.554 ± 0.023	2.055GlnIle: 2.055 ± 0.049	1.219GlnLys: 1.219 ± 0.034	2.539GlnLeu: 2.539 ± 0.046	1.045GlnMet: 1.045 ± 0.035	0.935GlnAsn: 0.935 ± 0.032	1.526GlnPro: 1.526 ± 0.033	0.965GlnGln: 0.965 ± 0.035	1.957GlnArg: 1.957 ± 0.045	1.826GlnSer: 1.826 ± 0.037	1.75GlnThr: 1.75 ± 0.04	2.178GlnVal: 2.178 ± 0.042	0.387GlnTrp: 0.387 ± 0.018	0.631GlnTyr: 0.631 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.345ArgAla: 7.345 ± 0.094	0.454ArgCys: 0.454 ± 0.019	4.077ArgAsp: 4.077 ± 0.061	4.019ArgGlu: 4.019 ± 0.059	2.642ArgPhe: 2.642 ± 0.049	4.356ArgGly: 4.356 ± 0.065	1.544ArgHis: 1.544 ± 0.042	3.641ArgIle: 3.641 ± 0.053	2.459ArgLys: 2.459 ± 0.045	7.033ArgLeu: 7.033 ± 0.101	1.941ArgMet: 1.941 ± 0.041	1.688ArgAsn: 1.688 ± 0.038	3.096ArgPro: 3.096 ± 0.061	2.193ArgGln: 2.193 ± 0.043	4.435ArgArg: 4.435 ± 0.076	3.06ArgSer: 3.06 ± 0.051	2.915ArgThr: 2.915 ± 0.048	4.475ArgVal: 4.475 ± 0.067	0.791ArgTrp: 0.791 ± 0.022	1.629ArgTyr: 1.629 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.695SerAla: 5.695 ± 0.069	0.484SerCys: 0.484 ± 0.021	3.348SerAsp: 3.348 ± 0.055	3.45SerGlu: 3.45 ± 0.059	2.344SerPhe: 2.344 ± 0.049	5.505SerGly: 5.505 ± 0.084	1.12SerHis: 1.12 ± 0.035	2.373SerIle: 2.373 ± 0.051	1.682SerLys: 1.682 ± 0.032	5.282SerLeu: 5.282 ± 0.082	1.416SerMet: 1.416 ± 0.031	1.363SerAsn: 1.363 ± 0.035	2.534SerPro: 2.534 ± 0.046	1.636SerGln: 1.636 ± 0.039	3.216SerArg: 3.216 ± 0.057	2.812SerSer: 2.812 ± 0.057	2.584SerThr: 2.584 ± 0.05	3.987SerVal: 3.987 ± 0.059	0.701SerTrp: 0.701 ± 0.025	1.532SerTyr: 1.532 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.115ThrAla: 6.115 ± 0.079	0.493ThrCys: 0.493 ± 0.021	3.178ThrAsp: 3.178 ± 0.051	3.397ThrGlu: 3.397 ± 0.055	1.98ThrPhe: 1.98 ± 0.048	5.431ThrGly: 5.431 ± 0.082	1.168ThrHis: 1.168 ± 0.029	2.741ThrIle: 2.741 ± 0.057	1.627ThrLys: 1.627 ± 0.038	6.366ThrLeu: 6.366 ± 0.074	1.402ThrMet: 1.402 ± 0.034	1.335ThrAsn: 1.335 ± 0.039	3.627ThrPro: 3.627 ± 0.056	1.596ThrGln: 1.596 ± 0.038	3.538ThrArg: 3.538 ± 0.057	2.834ThrSer: 2.834 ± 0.054	2.957ThrThr: 2.957 ± 0.064	4.51ThrVal: 4.51 ± 0.086	0.672ThrTrp: 0.672 ± 0.025	1.342ThrTyr: 1.342 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.383ValAla: 8.383 ± 0.102	0.585ValCys: 0.585 ± 0.02	4.018ValAsp: 4.018 ± 0.063	4.792ValGlu: 4.792 ± 0.07	2.925ValPhe: 2.925 ± 0.053	5.142ValGly: 5.142 ± 0.081	1.29ValHis: 1.29 ± 0.036	4.426ValIle: 4.426 ± 0.07	2.589ValLys: 2.589 ± 0.051	7.429ValLeu: 7.429 ± 0.094	2.227ValMet: 2.227 ± 0.047	1.922ValAsn: 1.922 ± 0.044	3.612ValPro: 3.612 ± 0.058	2.024ValGln: 2.024 ± 0.042	3.954ValArg: 3.954 ± 0.07	4.342ValSer: 4.342 ± 0.07	4.861ValThr: 4.861 ± 0.082	5.41ValVal: 5.41 ± 0.077	0.9ValTrp: 0.9 ± 0.03	1.538ValTyr: 1.538 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.309TrpAla: 1.309 ± 0.035	0.146TrpCys: 0.146 ± 0.01	0.76TrpAsp: 0.76 ± 0.025	0.68TrpGlu: 0.68 ± 0.021	0.574TrpPhe: 0.574 ± 0.022	1.043TrpGly: 1.043 ± 0.031	0.349TrpHis: 0.349 ± 0.018	0.729TrpIle: 0.729 ± 0.025	0.475TrpLys: 0.475 ± 0.022	1.563TrpLeu: 1.563 ± 0.043	0.41TrpMet: 0.41 ± 0.019	0.402TrpAsn: 0.402 ± 0.019	0.664TrpPro: 0.664 ± 0.024	0.569TrpGln: 0.569 ± 0.023	1.005TrpArg: 1.005 ± 0.03	0.738TrpSer: 0.738 ± 0.022	0.742TrpThr: 0.742 ± 0.027	0.886TrpVal: 0.886 ± 0.029	0.193TrpTrp: 0.193 ± 0.014	0.284TrpTyr: 0.284 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.675TyrAla: 2.675 ± 0.047	0.257TyrCys: 0.257 ± 0.014	1.696TyrAsp: 1.696 ± 0.04	1.486TyrGlu: 1.486 ± 0.035	0.949TyrPhe: 0.949 ± 0.027	2.208TyrGly: 2.208 ± 0.042	0.524TyrHis: 0.524 ± 0.022	1.014TyrIle: 1.014 ± 0.029	0.705TyrLys: 0.705 ± 0.027	2.317TyrLeu: 2.317 ± 0.045	0.544TyrMet: 0.544 ± 0.019	0.666TyrAsn: 0.666 ± 0.025	1.116TyrPro: 1.116 ± 0.028	0.664TyrGln: 0.664 ± 0.027	1.564TyrArg: 1.564 ± 0.04	1.15TyrSer: 1.15 ± 0.034	1.219TyrThr: 1.219 ± 0.034	1.693TyrVal: 1.693 ± 0.043	0.369TyrTrp: 0.369 ± 0.02	0.602TyrTyr: 0.602 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3982 proteins (1216105 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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