Amino acid dipepetide frequency for Flavobacterium pallidum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.264AlaAla: 6.264 ± 0.141
0.664AlaCys: 0.664 ± 0.032
4.361AlaAsp: 4.361 ± 0.104
4.371AlaGlu: 4.371 ± 0.099
3.662AlaPhe: 3.662 ± 0.067
5.29AlaGly: 5.29 ± 0.114
1.141AlaHis: 1.141 ± 0.035
5.332AlaIle: 5.332 ± 0.086
4.738AlaLys: 4.738 ± 0.109
6.615AlaLeu: 6.615 ± 0.112
1.793AlaMet: 1.793 ± 0.048
4.27AlaAsn: 4.27 ± 0.198
2.492AlaPro: 2.492 ± 0.108
2.669AlaGln: 2.669 ± 0.059
2.153AlaArg: 2.153 ± 0.046
4.885AlaSer: 4.885 ± 0.139
5.188AlaThr: 5.188 ± 0.269
5.043AlaVal: 5.043 ± 0.091
0.67AlaTrp: 0.67 ± 0.029
2.572AlaTyr: 2.572 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.589CysAla: 0.589 ± 0.033
0.126CysCys: 0.126 ± 0.011
0.562CysAsp: 0.562 ± 0.026
0.489CysGlu: 0.489 ± 0.027
0.466CysPhe: 0.466 ± 0.033
0.763CysGly: 0.763 ± 0.044
0.218CysHis: 0.218 ± 0.02
0.624CysIle: 0.624 ± 0.026
0.402CysLys: 0.402 ± 0.023
0.653CysLeu: 0.653 ± 0.028
0.139CysMet: 0.139 ± 0.011
0.5CysAsn: 0.5 ± 0.028
0.377CysPro: 0.377 ± 0.026
0.224CysGln: 0.224 ± 0.016
0.241CysArg: 0.241 ± 0.016
0.69CysSer: 0.69 ± 0.038
0.56CysThr: 0.56 ± 0.037
0.461CysVal: 0.461 ± 0.022
0.07CysTrp: 0.07 ± 0.008
0.302CysTyr: 0.302 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.422AspAla: 4.422 ± 0.079
0.497AspCys: 0.497 ± 0.032
3.237AspAsp: 3.237 ± 0.089
3.291AspGlu: 3.291 ± 0.074
3.874AspPhe: 3.874 ± 0.078
4.407AspGly: 4.407 ± 0.12
0.945AspHis: 0.945 ± 0.035
4.339AspIle: 4.339 ± 0.078
3.867AspLys: 3.867 ± 0.096
4.797AspLeu: 4.797 ± 0.074
1.263AspMet: 1.263 ± 0.038
3.431AspAsn: 3.431 ± 0.081
1.95AspPro: 1.95 ± 0.06
1.452AspGln: 1.452 ± 0.054
1.82AspArg: 1.82 ± 0.045
3.255AspSer: 3.255 ± 0.1
3.265AspThr: 3.265 ± 0.212
3.693AspVal: 3.693 ± 0.075
0.695AspTrp: 0.695 ± 0.032
2.981AspTyr: 2.981 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.273GluAla: 4.273 ± 0.094
0.337GluCys: 0.337 ± 0.02
2.93GluAsp: 2.93 ± 0.064
3.572GluGlu: 3.572 ± 0.091
2.568GluPhe: 2.568 ± 0.058
3.387GluGly: 3.387 ± 0.074
0.982GluHis: 0.982 ± 0.04
4.921GluIle: 4.921 ± 0.098
5.277GluLys: 5.277 ± 0.12
4.89GluLeu: 4.89 ± 0.105
1.591GluMet: 1.591 ± 0.047
4.255GluAsn: 4.255 ± 0.085
1.48GluPro: 1.48 ± 0.048
2.081GluGln: 2.081 ± 0.061
2.128GluArg: 2.128 ± 0.065
3.138GluSer: 3.138 ± 0.058
3.484GluThr: 3.484 ± 0.069
3.661GluVal: 3.661 ± 0.074
0.572GluTrp: 0.572 ± 0.026
1.975GluTyr: 1.975 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.388PheAla: 3.388 ± 0.057
0.508PheCys: 0.508 ± 0.025
3.399PheAsp: 3.399 ± 0.064
3.276PheGlu: 3.276 ± 0.062
2.591PhePhe: 2.591 ± 0.068
3.848PheGly: 3.848 ± 0.079
0.885PheHis: 0.885 ± 0.032
3.517PheIle: 3.517 ± 0.075
2.879PheLys: 2.879 ± 0.075
4.335PheLeu: 4.335 ± 0.096
1.194PheMet: 1.194 ± 0.04
3.138PheAsn: 3.138 ± 0.067
1.789PhePro: 1.789 ± 0.043
1.443PheGln: 1.443 ± 0.038
2.019PheArg: 2.019 ± 0.054
4.107PheSer: 4.107 ± 0.084
3.711PheThr: 3.711 ± 0.093
2.919PheVal: 2.919 ± 0.064
0.554PheTrp: 0.554 ± 0.025
2.145PheTyr: 2.145 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.722GlyAla: 4.722 ± 0.125
0.708GlyCys: 0.708 ± 0.044
3.554GlyAsp: 3.554 ± 0.082
3.258GlyGlu: 3.258 ± 0.07
3.819GlyPhe: 3.819 ± 0.067
4.805GlyGly: 4.805 ± 0.146
1.198GlyHis: 1.198 ± 0.038
5.525GlyIle: 5.525 ± 0.095
5.082GlyLys: 5.082 ± 0.116
5.503GlyLeu: 5.503 ± 0.089
1.73GlyMet: 1.73 ± 0.053
4.62GlyAsn: 4.62 ± 0.139
1.713GlyPro: 1.713 ± 0.105
2.168GlyGln: 2.168 ± 0.059
2.129GlyArg: 2.129 ± 0.057
4.698GlySer: 4.698 ± 0.134
5.668GlyThr: 5.668 ± 0.306
4.263GlyVal: 4.263 ± 0.082
0.723GlyTrp: 0.723 ± 0.027
2.871GlyTyr: 2.871 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.109HisAla: 1.109 ± 0.037
0.217HisCys: 0.217 ± 0.017
0.987HisAsp: 0.987 ± 0.033
0.929HisGlu: 0.929 ± 0.032
1.295HisPhe: 1.295 ± 0.041
1.101HisGly: 1.101 ± 0.037
0.491HisHis: 0.491 ± 0.029
1.325HisIle: 1.325 ± 0.045
1.071HisLys: 1.071 ± 0.04
1.591HisLeu: 1.591 ± 0.047
0.343HisMet: 0.343 ± 0.018
0.953HisAsn: 0.953 ± 0.035
0.868HisPro: 0.868 ± 0.032
0.63HisGln: 0.63 ± 0.025
0.686HisArg: 0.686 ± 0.031
0.996HisSer: 0.996 ± 0.034
0.95HisThr: 0.95 ± 0.036
0.972HisVal: 0.972 ± 0.032
0.199HisTrp: 0.199 ± 0.016
0.857HisTyr: 0.857 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.934IleAla: 5.934 ± 0.117
0.72IleCys: 0.72 ± 0.035
4.576IleAsp: 4.576 ± 0.081
4.442IleGlu: 4.442 ± 0.095
3.409IlePhe: 3.409 ± 0.072
4.895IleGly: 4.895 ± 0.094
1.303IleHis: 1.303 ± 0.045
5.396IleIle: 5.396 ± 0.1
4.576IleLys: 4.576 ± 0.093
6.188IleLeu: 6.188 ± 0.121
1.363IleMet: 1.363 ± 0.042
4.292IleAsn: 4.292 ± 0.071
3.239IlePro: 3.239 ± 0.067
2.299IleGln: 2.299 ± 0.05
2.99IleArg: 2.99 ± 0.066
5.603IleSer: 5.603 ± 0.091
5.291IleThr: 5.291 ± 0.128
4.705IleVal: 4.705 ± 0.079
0.677IleTrp: 0.677 ± 0.026
2.718IleTyr: 2.718 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.944LysAla: 4.944 ± 0.107
0.339LysCys: 0.339 ± 0.017
3.951LysAsp: 3.951 ± 0.097
4.431LysGlu: 4.431 ± 0.107
2.833LysPhe: 2.833 ± 0.068
4.009LysGly: 4.009 ± 0.094
1.194LysHis: 1.194 ± 0.035
5.677LysIle: 5.677 ± 0.112
5.86LysLys: 5.86 ± 0.128
5.617LysLeu: 5.617 ± 0.116
2.026LysMet: 2.026 ± 0.057
4.316LysAsn: 4.316 ± 0.096
2.529LysPro: 2.529 ± 0.063
2.29LysGln: 2.29 ± 0.066
2.4LysArg: 2.4 ± 0.068
4.31LysSer: 4.31 ± 0.094
4.256LysThr: 4.256 ± 0.091
4.238LysVal: 4.238 ± 0.092
0.696LysTrp: 0.696 ± 0.033
2.681LysTyr: 2.681 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
5.969LeuAla: 5.969 ± 0.092
0.717LeuCys: 0.717 ± 0.031
4.751LeuAsp: 4.751 ± 0.09
4.97LeuGlu: 4.97 ± 0.106
4.468LeuPhe: 4.468 ± 0.098
5.251LeuGly: 5.251 ± 0.084
1.664LeuHis: 1.664 ± 0.047
5.852LeuIle: 5.852 ± 0.117
6.334LeuLys: 6.334 ± 0.13
8.254LeuLeu: 8.254 ± 0.144
2.12LeuMet: 2.12 ± 0.06
4.856LeuAsn: 4.856 ± 0.089
3.663LeuPro: 3.663 ± 0.069
3.262LeuGln: 3.262 ± 0.073
3.187LeuArg: 3.187 ± 0.079
6.498LeuSer: 6.498 ± 0.089
5.359LeuThr: 5.359 ± 0.112
4.863LeuVal: 4.863 ± 0.08
0.796LeuTrp: 0.796 ± 0.032
3.123LeuTyr: 3.123 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
1.901MetAla: 1.901 ± 0.047
0.151MetCys: 0.151 ± 0.012
1.281MetAsp: 1.281 ± 0.039
1.419MetGlu: 1.419 ± 0.043
0.857MetPhe: 0.857 ± 0.03
1.464MetGly: 1.464 ± 0.045
0.473MetHis: 0.473 ± 0.021
1.619MetIle: 1.619 ± 0.05
2.256MetLys: 2.256 ± 0.057
1.998MetLeu: 1.998 ± 0.051
0.67MetMet: 0.67 ± 0.031
1.263MetAsn: 1.263 ± 0.033
1.014MetPro: 1.014 ± 0.032
0.924MetGln: 0.924 ± 0.035
0.875MetArg: 0.875 ± 0.034
1.456MetSer: 1.456 ± 0.039
1.372MetThr: 1.372 ± 0.039
1.459MetVal: 1.459 ± 0.039
0.167MetTrp: 0.167 ± 0.013
0.687MetTyr: 0.687 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
4.709AsnAla: 4.709 ± 0.105
0.483AsnCys: 0.483 ± 0.025
3.696AsnAsp: 3.696 ± 0.18
3.169AsnGlu: 3.169 ± 0.063
2.975AsnPhe: 2.975 ± 0.061
5.029AsnGly: 5.029 ± 0.221
1.057AsnHis: 1.057 ± 0.036
4.65AsnIle: 4.65 ± 0.08
3.412AsnLys: 3.412 ± 0.081
5.015AsnLeu: 5.015 ± 0.091
1.319AsnMet: 1.319 ± 0.038
3.879AsnAsn: 3.879 ± 0.138
3.189AsnPro: 3.189 ± 0.084
1.968AsnGln: 1.968 ± 0.049
2.01AsnArg: 2.01 ± 0.049
3.627AsnSer: 3.627 ± 0.094
4.0AsnThr: 4.0 ± 0.131
3.792AsnVal: 3.792 ± 0.111
0.722AsnTrp: 0.722 ± 0.03
2.633AsnTyr: 2.633 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
3.007ProAla: 3.007 ± 0.097
0.251ProCys: 0.251 ± 0.016
2.635ProAsp: 2.635 ± 0.085
2.853ProGlu: 2.853 ± 0.062
1.963ProPhe: 1.963 ± 0.044
2.582ProGly: 2.582 ± 0.068
0.545ProHis: 0.545 ± 0.027
2.393ProIle: 2.393 ± 0.052
2.305ProLys: 2.305 ± 0.059
3.048ProLeu: 3.048 ± 0.056
0.778ProMet: 0.778 ± 0.029
2.401ProAsn: 2.401 ± 0.122
0.981ProPro: 0.981 ± 0.044
1.262ProGln: 1.262 ± 0.046
0.857ProArg: 0.857 ± 0.032
2.495ProSer: 2.495 ± 0.088
2.28ProThr: 2.28 ± 0.121
3.163ProVal: 3.163 ± 0.105
0.292ProTrp: 0.292 ± 0.019
1.404ProTyr: 1.404 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.171GlnAla: 2.171 ± 0.055
0.245GlnCys: 0.245 ± 0.021
1.602GlnAsp: 1.602 ± 0.043
1.887GlnGlu: 1.887 ± 0.051
1.675GlnPhe: 1.675 ± 0.046
1.873GlnGly: 1.873 ± 0.052
0.67GlnHis: 0.67 ± 0.026
2.337GlnIle: 2.337 ± 0.061
2.657GlnLys: 2.657 ± 0.067
3.238GlnLeu: 3.238 ± 0.071
0.894GlnMet: 0.894 ± 0.028
2.103GlnAsn: 2.103 ± 0.05
1.28GlnPro: 1.28 ± 0.043
1.589GlnGln: 1.589 ± 0.043
1.283GlnArg: 1.283 ± 0.044
2.187GlnSer: 2.187 ± 0.054
1.999GlnThr: 1.999 ± 0.058
1.923GlnVal: 1.923 ± 0.045
0.346GlnTrp: 0.346 ± 0.021
1.465GlnTyr: 1.465 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.033ArgAla: 2.033 ± 0.051
0.229ArgCys: 0.229 ± 0.017
1.841ArgAsp: 1.841 ± 0.05
2.181ArgGlu: 2.181 ± 0.063
1.918ArgPhe: 1.918 ± 0.047
1.761ArgGly: 1.761 ± 0.054
0.663ArgHis: 0.663 ± 0.029
2.997ArgIle: 2.997 ± 0.07
2.913ArgLys: 2.913 ± 0.073
3.184ArgLeu: 3.184 ± 0.078
1.045ArgMet: 1.045 ± 0.033
2.191ArgAsn: 2.191 ± 0.049
1.095ArgPro: 1.095 ± 0.036
1.252ArgGln: 1.252 ± 0.038
1.248ArgArg: 1.248 ± 0.044
1.841ArgSer: 1.841 ± 0.045
1.808ArgThr: 1.808 ± 0.046
1.92ArgVal: 1.92 ± 0.052
0.361ArgTrp: 0.361 ± 0.022
1.467ArgTyr: 1.467 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.95SerAla: 4.95 ± 0.118
0.713SerCys: 0.713 ± 0.031
3.784SerAsp: 3.784 ± 0.071
3.685SerGlu: 3.685 ± 0.068
3.637SerPhe: 3.637 ± 0.072
6.003SerGly: 6.003 ± 0.18
1.168SerHis: 1.168 ± 0.038
4.642SerIle: 4.642 ± 0.08
4.004SerLys: 4.004 ± 0.09
5.583SerLeu: 5.583 ± 0.104
1.395SerMet: 1.395 ± 0.037
3.838SerAsn: 3.838 ± 0.109
2.345SerPro: 2.345 ± 0.066
2.238SerGln: 2.238 ± 0.055
2.087SerArg: 2.087 ± 0.048
3.957SerSer: 3.957 ± 0.115
3.963SerThr: 3.963 ± 0.16
4.561SerVal: 4.561 ± 0.096
0.777SerTrp: 0.777 ± 0.035
2.604SerTyr: 2.604 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
5.659ThrAla: 5.659 ± 0.28
0.484ThrCys: 0.484 ± 0.027
3.907ThrAsp: 3.907 ± 0.151
3.345ThrGlu: 3.345 ± 0.064
3.34ThrPhe: 3.34 ± 0.093
5.418ThrGly: 5.418 ± 0.207
0.967ThrHis: 0.967 ± 0.036
5.303ThrIle: 5.303 ± 0.22
3.315ThrLys: 3.315 ± 0.072
5.509ThrLeu: 5.509 ± 0.09
1.127ThrMet: 1.127 ± 0.035
3.545ThrAsn: 3.545 ± 0.109
3.305ThrPro: 3.305 ± 0.228
2.029ThrGln: 2.029 ± 0.054
1.684ThrArg: 1.684 ± 0.044
4.064ThrSer: 4.064 ± 0.139
4.358ThrThr: 4.358 ± 0.221
5.069ThrVal: 5.069 ± 0.232
0.601ThrTrp: 0.601 ± 0.036
2.722ThrTyr: 2.722 ± 0.114
0.0ThrXaa: 0.0 ± 0.0
Val
4.816ValAla: 4.816 ± 0.093
0.593ValCys: 0.593 ± 0.03
3.394ValAsp: 3.394 ± 0.07
3.154ValGlu: 3.154 ± 0.064
3.311ValPhe: 3.311 ± 0.067
3.642ValGly: 3.642 ± 0.075
0.96ValHis: 0.96 ± 0.036
4.81ValIle: 4.81 ± 0.083
4.275ValLys: 4.275 ± 0.097
5.593ValLeu: 5.593 ± 0.085
1.473ValMet: 1.473 ± 0.037
4.232ValAsn: 4.232 ± 0.183
2.44ValPro: 2.44 ± 0.075
1.829ValGln: 1.829 ± 0.043
2.241ValArg: 2.241 ± 0.051
4.888ValSer: 4.888 ± 0.096
4.766ValThr: 4.766 ± 0.231
4.231ValVal: 4.231 ± 0.087
0.613ValTrp: 0.613 ± 0.026
2.542ValTyr: 2.542 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.665TrpAla: 0.665 ± 0.029
0.099TrpCys: 0.099 ± 0.01
0.624TrpAsp: 0.624 ± 0.026
0.622TrpGlu: 0.622 ± 0.026
0.568TrpPhe: 0.568 ± 0.026
0.625TrpGly: 0.625 ± 0.028
0.224TrpHis: 0.224 ± 0.016
0.7TrpIle: 0.7 ± 0.031
0.738TrpLys: 0.738 ± 0.031
0.885TrpLeu: 0.885 ± 0.033
0.283TrpMet: 0.283 ± 0.017
0.698TrpAsn: 0.698 ± 0.035
0.233TrpPro: 0.233 ± 0.016
0.419TrpGln: 0.419 ± 0.021
0.344TrpArg: 0.344 ± 0.02
0.644TrpSer: 0.644 ± 0.034
0.613TrpThr: 0.613 ± 0.03
0.562TrpVal: 0.562 ± 0.025
0.124TrpTrp: 0.124 ± 0.013
0.46TrpTyr: 0.46 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.645TyrAla: 2.645 ± 0.062
0.376TyrCys: 0.376 ± 0.022
2.406TyrAsp: 2.406 ± 0.058
2.16TyrGlu: 2.16 ± 0.051
2.415TyrPhe: 2.415 ± 0.061
2.606TyrGly: 2.606 ± 0.058
0.825TyrHis: 0.825 ± 0.032
2.658TyrIle: 2.658 ± 0.054
2.637TyrLys: 2.637 ± 0.058
3.46TyrLeu: 3.46 ± 0.074
0.759TyrMet: 0.759 ± 0.028
2.553TyrAsn: 2.553 ± 0.058
1.512TyrPro: 1.512 ± 0.042
1.396TyrGln: 1.396 ± 0.035
1.565TyrArg: 1.565 ± 0.048
2.593TyrSer: 2.593 ± 0.06
2.859TyrThr: 2.859 ± 0.138
2.306TyrVal: 2.306 ± 0.049
0.477TyrTrp: 0.477 ± 0.022
1.91TyrTyr: 1.91 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2931 proteins (1068508 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski