Amino acid dipepetide frequency for Pseudaestuariivita atlantica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.37AlaAla: 17.37 ± 0.196	1.197AlaCys: 1.197 ± 0.036	7.775AlaAsp: 7.775 ± 0.093	8.191AlaGlu: 8.191 ± 0.099	4.531AlaPhe: 4.531 ± 0.065	11.055AlaGly: 11.055 ± 0.129	2.568AlaHis: 2.568 ± 0.052	5.745AlaIle: 5.745 ± 0.069	3.452AlaLys: 3.452 ± 0.059	14.166AlaLeu: 14.166 ± 0.142	3.959AlaMet: 3.959 ± 0.049	2.63AlaAsn: 2.63 ± 0.048	6.131AlaPro: 6.131 ± 0.099	4.388AlaGln: 4.388 ± 0.064	9.915AlaArg: 9.915 ± 0.107	5.632AlaSer: 5.632 ± 0.073	6.505AlaThr: 6.505 ± 0.083	8.599AlaVal: 8.599 ± 0.098	1.711AlaTrp: 1.711 ± 0.042	2.653AlaTyr: 2.653 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.135CysAla: 1.135 ± 0.033	0.106CysCys: 0.106 ± 0.009	0.665CysAsp: 0.665 ± 0.025	0.456CysGlu: 0.456 ± 0.019	0.305CysPhe: 0.305 ± 0.016	0.932CysGly: 0.932 ± 0.036	0.294CysHis: 0.294 ± 0.017	0.399CysIle: 0.399 ± 0.02	0.207CysLys: 0.207 ± 0.013	0.874CysLeu: 0.874 ± 0.031	0.176CysMet: 0.176 ± 0.012	0.219CysAsn: 0.219 ± 0.013	0.522CysPro: 0.522 ± 0.024	0.238CysGln: 0.238 ± 0.014	0.556CysArg: 0.556 ± 0.023	0.417CysSer: 0.417 ± 0.019	0.478CysThr: 0.478 ± 0.021	0.649CysVal: 0.649 ± 0.023	0.127CysTrp: 0.127 ± 0.009	0.215CysTyr: 0.215 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.702AspAla: 8.702 ± 0.109	0.512AspCys: 0.512 ± 0.024	3.921AspAsp: 3.921 ± 0.071	3.646AspGlu: 3.646 ± 0.064	2.363AspPhe: 2.363 ± 0.048	6.412AspGly: 6.412 ± 0.095	1.481AspHis: 1.481 ± 0.036	3.192AspIle: 3.192 ± 0.052	1.588AspLys: 1.588 ± 0.039	6.603AspLeu: 6.603 ± 0.083	1.838AspMet: 1.838 ± 0.04	1.336AspAsn: 1.336 ± 0.038	4.094AspPro: 4.094 ± 0.071	1.789AspGln: 1.789 ± 0.04	4.942AspArg: 4.942 ± 0.073	1.977AspSer: 1.977 ± 0.054	3.729AspThr: 3.729 ± 0.086	4.747AspVal: 4.747 ± 0.07	1.263AspTrp: 1.263 ± 0.036	1.475AspTyr: 1.475 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.595GluAla: 8.595 ± 0.101	0.374GluCys: 0.374 ± 0.018	3.672GluAsp: 3.672 ± 0.063	3.382GluGlu: 3.382 ± 0.067	1.761GluPhe: 1.761 ± 0.037	4.727GluGly: 4.727 ± 0.066	1.044GluHis: 1.044 ± 0.026	3.306GluIle: 3.306 ± 0.049	1.857GluLys: 1.857 ± 0.042	4.62GluLeu: 4.62 ± 0.068	1.805GluMet: 1.805 ± 0.04	1.465GluAsn: 1.465 ± 0.035	2.58GluPro: 2.58 ± 0.056	1.729GluGln: 1.729 ± 0.047	4.162GluArg: 4.162 ± 0.063	1.756GluSer: 1.756 ± 0.037	3.665GluThr: 3.665 ± 0.06	4.5GluVal: 4.5 ± 0.065	0.681GluTrp: 0.681 ± 0.025	1.04GluTyr: 1.04 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.604PheAla: 4.604 ± 0.069	0.407PheCys: 0.407 ± 0.02	3.107PheAsp: 3.107 ± 0.055	2.261PheGlu: 2.261 ± 0.049	1.446PhePhe: 1.446 ± 0.044	3.754PheGly: 3.754 ± 0.052	0.782PheHis: 0.782 ± 0.026	1.613PheIle: 1.613 ± 0.046	0.849PheLys: 0.849 ± 0.028	3.371PheLeu: 3.371 ± 0.059	0.816PheMet: 0.816 ± 0.023	0.997PheAsn: 0.997 ± 0.028	1.526PhePro: 1.526 ± 0.038	1.014PheGln: 1.014 ± 0.029	2.266PheArg: 2.266 ± 0.042	1.841PheSer: 1.841 ± 0.04	2.186PheThr: 2.186 ± 0.043	2.706PheVal: 2.706 ± 0.045	0.595PheTrp: 0.595 ± 0.025	0.916PheTyr: 0.916 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.473GlyAla: 10.473 ± 0.115	0.899GlyCys: 0.899 ± 0.027	5.322GlyAsp: 5.322 ± 0.093	4.69GlyGlu: 4.69 ± 0.075	3.623GlyPhe: 3.623 ± 0.059	7.788GlyGly: 7.788 ± 0.137	1.955GlyHis: 1.955 ± 0.04	4.441GlyIle: 4.441 ± 0.072	2.824GlyLys: 2.824 ± 0.057	9.017GlyLeu: 9.017 ± 0.1	2.607GlyMet: 2.607 ± 0.046	2.153GlyAsn: 2.153 ± 0.068	3.945GlyPro: 3.945 ± 0.055	3.011GlyGln: 3.011 ± 0.055	5.892GlyArg: 5.892 ± 0.086	4.227GlySer: 4.227 ± 0.071	5.249GlyThr: 5.249 ± 0.083	6.544GlyVal: 6.544 ± 0.073	1.599GlyTrp: 1.599 ± 0.038	2.305GlyTyr: 2.305 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.508HisAla: 2.508 ± 0.047	0.229HisCys: 0.229 ± 0.013	1.345HisAsp: 1.345 ± 0.031	0.976HisGlu: 0.976 ± 0.025	0.791HisPhe: 0.791 ± 0.028	2.044HisGly: 2.044 ± 0.044	0.586HisHis: 0.586 ± 0.026	0.862HisIle: 0.862 ± 0.027	0.489HisLys: 0.489 ± 0.02	2.251HisLeu: 2.251 ± 0.049	0.528HisMet: 0.528 ± 0.023	0.43HisAsn: 0.43 ± 0.017	1.454HisPro: 1.454 ± 0.035	0.503HisGln: 0.503 ± 0.018	1.466HisArg: 1.466 ± 0.038	0.85HisSer: 0.85 ± 0.025	0.889HisThr: 0.889 ± 0.025	1.715HisVal: 1.715 ± 0.041	0.385HisTrp: 0.385 ± 0.019	0.519HisTyr: 0.519 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.006IleAla: 7.006 ± 0.081	0.591IleCys: 0.591 ± 0.022	3.701IleAsp: 3.701 ± 0.059	3.347IleGlu: 3.347 ± 0.055	1.596IlePhe: 1.596 ± 0.044	4.611IleGly: 4.611 ± 0.054	0.835IleHis: 0.835 ± 0.024	1.925IleIle: 1.925 ± 0.052	1.186IleLys: 1.186 ± 0.034	4.704IleLeu: 4.704 ± 0.074	0.976IleMet: 0.976 ± 0.031	1.254IleAsn: 1.254 ± 0.034	2.259IlePro: 2.259 ± 0.048	1.09IleGln: 1.09 ± 0.033	3.02IleArg: 3.02 ± 0.052	2.53IleSer: 2.53 ± 0.049	2.868IleThr: 2.868 ± 0.048	3.828IleVal: 3.828 ± 0.069	0.679IleTrp: 0.679 ± 0.026	1.05IleTyr: 1.05 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.63LysAla: 3.63 ± 0.067	0.174LysCys: 0.174 ± 0.012	1.661LysAsp: 1.661 ± 0.039	1.437LysGlu: 1.437 ± 0.033	0.83LysPhe: 0.83 ± 0.026	2.464LysGly: 2.464 ± 0.045	0.552LysHis: 0.552 ± 0.021	1.353LysIle: 1.353 ± 0.034	1.016LysLys: 1.016 ± 0.03	2.604LysLeu: 2.604 ± 0.049	0.756LysMet: 0.756 ± 0.026	0.652LysAsn: 0.652 ± 0.022	1.635LysPro: 1.635 ± 0.038	0.786LysGln: 0.786 ± 0.025	2.1LysArg: 2.1 ± 0.044	1.617LysSer: 1.617 ± 0.039	1.765LysThr: 1.765 ± 0.041	2.198LysVal: 2.198 ± 0.046	0.35LysTrp: 0.35 ± 0.017	0.592LysTyr: 0.592 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.094LeuAla: 13.094 ± 0.125	0.895LeuCys: 0.895 ± 0.029	6.646LeuAsp: 6.646 ± 0.08	4.916LeuGlu: 4.916 ± 0.062	3.567LeuPhe: 3.567 ± 0.061	8.517LeuGly: 8.517 ± 0.093	1.908LeuHis: 1.908 ± 0.04	4.895LeuIle: 4.895 ± 0.067	3.083LeuLys: 3.083 ± 0.058	8.153LeuLeu: 8.153 ± 0.116	2.594LeuMet: 2.594 ± 0.047	2.449LeuAsn: 2.449 ± 0.046	5.4LeuPro: 5.4 ± 0.066	2.631LeuGln: 2.631 ± 0.045	6.794LeuArg: 6.794 ± 0.083	6.095LeuSer: 6.095 ± 0.077	6.138LeuThr: 6.138 ± 0.075	7.117LeuVal: 7.117 ± 0.086	1.378LeuTrp: 1.378 ± 0.036	1.97LeuTyr: 1.97 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.515MetAla: 3.515 ± 0.055	0.216MetCys: 0.216 ± 0.013	1.479MetAsp: 1.479 ± 0.035	1.383MetGlu: 1.383 ± 0.033	0.833MetPhe: 0.833 ± 0.024	2.268MetGly: 2.268 ± 0.041	0.48MetHis: 0.48 ± 0.022	1.475MetIle: 1.475 ± 0.04	0.95MetLys: 0.95 ± 0.026	2.556MetLeu: 2.556 ± 0.045	0.796MetMet: 0.796 ± 0.026	0.75MetAsn: 0.75 ± 0.027	1.532MetPro: 1.532 ± 0.032	1.002MetGln: 1.002 ± 0.029	2.02MetArg: 2.02 ± 0.04	1.68MetSer: 1.68 ± 0.038	2.102MetThr: 2.102 ± 0.041	1.862MetVal: 1.862 ± 0.041	0.271MetTrp: 0.271 ± 0.015	0.359MetTyr: 0.359 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.125AsnAla: 3.125 ± 0.044	0.271AsnCys: 0.271 ± 0.018	1.525AsnAsp: 1.525 ± 0.061	1.077AsnGlu: 1.077 ± 0.034	0.928AsnPhe: 0.928 ± 0.029	2.208AsnGly: 2.208 ± 0.049	0.471AsnHis: 0.471 ± 0.019	1.292AsnIle: 1.292 ± 0.032	0.528AsnLys: 0.528 ± 0.025	2.254AsnLeu: 2.254 ± 0.046	0.628AsnMet: 0.628 ± 0.024	0.583AsnAsn: 0.583 ± 0.027	1.736AsnPro: 1.736 ± 0.031	0.612AsnGln: 0.612 ± 0.023	1.668AsnArg: 1.668 ± 0.043	1.051AsnSer: 1.051 ± 0.032	1.288AsnThr: 1.288 ± 0.036	1.835AsnVal: 1.835 ± 0.044	0.429AsnTrp: 0.429 ± 0.018	0.615AsnTyr: 0.615 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.966ProAla: 5.966 ± 0.085	0.376ProCys: 0.376 ± 0.019	4.515ProAsp: 4.515 ± 0.069	3.82ProGlu: 3.82 ± 0.063	2.033ProPhe: 2.033 ± 0.042	4.816ProGly: 4.816 ± 0.069	1.152ProHis: 1.152 ± 0.032	2.125ProIle: 2.125 ± 0.045	1.48ProLys: 1.48 ± 0.04	4.573ProLeu: 4.573 ± 0.066	1.361ProMet: 1.361 ± 0.032	1.245ProAsn: 1.245 ± 0.035	2.399ProPro: 2.399 ± 0.055	1.528ProGln: 1.528 ± 0.039	3.098ProArg: 3.098 ± 0.056	2.373ProSer: 2.373 ± 0.05	2.459ProThr: 2.459 ± 0.045	4.548ProVal: 4.548 ± 0.065	0.737ProTrp: 0.737 ± 0.026	1.121ProTyr: 1.121 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.928GlnAla: 3.928 ± 0.066	0.186GlnCys: 0.186 ± 0.012	1.622GlnAsp: 1.622 ± 0.036	1.444GlnGlu: 1.444 ± 0.036	1.033GlnPhe: 1.033 ± 0.028	2.519GlnGly: 2.519 ± 0.044	0.537GlnHis: 0.537 ± 0.02	1.718GlnIle: 1.718 ± 0.044	0.981GlnLys: 0.981 ± 0.03	2.579GlnLeu: 2.579 ± 0.045	1.008GlnMet: 1.008 ± 0.032	0.855GlnAsn: 0.855 ± 0.029	1.574GlnPro: 1.574 ± 0.035	0.887GlnGln: 0.887 ± 0.034	1.987GlnArg: 1.987 ± 0.049	1.668GlnSer: 1.668 ± 0.047	1.785GlnThr: 1.785 ± 0.034	2.47GlnVal: 2.47 ± 0.045	0.366GlnTrp: 0.366 ± 0.016	0.543GlnTyr: 0.543 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.076ArgAla: 9.076 ± 0.116	0.491ArgCys: 0.491 ± 0.021	4.924ArgAsp: 4.924 ± 0.072	3.812ArgGlu: 3.812 ± 0.061	2.737ArgPhe: 2.737 ± 0.047	4.824ArgGly: 4.824 ± 0.068	1.651ArgHis: 1.651 ± 0.038	3.886ArgIle: 3.886 ± 0.058	2.083ArgLys: 2.083 ± 0.049	7.436ArgLeu: 7.436 ± 0.089	2.017ArgMet: 2.017 ± 0.042	1.713ArgAsn: 1.713 ± 0.042	3.332ArgPro: 3.332 ± 0.053	2.201ArgGln: 2.201 ± 0.049	5.077ArgArg: 5.077 ± 0.076	3.031ArgSer: 3.031 ± 0.058	3.221ArgThr: 3.221 ± 0.062	5.266ArgVal: 5.266 ± 0.068	1.04ArgTrp: 1.04 ± 0.032	1.582ArgTyr: 1.582 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.51SerAla: 5.51 ± 0.064	0.428SerCys: 0.428 ± 0.021	3.276SerAsp: 3.276 ± 0.051	2.507SerGlu: 2.507 ± 0.047	1.998SerPhe: 1.998 ± 0.04	5.095SerGly: 5.095 ± 0.074	0.993SerHis: 0.993 ± 0.032	2.246SerIle: 2.246 ± 0.045	1.331SerLys: 1.331 ± 0.034	4.583SerLeu: 4.583 ± 0.066	1.314SerMet: 1.314 ± 0.033	1.219SerAsn: 1.219 ± 0.033	2.35SerPro: 2.35 ± 0.042	1.366SerGln: 1.366 ± 0.032	3.155SerArg: 3.155 ± 0.056	2.187SerSer: 2.187 ± 0.043	2.333SerThr: 2.333 ± 0.045	3.706SerVal: 3.706 ± 0.054	0.66SerTrp: 0.66 ± 0.023	1.215SerTyr: 1.215 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.431ThrAla: 6.431 ± 0.085	0.566ThrCys: 0.566 ± 0.025	3.555ThrAsp: 3.555 ± 0.049	2.909ThrGlu: 2.909 ± 0.046	2.237ThrPhe: 2.237 ± 0.042	5.876ThrGly: 5.876 ± 0.075	1.239ThrHis: 1.239 ± 0.035	2.779ThrIle: 2.779 ± 0.06	1.323ThrLys: 1.323 ± 0.031	6.374ThrLeu: 6.374 ± 0.088	1.314ThrMet: 1.314 ± 0.03	1.301ThrAsn: 1.301 ± 0.036	3.48ThrPro: 3.48 ± 0.058	1.567ThrGln: 1.567 ± 0.036	3.902ThrArg: 3.902 ± 0.064	2.603ThrSer: 2.603 ± 0.049	2.93ThrThr: 2.93 ± 0.062	4.403ThrVal: 4.403 ± 0.077	0.779ThrTrp: 0.779 ± 0.027	1.33ThrTyr: 1.33 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.342ValAla: 9.342 ± 0.108	0.68ValCys: 0.68 ± 0.022	4.373ValAsp: 4.373 ± 0.063	4.549ValGlu: 4.549 ± 0.064	2.923ValPhe: 2.923 ± 0.049	5.539ValGly: 5.539 ± 0.077	1.413ValHis: 1.413 ± 0.033	4.183ValIle: 4.183 ± 0.066	2.055ValLys: 2.055 ± 0.041	7.597ValLeu: 7.597 ± 0.087	2.136ValMet: 2.136 ± 0.045	1.904ValAsn: 1.904 ± 0.038	4.017ValPro: 4.017 ± 0.054	2.123ValGln: 2.123 ± 0.041	4.611ValArg: 4.611 ± 0.058	4.052ValSer: 4.052 ± 0.063	5.253ValThr: 5.253 ± 0.077	5.92ValVal: 5.92 ± 0.088	1.062ValTrp: 1.062 ± 0.028	1.484ValTyr: 1.484 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.534TrpAla: 1.534 ± 0.043	0.139TrpCys: 0.139 ± 0.012	0.829TrpAsp: 0.829 ± 0.024	0.706TrpGlu: 0.706 ± 0.021	0.634TrpPhe: 0.634 ± 0.025	1.039TrpGly: 1.039 ± 0.029	0.34TrpHis: 0.34 ± 0.019	0.737TrpIle: 0.737 ± 0.026	0.385TrpLys: 0.385 ± 0.017	1.679TrpLeu: 1.679 ± 0.042	0.449TrpMet: 0.449 ± 0.021	0.414TrpAsn: 0.414 ± 0.02	0.745TrpPro: 0.745 ± 0.025	0.589TrpGln: 0.589 ± 0.02	1.192TrpArg: 1.192 ± 0.032	0.854TrpSer: 0.854 ± 0.028	0.904TrpThr: 0.904 ± 0.03	1.013TrpVal: 1.013 ± 0.031	0.271TrpTrp: 0.271 ± 0.014	0.288TrpTyr: 0.288 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.63TyrAla: 2.63 ± 0.046	0.233TyrCys: 0.233 ± 0.015	1.695TyrAsp: 1.695 ± 0.039	1.213TyrGlu: 1.213 ± 0.033	0.887TyrPhe: 0.887 ± 0.025	2.079TyrGly: 2.079 ± 0.043	0.54TyrHis: 0.54 ± 0.021	0.884TyrIle: 0.884 ± 0.029	0.505TyrLys: 0.505 ± 0.021	2.247TyrLeu: 2.247 ± 0.045	0.451TyrMet: 0.451 ± 0.017	0.553TyrAsn: 0.553 ± 0.021	1.016TyrPro: 1.016 ± 0.028	0.634TyrGln: 0.634 ± 0.025	1.574TyrArg: 1.574 ± 0.037	1.034TyrSer: 1.034 ± 0.028	1.148TyrThr: 1.148 ± 0.034	1.59TyrVal: 1.59 ± 0.034	0.356TyrTrp: 0.356 ± 0.018	0.545TyrTyr: 0.545 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3978 proteins (1234050 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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