Amino acid dipepetide frequency for Curvibacter phage P26059A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.991AlaAla: 8.991 ± 1.132
0.999AlaCys: 0.999 ± 0.17
4.196AlaAsp: 4.196 ± 0.407
5.435AlaGlu: 5.435 ± 0.568
2.757AlaPhe: 2.757 ± 0.247
6.673AlaGly: 6.673 ± 0.627
1.399AlaHis: 1.399 ± 0.237
5.355AlaIle: 5.355 ± 0.533
5.395AlaLys: 5.395 ± 0.61
6.194AlaLeu: 6.194 ± 0.693
2.398AlaMet: 2.398 ± 0.321
4.236AlaAsn: 4.236 ± 0.582
2.478AlaPro: 2.478 ± 0.39
3.157AlaGln: 3.157 ± 0.464
4.156AlaArg: 4.156 ± 0.545
6.114AlaSer: 6.114 ± 0.591
5.355AlaThr: 5.355 ± 0.56
7.672AlaVal: 7.672 ± 0.544
1.638AlaTrp: 1.638 ± 0.373
2.438AlaTyr: 2.438 ± 0.309
0.0AlaXaa: 0.0 ± 0.0
Cys
0.599CysAla: 0.599 ± 0.145
0.12CysCys: 0.12 ± 0.073
0.919CysAsp: 0.919 ± 0.15
0.519CysGlu: 0.519 ± 0.138
0.32CysPhe: 0.32 ± 0.112
0.959CysGly: 0.959 ± 0.297
0.2CysHis: 0.2 ± 0.111
0.799CysIle: 0.799 ± 0.165
0.839CysLys: 0.839 ± 0.169
0.879CysLeu: 0.879 ± 0.239
0.2CysMet: 0.2 ± 0.088
0.759CysAsn: 0.759 ± 0.193
0.48CysPro: 0.48 ± 0.18
0.519CysGln: 0.519 ± 0.16
0.639CysArg: 0.639 ± 0.165
1.079CysSer: 1.079 ± 0.23
0.919CysThr: 0.919 ± 0.202
0.719CysVal: 0.719 ± 0.181
0.16CysTrp: 0.16 ± 0.067
0.599CysTyr: 0.599 ± 0.194
0.0CysXaa: 0.0 ± 0.0
Asp
6.314AspAla: 6.314 ± 0.918
0.799AspCys: 0.799 ± 0.155
3.357AspAsp: 3.357 ± 0.429
4.076AspGlu: 4.076 ± 0.498
2.757AspPhe: 2.757 ± 0.399
4.076AspGly: 4.076 ± 0.507
1.119AspHis: 1.119 ± 0.259
3.237AspIle: 3.237 ± 0.374
3.397AspLys: 3.397 ± 0.423
3.916AspLeu: 3.916 ± 0.331
1.558AspMet: 1.558 ± 0.252
2.438AspAsn: 2.438 ± 0.282
1.878AspPro: 1.878 ± 0.264
1.199AspGln: 1.199 ± 0.2
2.158AspArg: 2.158 ± 0.279
3.876AspSer: 3.876 ± 0.571
3.676AspThr: 3.676 ± 0.414
3.556AspVal: 3.556 ± 0.378
0.639AspTrp: 0.639 ± 0.151
2.358AspTyr: 2.358 ± 0.297
0.0AspXaa: 0.0 ± 0.0
Glu
5.275GluAla: 5.275 ± 0.673
0.959GluCys: 0.959 ± 0.312
2.877GluAsp: 2.877 ± 0.397
4.276GluGlu: 4.276 ± 0.526
2.757GluPhe: 2.757 ± 0.415
3.317GluGly: 3.317 ± 0.353
1.718GluHis: 1.718 ± 0.331
3.157GluIle: 3.157 ± 0.344
3.996GluLys: 3.996 ± 0.712
6.274GluLeu: 6.274 ± 0.527
2.118GluMet: 2.118 ± 0.312
2.278GluAsn: 2.278 ± 0.311
2.038GluPro: 2.038 ± 0.341
2.637GluGln: 2.637 ± 0.412
2.717GluArg: 2.717 ± 0.285
4.116GluSer: 4.116 ± 0.524
3.077GluThr: 3.077 ± 0.351
4.795GluVal: 4.795 ± 0.459
0.999GluTrp: 0.999 ± 0.222
2.917GluTyr: 2.917 ± 0.299
0.0GluXaa: 0.0 ± 0.0
Phe
2.997PheAla: 2.997 ± 0.414
0.36PheCys: 0.36 ± 0.126
2.677PheAsp: 2.677 ± 0.333
2.318PheGlu: 2.318 ± 0.344
1.359PhePhe: 1.359 ± 0.272
2.597PheGly: 2.597 ± 0.315
0.639PheHis: 0.639 ± 0.168
1.878PheIle: 1.878 ± 0.255
3.077PheLys: 3.077 ± 0.375
2.118PheLeu: 2.118 ± 0.288
0.879PheMet: 0.879 ± 0.199
2.757PheAsn: 2.757 ± 0.367
1.079PhePro: 1.079 ± 0.213
1.518PheGln: 1.518 ± 0.214
1.718PheArg: 1.718 ± 0.259
3.237PheSer: 3.237 ± 0.36
3.157PheThr: 3.157 ± 0.412
2.837PheVal: 2.837 ± 0.414
0.44PheTrp: 0.44 ± 0.142
1.638PheTyr: 1.638 ± 0.227
0.0PheXaa: 0.0 ± 0.0
Gly
4.515GlyAla: 4.515 ± 0.552
0.4GlyCys: 0.4 ± 0.135
4.316GlyAsp: 4.316 ± 0.863
3.916GlyGlu: 3.916 ± 0.415
3.197GlyPhe: 3.197 ± 0.288
4.116GlyGly: 4.116 ± 0.571
0.799GlyHis: 0.799 ± 0.199
4.156GlyIle: 4.156 ± 0.384
5.155GlyLys: 5.155 ± 0.443
5.035GlyLeu: 5.035 ± 0.489
1.399GlyMet: 1.399 ± 0.189
2.597GlyAsn: 2.597 ± 0.43
1.119GlyPro: 1.119 ± 0.287
1.638GlyGln: 1.638 ± 0.227
2.158GlyArg: 2.158 ± 0.261
5.994GlySer: 5.994 ± 0.634
5.155GlyThr: 5.155 ± 0.679
5.475GlyVal: 5.475 ± 0.632
1.199GlyTrp: 1.199 ± 0.246
3.676GlyTyr: 3.676 ± 0.368
0.0GlyXaa: 0.0 ± 0.0
His
1.678HisAla: 1.678 ± 0.256
0.2HisCys: 0.2 ± 0.092
1.279HisAsp: 1.279 ± 0.254
0.919HisGlu: 0.919 ± 0.177
1.079HisPhe: 1.079 ± 0.257
1.598HisGly: 1.598 ± 0.332
0.639HisHis: 0.639 ± 0.243
1.239HisIle: 1.239 ± 0.184
0.839HisLys: 0.839 ± 0.213
1.479HisLeu: 1.479 ± 0.238
0.48HisMet: 0.48 ± 0.141
0.959HisAsn: 0.959 ± 0.184
0.759HisPro: 0.759 ± 0.187
0.519HisGln: 0.519 ± 0.154
1.279HisArg: 1.279 ± 0.261
1.239HisSer: 1.239 ± 0.238
1.159HisThr: 1.159 ± 0.231
0.919HisVal: 0.919 ± 0.185
0.24HisTrp: 0.24 ± 0.087
0.679HisTyr: 0.679 ± 0.181
0.0HisXaa: 0.0 ± 0.0
Ile
5.714IleAla: 5.714 ± 0.536
1.119IleCys: 1.119 ± 0.226
3.437IleAsp: 3.437 ± 0.387
3.796IleGlu: 3.796 ± 0.365
1.558IlePhe: 1.558 ± 0.258
3.277IleGly: 3.277 ± 0.401
0.719IleHis: 0.719 ± 0.154
2.198IleIle: 2.198 ± 0.259
4.835IleLys: 4.835 ± 0.421
3.277IleLeu: 3.277 ± 0.341
1.319IleMet: 1.319 ± 0.287
3.077IleAsn: 3.077 ± 0.374
1.758IlePro: 1.758 ± 0.369
2.438IleGln: 2.438 ± 0.293
3.077IleArg: 3.077 ± 0.34
3.916IleSer: 3.916 ± 0.463
4.196IleThr: 4.196 ± 0.496
3.077IleVal: 3.077 ± 0.411
0.639IleTrp: 0.639 ± 0.147
1.838IleTyr: 1.838 ± 0.317
0.0IleXaa: 0.0 ± 0.0
Lys
5.794LysAla: 5.794 ± 0.787
0.4LysCys: 0.4 ± 0.127
3.556LysAsp: 3.556 ± 0.44
5.035LysGlu: 5.035 ± 0.509
2.478LysPhe: 2.478 ± 0.331
4.715LysGly: 4.715 ± 0.518
1.598LysHis: 1.598 ± 0.296
3.437LysIle: 3.437 ± 0.366
3.796LysLys: 3.796 ± 0.487
5.794LysLeu: 5.794 ± 0.574
1.998LysMet: 1.998 ± 0.329
2.797LysAsn: 2.797 ± 0.331
3.037LysPro: 3.037 ± 0.421
3.397LysGln: 3.397 ± 0.444
3.037LysArg: 3.037 ± 0.441
4.915LysSer: 4.915 ± 0.55
3.397LysThr: 3.397 ± 0.314
4.875LysVal: 4.875 ± 0.492
0.599LysTrp: 0.599 ± 0.176
2.597LysTyr: 2.597 ± 0.335
0.0LysXaa: 0.0 ± 0.0
Leu
5.594LeuAla: 5.594 ± 0.479
0.759LeuCys: 0.759 ± 0.214
4.196LeuAsp: 4.196 ± 0.415
4.555LeuGlu: 4.555 ± 0.509
2.997LeuPhe: 2.997 ± 0.306
5.435LeuGly: 5.435 ± 0.508
1.598LeuHis: 1.598 ± 0.281
4.436LeuIle: 4.436 ± 0.389
5.195LeuLys: 5.195 ± 0.543
6.474LeuLeu: 6.474 ± 0.614
1.558LeuMet: 1.558 ± 0.268
4.555LeuAsn: 4.555 ± 0.433
3.636LeuPro: 3.636 ± 0.394
4.795LeuGln: 4.795 ± 0.484
3.716LeuArg: 3.716 ± 0.387
5.395LeuSer: 5.395 ± 0.437
5.834LeuThr: 5.834 ± 0.534
4.875LeuVal: 4.875 ± 0.45
0.999LeuTrp: 0.999 ± 0.185
2.358LeuTyr: 2.358 ± 0.307
0.0LeuXaa: 0.0 ± 0.0
Met
1.199MetAla: 1.199 ± 0.191
0.16MetCys: 0.16 ± 0.074
1.279MetAsp: 1.279 ± 0.206
0.999MetGlu: 0.999 ± 0.217
0.719MetPhe: 0.719 ± 0.166
1.079MetGly: 1.079 ± 0.23
0.48MetHis: 0.48 ± 0.136
1.279MetIle: 1.279 ± 0.26
2.358MetLys: 2.358 ± 0.347
2.757MetLeu: 2.757 ± 0.401
0.28MetMet: 0.28 ± 0.098
1.279MetAsn: 1.279 ± 0.224
0.679MetPro: 0.679 ± 0.153
2.398MetGln: 2.398 ± 0.278
1.039MetArg: 1.039 ± 0.221
1.678MetSer: 1.678 ± 0.26
1.998MetThr: 1.998 ± 0.251
1.359MetVal: 1.359 ± 0.224
0.2MetTrp: 0.2 ± 0.077
1.039MetTyr: 1.039 ± 0.21
0.0MetXaa: 0.0 ± 0.0
Asn
5.714AsnAla: 5.714 ± 0.53
0.879AsnCys: 0.879 ± 0.19
2.318AsnAsp: 2.318 ± 0.28
2.997AsnGlu: 2.997 ± 0.321
1.878AsnPhe: 1.878 ± 0.265
3.836AsnGly: 3.836 ± 0.43
0.839AsnHis: 0.839 ± 0.2
2.997AsnIle: 2.997 ± 0.32
3.676AsnLys: 3.676 ± 0.445
3.996AsnLeu: 3.996 ± 0.367
0.999AsnMet: 0.999 ± 0.169
2.637AsnAsn: 2.637 ± 0.307
2.198AsnPro: 2.198 ± 0.307
1.838AsnGln: 1.838 ± 0.304
2.677AsnArg: 2.677 ± 0.277
3.077AsnSer: 3.077 ± 0.462
3.277AsnThr: 3.277 ± 0.399
2.318AsnVal: 2.318 ± 0.409
0.679AsnTrp: 0.679 ± 0.175
1.878AsnTyr: 1.878 ± 0.224
0.0AsnXaa: 0.0 ± 0.0
Pro
3.237ProAla: 3.237 ± 0.411
0.36ProCys: 0.36 ± 0.12
2.597ProAsp: 2.597 ± 0.338
2.398ProGlu: 2.398 ± 0.393
1.079ProPhe: 1.079 ± 0.21
0.759ProGly: 0.759 ± 0.186
0.839ProHis: 0.839 ± 0.155
2.078ProIle: 2.078 ± 0.267
2.118ProLys: 2.118 ± 0.308
2.438ProLeu: 2.438 ± 0.307
0.719ProMet: 0.719 ± 0.146
1.638ProAsn: 1.638 ± 0.27
0.679ProPro: 0.679 ± 0.179
1.439ProGln: 1.439 ± 0.233
1.199ProArg: 1.199 ± 0.193
2.677ProSer: 2.677 ± 0.323
1.918ProThr: 1.918 ± 0.253
2.917ProVal: 2.917 ± 0.381
0.32ProTrp: 0.32 ± 0.1
1.079ProTyr: 1.079 ± 0.195
0.0ProXaa: 0.0 ± 0.0
Gln
3.676GlnAla: 3.676 ± 0.365
0.639GlnCys: 0.639 ± 0.185
1.758GlnAsp: 1.758 ± 0.237
2.917GlnGlu: 2.917 ± 0.37
1.399GlnPhe: 1.399 ± 0.205
2.597GlnGly: 2.597 ± 0.293
0.879GlnHis: 0.879 ± 0.185
2.158GlnIle: 2.158 ± 0.298
2.837GlnLys: 2.837 ± 0.387
3.796GlnLeu: 3.796 ± 0.366
1.319GlnMet: 1.319 ± 0.248
1.838GlnAsn: 1.838 ± 0.32
1.359GlnPro: 1.359 ± 0.196
2.398GlnGln: 2.398 ± 0.414
1.998GlnArg: 1.998 ± 0.338
2.797GlnSer: 2.797 ± 0.378
2.078GlnThr: 2.078 ± 0.26
3.477GlnVal: 3.477 ± 0.46
0.48GlnTrp: 0.48 ± 0.133
2.078GlnTyr: 2.078 ± 0.291
0.0GlnXaa: 0.0 ± 0.0
Arg
3.237ArgAla: 3.237 ± 0.413
0.519ArgCys: 0.519 ± 0.153
2.517ArgAsp: 2.517 ± 0.382
2.318ArgGlu: 2.318 ± 0.336
1.758ArgPhe: 1.758 ± 0.213
2.957ArgGly: 2.957 ± 0.316
1.039ArgHis: 1.039 ± 0.178
2.917ArgIle: 2.917 ± 0.455
3.357ArgLys: 3.357 ± 0.497
3.796ArgLeu: 3.796 ± 0.312
1.239ArgMet: 1.239 ± 0.251
2.637ArgAsn: 2.637 ± 0.338
0.959ArgPro: 0.959 ± 0.166
1.678ArgGln: 1.678 ± 0.23
1.678ArgArg: 1.678 ± 0.256
2.757ArgSer: 2.757 ± 0.339
2.517ArgThr: 2.517 ± 0.302
3.477ArgVal: 3.477 ± 0.473
0.599ArgTrp: 0.599 ± 0.153
1.958ArgTyr: 1.958 ± 0.268
0.0ArgXaa: 0.0 ± 0.0
Ser
6.314SerAla: 6.314 ± 0.627
0.759SerCys: 0.759 ± 0.2
4.196SerAsp: 4.196 ± 0.436
4.356SerGlu: 4.356 ± 0.439
3.357SerPhe: 3.357 ± 0.403
5.395SerGly: 5.395 ± 0.656
0.879SerHis: 0.879 ± 0.168
4.635SerIle: 4.635 ± 0.54
4.995SerLys: 4.995 ± 0.456
5.754SerLeu: 5.754 ± 0.487
1.718SerMet: 1.718 ± 0.244
4.196SerAsn: 4.196 ± 0.416
2.118SerPro: 2.118 ± 0.289
2.797SerGln: 2.797 ± 0.363
2.757SerArg: 2.757 ± 0.402
4.835SerSer: 4.835 ± 0.568
4.595SerThr: 4.595 ± 0.481
5.355SerVal: 5.355 ± 0.483
0.799SerTrp: 0.799 ± 0.172
2.597SerTyr: 2.597 ± 0.309
0.0SerXaa: 0.0 ± 0.0
Thr
6.513ThrAla: 6.513 ± 0.692
0.879ThrCys: 0.879 ± 0.171
3.876ThrAsp: 3.876 ± 0.429
3.956ThrGlu: 3.956 ± 0.61
2.877ThrPhe: 2.877 ± 0.348
5.315ThrGly: 5.315 ± 0.598
1.239ThrHis: 1.239 ± 0.219
3.077ThrIle: 3.077 ± 0.334
3.596ThrLys: 3.596 ± 0.391
4.875ThrLeu: 4.875 ± 0.376
1.479ThrMet: 1.479 ± 0.234
2.917ThrAsn: 2.917 ± 0.379
2.677ThrPro: 2.677 ± 0.341
2.358ThrGln: 2.358 ± 0.301
2.318ThrArg: 2.318 ± 0.32
5.035ThrSer: 5.035 ± 0.539
4.875ThrThr: 4.875 ± 0.569
4.515ThrVal: 4.515 ± 0.414
0.959ThrTrp: 0.959 ± 0.252
2.038ThrTyr: 2.038 ± 0.29
0.0ThrXaa: 0.0 ± 0.0
Val
5.674ValAla: 5.674 ± 0.58
0.799ValCys: 0.799 ± 0.168
3.756ValAsp: 3.756 ± 0.448
4.396ValGlu: 4.396 ± 0.467
2.837ValPhe: 2.837 ± 0.336
3.477ValGly: 3.477 ± 0.333
1.399ValHis: 1.399 ± 0.251
3.716ValIle: 3.716 ± 0.46
5.035ValLys: 5.035 ± 0.681
6.513ValLeu: 6.513 ± 0.521
1.319ValMet: 1.319 ± 0.231
3.716ValAsn: 3.716 ± 0.362
2.318ValPro: 2.318 ± 0.287
3.596ValGln: 3.596 ± 0.408
3.157ValArg: 3.157 ± 0.379
5.634ValSer: 5.634 ± 0.603
4.595ValThr: 4.595 ± 0.411
5.754ValVal: 5.754 ± 0.497
0.719ValTrp: 0.719 ± 0.145
3.397ValTyr: 3.397 ± 0.748
0.0ValXaa: 0.0 ± 0.0
Trp
0.959TrpAla: 0.959 ± 0.215
0.44TrpCys: 0.44 ± 0.133
1.039TrpAsp: 1.039 ± 0.193
0.519TrpGlu: 0.519 ± 0.16
0.599TrpPhe: 0.599 ± 0.135
0.639TrpGly: 0.639 ± 0.219
0.4TrpHis: 0.4 ± 0.136
0.559TrpIle: 0.559 ± 0.158
1.039TrpLys: 1.039 ± 0.222
0.879TrpLeu: 0.879 ± 0.189
0.2TrpMet: 0.2 ± 0.079
0.919TrpAsn: 0.919 ± 0.197
0.2TrpPro: 0.2 ± 0.089
0.679TrpGln: 0.679 ± 0.17
0.44TrpArg: 0.44 ± 0.149
0.919TrpSer: 0.919 ± 0.235
0.799TrpThr: 0.799 ± 0.231
1.239TrpVal: 1.239 ± 0.421
0.2TrpTrp: 0.2 ± 0.088
0.639TrpTyr: 0.639 ± 0.182
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.037TyrAla: 3.037 ± 0.357
0.679TyrCys: 0.679 ± 0.174
2.238TyrAsp: 2.238 ± 0.318
2.637TyrGlu: 2.637 ± 0.291
1.518TyrPhe: 1.518 ± 0.237
3.197TyrGly: 3.197 ± 0.673
0.759TyrHis: 0.759 ± 0.191
1.958TyrIle: 1.958 ± 0.242
1.718TyrLys: 1.718 ± 0.243
2.717TyrLeu: 2.717 ± 0.272
1.039TyrMet: 1.039 ± 0.192
2.478TyrAsn: 2.478 ± 0.379
1.039TyrPro: 1.039 ± 0.263
1.479TyrGln: 1.479 ± 0.206
1.998TyrArg: 1.998 ± 0.35
3.117TyrSer: 3.117 ± 0.322
2.797TyrThr: 2.797 ± 0.279
2.597TyrVal: 2.597 ± 0.356
0.799TyrTrp: 0.799 ± 0.167
1.558TyrTyr: 1.558 ± 0.291
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 124 proteins (25026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski