Amino acid dipepetide frequency for Sphaerochaeta coccoides (strain ATCC BAA-1237 / DSM 17374 / SPN1) (Spirochaeta coccoides)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.265AlaAla: 8.265 ± 0.147
0.987AlaCys: 0.987 ± 0.045
4.954AlaAsp: 4.954 ± 0.085
4.525AlaGlu: 4.525 ± 0.1
3.426AlaPhe: 3.426 ± 0.076
7.138AlaGly: 7.138 ± 0.135
1.787AlaHis: 1.787 ± 0.057
5.307AlaIle: 5.307 ± 0.097
3.303AlaLys: 3.303 ± 0.082
8.643AlaLeu: 8.643 ± 0.13
2.493AlaMet: 2.493 ± 0.063
2.381AlaAsn: 2.381 ± 0.069
2.782AlaPro: 2.782 ± 0.076
2.641AlaGln: 2.641 ± 0.068
4.925AlaArg: 4.925 ± 0.091
5.961AlaSer: 5.961 ± 0.109
4.756AlaThr: 4.756 ± 0.127
6.726AlaVal: 6.726 ± 0.121
1.065AlaTrp: 1.065 ± 0.046
2.706AlaTyr: 2.706 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.936CysAla: 0.936 ± 0.043
0.132CysCys: 0.132 ± 0.016
0.682CysAsp: 0.682 ± 0.039
0.519CysGlu: 0.519 ± 0.028
0.494CysPhe: 0.494 ± 0.03
1.034CysGly: 1.034 ± 0.042
0.298CysHis: 0.298 ± 0.02
0.669CysIle: 0.669 ± 0.033
0.338CysLys: 0.338 ± 0.021
0.821CysLeu: 0.821 ± 0.039
0.254CysMet: 0.254 ± 0.02
0.336CysAsn: 0.336 ± 0.022
0.55CysPro: 0.55 ± 0.031
0.214CysGln: 0.214 ± 0.02
0.563CysArg: 0.563 ± 0.032
0.739CysSer: 0.739 ± 0.033
0.545CysThr: 0.545 ± 0.034
0.677CysVal: 0.677 ± 0.036
0.111CysTrp: 0.111 ± 0.012
0.304CysTyr: 0.304 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
5.487AspAla: 5.487 ± 0.101
0.547AspCys: 0.547 ± 0.032
3.373AspAsp: 3.373 ± 0.094
3.982AspGlu: 3.982 ± 0.089
2.881AspPhe: 2.881 ± 0.072
5.367AspGly: 5.367 ± 0.121
0.909AspHis: 0.909 ± 0.038
4.637AspIle: 4.637 ± 0.09
2.728AspLys: 2.728 ± 0.071
4.206AspLeu: 4.206 ± 0.086
1.769AspMet: 1.769 ± 0.056
1.875AspAsn: 1.875 ± 0.06
1.957AspPro: 1.957 ± 0.046
1.106AspGln: 1.106 ± 0.04
2.77AspArg: 2.77 ± 0.097
3.762AspSer: 3.762 ± 0.08
3.399AspThr: 3.399 ± 0.092
4.874AspVal: 4.874 ± 0.101
0.75AspTrp: 0.75 ± 0.037
2.046AspTyr: 2.046 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
5.266GluAla: 5.266 ± 0.099
0.451GluCys: 0.451 ± 0.024
3.496GluAsp: 3.496 ± 0.085
3.732GluGlu: 3.732 ± 0.109
2.117GluPhe: 2.117 ± 0.065
4.062GluGly: 4.062 ± 0.087
1.26GluHis: 1.26 ± 0.041
4.121GluIle: 4.121 ± 0.076
4.639GluLys: 4.639 ± 0.095
5.193GluLeu: 5.193 ± 0.087
1.713GluMet: 1.713 ± 0.05
2.737GluAsn: 2.737 ± 0.069
2.026GluPro: 2.026 ± 0.064
2.176GluGln: 2.176 ± 0.059
3.615GluArg: 3.615 ± 0.088
3.199GluSer: 3.199 ± 0.074
3.291GluThr: 3.291 ± 0.073
3.568GluVal: 3.568 ± 0.088
0.668GluTrp: 0.668 ± 0.035
1.774GluTyr: 1.774 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.335PheAla: 3.335 ± 0.086
0.53PheCys: 0.53 ± 0.028
2.491PheAsp: 2.491 ± 0.073
1.928PheGlu: 1.928 ± 0.061
2.246PhePhe: 2.246 ± 0.069
3.256PheGly: 3.256 ± 0.082
0.978PheHis: 0.978 ± 0.04
3.096PheIle: 3.096 ± 0.071
1.458PheLys: 1.458 ± 0.049
4.5PheLeu: 4.5 ± 0.103
1.387PheMet: 1.387 ± 0.043
1.449PheAsn: 1.449 ± 0.044
2.11PhePro: 2.11 ± 0.057
1.119PheGln: 1.119 ± 0.042
2.037PheArg: 2.037 ± 0.063
4.325PheSer: 4.325 ± 0.099
2.793PheThr: 2.793 ± 0.067
2.653PheVal: 2.653 ± 0.071
0.426PheTrp: 0.426 ± 0.029
1.233PheTyr: 1.233 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
5.651GlyAla: 5.651 ± 0.105
0.872GlyCys: 0.872 ± 0.044
4.077GlyAsp: 4.077 ± 0.098
4.298GlyGlu: 4.298 ± 0.077
3.661GlyPhe: 3.661 ± 0.097
5.954GlyGly: 5.954 ± 0.156
1.545GlyHis: 1.545 ± 0.048
6.352GlyIle: 6.352 ± 0.104
4.833GlyLys: 4.833 ± 0.09
6.755GlyLeu: 6.755 ± 0.109
2.479GlyMet: 2.479 ± 0.062
3.064GlyAsn: 3.064 ± 0.073
1.748GlyPro: 1.748 ± 0.056
2.611GlyGln: 2.611 ± 0.084
4.501GlyArg: 4.501 ± 0.094
5.034GlySer: 5.034 ± 0.112
5.734GlyThr: 5.734 ± 0.139
5.396GlyVal: 5.396 ± 0.103
1.019GlyTrp: 1.019 ± 0.045
3.009GlyTyr: 3.009 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
1.925HisAla: 1.925 ± 0.057
0.239HisCys: 0.239 ± 0.021
1.446HisAsp: 1.446 ± 0.051
1.471HisGlu: 1.471 ± 0.049
0.845HisPhe: 0.845 ± 0.041
1.795HisGly: 1.795 ± 0.055
0.542HisHis: 0.542 ± 0.032
1.236HisIle: 1.236 ± 0.048
0.739HisLys: 0.739 ± 0.032
1.886HisLeu: 1.886 ± 0.055
0.554HisMet: 0.554 ± 0.028
0.632HisAsn: 0.632 ± 0.031
1.121HisPro: 1.121 ± 0.04
0.569HisGln: 0.569 ± 0.03
0.968HisArg: 0.968 ± 0.036
1.13HisSer: 1.13 ± 0.041
1.304HisThr: 1.304 ± 0.064
1.711HisVal: 1.711 ± 0.053
0.229HisTrp: 0.229 ± 0.019
0.665HisTyr: 0.665 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.814IleAla: 5.814 ± 0.119
0.777IleCys: 0.777 ± 0.036
3.718IleAsp: 3.718 ± 0.09
3.52IleGlu: 3.52 ± 0.075
2.85IlePhe: 2.85 ± 0.066
5.072IleGly: 5.072 ± 0.096
1.524IleHis: 1.524 ± 0.049
4.731IleIle: 4.731 ± 0.097
2.585IleLys: 2.585 ± 0.065
6.8IleLeu: 6.8 ± 0.104
1.822IleMet: 1.822 ± 0.059
2.232IleAsn: 2.232 ± 0.056
3.667IlePro: 3.667 ± 0.074
1.827IleGln: 1.827 ± 0.056
3.627IleArg: 3.627 ± 0.077
5.098IleSer: 5.098 ± 0.109
3.851IleThr: 3.851 ± 0.076
4.825IleVal: 4.825 ± 0.082
0.565IleTrp: 0.565 ± 0.034
1.814IleTyr: 1.814 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.394LysAla: 4.394 ± 0.072
0.242LysCys: 0.242 ± 0.021
3.58LysAsp: 3.58 ± 0.079
3.8LysGlu: 3.8 ± 0.08
1.449LysPhe: 1.449 ± 0.046
3.568LysGly: 3.568 ± 0.074
0.875LysHis: 0.875 ± 0.038
3.174LysIle: 3.174 ± 0.079
4.168LysLys: 4.168 ± 0.09
3.904LysLeu: 3.904 ± 0.079
1.398LysMet: 1.398 ± 0.046
2.49LysAsn: 2.49 ± 0.073
1.743LysPro: 1.743 ± 0.051
1.465LysGln: 1.465 ± 0.048
2.5LysArg: 2.5 ± 0.065
2.647LysSer: 2.647 ± 0.065
3.141LysThr: 3.141 ± 0.073
3.283LysVal: 3.283 ± 0.079
0.5LysTrp: 0.5 ± 0.024
1.369LysTyr: 1.369 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
8.16LeuAla: 8.16 ± 0.121
1.057LeuCys: 1.057 ± 0.046
5.548LeuAsp: 5.548 ± 0.107
5.651LeuGlu: 5.651 ± 0.104
4.182LeuPhe: 4.182 ± 0.088
6.994LeuGly: 6.994 ± 0.117
1.936LeuHis: 1.936 ± 0.057
5.611LeuIle: 5.611 ± 0.107
4.825LeuLys: 4.825 ± 0.086
8.875LeuLeu: 8.875 ± 0.143
2.603LeuMet: 2.603 ± 0.062
3.141LeuAsn: 3.141 ± 0.081
4.469LeuPro: 4.469 ± 0.092
2.513LeuGln: 2.513 ± 0.075
4.745LeuArg: 4.745 ± 0.078
7.324LeuSer: 7.324 ± 0.132
5.317LeuThr: 5.317 ± 0.084
6.714LeuVal: 6.714 ± 0.108
1.405LeuTrp: 1.405 ± 0.075
3.025LeuTyr: 3.025 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.419MetAla: 2.419 ± 0.059
0.242MetCys: 0.242 ± 0.019
1.81MetAsp: 1.81 ± 0.059
1.943MetGlu: 1.943 ± 0.064
1.021MetPhe: 1.021 ± 0.042
2.237MetGly: 2.237 ± 0.057
0.459MetHis: 0.459 ± 0.028
1.863MetIle: 1.863 ± 0.067
2.054MetLys: 2.054 ± 0.058
2.573MetLeu: 2.573 ± 0.07
0.835MetMet: 0.835 ± 0.041
1.28MetAsn: 1.28 ± 0.043
1.209MetPro: 1.209 ± 0.043
0.798MetGln: 0.798 ± 0.037
1.405MetArg: 1.405 ± 0.045
1.898MetSer: 1.898 ± 0.054
1.958MetThr: 1.958 ± 0.058
2.149MetVal: 2.149 ± 0.061
0.214MetTrp: 0.214 ± 0.017
0.728MetTyr: 0.728 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.958AsnAla: 2.958 ± 0.066
0.294AsnCys: 0.294 ± 0.02
2.023AsnAsp: 2.023 ± 0.064
1.901AsnGlu: 1.901 ± 0.057
1.368AsnPhe: 1.368 ± 0.047
2.92AsnGly: 2.92 ± 0.083
0.744AsnHis: 0.744 ± 0.032
2.546AsnIle: 2.546 ± 0.064
1.628AsnLys: 1.628 ± 0.058
3.429AsnLeu: 3.429 ± 0.081
0.987AsnMet: 0.987 ± 0.04
1.457AsnAsn: 1.457 ± 0.061
2.22AsnPro: 2.22 ± 0.059
1.009AsnGln: 1.009 ± 0.04
1.811AsnArg: 1.811 ± 0.054
2.085AsnSer: 2.085 ± 0.065
2.267AsnThr: 2.267 ± 0.083
2.535AsnVal: 2.535 ± 0.065
0.377AsnTrp: 0.377 ± 0.025
1.172AsnTyr: 1.172 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
3.538ProAla: 3.538 ± 0.079
0.388ProCys: 0.388 ± 0.027
2.791ProAsp: 2.791 ± 0.065
3.038ProGlu: 3.038 ± 0.075
1.922ProPhe: 1.922 ± 0.056
3.224ProGly: 3.224 ± 0.071
0.98ProHis: 0.98 ± 0.038
1.923ProIle: 1.923 ± 0.052
1.324ProLys: 1.324 ± 0.049
3.988ProLeu: 3.988 ± 0.081
1.022ProMet: 1.022 ± 0.039
1.106ProAsn: 1.106 ± 0.039
1.377ProPro: 1.377 ± 0.06
1.265ProGln: 1.265 ± 0.047
1.901ProArg: 1.901 ± 0.065
2.914ProSer: 2.914 ± 0.077
1.933ProThr: 1.933 ± 0.059
4.268ProVal: 4.268 ± 0.097
0.554ProTrp: 0.554 ± 0.03
1.557ProTyr: 1.557 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
2.667GlnAla: 2.667 ± 0.065
0.241GlnCys: 0.241 ± 0.019
1.827GlnAsp: 1.827 ± 0.052
2.276GlnGlu: 2.276 ± 0.066
1.054GlnPhe: 1.054 ± 0.032
2.298GlnGly: 2.298 ± 0.064
0.565GlnHis: 0.565 ± 0.03
1.739GlnIle: 1.739 ± 0.054
1.934GlnLys: 1.934 ± 0.063
2.6GlnLeu: 2.6 ± 0.069
0.888GlnMet: 0.888 ± 0.04
1.142GlnAsn: 1.142 ± 0.04
0.872GlnPro: 0.872 ± 0.037
0.974GlnGln: 0.974 ± 0.041
1.578GlnArg: 1.578 ± 0.056
1.631GlnSer: 1.631 ± 0.053
1.586GlnThr: 1.586 ± 0.045
2.232GlnVal: 2.232 ± 0.06
0.362GlnTrp: 0.362 ± 0.026
0.924GlnTyr: 0.924 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
3.553ArgAla: 3.553 ± 0.074
0.448ArgCys: 0.448 ± 0.03
2.876ArgAsp: 2.876 ± 0.069
3.559ArgGlu: 3.559 ± 0.091
2.463ArgPhe: 2.463 ± 0.067
3.026ArgGly: 3.026 ± 0.073
1.265ArgHis: 1.265 ± 0.042
4.032ArgIle: 4.032 ± 0.086
3.4ArgLys: 3.4 ± 0.075
5.496ArgLeu: 5.496 ± 0.086
1.808ArgMet: 1.808 ± 0.057
2.416ArgAsn: 2.416 ± 0.062
2.042ArgPro: 2.042 ± 0.078
1.948ArgGln: 1.948 ± 0.068
3.388ArgArg: 3.388 ± 0.091
3.193ArgSer: 3.193 ± 0.065
3.332ArgThr: 3.332 ± 0.073
3.056ArgVal: 3.056 ± 0.082
0.61ArgTrp: 0.61 ± 0.034
1.884ArgTyr: 1.884 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.231SerAla: 5.231 ± 0.108
0.822SerCys: 0.822 ± 0.036
3.509SerAsp: 3.509 ± 0.08
3.129SerGlu: 3.129 ± 0.067
3.553SerPhe: 3.553 ± 0.08
6.338SerGly: 6.338 ± 0.106
1.677SerHis: 1.677 ± 0.051
4.448SerIle: 4.448 ± 0.089
2.187SerLys: 2.187 ± 0.059
7.336SerLeu: 7.336 ± 0.125
1.836SerMet: 1.836 ± 0.057
1.898SerAsn: 1.898 ± 0.057
2.984SerPro: 2.984 ± 0.079
1.967SerGln: 1.967 ± 0.059
4.232SerArg: 4.232 ± 0.086
5.186SerSer: 5.186 ± 0.109
3.821SerThr: 3.821 ± 0.1
5.205SerVal: 5.205 ± 0.098
1.03SerTrp: 1.03 ± 0.04
2.249SerTyr: 2.249 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
5.062ThrAla: 5.062 ± 0.106
0.562ThrCys: 0.562 ± 0.033
3.611ThrAsp: 3.611 ± 0.094
3.082ThrGlu: 3.082 ± 0.072
2.425ThrPhe: 2.425 ± 0.057
5.761ThrGly: 5.761 ± 0.127
1.201ThrHis: 1.201 ± 0.039
3.826ThrIle: 3.826 ± 0.081
1.979ThrLys: 1.979 ± 0.062
6.187ThrLeu: 6.187 ± 0.129
1.899ThrMet: 1.899 ± 0.071
1.716ThrAsn: 1.716 ± 0.061
2.962ThrPro: 2.962 ± 0.081
1.614ThrGln: 1.614 ± 0.053
2.493ThrArg: 2.493 ± 0.062
3.886ThrSer: 3.886 ± 0.09
3.521ThrThr: 3.521 ± 0.1
4.825ThrVal: 4.825 ± 0.093
0.772ThrTrp: 0.772 ± 0.032
1.963ThrTyr: 1.963 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
6.144ValAla: 6.144 ± 0.125
0.884ValCys: 0.884 ± 0.036
3.886ValAsp: 3.886 ± 0.076
4.001ValGlu: 4.001 ± 0.083
3.455ValPhe: 3.455 ± 0.075
4.918ValGly: 4.918 ± 0.098
1.395ValHis: 1.395 ± 0.048
4.836ValIle: 4.836 ± 0.092
3.565ValLys: 3.565 ± 0.08
6.897ValLeu: 6.897 ± 0.095
2.178ValMet: 2.178 ± 0.062
2.51ValAsn: 2.51 ± 0.057
3.333ValPro: 3.333 ± 0.077
2.104ValGln: 2.104 ± 0.069
4.221ValArg: 4.221 ± 0.084
5.94ValSer: 5.94 ± 0.095
4.475ValThr: 4.475 ± 0.084
5.271ValVal: 5.271 ± 0.1
0.747ValTrp: 0.747 ± 0.034
2.149ValTyr: 2.149 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.092TrpAla: 1.092 ± 0.072
0.123TrpCys: 0.123 ± 0.015
0.741TrpAsp: 0.741 ± 0.038
0.797TrpGlu: 0.797 ± 0.037
0.527TrpPhe: 0.527 ± 0.03
0.928TrpGly: 0.928 ± 0.04
0.295TrpHis: 0.295 ± 0.02
0.692TrpIle: 0.692 ± 0.034
0.732TrpLys: 0.732 ± 0.035
1.092TrpLeu: 1.092 ± 0.041
0.377TrpMet: 0.377 ± 0.023
0.706TrpAsn: 0.706 ± 0.038
0.332TrpPro: 0.332 ± 0.022
0.485TrpGln: 0.485 ± 0.028
0.615TrpArg: 0.615 ± 0.031
0.65TrpSer: 0.65 ± 0.031
0.566TrpThr: 0.566 ± 0.032
0.636TrpVal: 0.636 ± 0.031
0.189TrpTrp: 0.189 ± 0.017
0.371TrpTyr: 0.371 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.876TyrAla: 2.876 ± 0.07
0.377TyrCys: 0.377 ± 0.025
1.984TyrAsp: 1.984 ± 0.056
1.952TyrGlu: 1.952 ± 0.055
1.415TyrPhe: 1.415 ± 0.05
2.702TyrGly: 2.702 ± 0.068
0.772TyrHis: 0.772 ± 0.034
1.881TyrIle: 1.881 ± 0.053
1.275TyrLys: 1.275 ± 0.049
2.914TyrLeu: 2.914 ± 0.069
0.789TyrMet: 0.789 ± 0.032
1.166TyrAsn: 1.166 ± 0.048
1.508TyrPro: 1.508 ± 0.049
0.986TyrGln: 0.986 ± 0.036
1.898TyrArg: 1.898 ± 0.053
2.036TyrSer: 2.036 ± 0.059
1.757TyrThr: 1.757 ± 0.06
2.302TyrVal: 2.302 ± 0.056
0.353TyrTrp: 0.353 ± 0.022
1.218TyrTyr: 1.218 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1819 proteins (660275 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski