Amino acid dipepetide frequency for Hazenella coriacea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.489AlaAla: 4.489 ± 0.081
0.632AlaCys: 0.632 ± 0.027
3.18AlaAsp: 3.18 ± 0.067
4.409AlaGlu: 4.409 ± 0.085
2.695AlaPhe: 2.695 ± 0.059
4.65AlaGly: 4.65 ± 0.086
1.475AlaHis: 1.475 ± 0.044
5.451AlaIle: 5.451 ± 0.084
4.275AlaLys: 4.275 ± 0.073
6.634AlaLeu: 6.634 ± 0.095
1.833AlaMet: 1.833 ± 0.045
2.382AlaAsn: 2.382 ± 0.053
2.046AlaPro: 2.046 ± 0.058
2.675AlaGln: 2.675 ± 0.064
2.864AlaArg: 2.864 ± 0.065
3.663AlaSer: 3.663 ± 0.072
3.574AlaThr: 3.574 ± 0.069
4.761AlaVal: 4.761 ± 0.083
0.723AlaTrp: 0.723 ± 0.033
2.176AlaTyr: 2.176 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.454CysAla: 0.454 ± 0.023
0.111CysCys: 0.111 ± 0.013
0.45CysAsp: 0.45 ± 0.025
0.535CysGlu: 0.535 ± 0.024
0.375CysPhe: 0.375 ± 0.019
0.735CysGly: 0.735 ± 0.031
0.238CysHis: 0.238 ± 0.02
0.562CysIle: 0.562 ± 0.028
0.386CysLys: 0.386 ± 0.022
0.839CysLeu: 0.839 ± 0.032
0.193CysMet: 0.193 ± 0.015
0.291CysAsn: 0.291 ± 0.019
0.401CysPro: 0.401 ± 0.024
0.399CysGln: 0.399 ± 0.024
0.396CysArg: 0.396 ± 0.022
0.604CysSer: 0.604 ± 0.027
0.469CysThr: 0.469 ± 0.022
0.477CysVal: 0.477 ± 0.024
0.127CysTrp: 0.127 ± 0.013
0.303CysTyr: 0.303 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
2.75AspAla: 2.75 ± 0.057
0.4AspCys: 0.4 ± 0.024
2.183AspAsp: 2.183 ± 0.058
4.196AspGlu: 4.196 ± 0.074
2.186AspPhe: 2.186 ± 0.057
3.215AspGly: 3.215 ± 0.07
1.599AspHis: 1.599 ± 0.048
3.02AspIle: 3.02 ± 0.07
2.058AspLys: 2.058 ± 0.056
5.949AspLeu: 5.949 ± 0.1
1.043AspMet: 1.043 ± 0.037
1.085AspAsn: 1.085 ± 0.04
2.637AspPro: 2.637 ± 0.063
3.348AspGln: 3.348 ± 0.074
2.684AspArg: 2.684 ± 0.059
2.58AspSer: 2.58 ± 0.057
2.005AspThr: 2.005 ± 0.051
3.47AspVal: 3.47 ± 0.067
0.835AspTrp: 0.835 ± 0.033
1.751AspTyr: 1.751 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
5.115GluAla: 5.115 ± 0.086
0.471GluCys: 0.471 ± 0.025
3.377GluAsp: 3.377 ± 0.07
6.696GluGlu: 6.696 ± 0.115
2.241GluPhe: 2.241 ± 0.049
4.162GluGly: 4.162 ± 0.076
1.535GluHis: 1.535 ± 0.042
5.559GluIle: 5.559 ± 0.084
5.818GluLys: 5.818 ± 0.091
7.176GluLeu: 7.176 ± 0.12
2.263GluMet: 2.263 ± 0.054
2.804GluAsn: 2.804 ± 0.064
2.233GluPro: 2.233 ± 0.051
4.323GluGln: 4.323 ± 0.08
3.933GluArg: 3.933 ± 0.096
3.619GluSer: 3.619 ± 0.07
3.454GluThr: 3.454 ± 0.066
5.275GluVal: 5.275 ± 0.084
1.051GluTrp: 1.051 ± 0.04
2.168GluTyr: 2.168 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.821PheAla: 2.821 ± 0.066
0.394PheCys: 0.394 ± 0.02
2.205PheAsp: 2.205 ± 0.053
2.592PheGlu: 2.592 ± 0.054
2.159PhePhe: 2.159 ± 0.068
2.827PheGly: 2.827 ± 0.071
1.08PheHis: 1.08 ± 0.036
3.338PheIle: 3.338 ± 0.072
1.973PheLys: 1.973 ± 0.052
4.288PheLeu: 4.288 ± 0.095
1.136PheMet: 1.136 ± 0.039
1.427PheAsn: 1.427 ± 0.045
1.83PhePro: 1.83 ± 0.045
1.95PheGln: 1.95 ± 0.05
1.847PheArg: 1.847 ± 0.051
3.093PheSer: 3.093 ± 0.068
2.438PheThr: 2.438 ± 0.06
2.878PheVal: 2.878 ± 0.055
0.496PheTrp: 0.496 ± 0.025
1.506PheTyr: 1.506 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.375GlyAla: 4.375 ± 0.091
0.72GlyCys: 0.72 ± 0.031
3.062GlyAsp: 3.062 ± 0.063
4.44GlyGlu: 4.44 ± 0.073
3.133GlyPhe: 3.133 ± 0.077
4.751GlyGly: 4.751 ± 0.103
1.454GlyHis: 1.454 ± 0.045
5.568GlyIle: 5.568 ± 0.1
4.973GlyLys: 4.973 ± 0.083
6.724GlyLeu: 6.724 ± 0.101
2.059GlyMet: 2.059 ± 0.052
2.225GlyAsn: 2.225 ± 0.063
1.849GlyPro: 1.849 ± 0.049
2.628GlyGln: 2.628 ± 0.083
3.052GlyArg: 3.052 ± 0.064
4.015GlySer: 4.015 ± 0.088
3.878GlyThr: 3.878 ± 0.074
5.336GlyVal: 5.336 ± 0.087
1.067GlyTrp: 1.067 ± 0.039
2.495GlyTyr: 2.495 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.405HisAla: 1.405 ± 0.042
0.263HisCys: 0.263 ± 0.02
0.967HisAsp: 0.967 ± 0.035
1.503HisGlu: 1.503 ± 0.043
1.159HisPhe: 1.159 ± 0.044
1.594HisGly: 1.594 ± 0.047
0.852HisHis: 0.852 ± 0.041
1.591HisIle: 1.591 ± 0.046
1.004HisLys: 1.004 ± 0.034
2.843HisLeu: 2.843 ± 0.06
0.601HisMet: 0.601 ± 0.023
0.64HisAsn: 0.64 ± 0.029
1.585HisPro: 1.585 ± 0.044
1.434HisGln: 1.434 ± 0.039
1.333HisArg: 1.333 ± 0.037
1.497HisSer: 1.497 ± 0.045
1.155HisThr: 1.155 ± 0.036
1.646HisVal: 1.646 ± 0.04
0.38HisTrp: 0.38 ± 0.023
0.839HisTyr: 0.839 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.493IleAla: 5.493 ± 0.098
0.746IleCys: 0.746 ± 0.03
4.057IleAsp: 4.057 ± 0.068
5.42IleGlu: 5.42 ± 0.09
2.996IlePhe: 2.996 ± 0.074
5.612IleGly: 5.612 ± 0.107
2.091IleHis: 2.091 ± 0.051
4.854IleIle: 4.854 ± 0.075
3.646IleLys: 3.646 ± 0.066
7.005IleLeu: 7.005 ± 0.126
1.536IleMet: 1.536 ± 0.046
2.557IleAsn: 2.557 ± 0.064
3.62IlePro: 3.62 ± 0.066
4.169IleGln: 4.169 ± 0.081
3.772IleArg: 3.772 ± 0.071
4.898IleSer: 4.898 ± 0.075
3.904IleThr: 3.904 ± 0.064
4.884IleVal: 4.884 ± 0.082
0.817IleTrp: 0.817 ± 0.032
2.443IleTyr: 2.443 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
3.936LysAla: 3.936 ± 0.056
0.34LysCys: 0.34 ± 0.018
3.227LysAsp: 3.227 ± 0.074
6.299LysGlu: 6.299 ± 0.091
1.489LysPhe: 1.489 ± 0.042
4.062LysGly: 4.062 ± 0.072
1.318LysHis: 1.318 ± 0.039
4.052LysIle: 4.052 ± 0.073
5.407LysLys: 5.407 ± 0.102
5.011LysLeu: 5.011 ± 0.084
1.915LysMet: 1.915 ± 0.051
2.671LysAsn: 2.671 ± 0.068
2.306LysPro: 2.306 ± 0.061
3.471LysGln: 3.471 ± 0.07
3.342LysArg: 3.342 ± 0.064
3.256LysSer: 3.256 ± 0.066
2.912LysThr: 2.912 ± 0.062
4.688LysVal: 4.688 ± 0.087
0.886LysTrp: 0.886 ± 0.032
1.878LysTyr: 1.878 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
7.353LeuAla: 7.353 ± 0.101
0.852LeuCys: 0.852 ± 0.032
5.233LeuAsp: 5.233 ± 0.087
6.95LeuGlu: 6.95 ± 0.116
4.857LeuPhe: 4.857 ± 0.099
6.818LeuGly: 6.818 ± 0.11
2.359LeuHis: 2.359 ± 0.051
7.357LeuIle: 7.357 ± 0.098
6.212LeuLys: 6.212 ± 0.093
10.779LeuLeu: 10.779 ± 0.167
2.483LeuMet: 2.483 ± 0.061
3.702LeuAsn: 3.702 ± 0.07
4.388LeuPro: 4.388 ± 0.076
4.65LeuGln: 4.65 ± 0.084
4.295LeuArg: 4.295 ± 0.081
7.225LeuSer: 7.225 ± 0.106
5.58LeuThr: 5.58 ± 0.076
6.728LeuVal: 6.728 ± 0.101
1.091LeuTrp: 1.091 ± 0.043
3.142LeuTyr: 3.142 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.844MetAla: 1.844 ± 0.048
0.155MetCys: 0.155 ± 0.014
1.528MetAsp: 1.528 ± 0.043
2.033MetGlu: 2.033 ± 0.053
0.954MetPhe: 0.954 ± 0.036
2.05MetGly: 2.05 ± 0.056
0.404MetHis: 0.404 ± 0.027
2.496MetIle: 2.496 ± 0.061
2.293MetLys: 2.293 ± 0.052
2.309MetLeu: 2.309 ± 0.055
0.921MetMet: 0.921 ± 0.033
1.406MetAsn: 1.406 ± 0.04
0.895MetPro: 0.895 ± 0.037
0.851MetGln: 0.851 ± 0.031
1.121MetArg: 1.121 ± 0.04
1.734MetSer: 1.734 ± 0.041
1.467MetThr: 1.467 ± 0.044
1.938MetVal: 1.938 ± 0.054
0.221MetTrp: 0.221 ± 0.015
0.704MetTyr: 0.704 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
1.892AsnAla: 1.892 ± 0.054
0.291AsnCys: 0.291 ± 0.02
1.733AsnAsp: 1.733 ± 0.049
2.729AsnGlu: 2.729 ± 0.061
1.256AsnPhe: 1.256 ± 0.038
2.495AsnGly: 2.495 ± 0.055
1.123AsnHis: 1.123 ± 0.042
2.542AsnIle: 2.542 ± 0.062
2.217AsnLys: 2.217 ± 0.055
3.375AsnLeu: 3.375 ± 0.074
0.944AsnMet: 0.944 ± 0.032
1.284AsnAsn: 1.284 ± 0.04
2.076AsnPro: 2.076 ± 0.052
2.489AsnGln: 2.489 ± 0.059
2.129AsnArg: 2.129 ± 0.051
1.908AsnSer: 1.908 ± 0.058
1.569AsnThr: 1.569 ± 0.039
2.187AsnVal: 2.187 ± 0.049
0.521AsnTrp: 0.521 ± 0.025
1.263AsnTyr: 1.263 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.172ProAla: 2.172 ± 0.055
0.263ProCys: 0.263 ± 0.018
2.289ProAsp: 2.289 ± 0.057
3.311ProGlu: 3.311 ± 0.07
2.101ProPhe: 2.101 ± 0.051
2.453ProGly: 2.453 ± 0.062
1.156ProHis: 1.156 ± 0.037
3.104ProIle: 3.104 ± 0.058
2.295ProLys: 2.295 ± 0.061
4.032ProLeu: 4.032 ± 0.073
1.0ProMet: 1.0 ± 0.039
1.645ProAsn: 1.645 ± 0.053
1.408ProPro: 1.408 ± 0.052
1.708ProGln: 1.708 ± 0.05
1.54ProArg: 1.54 ± 0.046
2.764ProSer: 2.764 ± 0.068
2.472ProThr: 2.472 ± 0.058
3.125ProVal: 3.125 ± 0.067
0.48ProTrp: 0.48 ± 0.026
1.449ProTyr: 1.449 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
3.619GlnAla: 3.619 ± 0.082
0.323GlnCys: 0.323 ± 0.02
1.852GlnAsp: 1.852 ± 0.047
3.599GlnGlu: 3.599 ± 0.075
1.798GlnPhe: 1.798 ± 0.042
2.959GlnGly: 2.959 ± 0.083
1.039GlnHis: 1.039 ± 0.035
3.609GlnIle: 3.609 ± 0.07
3.256GlnLys: 3.256 ± 0.063
5.699GlnLeu: 5.699 ± 0.095
1.626GlnMet: 1.626 ± 0.04
1.586GlnAsn: 1.586 ± 0.044
1.937GlnPro: 1.937 ± 0.053
2.865GlnGln: 2.865 ± 0.077
2.325GlnArg: 2.325 ± 0.054
2.78GlnSer: 2.78 ± 0.057
2.576GlnThr: 2.576 ± 0.054
4.009GlnVal: 4.009 ± 0.066
0.656GlnTrp: 0.656 ± 0.03
1.469GlnTyr: 1.469 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.535ArgAla: 2.535 ± 0.059
0.356ArgCys: 0.356 ± 0.025
2.215ArgAsp: 2.215 ± 0.049
3.531ArgGlu: 3.531 ± 0.075
2.272ArgPhe: 2.272 ± 0.056
2.751ArgGly: 2.751 ± 0.064
1.021ArgHis: 1.021 ± 0.033
3.529ArgIle: 3.529 ± 0.067
3.342ArgLys: 3.342 ± 0.068
5.213ArgLeu: 5.213 ± 0.105
1.504ArgMet: 1.504 ± 0.035
1.851ArgAsn: 1.851 ± 0.046
1.662ArgPro: 1.662 ± 0.049
2.129ArgGln: 2.129 ± 0.053
2.363ArgArg: 2.363 ± 0.059
2.795ArgSer: 2.795 ± 0.058
2.308ArgThr: 2.308 ± 0.056
3.457ArgVal: 3.457 ± 0.074
0.667ArgTrp: 0.667 ± 0.031
1.724ArgTyr: 1.724 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.424SerAla: 3.424 ± 0.066
0.475SerCys: 0.475 ± 0.024
2.768SerAsp: 2.768 ± 0.057
3.789SerGlu: 3.789 ± 0.072
3.243SerPhe: 3.243 ± 0.075
4.396SerGly: 4.396 ± 0.078
1.441SerHis: 1.441 ± 0.041
4.646SerIle: 4.646 ± 0.092
3.554SerLys: 3.554 ± 0.075
6.724SerLeu: 6.724 ± 0.111
1.884SerMet: 1.884 ± 0.05
2.162SerAsn: 2.162 ± 0.058
2.567SerPro: 2.567 ± 0.061
2.831SerGln: 2.831 ± 0.058
2.65SerArg: 2.65 ± 0.061
4.479SerSer: 4.479 ± 0.111
3.199SerThr: 3.199 ± 0.066
4.005SerVal: 4.005 ± 0.071
0.828SerTrp: 0.828 ± 0.034
2.201SerTyr: 2.201 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
3.401ThrAla: 3.401 ± 0.061
0.47ThrCys: 0.47 ± 0.024
2.531ThrAsp: 2.531 ± 0.064
3.238ThrGlu: 3.238 ± 0.061
2.315ThrPhe: 2.315 ± 0.056
4.093ThrGly: 4.093 ± 0.067
1.315ThrHis: 1.315 ± 0.043
4.04ThrIle: 4.04 ± 0.082
2.834ThrLys: 2.834 ± 0.058
5.344ThrLeu: 5.344 ± 0.078
1.259ThrMet: 1.259 ± 0.042
1.833ThrAsn: 1.833 ± 0.049
2.665ThrPro: 2.665 ± 0.058
2.187ThrGln: 2.187 ± 0.047
2.02ThrArg: 2.02 ± 0.057
3.314ThrSer: 3.314 ± 0.06
2.896ThrThr: 2.896 ± 0.066
3.801ThrVal: 3.801 ± 0.071
0.634ThrTrp: 0.634 ± 0.03
1.899ThrTyr: 1.899 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
4.931ValAla: 4.931 ± 0.076
0.688ValCys: 0.688 ± 0.027
3.858ValAsp: 3.858 ± 0.068
5.125ValGlu: 5.125 ± 0.087
2.833ValPhe: 2.833 ± 0.064
4.95ValGly: 4.95 ± 0.079
1.615ValHis: 1.615 ± 0.046
5.699ValIle: 5.699 ± 0.102
4.391ValLys: 4.391 ± 0.079
6.71ValLeu: 6.71 ± 0.086
1.807ValMet: 1.807 ± 0.052
2.787ValAsn: 2.787 ± 0.058
2.851ValPro: 2.851 ± 0.063
2.996ValGln: 2.996 ± 0.059
3.237ValArg: 3.237 ± 0.07
4.399ValSer: 4.399 ± 0.069
3.873ValThr: 3.873 ± 0.072
5.292ValVal: 5.292 ± 0.093
0.753ValTrp: 0.753 ± 0.03
2.218ValTyr: 2.218 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.672TrpAla: 0.672 ± 0.028
0.095TrpCys: 0.095 ± 0.012
0.585TrpAsp: 0.585 ± 0.032
0.808TrpGlu: 0.808 ± 0.028
0.643TrpPhe: 0.643 ± 0.029
0.856TrpGly: 0.856 ± 0.035
0.186TrpHis: 0.186 ± 0.017
1.267TrpIle: 1.267 ± 0.04
0.967TrpLys: 0.967 ± 0.034
1.569TrpLeu: 1.569 ± 0.053
0.527TrpMet: 0.527 ± 0.027
0.587TrpAsn: 0.587 ± 0.026
0.291TrpPro: 0.291 ± 0.016
0.45TrpGln: 0.45 ± 0.024
0.501TrpArg: 0.501 ± 0.023
0.774TrpSer: 0.774 ± 0.029
0.606TrpThr: 0.606 ± 0.028
0.951TrpVal: 0.951 ± 0.037
0.185TrpTrp: 0.185 ± 0.014
0.36TrpTyr: 0.36 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.904TyrAla: 1.904 ± 0.05
0.302TyrCys: 0.302 ± 0.02
1.696TyrAsp: 1.696 ± 0.051
2.066TyrGlu: 2.066 ± 0.053
1.578TyrPhe: 1.578 ± 0.047
2.375TyrGly: 2.375 ± 0.049
0.987TyrHis: 0.987 ± 0.037
2.234TyrIle: 2.234 ± 0.053
1.568TyrLys: 1.568 ± 0.045
3.83TyrLeu: 3.83 ± 0.073
0.788TyrMet: 0.788 ± 0.032
1.096TyrAsn: 1.096 ± 0.042
1.521TyrPro: 1.521 ± 0.052
2.03TyrGln: 2.03 ± 0.054
1.825TyrArg: 1.825 ± 0.049
1.87TyrSer: 1.87 ± 0.048
1.755TyrThr: 1.755 ± 0.052
2.105TyrVal: 2.105 ± 0.045
0.459TyrTrp: 0.459 ± 0.024
1.239TyrTyr: 1.239 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2870 proteins (845007 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski