Amino acid dipepetide frequency for Altererythrobacter epoxidivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.613AlaAla: 15.613 ± 0.19	1.051AlaCys: 1.051 ± 0.043	7.001AlaAsp: 7.001 ± 0.114	8.331AlaGlu: 8.331 ± 0.122	4.073AlaPhe: 4.073 ± 0.073	10.412AlaGly: 10.412 ± 0.114	2.096AlaHis: 2.096 ± 0.064	6.842AlaIle: 6.842 ± 0.099	4.791AlaLys: 4.791 ± 0.085	12.425AlaLeu: 12.425 ± 0.149	3.945AlaMet: 3.945 ± 0.07	3.236AlaAsn: 3.236 ± 0.071	5.093AlaPro: 5.093 ± 0.09	4.142AlaGln: 4.142 ± 0.078	8.135AlaArg: 8.135 ± 0.117	6.704AlaSer: 6.704 ± 0.114	5.689AlaThr: 5.689 ± 0.089	7.59AlaVal: 7.59 ± 0.116	1.51AlaTrp: 1.51 ± 0.052	2.436AlaTyr: 2.436 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.952CysAla: 0.952 ± 0.035	0.096CysCys: 0.096 ± 0.01	0.627CysAsp: 0.627 ± 0.028	0.581CysGlu: 0.581 ± 0.028	0.309CysPhe: 0.309 ± 0.021	0.884CysGly: 0.884 ± 0.035	0.216CysHis: 0.216 ± 0.017	0.396CysIle: 0.396 ± 0.022	0.218CysLys: 0.218 ± 0.015	0.703CysLeu: 0.703 ± 0.032	0.146CysMet: 0.146 ± 0.014	0.245CysAsn: 0.245 ± 0.018	0.419CysPro: 0.419 ± 0.023	0.209CysGln: 0.209 ± 0.016	0.5CysArg: 0.5 ± 0.027	0.494CysSer: 0.494 ± 0.025	0.422CysThr: 0.422 ± 0.023	0.601CysVal: 0.601 ± 0.028	0.104CysTrp: 0.104 ± 0.011	0.179CysTyr: 0.179 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.276AspAla: 7.276 ± 0.115	0.547AspCys: 0.547 ± 0.025	3.901AspAsp: 3.901 ± 0.086	4.429AspGlu: 4.429 ± 0.082	2.428AspPhe: 2.428 ± 0.058	5.88AspGly: 5.88 ± 0.132	1.362AspHis: 1.362 ± 0.047	3.105AspIle: 3.105 ± 0.068	2.204AspLys: 2.204 ± 0.054	5.911AspLeu: 5.911 ± 0.083	1.668AspMet: 1.668 ± 0.049	1.635AspAsn: 1.635 ± 0.052	3.737AspPro: 3.737 ± 0.07	1.891AspGln: 1.891 ± 0.044	4.677AspArg: 4.677 ± 0.086	2.509AspSer: 2.509 ± 0.063	2.834AspThr: 2.834 ± 0.063	3.925AspVal: 3.925 ± 0.066	1.19AspTrp: 1.19 ± 0.041	1.689AspTyr: 1.689 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	8.259GluAla: 8.259 ± 0.112	0.421GluCys: 0.421 ± 0.025	3.732GluAsp: 3.732 ± 0.07	4.42GluGlu: 4.42 ± 0.085	2.063GluPhe: 2.063 ± 0.057	5.297GluGly: 5.297 ± 0.089	1.306GluHis: 1.306 ± 0.042	3.714GluIle: 3.714 ± 0.069	2.83GluLys: 2.83 ± 0.065	6.025GluLeu: 6.025 ± 0.104	1.915GluMet: 1.915 ± 0.046	1.971GluAsn: 1.971 ± 0.052	2.892GluPro: 2.892 ± 0.064	2.529GluGln: 2.529 ± 0.055	5.242GluArg: 5.242 ± 0.09	2.789GluSer: 2.789 ± 0.058	3.6GluThr: 3.6 ± 0.062	4.301GluVal: 4.301 ± 0.071	0.99GluTrp: 0.99 ± 0.034	1.314GluTyr: 1.314 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.781PheAla: 4.781 ± 0.082	0.353PheCys: 0.353 ± 0.019	2.791PheAsp: 2.791 ± 0.06	2.427PheGlu: 2.427 ± 0.065	1.414PhePhe: 1.414 ± 0.047	3.767PheGly: 3.767 ± 0.072	0.658PheHis: 0.658 ± 0.029	1.722PheIle: 1.722 ± 0.045	1.01PheLys: 1.01 ± 0.034	3.132PheLeu: 3.132 ± 0.07	0.856PheMet: 0.856 ± 0.031	1.041PheAsn: 1.041 ± 0.04	1.574PhePro: 1.574 ± 0.043	0.931PheGln: 0.931 ± 0.03	2.134PheArg: 2.134 ± 0.05	2.142PheSer: 2.142 ± 0.053	1.994PheThr: 1.994 ± 0.055	2.678PheVal: 2.678 ± 0.064	0.575PheTrp: 0.575 ± 0.03	0.952PheTyr: 0.952 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	9.125GlyAla: 9.125 ± 0.116	0.868GlyCys: 0.868 ± 0.035	5.268GlyAsp: 5.268 ± 0.094	5.96GlyGlu: 5.96 ± 0.091	3.672GlyPhe: 3.672 ± 0.077	7.65GlyGly: 7.65 ± 0.128	1.82GlyHis: 1.82 ± 0.051	4.648GlyIle: 4.648 ± 0.093	3.843GlyLys: 3.843 ± 0.07	8.31GlyLeu: 8.31 ± 0.11	2.665GlyMet: 2.665 ± 0.061	2.565GlyAsn: 2.565 ± 0.065	3.433GlyPro: 3.433 ± 0.071	2.945GlyGln: 2.945 ± 0.057	5.549GlyArg: 5.549 ± 0.091	5.159GlySer: 5.159 ± 0.093	4.685GlyThr: 4.685 ± 0.101	5.818GlyVal: 5.818 ± 0.09	1.55GlyTrp: 1.55 ± 0.048	2.315GlyTyr: 2.315 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.216HisAla: 2.216 ± 0.062	0.248HisCys: 0.248 ± 0.016	1.222HisAsp: 1.222 ± 0.037	1.197HisGlu: 1.197 ± 0.043	0.879HisPhe: 0.879 ± 0.029	1.875HisGly: 1.875 ± 0.048	0.512HisHis: 0.512 ± 0.025	0.901HisIle: 0.901 ± 0.035	0.545HisLys: 0.545 ± 0.029	1.738HisLeu: 1.738 ± 0.046	0.469HisMet: 0.469 ± 0.024	0.48HisAsn: 0.48 ± 0.023	1.216HisPro: 1.216 ± 0.04	0.551HisGln: 0.551 ± 0.027	1.362HisArg: 1.362 ± 0.043	1.021HisSer: 1.021 ± 0.031	0.724HisThr: 0.724 ± 0.03	1.332HisVal: 1.332 ± 0.041	0.34HisTrp: 0.34 ± 0.021	0.532HisTyr: 0.532 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.568IleAla: 7.568 ± 0.114	0.481IleCys: 0.481 ± 0.025	3.994IleAsp: 3.994 ± 0.078	4.222IleGlu: 4.222 ± 0.071	1.691IlePhe: 1.691 ± 0.051	5.248IleGly: 5.248 ± 0.072	0.895IleHis: 0.895 ± 0.033	2.291IleIle: 2.291 ± 0.056	1.434IleLys: 1.434 ± 0.042	4.113IleLeu: 4.113 ± 0.066	1.021IleMet: 1.021 ± 0.038	1.366IleAsn: 1.366 ± 0.046	2.454IlePro: 2.454 ± 0.057	1.151IleGln: 1.151 ± 0.038	3.042IleArg: 3.042 ± 0.061	2.897IleSer: 2.897 ± 0.062	2.563IleThr: 2.563 ± 0.058	4.029IleVal: 4.029 ± 0.066	0.631IleTrp: 0.631 ± 0.03	1.092IleTyr: 1.092 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.459LysAla: 4.459 ± 0.096	0.197LysCys: 0.197 ± 0.015	1.968LysAsp: 1.968 ± 0.048	1.75LysGlu: 1.75 ± 0.053	1.041LysPhe: 1.041 ± 0.036	2.965LysGly: 2.965 ± 0.061	0.71LysHis: 0.71 ± 0.031	1.689LysIle: 1.689 ± 0.049	1.543LysLys: 1.543 ± 0.058	3.759LysLeu: 3.759 ± 0.066	0.896LysMet: 0.896 ± 0.035	0.91LysAsn: 0.91 ± 0.035	2.151LysPro: 2.151 ± 0.056	1.187LysGln: 1.187 ± 0.038	2.606LysArg: 2.606 ± 0.049	2.002LysSer: 2.002 ± 0.049	1.828LysThr: 1.828 ± 0.049	2.431LysVal: 2.431 ± 0.055	0.469LysTrp: 0.469 ± 0.024	0.743LysTyr: 0.743 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	13.112LeuAla: 13.112 ± 0.151	0.73LeuCys: 0.73 ± 0.028	6.241LeuAsp: 6.241 ± 0.087	5.669LeuGlu: 5.669 ± 0.086	3.543LeuPhe: 3.543 ± 0.081	8.3LeuGly: 8.3 ± 0.102	1.686LeuHis: 1.686 ± 0.038	4.547LeuIle: 4.547 ± 0.08	3.282LeuLys: 3.282 ± 0.061	8.932LeuLeu: 8.932 ± 0.125	2.327LeuMet: 2.327 ± 0.059	2.254LeuAsn: 2.254 ± 0.054	5.213LeuPro: 5.213 ± 0.07	2.55LeuGln: 2.55 ± 0.062	6.167LeuArg: 6.167 ± 0.098	5.997LeuSer: 5.997 ± 0.098	5.15LeuThr: 5.15 ± 0.083	7.332LeuVal: 7.332 ± 0.1	1.141LeuTrp: 1.141 ± 0.037	1.923LeuTyr: 1.923 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.307MetAla: 3.307 ± 0.076	0.18MetCys: 0.18 ± 0.013	1.325MetAsp: 1.325 ± 0.038	1.434MetGlu: 1.434 ± 0.046	0.75MetPhe: 0.75 ± 0.03	2.18MetGly: 2.18 ± 0.055	0.508MetHis: 0.508 ± 0.025	1.482MetIle: 1.482 ± 0.039	1.119MetLys: 1.119 ± 0.035	2.722MetLeu: 2.722 ± 0.065	0.741MetMet: 0.741 ± 0.031	0.782MetAsn: 0.782 ± 0.026	1.498MetPro: 1.498 ± 0.043	0.888MetGln: 0.888 ± 0.032	1.928MetArg: 1.928 ± 0.046	1.668MetSer: 1.668 ± 0.047	1.776MetThr: 1.776 ± 0.049	1.779MetVal: 1.779 ± 0.045	0.266MetTrp: 0.266 ± 0.02	0.313MetTyr: 0.313 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.256AsnAla: 3.256 ± 0.068	0.295AsnCys: 0.295 ± 0.02	1.538AsnAsp: 1.538 ± 0.054	1.472AsnGlu: 1.472 ± 0.041	1.147AsnPhe: 1.147 ± 0.045	2.487AsnGly: 2.487 ± 0.069	0.527AsnHis: 0.527 ± 0.024	1.344AsnIle: 1.344 ± 0.043	0.718AsnLys: 0.718 ± 0.028	2.647AsnLeu: 2.647 ± 0.062	0.624AsnMet: 0.624 ± 0.028	0.644AsnAsn: 0.644 ± 0.032	1.912AsnPro: 1.912 ± 0.05	0.717AsnGln: 0.717 ± 0.029	1.959AsnArg: 1.959 ± 0.048	1.411AsnSer: 1.411 ± 0.042	1.166AsnThr: 1.166 ± 0.042	1.976AsnVal: 1.976 ± 0.055	0.463AsnTrp: 0.463 ± 0.024	0.77AsnTyr: 0.77 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.694ProAla: 5.694 ± 0.093	0.317ProCys: 0.317 ± 0.02	3.816ProAsp: 3.816 ± 0.076	4.087ProGlu: 4.087 ± 0.08	1.892ProPhe: 1.892 ± 0.052	4.261ProGly: 4.261 ± 0.075	0.941ProHis: 0.941 ± 0.031	2.528ProIle: 2.528 ± 0.059	1.577ProLys: 1.577 ± 0.058	4.373ProLeu: 4.373 ± 0.078	1.195ProMet: 1.195 ± 0.037	1.236ProAsn: 1.236 ± 0.039	2.331ProPro: 2.331 ± 0.072	1.707ProGln: 1.707 ± 0.046	2.673ProArg: 2.673 ± 0.06	2.639ProSer: 2.639 ± 0.052	2.36ProThr: 2.36 ± 0.05	4.117ProVal: 4.117 ± 0.072	0.638ProTrp: 0.638 ± 0.027	1.14ProTyr: 1.14 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.889GlnAla: 3.889 ± 0.065	0.232GlnCys: 0.232 ± 0.017	1.599GlnAsp: 1.599 ± 0.042	1.635GlnGlu: 1.635 ± 0.05	1.217GlnPhe: 1.217 ± 0.038	2.545GlnGly: 2.545 ± 0.054	0.626GlnHis: 0.626 ± 0.025	1.768GlnIle: 1.768 ± 0.051	1.004GlnLys: 1.004 ± 0.032	3.15GlnLeu: 3.15 ± 0.054	0.937GlnMet: 0.937 ± 0.037	0.798GlnAsn: 0.798 ± 0.038	1.565GlnPro: 1.565 ± 0.043	1.251GlnGln: 1.251 ± 0.044	2.368GlnArg: 2.368 ± 0.066	1.884GlnSer: 1.884 ± 0.045	1.561GlnThr: 1.561 ± 0.046	2.381GlnVal: 2.381 ± 0.058	0.446GlnTrp: 0.446 ± 0.025	0.675GlnTyr: 0.675 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.107ArgAla: 7.107 ± 0.108	0.462ArgCys: 0.462 ± 0.022	4.227ArgAsp: 4.227 ± 0.081	4.791ArgGlu: 4.791 ± 0.083	2.906ArgPhe: 2.906 ± 0.066	4.776ArgGly: 4.776 ± 0.075	1.447ArgHis: 1.447 ± 0.048	3.958ArgIle: 3.958 ± 0.077	2.575ArgLys: 2.575 ± 0.058	7.148ArgLeu: 7.148 ± 0.107	1.94ArgMet: 1.94 ± 0.047	1.923ArgAsn: 1.923 ± 0.045	3.103ArgPro: 3.103 ± 0.065	2.392ArgGln: 2.392 ± 0.049	4.703ArgArg: 4.703 ± 0.095	3.66ArgSer: 3.66 ± 0.07	2.992ArgThr: 2.992 ± 0.057	4.361ArgVal: 4.361 ± 0.073	1.043ArgTrp: 1.043 ± 0.031	1.737ArgTyr: 1.737 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.257SerAla: 6.257 ± 0.089	0.471SerCys: 0.471 ± 0.027	3.663SerAsp: 3.663 ± 0.078	3.45SerGlu: 3.45 ± 0.069	2.178SerPhe: 2.178 ± 0.059	5.674SerGly: 5.674 ± 0.103	1.03SerHis: 1.03 ± 0.036	2.845SerIle: 2.845 ± 0.06	1.799SerLys: 1.799 ± 0.048	5.325SerLeu: 5.325 ± 0.083	1.428SerMet: 1.428 ± 0.042	1.552SerAsn: 1.552 ± 0.049	2.672SerPro: 2.672 ± 0.057	1.807SerGln: 1.807 ± 0.049	3.595SerArg: 3.595 ± 0.078	2.994SerSer: 2.994 ± 0.075	2.667SerThr: 2.667 ± 0.062	3.675SerVal: 3.675 ± 0.065	0.786SerTrp: 0.786 ± 0.033	1.361SerTyr: 1.361 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.733ThrAla: 5.733 ± 0.092	0.436ThrCys: 0.436 ± 0.026	3.013ThrAsp: 3.013 ± 0.08	2.719ThrGlu: 2.719 ± 0.053	1.805ThrPhe: 1.805 ± 0.048	5.075ThrGly: 5.075 ± 0.085	0.903ThrHis: 0.903 ± 0.034	2.904ThrIle: 2.904 ± 0.069	1.499ThrLys: 1.499 ± 0.044	5.17ThrLeu: 5.17 ± 0.086	1.238ThrMet: 1.238 ± 0.041	1.344ThrAsn: 1.344 ± 0.043	2.946ThrPro: 2.946 ± 0.062	1.434ThrGln: 1.434 ± 0.042	3.152ThrArg: 3.152 ± 0.055	2.892ThrSer: 2.892 ± 0.059	2.439ThrThr: 2.439 ± 0.063	3.979ThrVal: 3.979 ± 0.077	0.574ThrTrp: 0.574 ± 0.025	1.257ThrTyr: 1.257 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	8.702ValAla: 8.702 ± 0.109	0.541ValCys: 0.541 ± 0.027	4.417ValAsp: 4.417 ± 0.08	4.971ValGlu: 4.971 ± 0.072	2.342ValPhe: 2.342 ± 0.051	5.474ValGly: 5.474 ± 0.092	1.257ValHis: 1.257 ± 0.039	3.827ValIle: 3.827 ± 0.081	2.219ValLys: 2.219 ± 0.059	6.592ValLeu: 6.592 ± 0.1	1.824ValMet: 1.824 ± 0.045	1.94ValAsn: 1.94 ± 0.05	3.612ValPro: 3.612 ± 0.068	1.913ValGln: 1.913 ± 0.05	4.438ValArg: 4.438 ± 0.08	4.144ValSer: 4.144 ± 0.074	4.278ValThr: 4.278 ± 0.075	5.162ValVal: 5.162 ± 0.082	0.903ValTrp: 0.903 ± 0.035	1.262ValTyr: 1.262 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.331TrpAla: 1.331 ± 0.04	0.111TrpCys: 0.111 ± 0.011	0.782TrpAsp: 0.782 ± 0.031	0.706TrpGlu: 0.706 ± 0.029	0.634TrpPhe: 0.634 ± 0.029	0.991TrpGly: 0.991 ± 0.04	0.361TrpHis: 0.361 ± 0.023	0.725TrpIle: 0.725 ± 0.032	0.487TrpLys: 0.487 ± 0.024	1.755TrpLeu: 1.755 ± 0.051	0.377TrpMet: 0.377 ± 0.021	0.519TrpAsn: 0.519 ± 0.025	0.648TrpPro: 0.648 ± 0.031	0.652TrpGln: 0.652 ± 0.032	1.202TrpArg: 1.202 ± 0.044	0.86TrpSer: 0.86 ± 0.039	0.731TrpThr: 0.731 ± 0.027	0.827TrpVal: 0.827 ± 0.031	0.276TrpTrp: 0.276 ± 0.018	0.282TrpTyr: 0.282 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.476TyrAla: 2.476 ± 0.057	0.265TyrCys: 0.265 ± 0.019	1.674TyrAsp: 1.674 ± 0.05	1.36TyrGlu: 1.36 ± 0.042	0.951TyrPhe: 0.951 ± 0.032	2.105TyrGly: 2.105 ± 0.053	0.5TyrHis: 0.5 ± 0.026	0.949TyrIle: 0.949 ± 0.033	0.607TyrLys: 0.607 ± 0.03	2.168TyrLeu: 2.168 ± 0.053	0.431TyrMet: 0.431 ± 0.023	0.631TyrAsn: 0.631 ± 0.027	1.053TyrPro: 1.053 ± 0.031	0.685TyrGln: 0.685 ± 0.033	1.816TyrArg: 1.816 ± 0.05	1.361TyrSer: 1.361 ± 0.049	1.053TyrThr: 1.053 ± 0.044	1.523TyrVal: 1.523 ± 0.042	0.363TyrTrp: 0.363 ± 0.022	0.645TyrTyr: 0.645 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2773 proteins (853711 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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