Amino acid dipepetide frequency for Robertkochia marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.469AlaAla: 5.469 ± 0.088
0.589AlaCys: 0.589 ± 0.027
3.913AlaAsp: 3.913 ± 0.064
4.803AlaGlu: 4.803 ± 0.07
3.343AlaPhe: 3.343 ± 0.057
5.21AlaGly: 5.21 ± 0.085
1.279AlaHis: 1.279 ± 0.035
4.919AlaIle: 4.919 ± 0.071
3.748AlaLys: 3.748 ± 0.068
7.236AlaLeu: 7.236 ± 0.094
1.948AlaMet: 1.948 ± 0.05
3.081AlaAsn: 3.081 ± 0.057
2.407AlaPro: 2.407 ± 0.054
2.49AlaGln: 2.49 ± 0.056
2.897AlaArg: 2.897 ± 0.056
4.266AlaSer: 4.266 ± 0.067
3.585AlaThr: 3.585 ± 0.073
4.824AlaVal: 4.824 ± 0.083
0.8AlaTrp: 0.8 ± 0.033
2.746AlaTyr: 2.746 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.456CysAla: 0.456 ± 0.022
0.094CysCys: 0.094 ± 0.009
0.425CysAsp: 0.425 ± 0.024
0.469CysGlu: 0.469 ± 0.023
0.402CysPhe: 0.402 ± 0.019
0.655CysGly: 0.655 ± 0.029
0.173CysHis: 0.173 ± 0.014
0.481CysIle: 0.481 ± 0.023
0.406CysLys: 0.406 ± 0.02
0.635CysLeu: 0.635 ± 0.025
0.158CysMet: 0.158 ± 0.012
0.357CysAsn: 0.357 ± 0.019
0.354CysPro: 0.354 ± 0.023
0.216CysGln: 0.216 ± 0.014
0.255CysArg: 0.255 ± 0.017
0.529CysSer: 0.529 ± 0.029
0.431CysThr: 0.431 ± 0.028
0.417CysVal: 0.417 ± 0.024
0.063CysTrp: 0.063 ± 0.008
0.27CysTyr: 0.27 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.836AspAla: 3.836 ± 0.076
0.39AspCys: 0.39 ± 0.025
3.002AspAsp: 3.002 ± 0.077
3.793AspGlu: 3.793 ± 0.068
3.261AspPhe: 3.261 ± 0.067
3.904AspGly: 3.904 ± 0.087
1.507AspHis: 1.507 ± 0.036
4.004AspIle: 4.004 ± 0.065
3.346AspLys: 3.346 ± 0.063
6.077AspLeu: 6.077 ± 0.088
1.329AspMet: 1.329 ± 0.035
2.617AspAsn: 2.617 ± 0.055
2.699AspPro: 2.699 ± 0.064
2.115AspGln: 2.115 ± 0.043
2.634AspArg: 2.634 ± 0.056
3.017AspSer: 3.017 ± 0.061
2.995AspThr: 2.995 ± 0.057
3.281AspVal: 3.281 ± 0.066
0.717AspTrp: 0.717 ± 0.027
2.594AspTyr: 2.594 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
5.322GluAla: 5.322 ± 0.075
0.331GluCys: 0.331 ± 0.019
3.946GluAsp: 3.946 ± 0.067
6.237GluGlu: 6.237 ± 0.116
3.081GluPhe: 3.081 ± 0.056
4.762GluGly: 4.762 ± 0.065
1.435GluHis: 1.435 ± 0.037
5.101GluIle: 5.101 ± 0.077
5.607GluLys: 5.607 ± 0.104
6.725GluLeu: 6.725 ± 0.091
1.802GluMet: 1.802 ± 0.048
4.239GluAsn: 4.239 ± 0.069
1.975GluPro: 1.975 ± 0.052
2.736GluGln: 2.736 ± 0.051
3.114GluArg: 3.114 ± 0.06
3.403GluSer: 3.403 ± 0.064
3.579GluThr: 3.579 ± 0.059
5.412GluVal: 5.412 ± 0.08
0.743GluTrp: 0.743 ± 0.025
2.515GluTyr: 2.515 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
2.977PheAla: 2.977 ± 0.056
0.393PheCys: 0.393 ± 0.019
3.144PheAsp: 3.144 ± 0.054
3.351PheGlu: 3.351 ± 0.062
2.537PhePhe: 2.537 ± 0.058
3.544PheGly: 3.544 ± 0.066
0.91PheHis: 0.91 ± 0.032
3.375PheIle: 3.375 ± 0.063
3.062PheLys: 3.062 ± 0.057
4.674PheLeu: 4.674 ± 0.086
1.211PheMet: 1.211 ± 0.037
2.866PheAsn: 2.866 ± 0.052
1.789PhePro: 1.789 ± 0.045
1.512PheGln: 1.512 ± 0.036
2.078PheArg: 2.078 ± 0.048
3.597PheSer: 3.597 ± 0.057
2.987PheThr: 2.987 ± 0.069
2.718PheVal: 2.718 ± 0.058
0.612PheTrp: 0.612 ± 0.029
1.975PheTyr: 1.975 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.844GlyAla: 4.844 ± 0.077
0.735GlyCys: 0.735 ± 0.04
3.818GlyAsp: 3.818 ± 0.085
4.477GlyGlu: 4.477 ± 0.07
3.707GlyPhe: 3.707 ± 0.066
5.212GlyGly: 5.212 ± 0.117
1.329GlyHis: 1.329 ± 0.04
5.449GlyIle: 5.449 ± 0.069
4.83GlyLys: 4.83 ± 0.077
6.242GlyLeu: 6.242 ± 0.076
1.985GlyMet: 1.985 ± 0.045
3.518GlyAsn: 3.518 ± 0.075
1.703GlyPro: 1.703 ± 0.045
2.196GlyGln: 2.196 ± 0.048
2.725GlyArg: 2.725 ± 0.059
4.298GlySer: 4.298 ± 0.079
3.945GlyThr: 3.945 ± 0.079
5.149GlyVal: 5.149 ± 0.086
0.873GlyTrp: 0.873 ± 0.031
3.029GlyTyr: 3.029 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.162HisAla: 1.162 ± 0.033
0.209HisCys: 0.209 ± 0.017
0.968HisAsp: 0.968 ± 0.032
1.182HisGlu: 1.182 ± 0.035
1.154HisPhe: 1.154 ± 0.032
1.294HisGly: 1.294 ± 0.041
0.599HisHis: 0.599 ± 0.031
1.342HisIle: 1.342 ± 0.035
1.127HisLys: 1.127 ± 0.035
2.102HisLeu: 2.102 ± 0.048
0.432HisMet: 0.432 ± 0.022
0.893HisAsn: 0.893 ± 0.031
1.219HisPro: 1.219 ± 0.039
0.801HisGln: 0.801 ± 0.03
0.888HisArg: 0.888 ± 0.027
1.083HisSer: 1.083 ± 0.038
0.994HisThr: 0.994 ± 0.034
1.057HisVal: 1.057 ± 0.032
0.266HisTrp: 0.266 ± 0.017
0.881HisTyr: 0.881 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.342IleAla: 5.342 ± 0.083
0.509IleCys: 0.509 ± 0.021
4.278IleAsp: 4.278 ± 0.071
4.668IleGlu: 4.668 ± 0.077
3.11IlePhe: 3.11 ± 0.068
4.545IleGly: 4.545 ± 0.088
1.329IleHis: 1.329 ± 0.039
4.602IleIle: 4.602 ± 0.073
4.374IleLys: 4.374 ± 0.072
6.361IleLeu: 6.361 ± 0.095
1.391IleMet: 1.391 ± 0.034
3.705IleAsn: 3.705 ± 0.073
3.313IlePro: 3.313 ± 0.061
2.14IleGln: 2.14 ± 0.044
3.094IleArg: 3.094 ± 0.06
5.02IleSer: 5.02 ± 0.082
4.36IleThr: 4.36 ± 0.073
3.771IleVal: 3.771 ± 0.068
0.712IleTrp: 0.712 ± 0.027
2.545IleTyr: 2.545 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.881LysAla: 4.881 ± 0.081
0.283LysCys: 0.283 ± 0.016
4.105LysAsp: 4.105 ± 0.061
5.897LysGlu: 5.897 ± 0.101
2.297LysPhe: 2.297 ± 0.048
4.525LysGly: 4.525 ± 0.068
1.222LysHis: 1.222 ± 0.036
4.284LysIle: 4.284 ± 0.072
5.145LysLys: 5.145 ± 0.083
5.254LysLeu: 5.254 ± 0.078
1.756LysMet: 1.756 ± 0.042
3.592LysAsn: 3.592 ± 0.067
2.178LysPro: 2.178 ± 0.05
2.246LysGln: 2.246 ± 0.05
2.843LysArg: 2.843 ± 0.05
3.428LysSer: 3.428 ± 0.06
3.625LysThr: 3.625 ± 0.067
4.312LysVal: 4.312 ± 0.065
0.707LysTrp: 0.707 ± 0.027
2.478LysTyr: 2.478 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
6.254LeuAla: 6.254 ± 0.095
0.666LeuCys: 0.666 ± 0.024
5.269LeuAsp: 5.269 ± 0.087
7.117LeuGlu: 7.117 ± 0.091
4.744LeuPhe: 4.744 ± 0.071
6.39LeuGly: 6.39 ± 0.087
1.826LeuHis: 1.826 ± 0.046
6.51LeuIle: 6.51 ± 0.09
7.173LeuLys: 7.173 ± 0.112
9.499LeuLeu: 9.499 ± 0.139
2.39LeuMet: 2.39 ± 0.051
5.224LeuAsn: 5.224 ± 0.079
4.078LeuPro: 4.078 ± 0.056
3.442LeuGln: 3.442 ± 0.061
4.042LeuArg: 4.042 ± 0.075
6.554LeuSer: 6.554 ± 0.077
5.075LeuThr: 5.075 ± 0.079
5.601LeuVal: 5.601 ± 0.086
0.973LeuTrp: 0.973 ± 0.031
3.292LeuTyr: 3.292 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.077MetAla: 2.077 ± 0.05
0.146MetCys: 0.146 ± 0.012
1.265MetAsp: 1.265 ± 0.036
1.883MetGlu: 1.883 ± 0.046
0.951MetPhe: 0.951 ± 0.039
1.656MetGly: 1.656 ± 0.041
0.477MetHis: 0.477 ± 0.02
1.698MetIle: 1.698 ± 0.046
2.177MetLys: 2.177 ± 0.042
2.171MetLeu: 2.171 ± 0.047
0.651MetMet: 0.651 ± 0.028
1.428MetAsn: 1.428 ± 0.035
0.962MetPro: 0.962 ± 0.03
0.855MetGln: 0.855 ± 0.028
1.085MetArg: 1.085 ± 0.03
1.455MetSer: 1.455 ± 0.036
1.283MetThr: 1.283 ± 0.038
1.667MetVal: 1.667 ± 0.044
0.179MetTrp: 0.179 ± 0.013
0.698MetTyr: 0.698 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.614AsnAla: 3.614 ± 0.067
0.363AsnCys: 0.363 ± 0.021
3.024AsnAsp: 3.024 ± 0.063
3.263AsnGlu: 3.263 ± 0.063
2.542AsnPhe: 2.542 ± 0.056
3.713AsnGly: 3.713 ± 0.085
0.992AsnHis: 0.992 ± 0.032
3.738AsnIle: 3.738 ± 0.071
3.129AsnLys: 3.129 ± 0.058
4.694AsnLeu: 4.694 ± 0.079
1.217AsnMet: 1.217 ± 0.036
2.871AsnAsn: 2.871 ± 0.062
2.624AsnPro: 2.624 ± 0.052
1.756AsnGln: 1.756 ± 0.046
2.369AsnArg: 2.369 ± 0.051
3.099AsnSer: 3.099 ± 0.06
3.344AsnThr: 3.344 ± 0.065
2.816AsnVal: 2.816 ± 0.06
0.689AsnTrp: 0.689 ± 0.03
2.353AsnTyr: 2.353 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
2.537ProAla: 2.537 ± 0.054
0.253ProCys: 0.253 ± 0.016
2.761ProAsp: 2.761 ± 0.054
4.178ProGlu: 4.178 ± 0.067
2.003ProPhe: 2.003 ± 0.042
2.957ProGly: 2.957 ± 0.06
0.726ProHis: 0.726 ± 0.027
2.19ProIle: 2.19 ± 0.053
2.101ProLys: 2.101 ± 0.05
3.442ProLeu: 3.442 ± 0.06
0.915ProMet: 0.915 ± 0.03
1.809ProAsn: 1.809 ± 0.047
1.115ProPro: 1.115 ± 0.036
1.215ProGln: 1.215 ± 0.033
1.249ProArg: 1.249 ± 0.035
2.305ProSer: 2.305 ± 0.047
1.838ProThr: 1.838 ± 0.05
3.214ProVal: 3.214 ± 0.058
0.481ProTrp: 0.481 ± 0.022
1.555ProTyr: 1.555 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.309GlnAla: 2.309 ± 0.055
0.207GlnCys: 0.207 ± 0.017
1.779GlnAsp: 1.779 ± 0.042
2.712GlnGlu: 2.712 ± 0.056
1.555GlnPhe: 1.555 ± 0.042
2.253GlnGly: 2.253 ± 0.051
0.66GlnHis: 0.66 ± 0.025
2.171GlnIle: 2.171 ± 0.046
2.319GlnLys: 2.319 ± 0.056
3.563GlnLeu: 3.563 ± 0.061
0.927GlnMet: 0.927 ± 0.029
1.693GlnAsn: 1.693 ± 0.047
1.389GlnPro: 1.389 ± 0.04
1.521GlnGln: 1.521 ± 0.053
1.541GlnArg: 1.541 ± 0.04
1.743GlnSer: 1.743 ± 0.041
1.737GlnThr: 1.737 ± 0.04
2.194GlnVal: 2.194 ± 0.045
0.461GlnTrp: 0.461 ± 0.02
1.303GlnTyr: 1.303 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.656ArgAla: 2.656 ± 0.051
0.237ArgCys: 0.237 ± 0.014
2.266ArgAsp: 2.266 ± 0.044
3.214ArgGlu: 3.214 ± 0.059
2.33ArgPhe: 2.33 ± 0.054
2.458ArgGly: 2.458 ± 0.057
0.751ArgHis: 0.751 ± 0.028
3.42ArgIle: 3.42 ± 0.054
3.109ArgLys: 3.109 ± 0.058
4.039ArgLeu: 4.039 ± 0.071
1.141ArgMet: 1.141 ± 0.034
2.326ArgAsn: 2.326 ± 0.048
1.392ArgPro: 1.392 ± 0.038
1.303ArgGln: 1.303 ± 0.036
1.731ArgArg: 1.731 ± 0.048
2.818ArgSer: 2.818 ± 0.062
2.169ArgThr: 2.169 ± 0.047
2.821ArgVal: 2.821 ± 0.052
0.517ArgTrp: 0.517 ± 0.022
1.935ArgTyr: 1.935 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
3.958SerAla: 3.958 ± 0.064
0.605SerCys: 0.605 ± 0.025
3.332SerAsp: 3.332 ± 0.063
4.157SerGlu: 4.157 ± 0.069
3.459SerPhe: 3.459 ± 0.058
5.039SerGly: 5.039 ± 0.072
1.026SerHis: 1.026 ± 0.033
4.079SerIle: 4.079 ± 0.077
3.624SerLys: 3.624 ± 0.061
6.101SerLeu: 6.101 ± 0.086
1.512SerMet: 1.512 ± 0.038
3.01SerAsn: 3.01 ± 0.053
2.338SerPro: 2.338 ± 0.047
1.866SerGln: 1.866 ± 0.054
2.695SerArg: 2.695 ± 0.049
3.86SerSer: 3.86 ± 0.065
3.134SerThr: 3.134 ± 0.059
3.993SerVal: 3.993 ± 0.062
0.861SerTrp: 0.861 ± 0.03
2.554SerTyr: 2.554 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.054ThrAla: 4.054 ± 0.083
0.343ThrCys: 0.343 ± 0.025
3.272ThrAsp: 3.272 ± 0.078
3.373ThrGlu: 3.373 ± 0.06
2.613ThrPhe: 2.613 ± 0.056
4.523ThrGly: 4.523 ± 0.065
1.081ThrHis: 1.081 ± 0.028
3.828ThrIle: 3.828 ± 0.069
2.591ThrLys: 2.591 ± 0.056
5.687ThrLeu: 5.687 ± 0.076
1.1ThrMet: 1.1 ± 0.033
2.543ThrAsn: 2.543 ± 0.062
2.947ThrPro: 2.947 ± 0.065
1.683ThrGln: 1.683 ± 0.039
2.194ThrArg: 2.194 ± 0.042
3.407ThrSer: 3.407 ± 0.062
3.16ThrThr: 3.16 ± 0.073
3.553ThrVal: 3.553 ± 0.068
0.721ThrTrp: 0.721 ± 0.025
2.365ThrTyr: 2.365 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.53ValAla: 4.53 ± 0.07
0.491ValCys: 0.491 ± 0.022
3.534ValAsp: 3.534 ± 0.064
3.991ValGlu: 3.991 ± 0.064
3.352ValPhe: 3.352 ± 0.059
3.863ValGly: 3.863 ± 0.069
1.137ValHis: 1.137 ± 0.029
4.974ValIle: 4.974 ± 0.073
4.051ValLys: 4.051 ± 0.066
6.295ValLeu: 6.295 ± 0.08
1.68ValMet: 1.68 ± 0.04
3.55ValAsn: 3.55 ± 0.063
2.418ValPro: 2.418 ± 0.048
1.928ValGln: 1.928 ± 0.044
2.542ValArg: 2.542 ± 0.052
4.274ValSer: 4.274 ± 0.066
3.788ValThr: 3.788 ± 0.083
4.607ValVal: 4.607 ± 0.085
0.65ValTrp: 0.65 ± 0.026
2.579ValTyr: 2.579 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.69TrpAla: 0.69 ± 0.031
0.106TrpCys: 0.106 ± 0.011
0.685TrpAsp: 0.685 ± 0.027
0.823TrpGlu: 0.823 ± 0.031
0.622TrpPhe: 0.622 ± 0.023
0.766TrpGly: 0.766 ± 0.031
0.251TrpHis: 0.251 ± 0.015
0.744TrpIle: 0.744 ± 0.029
0.779TrpLys: 0.779 ± 0.027
1.141TrpLeu: 1.141 ± 0.039
0.38TrpMet: 0.38 ± 0.021
0.733TrpAsn: 0.733 ± 0.031
0.322TrpPro: 0.322 ± 0.02
0.452TrpGln: 0.452 ± 0.022
0.501TrpArg: 0.501 ± 0.022
0.699TrpSer: 0.699 ± 0.025
0.588TrpThr: 0.588 ± 0.024
0.734TrpVal: 0.734 ± 0.03
0.164TrpTrp: 0.164 ± 0.014
0.525TrpTyr: 0.525 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.589TyrAla: 2.589 ± 0.054
0.298TyrCys: 0.298 ± 0.016
2.328TyrAsp: 2.328 ± 0.051
2.476TyrGlu: 2.476 ± 0.052
2.252TyrPhe: 2.252 ± 0.05
2.798TyrGly: 2.798 ± 0.051
0.943TyrHis: 0.943 ± 0.031
2.262TyrIle: 2.262 ± 0.046
2.358TyrLys: 2.358 ± 0.049
4.178TyrLeu: 4.178 ± 0.067
0.837TyrMet: 0.837 ± 0.028
2.157TyrAsn: 2.157 ± 0.047
1.624TyrPro: 1.624 ± 0.044
1.563TyrGln: 1.563 ± 0.043
2.155TyrArg: 2.155 ± 0.049
2.346TyrSer: 2.346 ± 0.049
2.419TyrThr: 2.419 ± 0.059
2.093TyrVal: 2.093 ± 0.046
0.515TyrTrp: 0.515 ± 0.024
1.791TyrTyr: 1.791 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2974 proteins (1049829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski