Amino acid dipepetide frequency for Streptococcus phage Javan247

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.749AlaAla: 4.749 ± 1.621
0.186AlaCys: 0.186 ± 0.126
4.283AlaAsp: 4.283 ± 0.679
5.121AlaGlu: 5.121 ± 0.797
3.445AlaPhe: 3.445 ± 1.19
4.749AlaGly: 4.749 ± 1.146
0.466AlaHis: 0.466 ± 0.2
5.4AlaIle: 5.4 ± 0.65
5.959AlaLys: 5.959 ± 0.69
6.89AlaLeu: 6.89 ± 0.906
2.886AlaMet: 2.886 ± 0.809
2.793AlaAsn: 2.793 ± 0.499
3.631AlaPro: 3.631 ± 0.721
2.7AlaGln: 2.7 ± 0.646
2.7AlaArg: 2.7 ± 0.67
5.68AlaSer: 5.68 ± 1.687
3.631AlaThr: 3.631 ± 0.612
5.493AlaVal: 5.493 ± 1.605
1.024AlaTrp: 1.024 ± 0.263
2.7AlaTyr: 2.7 ± 0.459
0.0AlaXaa: 0.0 ± 0.0
Cys
0.279CysAla: 0.279 ± 0.149
0.0CysCys: 0.0 ± 0.0
0.279CysAsp: 0.279 ± 0.149
0.372CysGlu: 0.372 ± 0.226
0.0CysPhe: 0.0 ± 0.0
0.745CysGly: 0.745 ± 0.361
0.0CysHis: 0.0 ± 0.0
0.186CysIle: 0.186 ± 0.14
0.186CysLys: 0.186 ± 0.146
0.186CysLeu: 0.186 ± 0.132
0.093CysMet: 0.093 ± 0.095
0.093CysAsn: 0.093 ± 0.084
0.372CysPro: 0.372 ± 0.174
0.093CysGln: 0.093 ± 0.083
0.0CysArg: 0.0 ± 0.0
0.279CysSer: 0.279 ± 0.162
0.466CysThr: 0.466 ± 0.213
0.093CysVal: 0.093 ± 0.099
0.186CysTrp: 0.186 ± 0.161
0.279CysTyr: 0.279 ± 0.128
0.0CysXaa: 0.0 ± 0.0
Asp
3.166AspAla: 3.166 ± 0.7
0.186AspCys: 0.186 ± 0.136
4.749AspAsp: 4.749 ± 1.065
5.4AspGlu: 5.4 ± 0.965
2.607AspPhe: 2.607 ± 0.45
4.842AspGly: 4.842 ± 0.581
1.117AspHis: 1.117 ± 0.331
4.19AspIle: 4.19 ± 0.763
5.307AspLys: 5.307 ± 0.852
5.493AspLeu: 5.493 ± 1.013
1.955AspMet: 1.955 ± 0.386
3.724AspAsn: 3.724 ± 0.543
1.769AspPro: 1.769 ± 0.587
1.49AspGln: 1.49 ± 0.311
2.98AspArg: 2.98 ± 0.567
3.166AspSer: 3.166 ± 0.551
4.19AspThr: 4.19 ± 0.767
4.19AspVal: 4.19 ± 0.723
0.279AspTrp: 0.279 ± 0.173
3.445AspTyr: 3.445 ± 0.707
0.0AspXaa: 0.0 ± 0.0
Glu
4.562GluAla: 4.562 ± 0.726
0.279GluCys: 0.279 ± 0.174
3.818GluAsp: 3.818 ± 0.787
4.283GluGlu: 4.283 ± 0.793
2.886GluPhe: 2.886 ± 0.631
3.911GluGly: 3.911 ± 0.532
0.931GluHis: 0.931 ± 0.287
4.469GluIle: 4.469 ± 0.752
5.773GluLys: 5.773 ± 0.998
8.38GluLeu: 8.38 ± 1.047
2.048GluMet: 2.048 ± 0.387
4.19GluAsn: 4.19 ± 0.715
1.583GluPro: 1.583 ± 0.492
3.352GluGln: 3.352 ± 0.697
3.724GluArg: 3.724 ± 0.662
3.166GluSer: 3.166 ± 0.516
3.073GluThr: 3.073 ± 0.543
5.028GluVal: 5.028 ± 0.979
1.117GluTrp: 1.117 ± 0.27
2.514GluTyr: 2.514 ± 0.697
0.0GluXaa: 0.0 ± 0.0
Phe
2.514PheAla: 2.514 ± 0.612
0.279PheCys: 0.279 ± 0.168
3.352PheAsp: 3.352 ± 0.593
3.259PheGlu: 3.259 ± 0.858
1.024PhePhe: 1.024 ± 0.333
3.724PheGly: 3.724 ± 0.865
0.186PheHis: 0.186 ± 0.124
2.607PheIle: 2.607 ± 0.615
4.097PheLys: 4.097 ± 0.645
3.073PheLeu: 3.073 ± 0.478
0.931PheMet: 0.931 ± 0.278
2.328PheAsn: 2.328 ± 0.392
0.652PhePro: 0.652 ± 0.328
1.304PheGln: 1.304 ± 0.337
1.024PheArg: 1.024 ± 0.346
2.235PheSer: 2.235 ± 0.318
3.259PheThr: 3.259 ± 0.376
2.235PheVal: 2.235 ± 0.447
0.279PheTrp: 0.279 ± 0.153
1.21PheTyr: 1.21 ± 0.494
0.0PheXaa: 0.0 ± 0.0
Gly
5.587GlyAla: 5.587 ± 1.205
0.093GlyCys: 0.093 ± 0.083
3.538GlyAsp: 3.538 ± 0.621
4.655GlyGlu: 4.655 ± 0.795
2.793GlyPhe: 2.793 ± 0.36
4.842GlyGly: 4.842 ± 0.669
0.838GlyHis: 0.838 ± 0.237
5.307GlyIle: 5.307 ± 1.433
4.469GlyLys: 4.469 ± 0.583
4.935GlyLeu: 4.935 ± 1.047
2.607GlyMet: 2.607 ± 0.587
4.562GlyAsn: 4.562 ± 0.65
0.559GlyPro: 0.559 ± 0.227
3.166GlyGln: 3.166 ± 0.653
3.724GlyArg: 3.724 ± 0.491
4.283GlySer: 4.283 ± 0.908
3.724GlyThr: 3.724 ± 0.686
5.4GlyVal: 5.4 ± 0.687
0.745GlyTrp: 0.745 ± 0.278
2.421GlyTyr: 2.421 ± 0.674
0.0GlyXaa: 0.0 ± 0.0
His
0.931HisAla: 0.931 ± 0.234
0.0HisCys: 0.0 ± 0.0
0.838HisAsp: 0.838 ± 0.26
1.676HisGlu: 1.676 ± 0.34
0.466HisPhe: 0.466 ± 0.307
0.559HisGly: 0.559 ± 0.346
0.466HisHis: 0.466 ± 0.273
0.652HisIle: 0.652 ± 0.307
1.21HisLys: 1.21 ± 0.354
0.931HisLeu: 0.931 ± 0.295
0.279HisMet: 0.279 ± 0.177
0.745HisAsn: 0.745 ± 0.302
0.466HisPro: 0.466 ± 0.177
0.652HisGln: 0.652 ± 0.236
0.466HisArg: 0.466 ± 0.222
0.745HisSer: 0.745 ± 0.343
0.559HisThr: 0.559 ± 0.186
1.024HisVal: 1.024 ± 0.32
0.279HisTrp: 0.279 ± 0.148
0.279HisTyr: 0.279 ± 0.181
0.0HisXaa: 0.0 ± 0.0
Ile
4.469IleAla: 4.469 ± 0.816
0.186IleCys: 0.186 ± 0.148
6.052IleAsp: 6.052 ± 0.684
5.307IleGlu: 5.307 ± 0.957
1.955IlePhe: 1.955 ± 0.554
4.469IleGly: 4.469 ± 0.875
1.21IleHis: 1.21 ± 0.339
3.631IleIle: 3.631 ± 0.778
5.68IleLys: 5.68 ± 0.591
4.004IleLeu: 4.004 ± 0.581
1.397IleMet: 1.397 ± 0.334
4.469IleAsn: 4.469 ± 0.674
2.048IlePro: 2.048 ± 0.44
2.607IleGln: 2.607 ± 0.619
3.911IleArg: 3.911 ± 0.586
4.562IleSer: 4.562 ± 0.62
3.538IleThr: 3.538 ± 0.639
4.004IleVal: 4.004 ± 0.674
0.279IleTrp: 0.279 ± 0.157
2.235IleTyr: 2.235 ± 0.429
0.0IleXaa: 0.0 ± 0.0
Lys
6.704LysAla: 6.704 ± 0.797
0.279LysCys: 0.279 ± 0.157
5.121LysAsp: 5.121 ± 0.876
5.307LysGlu: 5.307 ± 0.941
2.514LysPhe: 2.514 ± 0.4
4.469LysGly: 4.469 ± 0.816
1.117LysHis: 1.117 ± 0.418
5.4LysIle: 5.4 ± 0.584
5.959LysLys: 5.959 ± 1.07
7.263LysLeu: 7.263 ± 0.879
2.607LysMet: 2.607 ± 0.464
3.445LysAsn: 3.445 ± 0.508
2.793LysPro: 2.793 ± 0.643
4.842LysGln: 4.842 ± 0.97
4.004LysArg: 4.004 ± 0.749
5.587LysSer: 5.587 ± 0.641
4.19LysThr: 4.19 ± 0.724
6.331LysVal: 6.331 ± 0.809
0.745LysTrp: 0.745 ± 0.219
2.886LysTyr: 2.886 ± 0.539
0.0LysXaa: 0.0 ± 0.0
Leu
5.959LeuAla: 5.959 ± 0.744
0.652LeuCys: 0.652 ± 0.227
6.238LeuAsp: 6.238 ± 0.797
5.307LeuGlu: 5.307 ± 0.75
2.7LeuPhe: 2.7 ± 0.601
5.866LeuGly: 5.866 ± 1.019
1.117LeuHis: 1.117 ± 0.336
4.469LeuIle: 4.469 ± 0.791
7.263LeuLys: 7.263 ± 0.976
3.538LeuLeu: 3.538 ± 0.662
1.304LeuMet: 1.304 ± 0.316
5.121LeuAsn: 5.121 ± 0.868
2.7LeuPro: 2.7 ± 0.471
3.911LeuGln: 3.911 ± 0.555
2.793LeuArg: 2.793 ± 0.649
6.89LeuSer: 6.89 ± 0.672
5.307LeuThr: 5.307 ± 0.626
5.121LeuVal: 5.121 ± 0.772
0.838LeuTrp: 0.838 ± 0.385
2.421LeuTyr: 2.421 ± 0.545
0.0LeuXaa: 0.0 ± 0.0
Met
3.259MetAla: 3.259 ± 0.864
0.186MetCys: 0.186 ± 0.124
1.49MetAsp: 1.49 ± 0.35
1.304MetGlu: 1.304 ± 0.384
0.745MetPhe: 0.745 ± 0.386
1.769MetGly: 1.769 ± 0.323
0.372MetHis: 0.372 ± 0.203
1.955MetIle: 1.955 ± 0.389
2.421MetLys: 2.421 ± 0.523
1.583MetLeu: 1.583 ± 0.352
0.838MetMet: 0.838 ± 0.404
1.21MetAsn: 1.21 ± 0.316
1.49MetPro: 1.49 ± 0.404
1.397MetGln: 1.397 ± 0.475
0.652MetArg: 0.652 ± 0.265
2.328MetSer: 2.328 ± 0.71
2.421MetThr: 2.421 ± 0.397
1.862MetVal: 1.862 ± 0.464
0.093MetTrp: 0.093 ± 0.091
0.745MetTyr: 0.745 ± 0.254
0.0MetXaa: 0.0 ± 0.0
Asn
4.376AsnAla: 4.376 ± 0.873
0.186AsnCys: 0.186 ± 0.137
3.911AsnAsp: 3.911 ± 0.685
4.097AsnGlu: 4.097 ± 0.651
2.142AsnPhe: 2.142 ± 0.475
4.19AsnGly: 4.19 ± 0.402
1.024AsnHis: 1.024 ± 0.334
2.793AsnIle: 2.793 ± 0.6
4.935AsnLys: 4.935 ± 0.797
4.935AsnLeu: 4.935 ± 0.674
1.304AsnMet: 1.304 ± 0.363
3.259AsnAsn: 3.259 ± 0.781
2.421AsnPro: 2.421 ± 0.4
2.7AsnGln: 2.7 ± 0.558
1.49AsnArg: 1.49 ± 0.394
4.097AsnSer: 4.097 ± 0.684
2.328AsnThr: 2.328 ± 0.329
3.724AsnVal: 3.724 ± 0.672
0.372AsnTrp: 0.372 ± 0.176
1.862AsnTyr: 1.862 ± 0.477
0.0AsnXaa: 0.0 ± 0.0
Pro
2.142ProAla: 2.142 ± 0.402
0.093ProCys: 0.093 ± 0.11
1.955ProAsp: 1.955 ± 0.469
2.514ProGlu: 2.514 ± 0.47
1.769ProPhe: 1.769 ± 0.551
1.583ProGly: 1.583 ± 0.351
0.372ProHis: 0.372 ± 0.165
2.514ProIle: 2.514 ± 0.487
3.166ProLys: 3.166 ± 0.571
2.421ProLeu: 2.421 ± 0.551
0.931ProMet: 0.931 ± 0.302
1.117ProAsn: 1.117 ± 0.323
1.21ProPro: 1.21 ± 0.315
1.397ProGln: 1.397 ± 0.359
0.931ProArg: 0.931 ± 0.345
1.862ProSer: 1.862 ± 0.289
1.769ProThr: 1.769 ± 0.451
2.607ProVal: 2.607 ± 0.571
0.279ProTrp: 0.279 ± 0.155
1.397ProTyr: 1.397 ± 0.333
0.0ProXaa: 0.0 ± 0.0
Gln
4.376GlnAla: 4.376 ± 1.3
0.186GlnCys: 0.186 ± 0.154
1.769GlnAsp: 1.769 ± 0.358
2.886GlnGlu: 2.886 ± 0.789
1.304GlnPhe: 1.304 ± 0.409
2.98GlnGly: 2.98 ± 0.7
0.652GlnHis: 0.652 ± 0.221
3.818GlnIle: 3.818 ± 0.555
3.445GlnLys: 3.445 ± 0.528
3.818GlnLeu: 3.818 ± 0.634
1.21GlnMet: 1.21 ± 0.429
3.352GlnAsn: 3.352 ± 0.75
0.838GlnPro: 0.838 ± 0.269
2.048GlnGln: 2.048 ± 0.433
1.955GlnArg: 1.955 ± 0.423
2.235GlnSer: 2.235 ± 0.448
1.397GlnThr: 1.397 ± 0.329
3.631GlnVal: 3.631 ± 0.657
0.372GlnTrp: 0.372 ± 0.188
1.676GlnTyr: 1.676 ± 0.439
0.0GlnXaa: 0.0 ± 0.0
Arg
2.607ArgAla: 2.607 ± 0.439
0.0ArgCys: 0.0 ± 0.0
1.955ArgAsp: 1.955 ± 0.416
2.421ArgGlu: 2.421 ± 0.434
1.862ArgPhe: 1.862 ± 0.372
2.328ArgGly: 2.328 ± 0.504
0.559ArgHis: 0.559 ± 0.206
2.607ArgIle: 2.607 ± 0.517
3.352ArgLys: 3.352 ± 0.707
3.631ArgLeu: 3.631 ± 0.61
0.745ArgMet: 0.745 ± 0.231
2.607ArgAsn: 2.607 ± 0.465
1.304ArgPro: 1.304 ± 0.294
2.142ArgGln: 2.142 ± 0.565
1.304ArgArg: 1.304 ± 0.391
3.445ArgSer: 3.445 ± 0.614
1.21ArgThr: 1.21 ± 0.351
2.607ArgVal: 2.607 ± 0.446
0.745ArgTrp: 0.745 ± 0.405
2.048ArgTyr: 2.048 ± 0.406
0.0ArgXaa: 0.0 ± 0.0
Ser
6.052SerAla: 6.052 ± 1.536
0.279SerCys: 0.279 ± 0.175
3.631SerAsp: 3.631 ± 0.538
3.724SerGlu: 3.724 ± 0.798
2.793SerPhe: 2.793 ± 0.561
4.469SerGly: 4.469 ± 1.015
0.466SerHis: 0.466 ± 0.234
4.097SerIle: 4.097 ± 0.737
4.655SerLys: 4.655 ± 0.654
6.145SerLeu: 6.145 ± 0.824
2.235SerMet: 2.235 ± 0.476
3.538SerAsn: 3.538 ± 0.588
1.955SerPro: 1.955 ± 0.395
3.166SerGln: 3.166 ± 0.482
2.514SerArg: 2.514 ± 0.546
5.493SerSer: 5.493 ± 1.447
3.259SerThr: 3.259 ± 0.603
5.028SerVal: 5.028 ± 1.359
0.745SerTrp: 0.745 ± 0.308
2.421SerTyr: 2.421 ± 0.661
0.0SerXaa: 0.0 ± 0.0
Thr
5.214ThrAla: 5.214 ± 0.551
0.0ThrCys: 0.0 ± 0.0
3.166ThrAsp: 3.166 ± 0.687
3.538ThrGlu: 3.538 ± 0.519
3.073ThrPhe: 3.073 ± 0.339
4.283ThrGly: 4.283 ± 0.596
0.745ThrHis: 0.745 ± 0.241
4.842ThrIle: 4.842 ± 0.917
3.073ThrLys: 3.073 ± 0.507
4.376ThrLeu: 4.376 ± 0.61
1.304ThrMet: 1.304 ± 0.273
2.7ThrAsn: 2.7 ± 0.527
2.048ThrPro: 2.048 ± 0.374
2.886ThrGln: 2.886 ± 0.603
1.117ThrArg: 1.117 ± 0.435
3.166ThrSer: 3.166 ± 0.609
3.445ThrThr: 3.445 ± 0.518
4.655ThrVal: 4.655 ± 0.574
0.559ThrTrp: 0.559 ± 0.212
2.235ThrTyr: 2.235 ± 0.534
0.0ThrXaa: 0.0 ± 0.0
Val
5.307ValAla: 5.307 ± 0.878
0.279ValCys: 0.279 ± 0.196
4.749ValAsp: 4.749 ± 0.656
4.655ValGlu: 4.655 ± 0.747
2.607ValPhe: 2.607 ± 0.455
5.587ValGly: 5.587 ± 0.985
0.745ValHis: 0.745 ± 0.325
3.911ValIle: 3.911 ± 0.736
5.959ValLys: 5.959 ± 0.721
4.469ValLeu: 4.469 ± 0.876
2.142ValMet: 2.142 ± 0.366
4.004ValAsn: 4.004 ± 0.628
2.142ValPro: 2.142 ± 0.467
2.421ValGln: 2.421 ± 0.728
2.235ValArg: 2.235 ± 0.422
5.68ValSer: 5.68 ± 0.69
5.866ValThr: 5.866 ± 0.798
4.655ValVal: 4.655 ± 0.609
0.745ValTrp: 0.745 ± 0.173
2.142ValTyr: 2.142 ± 0.494
0.0ValXaa: 0.0 ± 0.0
Trp
0.652TrpAla: 0.652 ± 0.23
0.0TrpCys: 0.0 ± 0.0
0.652TrpAsp: 0.652 ± 0.345
0.559TrpGlu: 0.559 ± 0.187
0.559TrpPhe: 0.559 ± 0.247
0.652TrpGly: 0.652 ± 0.206
0.186TrpHis: 0.186 ± 0.136
0.559TrpIle: 0.559 ± 0.244
1.304TrpLys: 1.304 ± 0.347
0.838TrpLeu: 0.838 ± 0.233
0.279TrpMet: 0.279 ± 0.133
0.652TrpAsn: 0.652 ± 0.29
0.279TrpPro: 0.279 ± 0.167
0.466TrpGln: 0.466 ± 0.178
0.559TrpArg: 0.559 ± 0.211
0.466TrpSer: 0.466 ± 0.193
0.838TrpThr: 0.838 ± 0.31
0.372TrpVal: 0.372 ± 0.175
0.093TrpTrp: 0.093 ± 0.094
0.186TrpTyr: 0.186 ± 0.158
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.583TyrAla: 1.583 ± 0.377
0.838TyrCys: 0.838 ± 0.397
2.7TyrAsp: 2.7 ± 0.558
2.7TyrGlu: 2.7 ± 0.482
2.328TyrPhe: 2.328 ± 0.647
2.235TyrGly: 2.235 ± 0.507
0.652TyrHis: 0.652 ± 0.211
2.607TyrIle: 2.607 ± 0.514
3.352TyrLys: 3.352 ± 0.593
2.607TyrLeu: 2.607 ± 0.639
0.931TyrMet: 0.931 ± 0.353
2.328TyrAsn: 2.328 ± 0.621
1.769TyrPro: 1.769 ± 0.449
1.21TyrGln: 1.21 ± 0.432
1.397TyrArg: 1.397 ± 0.484
1.304TyrSer: 1.304 ± 0.313
1.955TyrThr: 1.955 ± 0.437
2.235TyrVal: 2.235 ± 0.392
0.372TyrTrp: 0.372 ± 0.183
1.49TyrTyr: 1.49 ± 0.467
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (10741 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski