Amino acid dipepetide frequency for Granulicatella elegans ATCC 700633

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.067AlaAla: 5.067 ± 0.166
0.495AlaCys: 0.495 ± 0.029
3.097AlaAsp: 3.097 ± 0.102
4.397AlaGlu: 4.397 ± 0.122
2.929AlaPhe: 2.929 ± 0.092
4.437AlaGly: 4.437 ± 0.107
1.122AlaHis: 1.122 ± 0.052
5.994AlaIle: 5.994 ± 0.152
5.598AlaLys: 5.598 ± 0.258
6.816AlaLeu: 6.816 ± 0.165
1.766AlaMet: 1.766 ± 0.076
2.96AlaAsn: 2.96 ± 0.096
1.956AlaPro: 1.956 ± 0.077
2.554AlaGln: 2.554 ± 0.078
2.437AlaArg: 2.437 ± 0.082
4.11AlaSer: 4.11 ± 0.098
4.579AlaThr: 4.579 ± 0.155
4.805AlaVal: 4.805 ± 0.108
0.466AlaTrp: 0.466 ± 0.03
2.368AlaTyr: 2.368 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
0.384CysAla: 0.384 ± 0.031
0.121CysCys: 0.121 ± 0.017
0.343CysAsp: 0.343 ± 0.027
0.394CysGlu: 0.394 ± 0.032
0.317CysPhe: 0.317 ± 0.025
0.598CysGly: 0.598 ± 0.038
0.196CysHis: 0.196 ± 0.021
0.539CysIle: 0.539 ± 0.035
0.309CysLys: 0.309 ± 0.022
0.585CysLeu: 0.585 ± 0.036
0.162CysMet: 0.162 ± 0.017
0.228CysAsn: 0.228 ± 0.02
0.297CysPro: 0.297 ± 0.026
0.307CysGln: 0.307 ± 0.024
0.262CysArg: 0.262 ± 0.024
0.44CysSer: 0.44 ± 0.032
0.285CysThr: 0.285 ± 0.026
0.43CysVal: 0.43 ± 0.033
0.042CysTrp: 0.042 ± 0.009
0.283CysTyr: 0.283 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.731AspAla: 3.731 ± 0.148
0.359AspCys: 0.359 ± 0.028
2.31AspAsp: 2.31 ± 0.069
4.518AspGlu: 4.518 ± 0.102
2.584AspPhe: 2.584 ± 0.075
3.808AspGly: 3.808 ± 0.184
0.971AspHis: 0.971 ± 0.073
3.955AspIle: 3.955 ± 0.099
3.6AspLys: 3.6 ± 0.129
4.431AspLeu: 4.431 ± 0.104
1.169AspMet: 1.169 ± 0.055
1.896AspAsn: 1.896 ± 0.087
1.688AspPro: 1.688 ± 0.113
1.458AspGln: 1.458 ± 0.052
1.643AspArg: 1.643 ± 0.062
2.879AspSer: 2.879 ± 0.071
2.786AspThr: 2.786 ± 0.102
3.606AspVal: 3.606 ± 0.088
0.579AspTrp: 0.579 ± 0.039
2.344AspTyr: 2.344 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
5.459GluAla: 5.459 ± 0.134
0.404GluCys: 0.404 ± 0.032
3.927GluAsp: 3.927 ± 0.1
7.892GluGlu: 7.892 ± 0.176
3.105GluPhe: 3.105 ± 0.081
4.419GluGly: 4.419 ± 0.127
1.441GluHis: 1.441 ± 0.086
5.946GluIle: 5.946 ± 0.126
7.256GluLys: 7.256 ± 0.153
7.29GluLeu: 7.29 ± 0.154
2.221GluMet: 2.221 ± 0.079
4.011GluAsn: 4.011 ± 0.097
1.773GluPro: 1.773 ± 0.07
3.525GluGln: 3.525 ± 0.091
2.998GluArg: 2.998 ± 0.077
3.701GluSer: 3.701 ± 0.083
4.137GluThr: 4.137 ± 0.112
6.145GluVal: 6.145 ± 0.124
0.864GluTrp: 0.864 ± 0.048
2.653GluTyr: 2.653 ± 0.082
0.0GluXaa: 0.0 ± 0.0
Phe
2.768PheAla: 2.768 ± 0.094
0.331PheCys: 0.331 ± 0.024
2.457PheAsp: 2.457 ± 0.078
3.315PheGlu: 3.315 ± 0.077
2.087PhePhe: 2.087 ± 0.085
3.077PheGly: 3.077 ± 0.095
0.87PheHis: 0.87 ± 0.043
3.692PheIle: 3.692 ± 0.123
2.657PheLys: 2.657 ± 0.081
4.298PheLeu: 4.298 ± 0.137
1.086PheMet: 1.086 ± 0.054
2.015PheAsn: 2.015 ± 0.069
1.456PhePro: 1.456 ± 0.063
1.68PheGln: 1.68 ± 0.07
1.387PheArg: 1.387 ± 0.058
3.256PheSer: 3.256 ± 0.102
2.552PheThr: 2.552 ± 0.091
3.503PheVal: 3.503 ± 0.102
0.418PheTrp: 0.418 ± 0.036
1.857PheTyr: 1.857 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.242GlyAla: 4.242 ± 0.129
0.442GlyCys: 0.442 ± 0.034
3.006GlyAsp: 3.006 ± 0.108
4.639GlyGlu: 4.639 ± 0.113
3.075GlyPhe: 3.075 ± 0.09
3.999GlyGly: 3.999 ± 0.105
1.217GlyHis: 1.217 ± 0.052
5.566GlyIle: 5.566 ± 0.127
5.158GlyLys: 5.158 ± 0.169
6.026GlyLeu: 6.026 ± 0.155
1.878GlyMet: 1.878 ± 0.07
2.804GlyAsn: 2.804 ± 0.089
1.282GlyPro: 1.282 ± 0.056
2.354GlyGln: 2.354 ± 0.083
2.4GlyArg: 2.4 ± 0.093
3.6GlySer: 3.6 ± 0.088
4.262GlyThr: 4.262 ± 0.185
5.106GlyVal: 5.106 ± 0.106
0.642GlyTrp: 0.642 ± 0.043
2.776GlyTyr: 2.776 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
1.096HisAla: 1.096 ± 0.043
0.2HisCys: 0.2 ± 0.021
0.951HisAsp: 0.951 ± 0.078
1.49HisGlu: 1.49 ± 0.096
1.062HisPhe: 1.062 ± 0.059
1.147HisGly: 1.147 ± 0.059
0.785HisHis: 0.785 ± 0.095
1.318HisIle: 1.318 ± 0.05
1.024HisLys: 1.024 ± 0.044
2.005HisLeu: 2.005 ± 0.075
0.367HisMet: 0.367 ± 0.025
0.636HisAsn: 0.636 ± 0.033
0.973HisPro: 0.973 ± 0.042
1.068HisGln: 1.068 ± 0.05
0.779HisArg: 0.779 ± 0.039
1.181HisSer: 1.181 ± 0.062
1.082HisThr: 1.082 ± 0.053
1.215HisVal: 1.215 ± 0.051
0.159HisTrp: 0.159 ± 0.017
1.022HisTyr: 1.022 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
5.742IleAla: 5.742 ± 0.126
0.672IleCys: 0.672 ± 0.038
4.328IleAsp: 4.328 ± 0.117
5.79IleGlu: 5.79 ± 0.139
3.569IlePhe: 3.569 ± 0.128
5.229IleGly: 5.229 ± 0.122
1.702IleHis: 1.702 ± 0.065
5.402IleIle: 5.402 ± 0.157
4.177IleLys: 4.177 ± 0.098
7.359IleLeu: 7.359 ± 0.165
1.609IleMet: 1.609 ± 0.061
2.752IleAsn: 2.752 ± 0.087
3.481IlePro: 3.481 ± 0.087
3.856IleGln: 3.856 ± 0.102
2.99IleArg: 2.99 ± 0.087
4.964IleSer: 4.964 ± 0.125
4.338IleThr: 4.338 ± 0.103
5.814IleVal: 5.814 ± 0.121
0.527IleTrp: 0.527 ± 0.037
2.643IleTyr: 2.643 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
5.033LysAla: 5.033 ± 0.221
0.269LysCys: 0.269 ± 0.021
4.343LysAsp: 4.343 ± 0.168
7.482LysGlu: 7.482 ± 0.137
2.225LysPhe: 2.225 ± 0.059
4.389LysGly: 4.389 ± 0.109
1.227LysHis: 1.227 ± 0.05
5.1LysIle: 5.1 ± 0.108
5.927LysLys: 5.927 ± 0.129
5.257LysLeu: 5.257 ± 0.096
2.14LysMet: 2.14 ± 0.076
3.87LysAsn: 3.87 ± 0.102
2.358LysPro: 2.358 ± 0.124
3.478LysGln: 3.478 ± 0.095
2.766LysArg: 2.766 ± 0.084
3.501LysSer: 3.501 ± 0.104
4.076LysThr: 4.076 ± 0.137
5.267LysVal: 5.267 ± 0.173
0.751LysTrp: 0.751 ± 0.044
2.501LysTyr: 2.501 ± 0.089
0.0LysXaa: 0.0 ± 0.0
Leu
6.82LeuAla: 6.82 ± 0.126
0.626LeuCys: 0.626 ± 0.038
4.577LeuAsp: 4.577 ± 0.105
7.787LeuGlu: 7.787 ± 0.182
4.403LeuPhe: 4.403 ± 0.139
6.069LeuGly: 6.069 ± 0.162
1.55LeuHis: 1.55 ± 0.06
6.091LeuIle: 6.091 ± 0.159
6.585LeuLys: 6.585 ± 0.128
9.727LeuLeu: 9.727 ± 0.289
2.517LeuMet: 2.517 ± 0.103
4.217LeuAsn: 4.217 ± 0.1
3.642LeuPro: 3.642 ± 0.1
3.834LeuGln: 3.834 ± 0.117
3.264LeuArg: 3.264 ± 0.096
6.672LeuSer: 6.672 ± 0.158
5.623LeuThr: 5.623 ± 0.11
6.45LeuVal: 6.45 ± 0.132
0.755LeuTrp: 0.755 ± 0.048
2.903LeuTyr: 2.903 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
1.609MetAla: 1.609 ± 0.065
0.161MetCys: 0.161 ± 0.019
1.387MetAsp: 1.387 ± 0.051
1.795MetGlu: 1.795 ± 0.073
0.906MetPhe: 0.906 ± 0.048
1.544MetGly: 1.544 ± 0.067
0.365MetHis: 0.365 ± 0.025
2.322MetIle: 2.322 ± 0.081
2.392MetLys: 2.392 ± 0.075
1.924MetLeu: 1.924 ± 0.073
0.957MetMet: 0.957 ± 0.051
1.607MetAsn: 1.607 ± 0.057
0.789MetPro: 0.789 ± 0.045
0.927MetGln: 0.927 ± 0.046
0.913MetArg: 0.913 ± 0.051
1.553MetSer: 1.553 ± 0.055
1.569MetThr: 1.569 ± 0.061
1.664MetVal: 1.664 ± 0.059
0.164MetTrp: 0.164 ± 0.017
0.696MetTyr: 0.696 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.845AsnAla: 2.845 ± 0.085
0.281AsnCys: 0.281 ± 0.024
2.231AsnAsp: 2.231 ± 0.092
3.065AsnGlu: 3.065 ± 0.09
1.985AsnPhe: 1.985 ± 0.067
3.707AsnGly: 3.707 ± 0.164
1.254AsnHis: 1.254 ± 0.049
3.44AsnIle: 3.44 ± 0.081
2.804AsnLys: 2.804 ± 0.091
3.67AsnLeu: 3.67 ± 0.089
0.886AsnMet: 0.886 ± 0.047
1.904AsnAsn: 1.904 ± 0.084
2.334AsnPro: 2.334 ± 0.079
2.344AsnGln: 2.344 ± 0.08
2.12AsnArg: 2.12 ± 0.068
2.402AsnSer: 2.402 ± 0.08
2.297AsnThr: 2.297 ± 0.081
2.901AsnVal: 2.901 ± 0.101
0.499AsnTrp: 0.499 ± 0.034
1.767AsnTyr: 1.767 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
2.316ProAla: 2.316 ± 0.142
0.137ProCys: 0.137 ± 0.018
1.728ProAsp: 1.728 ± 0.079
3.26ProGlu: 3.26 ± 0.097
1.769ProPhe: 1.769 ± 0.076
1.92ProGly: 1.92 ± 0.086
0.67ProHis: 0.67 ± 0.038
2.667ProIle: 2.667 ± 0.082
2.35ProLys: 2.35 ± 0.106
2.968ProLeu: 2.968 ± 0.075
0.767ProMet: 0.767 ± 0.04
1.791ProAsn: 1.791 ± 0.095
0.614ProPro: 0.614 ± 0.038
1.334ProGln: 1.334 ± 0.051
0.88ProArg: 0.88 ± 0.047
2.118ProSer: 2.118 ± 0.062
2.782ProThr: 2.782 ± 0.165
3.057ProVal: 3.057 ± 0.139
0.266ProTrp: 0.266 ± 0.023
1.397ProTyr: 1.397 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
3.065GlnAla: 3.065 ± 0.09
0.192GlnCys: 0.192 ± 0.019
1.769GlnAsp: 1.769 ± 0.072
4.042GlnGlu: 4.042 ± 0.109
1.781GlnPhe: 1.781 ± 0.068
2.265GlnGly: 2.265 ± 0.069
0.686GlnHis: 0.686 ± 0.038
2.719GlnIle: 2.719 ± 0.088
3.557GlnLys: 3.557 ± 0.098
4.873GlnLeu: 4.873 ± 0.136
1.116GlnMet: 1.116 ± 0.05
1.825GlnAsn: 1.825 ± 0.07
1.318GlnPro: 1.318 ± 0.069
2.402GlnGln: 2.402 ± 0.104
1.559GlnArg: 1.559 ± 0.059
2.215GlnSer: 2.215 ± 0.067
2.513GlnThr: 2.513 ± 0.067
2.867GlnVal: 2.867 ± 0.079
0.448GlnTrp: 0.448 ± 0.031
1.605GlnTyr: 1.605 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
2.12ArgAla: 2.12 ± 0.078
0.218ArgCys: 0.218 ± 0.022
1.801ArgAsp: 1.801 ± 0.058
2.891ArgGlu: 2.891 ± 0.097
1.746ArgPhe: 1.746 ± 0.059
2.075ArgGly: 2.075 ± 0.087
0.668ArgHis: 0.668 ± 0.034
2.937ArgIle: 2.937 ± 0.091
2.847ArgLys: 2.847 ± 0.094
3.658ArgLeu: 3.658 ± 0.114
1.147ArgMet: 1.147 ± 0.044
1.744ArgAsn: 1.744 ± 0.056
1.211ArgPro: 1.211 ± 0.057
1.67ArgGln: 1.67 ± 0.066
1.668ArgArg: 1.668 ± 0.068
1.797ArgSer: 1.797 ± 0.06
1.946ArgThr: 1.946 ± 0.071
2.622ArgVal: 2.622 ± 0.082
0.297ArgTrp: 0.297 ± 0.03
1.528ArgTyr: 1.528 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
3.43SerAla: 3.43 ± 0.092
0.394SerCys: 0.394 ± 0.028
2.79SerAsp: 2.79 ± 0.078
3.761SerGlu: 3.761 ± 0.096
2.948SerPhe: 2.948 ± 0.094
4.046SerGly: 4.046 ± 0.108
1.223SerHis: 1.223 ± 0.052
5.182SerIle: 5.182 ± 0.135
4.155SerLys: 4.155 ± 0.089
5.905SerLeu: 5.905 ± 0.136
1.466SerMet: 1.466 ± 0.059
2.738SerAsn: 2.738 ± 0.083
2.098SerPro: 2.098 ± 0.067
2.455SerGln: 2.455 ± 0.08
2.035SerArg: 2.035 ± 0.068
3.943SerSer: 3.943 ± 0.114
3.64SerThr: 3.64 ± 0.102
4.258SerVal: 4.258 ± 0.087
0.478SerTrp: 0.478 ± 0.032
2.338SerTyr: 2.338 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.116ThrAla: 4.116 ± 0.17
0.307ThrCys: 0.307 ± 0.025
2.875ThrAsp: 2.875 ± 0.105
3.63ThrGlu: 3.63 ± 0.129
2.624ThrPhe: 2.624 ± 0.088
4.165ThrGly: 4.165 ± 0.12
1.199ThrHis: 1.199 ± 0.046
5.051ThrIle: 5.051 ± 0.108
4.034ThrLys: 4.034 ± 0.13
5.54ThrLeu: 5.54 ± 0.116
1.236ThrMet: 1.236 ± 0.054
2.657ThrAsn: 2.657 ± 0.086
3.202ThrPro: 3.202 ± 0.25
2.148ThrGln: 2.148 ± 0.084
1.94ThrArg: 1.94 ± 0.062
3.426ThrSer: 3.426 ± 0.109
4.345ThrThr: 4.345 ± 0.227
5.195ThrVal: 5.195 ± 0.218
0.525ThrTrp: 0.525 ± 0.037
2.241ThrTyr: 2.241 ± 0.109
0.0ThrXaa: 0.0 ± 0.0
Val
5.388ValAla: 5.388 ± 0.114
0.563ValCys: 0.563 ± 0.039
3.991ValAsp: 3.991 ± 0.124
5.816ValGlu: 5.816 ± 0.132
3.135ValPhe: 3.135 ± 0.104
4.767ValGly: 4.767 ± 0.115
1.29ValHis: 1.29 ± 0.051
5.618ValIle: 5.618 ± 0.127
4.591ValLys: 4.591 ± 0.15
6.987ValLeu: 6.987 ± 0.157
1.694ValMet: 1.694 ± 0.066
3.117ValAsn: 3.117 ± 0.108
2.772ValPro: 2.772 ± 0.137
2.899ValGln: 2.899 ± 0.081
2.602ValArg: 2.602 ± 0.081
4.766ValSer: 4.766 ± 0.105
5.043ValThr: 5.043 ± 0.243
5.796ValVal: 5.796 ± 0.15
0.507ValTrp: 0.507 ± 0.035
2.429ValTyr: 2.429 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.44TrpAla: 0.44 ± 0.029
0.059TrpCys: 0.059 ± 0.012
0.375TrpAsp: 0.375 ± 0.029
0.547TrpGlu: 0.547 ± 0.035
0.468TrpPhe: 0.468 ± 0.035
0.501TrpGly: 0.501 ± 0.038
0.157TrpHis: 0.157 ± 0.02
0.921TrpIle: 0.921 ± 0.048
0.765TrpLys: 0.765 ± 0.045
0.874TrpLeu: 0.874 ± 0.047
0.291TrpMet: 0.291 ± 0.029
0.551TrpAsn: 0.551 ± 0.037
0.172TrpPro: 0.172 ± 0.021
0.349TrpGln: 0.349 ± 0.03
0.277TrpArg: 0.277 ± 0.024
0.44TrpSer: 0.44 ± 0.033
0.485TrpThr: 0.485 ± 0.03
0.583TrpVal: 0.583 ± 0.035
0.097TrpTrp: 0.097 ± 0.017
0.489TrpTyr: 0.489 ± 0.048
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.279TyrAla: 2.279 ± 0.071
0.291TyrCys: 0.291 ± 0.026
2.029TyrAsp: 2.029 ± 0.068
2.657TyrGlu: 2.657 ± 0.079
2.045TyrPhe: 2.045 ± 0.079
2.31TyrGly: 2.31 ± 0.069
0.971TyrHis: 0.971 ± 0.052
2.485TyrIle: 2.485 ± 0.089
2.174TyrLys: 2.174 ± 0.086
3.919TyrLeu: 3.919 ± 0.111
0.767TyrMet: 0.767 ± 0.045
1.415TyrAsn: 1.415 ± 0.054
1.373TyrPro: 1.373 ± 0.058
2.174TyrGln: 2.174 ± 0.083
1.672TyrArg: 1.672 ± 0.067
2.32TyrSer: 2.32 ± 0.073
2.116TyrThr: 2.116 ± 0.114
2.485TyrVal: 2.485 ± 0.095
0.359TyrTrp: 0.359 ± 0.028
1.855TyrTyr: 1.855 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1562 proteins (504669 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski