Amino acid dipepetide frequency for Ophiophagus hannah (King cobra) (Naja hannah)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.215AlaAla: 5.215 ± 0.041	1.295AlaCys: 1.295 ± 0.014	2.667AlaAsp: 2.667 ± 0.018	4.392AlaGlu: 4.392 ± 0.031	2.535AlaPhe: 2.535 ± 0.019	3.894AlaGly: 3.894 ± 0.033	1.368AlaHis: 1.368 ± 0.014	3.044AlaIle: 3.044 ± 0.022	3.569AlaLys: 3.569 ± 0.029	6.166AlaLeu: 6.166 ± 0.039	1.463AlaMet: 1.463 ± 0.014	2.23AlaAsn: 2.23 ± 0.018	3.011AlaPro: 3.011 ± 0.029	2.67AlaGln: 2.67 ± 0.026	2.935AlaArg: 2.935 ± 0.024	5.268AlaSer: 5.268 ± 0.031	3.38AlaThr: 3.38 ± 0.022	4.138AlaVal: 4.138 ± 0.026	0.737AlaTrp: 0.737 ± 0.009	1.45AlaTyr: 1.45 ± 0.017	0.011AlaXaa: 0.011 ± 0.001
Cys	1.121CysAla: 1.121 ± 0.016	0.69CysCys: 0.69 ± 0.012	0.988CysAsp: 0.988 ± 0.015	1.203CysGlu: 1.203 ± 0.015	0.928CysPhe: 0.928 ± 0.013	1.419CysGly: 1.419 ± 0.02	0.676CysHis: 0.676 ± 0.011	1.128CysIle: 1.128 ± 0.015	1.297CysLys: 1.297 ± 0.014	2.282CysLeu: 2.282 ± 0.021	0.446CysMet: 0.446 ± 0.009	0.927CysAsn: 0.927 ± 0.013	1.362CysPro: 1.362 ± 0.021	1.106CysGln: 1.106 ± 0.016	1.215CysArg: 1.215 ± 0.015	2.03CysSer: 2.03 ± 0.022	1.136CysThr: 1.136 ± 0.014	1.219CysVal: 1.219 ± 0.015	0.322CysTrp: 0.322 ± 0.007	0.65CysTyr: 0.65 ± 0.012	0.003CysXaa: 0.003 ± 0.001
Asp	2.593AspAla: 2.593 ± 0.021	1.063AspCys: 1.063 ± 0.017	2.536AspAsp: 2.536 ± 0.023	3.337AspGlu: 3.337 ± 0.026	2.135AspPhe: 2.135 ± 0.019	3.18AspGly: 3.18 ± 0.026	1.136AspHis: 1.136 ± 0.013	2.851AspIle: 2.851 ± 0.027	2.623AspLys: 2.623 ± 0.022	4.848AspLeu: 4.848 ± 0.034	1.1AspMet: 1.1 ± 0.014	1.909AspAsn: 1.909 ± 0.019	2.568AspPro: 2.568 ± 0.022	1.836AspGln: 1.836 ± 0.018	2.309AspArg: 2.309 ± 0.019	3.952AspSer: 3.952 ± 0.028	2.304AspThr: 2.304 ± 0.02	2.841AspVal: 2.841 ± 0.034	0.628AspTrp: 0.628 ± 0.01	1.503AspTyr: 1.503 ± 0.016	0.003AspXaa: 0.003 ± 0.001
Glu	4.666GluAla: 4.666 ± 0.035	1.224GluCys: 1.224 ± 0.019	4.256GluAsp: 4.256 ± 0.028	8.932GluGlu: 8.932 ± 0.091	2.15GluPhe: 2.15 ± 0.019	5.627GluGly: 5.627 ± 0.066	1.474GluHis: 1.474 ± 0.015	3.699GluIle: 3.699 ± 0.028	6.37GluLys: 6.37 ± 0.062	6.068GluLeu: 6.068 ± 0.048	1.893GluMet: 1.893 ± 0.019	3.442GluAsn: 3.442 ± 0.027	2.673GluPro: 2.673 ± 0.025	3.129GluGln: 3.129 ± 0.03	5.191GluArg: 5.191 ± 0.057	4.491GluSer: 4.491 ± 0.032	3.583GluThr: 3.583 ± 0.027	3.97GluVal: 3.97 ± 0.029	0.783GluTrp: 0.783 ± 0.011	1.627GluTyr: 1.627 ± 0.017	0.011GluXaa: 0.011 ± 0.001
Phe	2.067PheAla: 2.067 ± 0.018	1.04PheCys: 1.04 ± 0.012	1.678PheAsp: 1.678 ± 0.016	2.05PheGlu: 2.05 ± 0.016	1.784PhePhe: 1.784 ± 0.021	2.248PheGly: 2.248 ± 0.019	1.141PheHis: 1.141 ± 0.011	2.005PheIle: 2.005 ± 0.018	1.94PheLys: 1.94 ± 0.019	4.321PheLeu: 4.321 ± 0.031	0.806PheMet: 0.806 ± 0.011	1.48PheAsn: 1.48 ± 0.015	2.183PhePro: 2.183 ± 0.017	1.928PheGln: 1.928 ± 0.016	1.889PheArg: 1.889 ± 0.017	3.571PheSer: 3.571 ± 0.027	2.041PheThr: 2.041 ± 0.019	2.16PheVal: 2.16 ± 0.019	0.546PheTrp: 0.546 ± 0.009	1.253PheTyr: 1.253 ± 0.014	0.002PheXaa: 0.002 ± 0.0
Gly	3.487GlyAla: 3.487 ± 0.032	1.283GlyCys: 1.283 ± 0.015	2.826GlyAsp: 2.826 ± 0.024	4.348GlyGlu: 4.348 ± 0.04	2.401GlyPhe: 2.401 ± 0.025	5.106GlyGly: 5.106 ± 0.053	1.602GlyHis: 1.602 ± 0.015	3.12GlyIle: 3.12 ± 0.026	4.646GlyLys: 4.646 ± 0.04	5.364GlyLeu: 5.364 ± 0.037	1.381GlyMet: 1.381 ± 0.016	2.64GlyAsn: 2.64 ± 0.022	3.029GlyPro: 3.029 ± 0.055	2.619GlyGln: 2.619 ± 0.02	4.994GlyArg: 4.994 ± 0.065	5.204GlySer: 5.204 ± 0.031	3.34GlyThr: 3.34 ± 0.023	3.185GlyVal: 3.185 ± 0.025	0.882GlyTrp: 0.882 ± 0.014	1.732GlyTyr: 1.732 ± 0.019	0.015GlyXaa: 0.015 ± 0.001
His	1.267HisAla: 1.267 ± 0.014	0.726HisCys: 0.726 ± 0.012	0.91HisAsp: 0.91 ± 0.012	1.332HisGlu: 1.332 ± 0.014	1.181HisPhe: 1.181 ± 0.014	1.475HisGly: 1.475 ± 0.016	0.917HisHis: 0.917 ± 0.015	1.343HisIle: 1.343 ± 0.015	1.369HisLys: 1.369 ± 0.015	2.99HisLeu: 2.99 ± 0.021	0.585HisMet: 0.585 ± 0.01	1.013HisAsn: 1.013 ± 0.012	1.65HisPro: 1.65 ± 0.017	1.286HisGln: 1.286 ± 0.014	1.429HisArg: 1.429 ± 0.015	2.271HisSer: 2.271 ± 0.02	1.28HisThr: 1.28 ± 0.015	1.368HisVal: 1.368 ± 0.015	0.359HisTrp: 0.359 ± 0.007	0.817HisTyr: 0.817 ± 0.012	0.003HisXaa: 0.003 ± 0.001
Ile	2.861IleAla: 2.861 ± 0.021	1.274IleCys: 1.274 ± 0.016	2.237IleAsp: 2.237 ± 0.021	2.912IleGlu: 2.912 ± 0.023	2.152IlePhe: 2.152 ± 0.019	2.542IleGly: 2.542 ± 0.023	1.411IleHis: 1.411 ± 0.015	2.787IleIle: 2.787 ± 0.027	3.033IleLys: 3.033 ± 0.026	5.141IleLeu: 5.141 ± 0.03	1.107IleMet: 1.107 ± 0.012	2.21IleAsn: 2.21 ± 0.021	2.94IlePro: 2.94 ± 0.024	2.562IleGln: 2.562 ± 0.022	2.458IleArg: 2.458 ± 0.02	4.314IleSer: 4.314 ± 0.03	2.792IleThr: 2.792 ± 0.021	2.788IleVal: 2.788 ± 0.025	0.618IleTrp: 0.618 ± 0.011	1.58IleTyr: 1.58 ± 0.017	0.002IleXaa: 0.002 ± 0.0
Lys	3.975LysAla: 3.975 ± 0.028	1.188LysCys: 1.188 ± 0.016	3.336LysAsp: 3.336 ± 0.032	7.33LysGlu: 7.33 ± 0.071	1.826LysPhe: 1.826 ± 0.017	4.182LysGly: 4.182 ± 0.049	1.539LysHis: 1.539 ± 0.015	3.266LysIle: 3.266 ± 0.029	6.039LysLys: 6.039 ± 0.056	5.518LysLeu: 5.518 ± 0.037	1.733LysMet: 1.733 ± 0.02	2.881LysAsn: 2.881 ± 0.024	2.99LysPro: 2.99 ± 0.023	2.94LysGln: 2.94 ± 0.027	4.126LysArg: 4.126 ± 0.038	4.196LysSer: 4.196 ± 0.03	3.352LysThr: 3.352 ± 0.025	3.533LysVal: 3.533 ± 0.029	0.725LysTrp: 0.725 ± 0.01	1.73LysTyr: 1.73 ± 0.02	0.005LysXaa: 0.005 ± 0.001
Leu	6.156LeuAla: 6.156 ± 0.033	2.214LeuCys: 2.214 ± 0.023	4.618LeuAsp: 4.618 ± 0.031	6.949LeuGlu: 6.949 ± 0.052	3.564LeuPhe: 3.564 ± 0.026	5.331LeuGly: 5.331 ± 0.033	2.741LeuHis: 2.741 ± 0.021	4.244LeuIle: 4.244 ± 0.026	6.281LeuLys: 6.281 ± 0.037	10.188LeuLeu: 10.188 ± 0.058	2.051LeuMet: 2.051 ± 0.018	3.925LeuAsn: 3.925 ± 0.028	5.855LeuPro: 5.855 ± 0.037	5.612LeuGln: 5.612 ± 0.043	5.162LeuArg: 5.162 ± 0.033	7.945LeuSer: 7.945 ± 0.042	4.825LeuThr: 4.825 ± 0.029	5.12LeuVal: 5.12 ± 0.029	1.149LeuTrp: 1.149 ± 0.013	2.558LeuTyr: 2.558 ± 0.02	0.01LeuXaa: 0.01 ± 0.001
Met	1.776MetAla: 1.776 ± 0.015	0.406MetCys: 0.406 ± 0.007	1.336MetAsp: 1.336 ± 0.015	2.08MetGlu: 2.08 ± 0.017	0.801MetPhe: 0.801 ± 0.011	1.362MetGly: 1.362 ± 0.014	0.503MetHis: 0.503 ± 0.008	0.971MetIle: 0.971 ± 0.011	1.656MetLys: 1.656 ± 0.015	2.039MetLeu: 2.039 ± 0.018	0.602MetMet: 0.602 ± 0.01	1.006MetAsn: 1.006 ± 0.014	1.166MetPro: 1.166 ± 0.022	1.028MetGln: 1.028 ± 0.012	1.065MetArg: 1.065 ± 0.012	1.569MetSer: 1.569 ± 0.014	1.152MetThr: 1.152 ± 0.013	1.397MetVal: 1.397 ± 0.014	0.249MetTrp: 0.249 ± 0.007	0.593MetTyr: 0.593 ± 0.008	0.001MetXaa: 0.001 ± 0.0
Asn	2.205AsnAla: 2.205 ± 0.019	0.986AsnCys: 0.986 ± 0.013	1.706AsnAsp: 1.706 ± 0.016	2.607AsnGlu: 2.607 ± 0.025	1.64AsnPhe: 1.64 ± 0.017	2.728AsnGly: 2.728 ± 0.027	1.076AsnHis: 1.076 ± 0.012	2.606AsnIle: 2.606 ± 0.023	2.567AsnLys: 2.567 ± 0.022	4.099AsnLeu: 4.099 ± 0.031	1.04AsnMet: 1.04 ± 0.012	1.905AsnAsn: 1.905 ± 0.02	2.334AsnPro: 2.334 ± 0.021	1.886AsnGln: 1.886 ± 0.017	2.037AsnArg: 2.037 ± 0.016	3.521AsnSer: 3.521 ± 0.026	2.157AsnThr: 2.157 ± 0.021	2.382AsnVal: 2.382 ± 0.02	0.53AsnTrp: 0.53 ± 0.009	1.282AsnTyr: 1.282 ± 0.016	0.003AsnXaa: 0.003 ± 0.001
Pro	3.71ProAla: 3.71 ± 0.033	1.152ProCys: 1.152 ± 0.017	2.523ProAsp: 2.523 ± 0.027	3.848ProGlu: 3.848 ± 0.032	2.104ProPhe: 2.104 ± 0.021	3.907ProGly: 3.907 ± 0.062	1.358ProHis: 1.358 ± 0.015	2.152ProIle: 2.152 ± 0.018	2.917ProLys: 2.917 ± 0.045	5.034ProLeu: 5.034 ± 0.032	1.0ProMet: 1.0 ± 0.014	2.002ProAsn: 2.002 ± 0.019	4.805ProPro: 4.805 ± 0.059	2.464ProGln: 2.464 ± 0.025	2.653ProArg: 2.653 ± 0.026	5.377ProSer: 5.377 ± 0.039	2.838ProThr: 2.838 ± 0.027	3.508ProVal: 3.508 ± 0.024	0.652ProTrp: 0.652 ± 0.011	1.362ProTyr: 1.362 ± 0.017	0.013ProXaa: 0.013 ± 0.001
Gln	3.05GlnAla: 3.05 ± 0.024	0.924GlnCys: 0.924 ± 0.013	2.19GlnAsp: 2.19 ± 0.017	3.811GlnGlu: 3.811 ± 0.034	1.46GlnPhe: 1.46 ± 0.015	2.631GlnGly: 2.631 ± 0.022	1.275GlnHis: 1.275 ± 0.013	2.282GlnIle: 2.282 ± 0.018	3.253GlnLys: 3.253 ± 0.029	4.63GlnLeu: 4.63 ± 0.035	1.182GlnMet: 1.182 ± 0.015	2.172GlnAsn: 2.172 ± 0.019	2.537GlnPro: 2.537 ± 0.025	3.016GlnGln: 3.016 ± 0.044	2.753GlnArg: 2.753 ± 0.025	3.178GlnSer: 3.178 ± 0.027	2.336GlnThr: 2.336 ± 0.019	2.617GlnVal: 2.617 ± 0.021	0.554GlnTrp: 0.554 ± 0.009	1.192GlnTyr: 1.192 ± 0.013	0.005GlnXaa: 0.005 ± 0.001
Arg	3.024ArgAla: 3.024 ± 0.025	1.118ArgCys: 1.118 ± 0.016	2.49ArgAsp: 2.49 ± 0.02	5.032ArgGlu: 5.032 ± 0.056	1.848ArgPhe: 1.848 ± 0.018	3.552ArgGly: 3.552 ± 0.034	1.421ArgHis: 1.421 ± 0.016	2.61ArgIle: 2.61 ± 0.02	5.509ArgLys: 5.509 ± 0.063	4.741ArgLeu: 4.741 ± 0.031	1.277ArgMet: 1.277 ± 0.013	2.307ArgAsn: 2.307 ± 0.018	2.556ArgPro: 2.556 ± 0.025	2.54ArgGln: 2.54 ± 0.022	4.583ArgArg: 4.583 ± 0.046	3.983ArgSer: 3.983 ± 0.036	2.687ArgThr: 2.687 ± 0.02	2.709ArgVal: 2.709 ± 0.018	0.724ArgTrp: 0.724 ± 0.012	1.429ArgTyr: 1.429 ± 0.015	0.012ArgXaa: 0.012 ± 0.001
Ser	4.79SerAla: 4.79 ± 0.028	1.943SerCys: 1.943 ± 0.02	3.781SerAsp: 3.781 ± 0.029	5.153SerGlu: 5.153 ± 0.036	3.289SerPhe: 3.289 ± 0.018	5.096SerGly: 5.096 ± 0.033	2.128SerHis: 2.128 ± 0.019	3.723SerIle: 3.723 ± 0.024	4.483SerLys: 4.483 ± 0.033	8.246SerLeu: 8.246 ± 0.042	1.659SerMet: 1.659 ± 0.019	3.143SerAsn: 3.143 ± 0.027	5.52SerPro: 5.52 ± 0.046	3.792SerGln: 3.792 ± 0.03	4.221SerArg: 4.221 ± 0.032	9.256SerSer: 9.256 ± 0.072	4.433SerThr: 4.433 ± 0.034	4.697SerVal: 4.697 ± 0.032	1.083SerTrp: 1.083 ± 0.013	2.123SerTyr: 2.123 ± 0.017	0.008SerXaa: 0.008 ± 0.001
Thr	3.469ThrAla: 3.469 ± 0.026	1.257ThrCys: 1.257 ± 0.02	2.449ThrAsp: 2.449 ± 0.018	3.663ThrGlu: 3.663 ± 0.029	2.162ThrPhe: 2.162 ± 0.021	3.297ThrGly: 3.297 ± 0.026	1.232ThrHis: 1.232 ± 0.015	2.679ThrIle: 2.679 ± 0.021	2.844ThrLys: 2.844 ± 0.024	5.053ThrLeu: 5.053 ± 0.031	1.178ThrMet: 1.178 ± 0.012	1.974ThrAsn: 1.974 ± 0.019	3.111ThrPro: 3.111 ± 0.031	2.16ThrGln: 2.16 ± 0.02	2.261ThrArg: 2.261 ± 0.016	4.65ThrSer: 4.65 ± 0.033	2.996ThrThr: 2.996 ± 0.029	3.588ThrVal: 3.588 ± 0.027	0.692ThrTrp: 0.692 ± 0.012	1.441ThrTyr: 1.441 ± 0.013	0.004ThrXaa: 0.004 ± 0.001
Val	3.855ValAla: 3.855 ± 0.024	1.393ValCys: 1.393 ± 0.014	2.743ValAsp: 2.743 ± 0.027	3.772ValGlu: 3.772 ± 0.024	2.377ValPhe: 2.377 ± 0.023	3.204ValGly: 3.204 ± 0.027	1.472ValHis: 1.472 ± 0.016	3.0ValIle: 3.0 ± 0.022	3.469ValLys: 3.469 ± 0.026	5.723ValLeu: 5.723 ± 0.035	1.292ValMet: 1.292 ± 0.014	2.283ValAsn: 2.283 ± 0.018	3.243ValPro: 3.243 ± 0.025	2.622ValGln: 2.622 ± 0.022	2.647ValArg: 2.647 ± 0.021	4.637ValSer: 4.637 ± 0.03	3.402ValThr: 3.402 ± 0.025	3.683ValVal: 3.683 ± 0.028	0.682ValTrp: 0.682 ± 0.012	1.58ValTyr: 1.58 ± 0.015	0.005ValXaa: 0.005 ± 0.001
Trp	0.734TrpAla: 0.734 ± 0.01	0.257TrpCys: 0.257 ± 0.006	0.653TrpAsp: 0.653 ± 0.011	0.856TrpGlu: 0.856 ± 0.013	0.477TrpPhe: 0.477 ± 0.008	0.757TrpGly: 0.757 ± 0.011	0.326TrpHis: 0.326 ± 0.007	0.655TrpIle: 0.655 ± 0.012	0.959TrpLys: 0.959 ± 0.012	1.278TrpLeu: 1.278 ± 0.015	0.353TrpMet: 0.353 ± 0.007	0.592TrpAsn: 0.592 ± 0.01	0.535TrpPro: 0.535 ± 0.009	0.571TrpGln: 0.571 ± 0.008	0.735TrpArg: 0.735 ± 0.011	0.899TrpSer: 0.899 ± 0.012	0.635TrpThr: 0.635 ± 0.011	0.678TrpVal: 0.678 ± 0.01	0.214TrpTrp: 0.214 ± 0.006	0.34TrpTyr: 0.34 ± 0.008	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.407TyrAla: 1.407 ± 0.016	0.712TyrCys: 0.712 ± 0.011	1.331TyrAsp: 1.331 ± 0.015	1.643TyrGlu: 1.643 ± 0.017	1.316TyrPhe: 1.316 ± 0.014	1.658TyrGly: 1.658 ± 0.016	0.774TyrHis: 0.774 ± 0.01	1.549TyrIle: 1.549 ± 0.016	1.58TyrLys: 1.58 ± 0.022	2.761TyrLeu: 2.761 ± 0.022	0.608TyrMet: 0.608 ± 0.009	1.253TyrAsn: 1.253 ± 0.014	1.299TyrPro: 1.299 ± 0.015	1.274TyrGln: 1.274 ± 0.015	1.474TyrArg: 1.474 ± 0.016	2.246TyrSer: 2.246 ± 0.02	1.483TyrThr: 1.483 ± 0.017	1.499TyrVal: 1.499 ± 0.016	0.373TyrTrp: 0.373 ± 0.009	0.997TyrTyr: 0.997 ± 0.011	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.013XaaAla: 0.013 ± 0.001	0.002XaaCys: 0.002 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.01XaaGlu: 0.01 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.012XaaGly: 0.012 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.001XaaIle: 0.001 ± 0.0	0.006XaaLys: 0.006 ± 0.001	0.009XaaLeu: 0.009 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.014XaaPro: 0.014 ± 0.001	0.007XaaGln: 0.007 ± 0.001	0.013XaaArg: 0.013 ± 0.001	0.008XaaSer: 0.008 ± 0.001	0.004XaaThr: 0.004 ± 0.001	0.006XaaVal: 0.006 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.045XaaXaa: 0.045 ± 0.005

Statistics based on 18387 proteins (7683767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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