Amino acid dipepetide frequency for Flavobacterium macacae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.848AlaAla: 3.848 ± 0.101	0.555AlaCys: 0.555 ± 0.026	3.402AlaAsp: 3.402 ± 0.061	4.183AlaGlu: 4.183 ± 0.077	3.544AlaPhe: 3.544 ± 0.065	4.48AlaGly: 4.48 ± 0.094	1.034AlaHis: 1.034 ± 0.032	5.455AlaIle: 5.455 ± 0.077	5.188AlaLys: 5.188 ± 0.108	6.317AlaLeu: 6.317 ± 0.098	1.62AlaMet: 1.62 ± 0.043	3.499AlaAsn: 3.499 ± 0.076	2.078AlaPro: 2.078 ± 0.056	2.468AlaGln: 2.468 ± 0.056	2.005AlaArg: 2.005 ± 0.056	4.622AlaSer: 4.622 ± 0.077	4.22AlaThr: 4.22 ± 0.113	4.479AlaVal: 4.479 ± 0.081	0.566AlaTrp: 0.566 ± 0.024	2.349AlaTyr: 2.349 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.451CysAla: 0.451 ± 0.024	0.103CysCys: 0.103 ± 0.012	0.445CysAsp: 0.445 ± 0.024	0.446CysGlu: 0.446 ± 0.021	0.425CysPhe: 0.425 ± 0.021	0.652CysGly: 0.652 ± 0.03	0.18CysHis: 0.18 ± 0.014	0.591CysIle: 0.591 ± 0.031	0.448CysLys: 0.448 ± 0.026	0.594CysLeu: 0.594 ± 0.025	0.139CysMet: 0.139 ± 0.014	0.436CysAsn: 0.436 ± 0.022	0.326CysPro: 0.326 ± 0.021	0.246CysGln: 0.246 ± 0.018	0.215CysArg: 0.215 ± 0.015	0.559CysSer: 0.559 ± 0.03	0.395CysThr: 0.395 ± 0.021	0.421CysVal: 0.421 ± 0.023	0.047CysTrp: 0.047 ± 0.007	0.272CysTyr: 0.272 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.67AspAla: 3.67 ± 0.059	0.381AspCys: 0.381 ± 0.021	2.673AspAsp: 2.673 ± 0.068	3.708AspGlu: 3.708 ± 0.073	3.889AspPhe: 3.889 ± 0.065	3.563AspGly: 3.563 ± 0.068	0.831AspHis: 0.831 ± 0.032	4.05AspIle: 4.05 ± 0.067	4.137AspLys: 4.137 ± 0.071	5.253AspLeu: 5.253 ± 0.084	1.067AspMet: 1.067 ± 0.029	3.009AspAsn: 3.009 ± 0.062	1.606AspPro: 1.606 ± 0.046	1.472AspGln: 1.472 ± 0.043	1.882AspArg: 1.882 ± 0.052	3.164AspSer: 3.164 ± 0.067	2.542AspThr: 2.542 ± 0.059	3.434AspVal: 3.434 ± 0.062	0.711AspTrp: 0.711 ± 0.026	2.74AspTyr: 2.74 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.526GluAla: 4.526 ± 0.076	0.369GluCys: 0.369 ± 0.022	3.369GluAsp: 3.369 ± 0.07	5.195GluGlu: 5.195 ± 0.104	3.207GluPhe: 3.207 ± 0.064	3.527GluGly: 3.527 ± 0.063	1.053GluHis: 1.053 ± 0.035	6.164GluIle: 6.164 ± 0.102	6.885GluLys: 6.885 ± 0.11	5.773GluLeu: 5.773 ± 0.08	1.755GluMet: 1.755 ± 0.044	5.349GluAsn: 5.349 ± 0.082	1.513GluPro: 1.513 ± 0.039	2.244GluGln: 2.244 ± 0.054	2.527GluArg: 2.527 ± 0.063	3.498GluSer: 3.498 ± 0.06	3.769GluThr: 3.769 ± 0.075	4.1GluVal: 4.1 ± 0.064	0.576GluTrp: 0.576 ± 0.024	2.4GluTyr: 2.4 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.51PheAla: 3.51 ± 0.067	0.522PheCys: 0.522 ± 0.025	3.427PheAsp: 3.427 ± 0.073	3.886PheGlu: 3.886 ± 0.076	2.994PhePhe: 2.994 ± 0.075	3.907PheGly: 3.907 ± 0.087	0.935PheHis: 0.935 ± 0.031	3.906PheIle: 3.906 ± 0.079	3.842PheLys: 3.842 ± 0.071	5.083PheLeu: 5.083 ± 0.095	1.148PheMet: 1.148 ± 0.038	3.092PheAsn: 3.092 ± 0.065	1.829PhePro: 1.829 ± 0.045	1.764PheGln: 1.764 ± 0.042	1.601PheArg: 1.601 ± 0.043	4.226PheSer: 4.226 ± 0.068	3.184PheThr: 3.184 ± 0.068	3.183PheVal: 3.183 ± 0.067	0.545PheTrp: 0.545 ± 0.029	2.272PheTyr: 2.272 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.172GlyAla: 4.172 ± 0.084	0.597GlyCys: 0.597 ± 0.029	3.102GlyAsp: 3.102 ± 0.062	3.591GlyGlu: 3.591 ± 0.065	3.73GlyPhe: 3.73 ± 0.071	4.422GlyGly: 4.422 ± 0.094	1.15GlyHis: 1.15 ± 0.044	5.521GlyIle: 5.521 ± 0.074	5.177GlyLys: 5.177 ± 0.079	5.418GlyLeu: 5.418 ± 0.085	1.592GlyMet: 1.592 ± 0.045	3.894GlyAsn: 3.894 ± 0.087	1.275GlyPro: 1.275 ± 0.038	2.002GlyGln: 2.002 ± 0.045	2.08GlyArg: 2.08 ± 0.053	4.033GlySer: 4.033 ± 0.087	4.235GlyThr: 4.235 ± 0.128	3.958GlyVal: 3.958 ± 0.083	0.697GlyTrp: 0.697 ± 0.029	2.689GlyTyr: 2.689 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.936HisAla: 0.936 ± 0.036	0.172HisCys: 0.172 ± 0.013	0.883HisAsp: 0.883 ± 0.034	0.979HisGlu: 0.979 ± 0.031	1.203HisPhe: 1.203 ± 0.041	0.998HisGly: 0.998 ± 0.036	0.441HisHis: 0.441 ± 0.022	1.318HisIle: 1.318 ± 0.038	1.142HisLys: 1.142 ± 0.036	1.675HisLeu: 1.675 ± 0.044	0.312HisMet: 0.312 ± 0.018	0.953HisAsn: 0.953 ± 0.033	0.796HisPro: 0.796 ± 0.033	0.659HisGln: 0.659 ± 0.024	0.65HisArg: 0.65 ± 0.026	1.061HisSer: 1.061 ± 0.035	0.877HisThr: 0.877 ± 0.03	0.834HisVal: 0.834 ± 0.03	0.199HisTrp: 0.199 ± 0.014	0.797HisTyr: 0.797 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.694IleAla: 5.694 ± 0.081	0.613IleCys: 0.613 ± 0.029	4.639IleAsp: 4.639 ± 0.071	5.472IleGlu: 5.472 ± 0.072	3.829IlePhe: 3.829 ± 0.074	5.181IleGly: 5.181 ± 0.079	1.334IleHis: 1.334 ± 0.035	6.208IleIle: 6.208 ± 0.106	5.776IleLys: 5.776 ± 0.08	7.191IleLeu: 7.191 ± 0.105	1.454IleMet: 1.454 ± 0.04	4.492IleAsn: 4.492 ± 0.067	3.221IlePro: 3.221 ± 0.054	2.688IleGln: 2.688 ± 0.052	2.608IleArg: 2.608 ± 0.058	6.007IleSer: 6.007 ± 0.076	4.722IleThr: 4.722 ± 0.086	4.749IleVal: 4.749 ± 0.086	0.677IleTrp: 0.677 ± 0.028	2.867IleTyr: 2.867 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	5.172LysAla: 5.172 ± 0.092	0.356LysCys: 0.356 ± 0.021	4.395LysAsp: 4.395 ± 0.083	6.265LysGlu: 6.265 ± 0.104	3.402LysPhe: 3.402 ± 0.073	4.378LysGly: 4.378 ± 0.076	1.206LysHis: 1.206 ± 0.036	6.933LysIle: 6.933 ± 0.109	7.439LysLys: 7.439 ± 0.127	6.624LysLeu: 6.624 ± 0.088	2.351LysMet: 2.351 ± 0.057	5.667LysAsn: 5.667 ± 0.098	2.541LysPro: 2.541 ± 0.047	2.569LysGln: 2.569 ± 0.054	2.625LysArg: 2.625 ± 0.064	4.852LysSer: 4.852 ± 0.079	4.768LysThr: 4.768 ± 0.07	4.775LysVal: 4.775 ± 0.083	0.717LysTrp: 0.717 ± 0.032	3.161LysTyr: 3.161 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.01LeuAla: 6.01 ± 0.091	0.62LeuCys: 0.62 ± 0.022	4.908LeuAsp: 4.908 ± 0.086	6.274LeuGlu: 6.274 ± 0.106	5.059LeuPhe: 5.059 ± 0.095	5.609LeuGly: 5.609 ± 0.085	1.582LeuHis: 1.582 ± 0.044	6.614LeuIle: 6.614 ± 0.093	7.772LeuLys: 7.772 ± 0.109	8.585LeuLeu: 8.585 ± 0.13	2.03LeuMet: 2.03 ± 0.053	5.474LeuAsn: 5.474 ± 0.088	3.566LeuPro: 3.566 ± 0.06	3.267LeuGln: 3.267 ± 0.067	3.03LeuArg: 3.03 ± 0.059	6.632LeuSer: 6.632 ± 0.084	4.927LeuThr: 4.927 ± 0.082	5.327LeuVal: 5.327 ± 0.08	0.684LeuTrp: 0.684 ± 0.027	3.063LeuTyr: 3.063 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.726MetAla: 1.726 ± 0.042	0.128MetCys: 0.128 ± 0.011	1.194MetAsp: 1.194 ± 0.039	1.523MetGlu: 1.523 ± 0.042	0.834MetPhe: 0.834 ± 0.028	1.368MetGly: 1.368 ± 0.036	0.408MetHis: 0.408 ± 0.02	1.662MetIle: 1.662 ± 0.045	2.385MetLys: 2.385 ± 0.048	1.959MetLeu: 1.959 ± 0.048	0.622MetMet: 0.622 ± 0.03	1.324MetAsn: 1.324 ± 0.033	0.893MetPro: 0.893 ± 0.031	0.874MetGln: 0.874 ± 0.03	0.778MetArg: 0.778 ± 0.03	1.438MetSer: 1.438 ± 0.04	1.25MetThr: 1.25 ± 0.039	1.314MetVal: 1.314 ± 0.041	0.175MetTrp: 0.175 ± 0.013	0.686MetTyr: 0.686 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.145AsnAla: 4.145 ± 0.072	0.479AsnCys: 0.479 ± 0.027	3.196AsnAsp: 3.196 ± 0.061	3.715AsnGlu: 3.715 ± 0.06	3.403AsnPhe: 3.403 ± 0.061	4.084AsnGly: 4.084 ± 0.087	1.063AsnHis: 1.063 ± 0.039	4.504AsnIle: 4.504 ± 0.076	4.249AsnLys: 4.249 ± 0.083	5.608AsnLeu: 5.608 ± 0.07	1.228AsnMet: 1.228 ± 0.038	3.566AsnAsn: 3.566 ± 0.075	2.957AsnPro: 2.957 ± 0.069	2.329AsnGln: 2.329 ± 0.056	2.079AsnArg: 2.079 ± 0.052	4.126AsnSer: 4.126 ± 0.088	3.274AsnThr: 3.274 ± 0.081	3.742AsnVal: 3.742 ± 0.07	0.756AsnTrp: 0.756 ± 0.029	2.904AsnTyr: 2.904 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	2.25ProAla: 2.25 ± 0.059	0.206ProCys: 0.206 ± 0.016	1.905ProAsp: 1.905 ± 0.042	2.909ProGlu: 2.909 ± 0.059	1.938ProPhe: 1.938 ± 0.045	1.934ProGly: 1.934 ± 0.059	0.53ProHis: 0.53 ± 0.023	2.635ProIle: 2.635 ± 0.047	2.667ProLys: 2.667 ± 0.055	2.955ProLeu: 2.955 ± 0.06	0.759ProMet: 0.759 ± 0.027	2.228ProAsn: 2.228 ± 0.063	0.758ProPro: 0.758 ± 0.029	1.087ProGln: 1.087 ± 0.031	0.897ProArg: 0.897 ± 0.031	2.131ProSer: 2.131 ± 0.043	2.082ProThr: 2.082 ± 0.055	2.444ProVal: 2.444 ± 0.058	0.269ProTrp: 0.269 ± 0.015	1.296ProTyr: 1.296 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.089GlnAla: 2.089 ± 0.053	0.206GlnCys: 0.206 ± 0.017	1.699GlnAsp: 1.699 ± 0.042	2.451GlnGlu: 2.451 ± 0.051	1.788GlnPhe: 1.788 ± 0.046	1.812GlnGly: 1.812 ± 0.046	0.578GlnHis: 0.578 ± 0.025	2.803GlnIle: 2.803 ± 0.062	3.098GlnLys: 3.098 ± 0.065	3.248GlnLeu: 3.248 ± 0.061	0.853GlnMet: 0.853 ± 0.029	2.411GlnAsn: 2.411 ± 0.058	1.031GlnPro: 1.031 ± 0.032	1.295GlnGln: 1.295 ± 0.039	1.174GlnArg: 1.174 ± 0.038	1.967GlnSer: 1.967 ± 0.047	1.918GlnThr: 1.918 ± 0.055	1.994GlnVal: 1.994 ± 0.048	0.328GlnTrp: 0.328 ± 0.018	1.253GlnTyr: 1.253 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	1.968ArgAla: 1.968 ± 0.049	0.189ArgCys: 0.189 ± 0.014	1.683ArgAsp: 1.683 ± 0.045	2.221ArgGlu: 2.221 ± 0.051	1.859ArgPhe: 1.859 ± 0.047	1.764ArgGly: 1.764 ± 0.056	0.626ArgHis: 0.626 ± 0.027	2.875ArgIle: 2.875 ± 0.06	2.831ArgLys: 2.831 ± 0.063	3.086ArgLeu: 3.086 ± 0.072	0.984ArgMet: 0.984 ± 0.03	2.133ArgAsn: 2.133 ± 0.049	1.042ArgPro: 1.042 ± 0.035	1.086ArgGln: 1.086 ± 0.039	1.253ArgArg: 1.253 ± 0.04	1.845ArgSer: 1.845 ± 0.048	1.786ArgThr: 1.786 ± 0.042	1.985ArgVal: 1.985 ± 0.046	0.38ArgTrp: 0.38 ± 0.018	1.422ArgTyr: 1.422 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.978SerAla: 3.978 ± 0.077	0.672SerCys: 0.672 ± 0.027	3.6SerAsp: 3.6 ± 0.058	4.565SerGlu: 4.565 ± 0.068	3.972SerPhe: 3.972 ± 0.082	4.768SerGly: 4.768 ± 0.095	1.099SerHis: 1.099 ± 0.029	5.18SerIle: 5.18 ± 0.074	5.019SerLys: 5.019 ± 0.095	5.917SerLeu: 5.917 ± 0.087	1.346SerMet: 1.346 ± 0.038	3.892SerAsn: 3.892 ± 0.074	2.178SerPro: 2.178 ± 0.057	2.295SerGln: 2.295 ± 0.05	2.151SerArg: 2.151 ± 0.048	4.368SerSer: 4.368 ± 0.095	3.508SerThr: 3.508 ± 0.084	4.257SerVal: 4.257 ± 0.076	0.642SerTrp: 0.642 ± 0.032	2.666SerTyr: 2.666 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	4.268ThrAla: 4.268 ± 0.1	0.356ThrCys: 0.356 ± 0.02	3.086ThrAsp: 3.086 ± 0.056	3.585ThrGlu: 3.585 ± 0.063	3.162ThrPhe: 3.162 ± 0.072	4.04ThrGly: 4.04 ± 0.096	0.912ThrHis: 0.912 ± 0.026	4.796ThrIle: 4.796 ± 0.082	3.87ThrLys: 3.87 ± 0.071	5.241ThrLeu: 5.241 ± 0.09	0.981ThrMet: 0.981 ± 0.032	3.205ThrAsn: 3.205 ± 0.079	2.486ThrPro: 2.486 ± 0.079	1.858ThrGln: 1.858 ± 0.061	1.543ThrArg: 1.543 ± 0.043	3.755ThrSer: 3.755 ± 0.077	3.578ThrThr: 3.578 ± 0.109	4.047ThrVal: 4.047 ± 0.1	0.591ThrTrp: 0.591 ± 0.031	2.244ThrTyr: 2.244 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	4.506ValAla: 4.506 ± 0.083	0.488ValCys: 0.488 ± 0.027	3.368ValAsp: 3.368 ± 0.057	3.82ValGlu: 3.82 ± 0.069	3.437ValPhe: 3.437 ± 0.063	3.78ValGly: 3.78 ± 0.069	0.953ValHis: 0.953 ± 0.033	4.795ValIle: 4.795 ± 0.083	4.579ValLys: 4.579 ± 0.066	5.844ValLeu: 5.844 ± 0.072	1.318ValMet: 1.318 ± 0.033	3.668ValAsn: 3.668 ± 0.073	2.216ValPro: 2.216 ± 0.051	1.903ValGln: 1.903 ± 0.044	2.014ValArg: 2.014 ± 0.048	4.484ValSer: 4.484 ± 0.082	3.802ValThr: 3.802 ± 0.096	4.091ValVal: 4.091 ± 0.076	0.552ValTrp: 0.552 ± 0.024	2.254ValTyr: 2.254 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.593TrpAla: 0.593 ± 0.029	0.073TrpCys: 0.073 ± 0.008	0.532TrpAsp: 0.532 ± 0.023	0.634TrpGlu: 0.634 ± 0.026	0.546TrpPhe: 0.546 ± 0.027	0.583TrpGly: 0.583 ± 0.028	0.21TrpHis: 0.21 ± 0.017	0.753TrpIle: 0.753 ± 0.028	0.828TrpLys: 0.828 ± 0.031	0.848TrpLeu: 0.848 ± 0.033	0.262TrpMet: 0.262 ± 0.014	0.684TrpAsn: 0.684 ± 0.029	0.2TrpPro: 0.2 ± 0.017	0.37TrpGln: 0.37 ± 0.019	0.349TrpArg: 0.349 ± 0.021	0.566TrpSer: 0.566 ± 0.026	0.569TrpThr: 0.569 ± 0.031	0.557TrpVal: 0.557 ± 0.027	0.116TrpTrp: 0.116 ± 0.01	0.357TrpTyr: 0.357 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.402TyrAla: 2.402 ± 0.048	0.31TyrCys: 0.31 ± 0.018	2.274TyrAsp: 2.274 ± 0.056	2.377TyrGlu: 2.377 ± 0.049	2.636TyrPhe: 2.636 ± 0.068	2.488TyrGly: 2.488 ± 0.058	0.76TyrHis: 0.76 ± 0.029	2.659TyrIle: 2.659 ± 0.054	2.861TyrLys: 2.861 ± 0.053	3.813TyrLeu: 3.813 ± 0.063	0.721TyrMet: 0.721 ± 0.03	2.431TyrAsn: 2.431 ± 0.058	1.365TyrPro: 1.365 ± 0.041	1.52TyrGln: 1.52 ± 0.045	1.56TyrArg: 1.56 ± 0.047	2.737TyrSer: 2.737 ± 0.054	2.195TyrThr: 2.195 ± 0.064	2.181TyrVal: 2.181 ± 0.053	0.4TyrTrp: 0.4 ± 0.023	1.675TyrTyr: 1.675 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3009 proteins (977937 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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