Amino acid dipepetide frequency for Amantichitinum ursilacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.211AlaAla: 17.211 ± 0.148
1.15AlaCys: 1.15 ± 0.033
6.671AlaAsp: 6.671 ± 0.073
6.227AlaGlu: 6.227 ± 0.068
3.837AlaPhe: 3.837 ± 0.053
10.034AlaGly: 10.034 ± 0.123
2.812AlaHis: 2.812 ± 0.05
5.515AlaIle: 5.515 ± 0.069
3.281AlaLys: 3.281 ± 0.061
14.628AlaLeu: 14.628 ± 0.128
3.164AlaMet: 3.164 ± 0.046
3.612AlaAsn: 3.612 ± 0.063
5.933AlaPro: 5.933 ± 0.1
6.26AlaGln: 6.26 ± 0.081
7.93AlaArg: 7.93 ± 0.097
6.85AlaSer: 6.85 ± 0.089
6.634AlaThr: 6.634 ± 0.09
8.521AlaVal: 8.521 ± 0.083
1.976AlaTrp: 1.976 ± 0.05
2.512AlaTyr: 2.512 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.058CysAla: 1.058 ± 0.031
0.108CysCys: 0.108 ± 0.008
0.431CysAsp: 0.431 ± 0.018
0.375CysGlu: 0.375 ± 0.017
0.297CysPhe: 0.297 ± 0.013
0.893CysGly: 0.893 ± 0.027
0.255CysHis: 0.255 ± 0.015
0.378CysIle: 0.378 ± 0.017
0.223CysLys: 0.223 ± 0.014
0.796CysLeu: 0.796 ± 0.024
0.201CysMet: 0.201 ± 0.012
0.261CysAsn: 0.261 ± 0.014
0.429CysPro: 0.429 ± 0.02
0.294CysGln: 0.294 ± 0.014
0.528CysArg: 0.528 ± 0.021
0.494CysSer: 0.494 ± 0.018
0.433CysThr: 0.433 ± 0.019
0.676CysVal: 0.676 ± 0.024
0.117CysTrp: 0.117 ± 0.009
0.232CysTyr: 0.232 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.92AspAla: 6.92 ± 0.077
0.452AspCys: 0.452 ± 0.018
2.885AspAsp: 2.885 ± 0.045
2.992AspGlu: 2.992 ± 0.059
2.151AspPhe: 2.151 ± 0.045
4.454AspGly: 4.454 ± 0.06
1.229AspHis: 1.229 ± 0.033
2.848AspIle: 2.848 ± 0.051
1.92AspLys: 1.92 ± 0.04
5.538AspLeu: 5.538 ± 0.067
1.191AspMet: 1.191 ± 0.03
1.594AspAsn: 1.594 ± 0.036
2.715AspPro: 2.715 ± 0.046
2.23AspGln: 2.23 ± 0.042
2.845AspArg: 2.845 ± 0.052
2.595AspSer: 2.595 ± 0.046
2.742AspThr: 2.742 ± 0.049
4.154AspVal: 4.154 ± 0.058
1.042AspTrp: 1.042 ± 0.028
1.721AspTyr: 1.721 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
5.772GluAla: 5.772 ± 0.08
0.348GluCys: 0.348 ± 0.018
2.152GluAsp: 2.152 ± 0.042
2.285GluGlu: 2.285 ± 0.048
1.712GluPhe: 1.712 ± 0.035
3.111GluGly: 3.111 ± 0.055
1.363GluHis: 1.363 ± 0.034
2.876GluIle: 2.876 ± 0.05
1.766GluLys: 1.766 ± 0.042
5.398GluLeu: 5.398 ± 0.076
1.232GluMet: 1.232 ± 0.032
1.462GluAsn: 1.462 ± 0.033
2.172GluPro: 2.172 ± 0.046
2.659GluGln: 2.659 ± 0.048
3.545GluArg: 3.545 ± 0.063
2.141GluSer: 2.141 ± 0.039
2.667GluThr: 2.667 ± 0.047
3.491GluVal: 3.491 ± 0.053
0.68GluTrp: 0.68 ± 0.022
1.236GluTyr: 1.236 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.417PheAla: 4.417 ± 0.056
0.415PheCys: 0.415 ± 0.016
2.444PheAsp: 2.444 ± 0.047
1.957PheGlu: 1.957 ± 0.041
1.354PhePhe: 1.354 ± 0.04
3.275PheGly: 3.275 ± 0.043
0.68PheHis: 0.68 ± 0.021
1.667PheIle: 1.667 ± 0.034
1.247PheLys: 1.247 ± 0.033
2.788PheLeu: 2.788 ± 0.051
0.861PheMet: 0.861 ± 0.025
1.465PheAsn: 1.465 ± 0.032
1.328PhePro: 1.328 ± 0.032
1.028PheGln: 1.028 ± 0.023
1.707PheArg: 1.707 ± 0.035
2.389PheSer: 2.389 ± 0.047
1.945PheThr: 1.945 ± 0.039
2.643PheVal: 2.643 ± 0.048
0.569PheTrp: 0.569 ± 0.021
1.063PheTyr: 1.063 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
8.172GlyAla: 8.172 ± 0.113
0.783GlyCys: 0.783 ± 0.02
4.057GlyAsp: 4.057 ± 0.061
3.943GlyGlu: 3.943 ± 0.061
3.198GlyPhe: 3.198 ± 0.051
6.427GlyGly: 6.427 ± 0.095
1.839GlyHis: 1.839 ± 0.043
4.069GlyIle: 4.069 ± 0.058
3.52GlyLys: 3.52 ± 0.058
8.229GlyLeu: 8.229 ± 0.086
2.25GlyMet: 2.25 ± 0.037
2.691GlyAsn: 2.691 ± 0.069
2.614GlyPro: 2.614 ± 0.041
3.544GlyGln: 3.544 ± 0.056
4.469GlyArg: 4.469 ± 0.064
4.419GlySer: 4.419 ± 0.089
4.273GlyThr: 4.273 ± 0.085
6.484GlyVal: 6.484 ± 0.08
1.414GlyTrp: 1.414 ± 0.035
2.469GlyTyr: 2.469 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.933HisAla: 2.933 ± 0.04
0.244HisCys: 0.244 ± 0.015
1.353HisAsp: 1.353 ± 0.03
1.063HisGlu: 1.063 ± 0.028
0.998HisPhe: 0.998 ± 0.028
2.111HisGly: 2.111 ± 0.039
0.645HisHis: 0.645 ± 0.023
1.177HisIle: 1.177 ± 0.03
0.684HisLys: 0.684 ± 0.025
2.308HisLeu: 2.308 ± 0.045
0.525HisMet: 0.525 ± 0.022
0.671HisAsn: 0.671 ± 0.023
1.349HisPro: 1.349 ± 0.029
0.833HisGln: 0.833 ± 0.026
1.228HisArg: 1.228 ± 0.03
1.155HisSer: 1.155 ± 0.027
1.189HisThr: 1.189 ± 0.032
1.576HisVal: 1.576 ± 0.038
0.472HisTrp: 0.472 ± 0.019
0.762HisTyr: 0.762 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.417IleAla: 6.417 ± 0.065
0.45IleCys: 0.45 ± 0.017
3.391IleAsp: 3.391 ± 0.049
3.054IleGlu: 3.054 ± 0.053
1.365IlePhe: 1.365 ± 0.029
4.272IleGly: 4.272 ± 0.058
0.955IleHis: 0.955 ± 0.026
1.966IleIle: 1.966 ± 0.038
1.988IleLys: 1.988 ± 0.046
3.779IleLeu: 3.779 ± 0.061
0.821IleMet: 0.821 ± 0.026
2.02IleAsn: 2.02 ± 0.058
2.145IlePro: 2.145 ± 0.041
1.549IleGln: 1.549 ± 0.037
2.623IleArg: 2.623 ± 0.042
3.079IleSer: 3.079 ± 0.045
2.967IleThr: 2.967 ± 0.05
3.405IleVal: 3.405 ± 0.055
0.57IleTrp: 0.57 ± 0.023
1.169IleTyr: 1.169 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.117LysAla: 4.117 ± 0.076
0.154LysCys: 0.154 ± 0.011
1.681LysAsp: 1.681 ± 0.039
1.367LysGlu: 1.367 ± 0.037
0.892LysPhe: 0.892 ± 0.03
2.373LysGly: 2.373 ± 0.044
0.747LysHis: 0.747 ± 0.024
1.553LysIle: 1.553 ± 0.041
1.286LysLys: 1.286 ± 0.043
3.769LysLeu: 3.769 ± 0.056
0.802LysMet: 0.802 ± 0.025
1.069LysAsn: 1.069 ± 0.031
2.178LysPro: 2.178 ± 0.047
1.603LysGln: 1.603 ± 0.036
1.99LysArg: 1.99 ± 0.045
1.682LysSer: 1.682 ± 0.035
2.001LysThr: 2.001 ± 0.041
2.495LysVal: 2.495 ± 0.044
0.407LysTrp: 0.407 ± 0.017
0.744LysTyr: 0.744 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.601LeuAla: 14.601 ± 0.156
0.966LeuCys: 0.966 ± 0.028
6.168LeuAsp: 6.168 ± 0.082
4.918LeuGlu: 4.918 ± 0.07
3.605LeuPhe: 3.605 ± 0.055
8.136LeuGly: 8.136 ± 0.084
2.465LeuHis: 2.465 ± 0.041
5.095LeuIle: 5.095 ± 0.076
3.69LeuLys: 3.69 ± 0.056
11.664LeuLeu: 11.664 ± 0.137
2.371LeuMet: 2.371 ± 0.046
3.45LeuAsn: 3.45 ± 0.067
6.189LeuPro: 6.189 ± 0.084
5.18LeuGln: 5.18 ± 0.071
6.747LeuArg: 6.747 ± 0.094
6.216LeuSer: 6.216 ± 0.071
6.048LeuThr: 6.048 ± 0.075
7.396LeuVal: 7.396 ± 0.076
1.38LeuTrp: 1.38 ± 0.035
2.381LeuTyr: 2.381 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.846MetAla: 2.846 ± 0.047
0.133MetCys: 0.133 ± 0.01
1.055MetAsp: 1.055 ± 0.031
0.835MetGlu: 0.835 ± 0.027
0.738MetPhe: 0.738 ± 0.024
1.674MetGly: 1.674 ± 0.04
0.548MetHis: 0.548 ± 0.021
1.048MetIle: 1.048 ± 0.028
0.895MetLys: 0.895 ± 0.026
2.832MetLeu: 2.832 ± 0.043
0.564MetMet: 0.564 ± 0.02
0.831MetAsn: 0.831 ± 0.024
1.475MetPro: 1.475 ± 0.034
1.25MetGln: 1.25 ± 0.028
1.496MetArg: 1.496 ± 0.034
1.549MetSer: 1.549 ± 0.029
1.503MetThr: 1.503 ± 0.036
1.544MetVal: 1.544 ± 0.035
0.229MetTrp: 0.229 ± 0.011
0.427MetTyr: 0.427 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
4.065AsnAla: 4.065 ± 0.077
0.219AsnCys: 0.219 ± 0.015
1.643AsnAsp: 1.643 ± 0.038
1.378AsnGlu: 1.378 ± 0.031
1.038AsnPhe: 1.038 ± 0.027
2.958AsnGly: 2.958 ± 0.072
0.663AsnHis: 0.663 ± 0.022
1.494AsnIle: 1.494 ± 0.039
1.069AsnLys: 1.069 ± 0.028
3.224AsnLeu: 3.224 ± 0.053
0.665AsnMet: 0.665 ± 0.02
1.216AsnAsn: 1.216 ± 0.048
2.042AsnPro: 2.042 ± 0.042
1.346AsnGln: 1.346 ± 0.037
1.817AsnArg: 1.817 ± 0.034
1.583AsnSer: 1.583 ± 0.053
1.879AsnThr: 1.879 ± 0.048
2.346AsnVal: 2.346 ± 0.052
0.5AsnTrp: 0.5 ± 0.02
0.886AsnTyr: 0.886 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
7.052ProAla: 7.052 ± 0.107
0.313ProCys: 0.313 ± 0.016
3.418ProAsp: 3.418 ± 0.053
3.013ProGlu: 3.013 ± 0.055
1.764ProPhe: 1.764 ± 0.035
3.969ProGly: 3.969 ± 0.055
1.175ProHis: 1.175 ± 0.03
1.978ProIle: 1.978 ± 0.038
1.411ProLys: 1.411 ± 0.038
5.332ProLeu: 5.332 ± 0.071
1.055ProMet: 1.055 ± 0.025
1.39ProAsn: 1.39 ± 0.03
2.414ProPro: 2.414 ± 0.046
2.312ProGln: 2.312 ± 0.043
2.552ProArg: 2.552 ± 0.05
2.396ProSer: 2.396 ± 0.042
3.035ProThr: 3.035 ± 0.1
4.245ProVal: 4.245 ± 0.062
0.793ProTrp: 0.793 ± 0.027
1.25ProTyr: 1.25 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
5.613GlnAla: 5.613 ± 0.069
0.309GlnCys: 0.309 ± 0.016
1.856GlnAsp: 1.856 ± 0.032
1.547GlnGlu: 1.547 ± 0.036
1.563GlnPhe: 1.563 ± 0.036
2.993GlnGly: 2.993 ± 0.046
1.281GlnHis: 1.281 ± 0.03
2.489GlnIle: 2.489 ± 0.039
1.413GlnLys: 1.413 ± 0.034
5.286GlnLeu: 5.286 ± 0.073
1.173GlnMet: 1.173 ± 0.031
1.266GlnAsn: 1.266 ± 0.035
2.576GlnPro: 2.576 ± 0.044
2.912GlnGln: 2.912 ± 0.056
3.49GlnArg: 3.49 ± 0.059
2.448GlnSer: 2.448 ± 0.046
2.532GlnThr: 2.532 ± 0.048
3.05GlnVal: 3.05 ± 0.049
0.799GlnTrp: 0.799 ± 0.025
1.175GlnTyr: 1.175 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
6.538ArgAla: 6.538 ± 0.088
0.47ArgCys: 0.47 ± 0.02
3.388ArgAsp: 3.388 ± 0.06
3.218ArgGlu: 3.218 ± 0.056
2.611ArgPhe: 2.611 ± 0.048
3.739ArgGly: 3.739 ± 0.05
1.634ArgHis: 1.634 ± 0.037
3.447ArgIle: 3.447 ± 0.05
2.088ArgLys: 2.088 ± 0.04
6.901ArgLeu: 6.901 ± 0.091
1.7ArgMet: 1.7 ± 0.037
2.051ArgAsn: 2.051 ± 0.034
2.691ArgPro: 2.691 ± 0.047
3.031ArgGln: 3.031 ± 0.045
3.806ArgArg: 3.806 ± 0.066
2.864ArgSer: 2.864 ± 0.041
2.839ArgThr: 2.839 ± 0.043
4.519ArgVal: 4.519 ± 0.058
1.064ArgTrp: 1.064 ± 0.028
2.018ArgTyr: 2.018 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
7.033SerAla: 7.033 ± 0.088
0.43SerCys: 0.43 ± 0.018
2.708SerAsp: 2.708 ± 0.046
2.267SerGlu: 2.267 ± 0.039
1.981SerPhe: 1.981 ± 0.043
5.21SerGly: 5.21 ± 0.098
1.222SerHis: 1.222 ± 0.032
2.598SerIle: 2.598 ± 0.05
1.733SerLys: 1.733 ± 0.039
5.602SerLeu: 5.602 ± 0.071
1.311SerMet: 1.311 ± 0.032
1.816SerAsn: 1.816 ± 0.049
2.62SerPro: 2.62 ± 0.047
2.103SerGln: 2.103 ± 0.04
3.166SerArg: 3.166 ± 0.052
3.291SerSer: 3.291 ± 0.072
3.189SerThr: 3.189 ± 0.07
4.156SerVal: 4.156 ± 0.067
0.841SerTrp: 0.841 ± 0.027
1.424SerTyr: 1.424 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.431ThrAla: 6.431 ± 0.086
0.409ThrCys: 0.409 ± 0.018
2.749ThrAsp: 2.749 ± 0.046
2.445ThrGlu: 2.445 ± 0.037
1.864ThrPhe: 1.864 ± 0.039
4.775ThrGly: 4.775 ± 0.083
1.274ThrHis: 1.274 ± 0.03
2.28ThrIle: 2.28 ± 0.048
1.082ThrLys: 1.082 ± 0.032
7.254ThrLeu: 7.254 ± 0.097
0.98ThrMet: 0.98 ± 0.027
1.455ThrAsn: 1.455 ± 0.041
4.169ThrPro: 4.169 ± 0.095
2.386ThrGln: 2.386 ± 0.047
3.408ThrArg: 3.408 ± 0.05
2.932ThrSer: 2.932 ± 0.056
3.096ThrThr: 3.096 ± 0.064
4.357ThrVal: 4.357 ± 0.068
0.881ThrTrp: 0.881 ± 0.028
1.258ThrTyr: 1.258 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
9.209ValAla: 9.209 ± 0.091
0.714ValCys: 0.714 ± 0.025
4.085ValAsp: 4.085 ± 0.051
3.641ValGlu: 3.641 ± 0.062
2.6ValPhe: 2.6 ± 0.051
5.388ValGly: 5.388 ± 0.077
1.446ValHis: 1.446 ± 0.031
3.753ValIle: 3.753 ± 0.057
2.403ValLys: 2.403 ± 0.044
8.192ValLeu: 8.192 ± 0.08
1.785ValMet: 1.785 ± 0.033
2.375ValAsn: 2.375 ± 0.055
3.629ValPro: 3.629 ± 0.055
2.886ValGln: 2.886 ± 0.049
4.268ValArg: 4.268 ± 0.057
4.359ValSer: 4.359 ± 0.056
4.335ValThr: 4.335 ± 0.066
5.777ValVal: 5.777 ± 0.075
0.966ValTrp: 0.966 ± 0.027
1.771ValTyr: 1.771 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.345TrpAla: 1.345 ± 0.037
0.153TrpCys: 0.153 ± 0.01
0.619TrpAsp: 0.619 ± 0.023
0.488TrpGlu: 0.488 ± 0.019
0.629TrpPhe: 0.629 ± 0.024
0.94TrpGly: 0.94 ± 0.029
0.468TrpHis: 0.468 ± 0.017
0.699TrpIle: 0.699 ± 0.021
0.434TrpLys: 0.434 ± 0.018
2.415TrpLeu: 2.415 ± 0.054
0.366TrpMet: 0.366 ± 0.016
0.493TrpAsn: 0.493 ± 0.022
0.815TrpPro: 0.815 ± 0.028
1.126TrpGln: 1.126 ± 0.029
1.249TrpArg: 1.249 ± 0.031
0.834TrpSer: 0.834 ± 0.027
0.713TrpThr: 0.713 ± 0.023
0.957TrpVal: 0.957 ± 0.029
0.294TrpTrp: 0.294 ± 0.015
0.377TrpTyr: 0.377 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.004TyrAla: 3.004 ± 0.049
0.259TyrCys: 0.259 ± 0.014
1.463TyrAsp: 1.463 ± 0.03
1.055TyrGlu: 1.055 ± 0.027
1.043TyrPhe: 1.043 ± 0.031
2.132TyrGly: 2.132 ± 0.045
0.575TyrHis: 0.575 ± 0.02
1.052TyrIle: 1.052 ± 0.024
0.777TyrLys: 0.777 ± 0.024
2.732TyrLeu: 2.732 ± 0.051
0.456TyrMet: 0.456 ± 0.019
0.844TyrAsn: 0.844 ± 0.03
1.388TyrPro: 1.388 ± 0.037
1.24TyrGln: 1.24 ± 0.033
1.755TyrArg: 1.755 ± 0.038
1.426TyrSer: 1.426 ± 0.034
1.465TyrThr: 1.465 ± 0.04
1.788TyrVal: 1.788 ± 0.038
0.423TyrTrp: 0.423 ± 0.019
0.727TyrTyr: 0.727 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4368 proteins (1441360 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski