Amino acid dipepetide frequency for Salix brachista

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.179AlaAla: 6.179 ± 0.032
1.342AlaCys: 1.342 ± 0.012
3.111AlaAsp: 3.111 ± 0.017
4.177AlaGlu: 4.177 ± 0.023
2.779AlaPhe: 2.779 ± 0.015
4.322AlaGly: 4.322 ± 0.021
1.294AlaHis: 1.294 ± 0.009
3.745AlaIle: 3.745 ± 0.018
3.778AlaLys: 3.778 ± 0.021
6.564AlaLeu: 6.564 ± 0.03
1.874AlaMet: 1.874 ± 0.011
2.571AlaAsn: 2.571 ± 0.015
2.804AlaPro: 2.804 ± 0.018
2.092AlaGln: 2.092 ± 0.014
3.489AlaArg: 3.489 ± 0.018
6.178AlaSer: 6.178 ± 0.024
3.596AlaThr: 3.596 ± 0.018
4.78AlaVal: 4.78 ± 0.022
0.798AlaTrp: 0.798 ± 0.009
1.799AlaTyr: 1.799 ± 0.013
0.0AlaXaa: 0.0 ± 0.0
Cys
1.025CysAla: 1.025 ± 0.01
0.556CysCys: 0.556 ± 0.007
0.885CysAsp: 0.885 ± 0.009
0.918CysGlu: 0.918 ± 0.009
0.962CysPhe: 0.962 ± 0.008
1.419CysGly: 1.419 ± 0.013
0.497CysHis: 0.497 ± 0.007
1.009CysIle: 1.009 ± 0.009
1.189CysLys: 1.189 ± 0.011
1.988CysLeu: 1.988 ± 0.015
0.464CysMet: 0.464 ± 0.005
0.894CysAsn: 0.894 ± 0.01
0.941CysPro: 0.941 ± 0.009
0.645CysGln: 0.645 ± 0.006
1.078CysArg: 1.078 ± 0.01
1.943CysSer: 1.943 ± 0.015
0.885CysThr: 0.885 ± 0.008
1.09CysVal: 1.09 ± 0.01
0.258CysTrp: 0.258 ± 0.004
0.591CysTyr: 0.591 ± 0.007
0.0CysXaa: 0.0 ± 0.0
Asp
3.405AspAla: 3.405 ± 0.019
1.007AspCys: 1.007 ± 0.01
3.493AspAsp: 3.493 ± 0.02
3.881AspGlu: 3.881 ± 0.021
2.411AspPhe: 2.411 ± 0.013
3.883AspGly: 3.883 ± 0.02
1.303AspHis: 1.303 ± 0.012
2.875AspIle: 2.875 ± 0.014
2.69AspLys: 2.69 ± 0.015
5.105AspLeu: 5.105 ± 0.024
1.345AspMet: 1.345 ± 0.011
2.033AspAsn: 2.033 ± 0.012
2.602AspPro: 2.602 ± 0.017
1.816AspGln: 1.816 ± 0.013
2.465AspArg: 2.465 ± 0.016
4.404AspSer: 4.404 ± 0.022
2.167AspThr: 2.167 ± 0.012
3.475AspVal: 3.475 ± 0.019
0.717AspTrp: 0.717 ± 0.008
1.535AspTyr: 1.535 ± 0.011
0.0AspXaa: 0.0 ± 0.0
Glu
4.672GluAla: 4.672 ± 0.025
0.888GluCys: 0.888 ± 0.009
3.877GluAsp: 3.877 ± 0.02
6.147GluGlu: 6.147 ± 0.036
2.371GluPhe: 2.371 ± 0.014
3.741GluGly: 3.741 ± 0.018
1.229GluHis: 1.229 ± 0.011
3.799GluIle: 3.799 ± 0.018
4.822GluLys: 4.822 ± 0.03
5.897GluLeu: 5.897 ± 0.027
1.884GluMet: 1.884 ± 0.016
3.183GluAsn: 3.183 ± 0.018
2.107GluPro: 2.107 ± 0.014
2.107GluGln: 2.107 ± 0.016
3.418GluArg: 3.418 ± 0.021
4.711GluSer: 4.711 ± 0.023
3.121GluThr: 3.121 ± 0.017
4.131GluVal: 4.131 ± 0.023
0.752GluTrp: 0.752 ± 0.007
1.542GluTyr: 1.542 ± 0.012
0.0GluXaa: 0.0 ± 0.0
Phe
2.5PheAla: 2.5 ± 0.016
0.996PheCys: 0.996 ± 0.01
2.393PheAsp: 2.393 ± 0.014
2.349PheGlu: 2.349 ± 0.014
2.052PhePhe: 2.052 ± 0.014
2.992PheGly: 2.992 ± 0.016
1.162PheHis: 1.162 ± 0.009
2.127PheIle: 2.127 ± 0.014
2.172PheLys: 2.172 ± 0.012
4.556PheLeu: 4.556 ± 0.021
0.991PheMet: 0.991 ± 0.01
1.808PheAsn: 1.808 ± 0.014
2.137PhePro: 2.137 ± 0.015
1.631PheGln: 1.631 ± 0.011
2.014PheArg: 2.014 ± 0.015
4.262PheSer: 4.262 ± 0.02
2.024PheThr: 2.024 ± 0.015
2.77PheVal: 2.77 ± 0.016
0.576PheTrp: 0.576 ± 0.006
1.29PheTyr: 1.29 ± 0.011
0.0PheXaa: 0.0 ± 0.0
Gly
3.928GlyAla: 3.928 ± 0.023
1.328GlyCys: 1.328 ± 0.012
3.451GlyAsp: 3.451 ± 0.016
3.734GlyGlu: 3.734 ± 0.019
3.306GlyPhe: 3.306 ± 0.02
5.427GlyGly: 5.427 ± 0.043
1.562GlyHis: 1.562 ± 0.011
3.61GlyIle: 3.61 ± 0.02
4.154GlyLys: 4.154 ± 0.019
6.05GlyLeu: 6.05 ± 0.023
1.589GlyMet: 1.589 ± 0.013
3.205GlyAsn: 3.205 ± 0.017
2.412GlyPro: 2.412 ± 0.015
2.121GlyGln: 2.121 ± 0.015
3.57GlyArg: 3.57 ± 0.019
6.146GlySer: 6.146 ± 0.026
3.188GlyThr: 3.188 ± 0.018
4.196GlyVal: 4.196 ± 0.019
0.895GlyTrp: 0.895 ± 0.01
2.058GlyTyr: 2.058 ± 0.016
0.0GlyXaa: 0.0 ± 0.0
His
1.476HisAla: 1.476 ± 0.011
0.527HisCys: 0.527 ± 0.007
1.149HisAsp: 1.149 ± 0.01
1.314HisGlu: 1.314 ± 0.011
1.089HisPhe: 1.089 ± 0.009
1.83HisGly: 1.83 ± 0.013
0.921HisHis: 0.921 ± 0.011
1.179HisIle: 1.179 ± 0.009
1.148HisLys: 1.148 ± 0.009
2.433HisLeu: 2.433 ± 0.016
0.538HisMet: 0.538 ± 0.006
0.941HisAsn: 0.941 ± 0.009
1.348HisPro: 1.348 ± 0.012
1.049HisGln: 1.049 ± 0.01
1.339HisArg: 1.339 ± 0.01
1.995HisSer: 1.995 ± 0.013
0.941HisThr: 0.941 ± 0.009
1.557HisVal: 1.557 ± 0.011
0.302HisTrp: 0.302 ± 0.005
0.708HisTyr: 0.708 ± 0.008
0.0HisXaa: 0.0 ± 0.0
Ile
3.573IleAla: 3.573 ± 0.017
1.13IleCys: 1.13 ± 0.011
2.859IleAsp: 2.859 ± 0.017
3.172IleGlu: 3.172 ± 0.017
2.314IlePhe: 2.314 ± 0.015
3.299IleGly: 3.299 ± 0.016
1.307IleHis: 1.307 ± 0.011
2.733IleIle: 2.733 ± 0.014
2.902IleLys: 2.902 ± 0.015
5.253IleLeu: 5.253 ± 0.023
1.171IleMet: 1.171 ± 0.009
2.203IleAsn: 2.203 ± 0.014
2.961IlePro: 2.961 ± 0.02
1.973IleGln: 1.973 ± 0.012
2.576IleArg: 2.576 ± 0.016
5.03IleSer: 5.03 ± 0.019
2.613IleThr: 2.613 ± 0.014
3.35IleVal: 3.35 ± 0.017
0.701IleTrp: 0.701 ± 0.008
1.495IleTyr: 1.495 ± 0.012
0.0IleXaa: 0.0 ± 0.0
Lys
3.994LysAla: 3.994 ± 0.02
0.983LysCys: 0.983 ± 0.01
3.207LysAsp: 3.207 ± 0.018
4.583LysGlu: 4.583 ± 0.028
2.164LysPhe: 2.164 ± 0.015
3.625LysGly: 3.625 ± 0.019
1.351LysHis: 1.351 ± 0.011
3.227LysIle: 3.227 ± 0.016
4.696LysLys: 4.696 ± 0.028
5.962LysLeu: 5.962 ± 0.025
1.558LysMet: 1.558 ± 0.011
2.731LysAsn: 2.731 ± 0.015
2.829LysPro: 2.829 ± 0.018
2.307LysGln: 2.307 ± 0.014
3.589LysArg: 3.589 ± 0.019
4.696LysSer: 4.696 ± 0.022
2.957LysThr: 2.957 ± 0.015
3.837LysVal: 3.837 ± 0.021
0.819LysTrp: 0.819 ± 0.009
1.54LysTyr: 1.54 ± 0.011
0.0LysXaa: 0.0 ± 0.0
Leu
6.588LeuAla: 6.588 ± 0.024
1.923LeuCys: 1.923 ± 0.013
5.133LeuAsp: 5.133 ± 0.02
6.327LeuGlu: 6.327 ± 0.028
4.002LeuPhe: 4.002 ± 0.018
5.798LeuGly: 5.798 ± 0.024
2.579LeuHis: 2.579 ± 0.014
4.679LeuIle: 4.679 ± 0.022
6.223LeuLys: 6.223 ± 0.03
10.126LeuLeu: 10.126 ± 0.043
2.2LeuMet: 2.2 ± 0.015
4.064LeuAsn: 4.064 ± 0.023
5.144LeuPro: 5.144 ± 0.024
4.319LeuGln: 4.319 ± 0.023
5.226LeuArg: 5.226 ± 0.021
8.925LeuSer: 8.925 ± 0.039
4.441LeuThr: 4.441 ± 0.02
6.433LeuVal: 6.433 ± 0.025
1.19LeuTrp: 1.19 ± 0.011
2.522LeuTyr: 2.522 ± 0.015
0.0LeuXaa: 0.0 ± 0.0
Met
2.138MetAla: 2.138 ± 0.013
0.319MetCys: 0.319 ± 0.005
1.482MetAsp: 1.482 ± 0.012
2.088MetGlu: 2.088 ± 0.014
0.858MetPhe: 0.858 ± 0.008
1.648MetGly: 1.648 ± 0.011
0.554MetHis: 0.554 ± 0.007
1.275MetIle: 1.275 ± 0.009
1.665MetLys: 1.665 ± 0.011
2.245MetLeu: 2.245 ± 0.014
0.685MetMet: 0.685 ± 0.009
1.065MetAsn: 1.065 ± 0.01
1.087MetPro: 1.087 ± 0.011
0.958MetGln: 0.958 ± 0.009
1.197MetArg: 1.197 ± 0.01
1.804MetSer: 1.804 ± 0.011
1.027MetThr: 1.027 ± 0.009
1.706MetVal: 1.706 ± 0.011
0.26MetTrp: 0.26 ± 0.005
0.578MetTyr: 0.578 ± 0.007
0.0MetXaa: 0.0 ± 0.0
Asn
2.681AsnAla: 2.681 ± 0.016
0.904AsnCys: 0.904 ± 0.009
2.11AsnAsp: 2.11 ± 0.014
2.519AsnGlu: 2.519 ± 0.014
1.922AsnPhe: 1.922 ± 0.013
3.376AsnGly: 3.376 ± 0.02
1.164AsnHis: 1.164 ± 0.009
2.371AsnIle: 2.371 ± 0.014
2.379AsnLys: 2.379 ± 0.013
4.646AsnLeu: 4.646 ± 0.026
1.096AsnMet: 1.096 ± 0.009
2.219AsnAsn: 2.219 ± 0.015
2.423AsnPro: 2.423 ± 0.016
1.783AsnGln: 1.783 ± 0.013
2.036AsnArg: 2.036 ± 0.012
4.114AsnSer: 4.114 ± 0.022
1.959AsnThr: 1.959 ± 0.014
2.754AsnVal: 2.754 ± 0.017
0.567AsnTrp: 0.567 ± 0.007
1.29AsnTyr: 1.29 ± 0.011
0.0AsnXaa: 0.0 ± 0.0
Pro
3.165ProAla: 3.165 ± 0.02
0.838ProCys: 0.838 ± 0.008
2.517ProAsp: 2.517 ± 0.017
3.055ProGlu: 3.055 ± 0.017
2.087ProPhe: 2.087 ± 0.014
2.845ProGly: 2.845 ± 0.016
1.058ProHis: 1.058 ± 0.009
2.261ProIle: 2.261 ± 0.014
2.605ProLys: 2.605 ± 0.016
4.365ProLeu: 4.365 ± 0.019
0.958ProMet: 0.958 ± 0.009
2.17ProAsn: 2.17 ± 0.016
3.957ProPro: 3.957 ± 0.061
1.819ProGln: 1.819 ± 0.014
2.398ProArg: 2.398 ± 0.016
5.227ProSer: 5.227 ± 0.029
2.526ProThr: 2.526 ± 0.017
3.206ProVal: 3.206 ± 0.019
0.615ProTrp: 0.615 ± 0.007
1.329ProTyr: 1.329 ± 0.015
0.0ProXaa: 0.0 ± 0.0
Gln
2.444GlnAla: 2.444 ± 0.017
0.603GlnCys: 0.603 ± 0.007
1.71GlnAsp: 1.71 ± 0.014
2.5GlnGlu: 2.5 ± 0.015
1.413GlnPhe: 1.413 ± 0.01
2.142GlnGly: 2.142 ± 0.014
0.916GlnHis: 0.916 ± 0.009
2.006GlnIle: 2.006 ± 0.014
2.356GlnLys: 2.356 ± 0.016
3.62GlnLeu: 3.62 ± 0.019
0.978GlnMet: 0.978 ± 0.01
1.894GlnAsn: 1.894 ± 0.013
1.792GlnPro: 1.792 ± 0.014
2.11GlnGln: 2.11 ± 0.028
2.04GlnArg: 2.04 ± 0.012
2.881GlnSer: 2.881 ± 0.018
1.735GlnThr: 1.735 ± 0.012
2.362GlnVal: 2.362 ± 0.014
0.459GlnTrp: 0.459 ± 0.006
0.942GlnTyr: 0.942 ± 0.01
0.0GlnXaa: 0.0 ± 0.0
Arg
3.261ArgAla: 3.261 ± 0.017
0.983ArgCys: 0.983 ± 0.009
2.63ArgAsp: 2.63 ± 0.016
3.413ArgGlu: 3.413 ± 0.02
2.238ArgPhe: 2.238 ± 0.014
3.219ArgGly: 3.219 ± 0.021
1.242ArgHis: 1.242 ± 0.01
2.872ArgIle: 2.872 ± 0.016
3.838ArgLys: 3.838 ± 0.019
4.927ArgLeu: 4.927 ± 0.021
1.327ArgMet: 1.327 ± 0.01
2.511ArgAsn: 2.511 ± 0.014
2.278ArgPro: 2.278 ± 0.014
1.865ArgGln: 1.865 ± 0.011
3.759ArgArg: 3.759 ± 0.025
4.372ArgSer: 4.372 ± 0.022
2.389ArgThr: 2.389 ± 0.014
3.317ArgVal: 3.317 ± 0.021
0.729ArgTrp: 0.729 ± 0.008
1.398ArgTyr: 1.398 ± 0.009
0.0ArgXaa: 0.0 ± 0.0
Ser
5.486SerAla: 5.486 ± 0.021
1.872SerCys: 1.872 ± 0.015
4.454SerAsp: 4.454 ± 0.02
4.788SerGlu: 4.788 ± 0.023
4.139SerPhe: 4.139 ± 0.017
6.089SerGly: 6.089 ± 0.026
2.087SerHis: 2.087 ± 0.013
4.668SerIle: 4.668 ± 0.02
5.05SerLys: 5.05 ± 0.022
9.153SerLeu: 9.153 ± 0.037
2.212SerMet: 2.212 ± 0.015
4.206SerAsn: 4.206 ± 0.023
4.713SerPro: 4.713 ± 0.033
3.084SerGln: 3.084 ± 0.018
4.599SerArg: 4.599 ± 0.021
11.306SerSer: 11.306 ± 0.045
4.868SerThr: 4.868 ± 0.022
5.342SerVal: 5.342 ± 0.021
1.187SerTrp: 1.187 ± 0.011
2.368SerTyr: 2.368 ± 0.015
0.0SerXaa: 0.0 ± 0.0
Thr
3.469ThrAla: 3.469 ± 0.018
0.961ThrCys: 0.961 ± 0.009
2.295ThrAsp: 2.295 ± 0.012
2.81ThrGlu: 2.81 ± 0.016
2.027ThrPhe: 2.027 ± 0.013
3.407ThrGly: 3.407 ± 0.02
1.014ThrHis: 1.014 ± 0.008
2.644ThrIle: 2.644 ± 0.015
2.601ThrLys: 2.601 ± 0.016
4.566ThrLeu: 4.566 ± 0.023
1.164ThrMet: 1.164 ± 0.01
2.01ThrAsn: 2.01 ± 0.011
2.593ThrPro: 2.593 ± 0.016
1.526ThrGln: 1.526 ± 0.012
2.457ThrArg: 2.457 ± 0.013
4.688ThrSer: 4.688 ± 0.02
2.92ThrThr: 2.92 ± 0.019
3.347ThrVal: 3.347 ± 0.019
0.645ThrTrp: 0.645 ± 0.007
1.319ThrTyr: 1.319 ± 0.01
0.0ThrXaa: 0.0 ± 0.0
Val
4.786ValAla: 4.786 ± 0.021
1.194ValCys: 1.194 ± 0.009
3.661ValAsp: 3.661 ± 0.019
4.333ValGlu: 4.333 ± 0.022
2.824ValPhe: 2.824 ± 0.016
4.034ValGly: 4.034 ± 0.021
1.513ValHis: 1.513 ± 0.011
3.401ValIle: 3.401 ± 0.018
3.9ValLys: 3.9 ± 0.02
6.428ValLeu: 6.428 ± 0.021
1.53ValMet: 1.53 ± 0.011
2.613ValAsn: 2.613 ± 0.015
3.12ValPro: 3.12 ± 0.019
2.276ValGln: 2.276 ± 0.013
3.037ValArg: 3.037 ± 0.017
5.651ValSer: 5.651 ± 0.023
3.184ValThr: 3.184 ± 0.015
4.783ValVal: 4.783 ± 0.024
0.785ValTrp: 0.785 ± 0.009
1.888ValTyr: 1.888 ± 0.012
0.0ValXaa: 0.0 ± 0.0
Trp
0.762TrpAla: 0.762 ± 0.008
0.241TrpCys: 0.241 ± 0.005
0.713TrpAsp: 0.713 ± 0.009
0.76TrpGlu: 0.76 ± 0.009
0.551TrpPhe: 0.551 ± 0.007
0.747TrpGly: 0.747 ± 0.008
0.312TrpHis: 0.312 ± 0.005
0.732TrpIle: 0.732 ± 0.008
0.978TrpLys: 0.978 ± 0.009
1.246TrpLeu: 1.246 ± 0.009
0.354TrpMet: 0.354 ± 0.005
0.726TrpAsn: 0.726 ± 0.008
0.496TrpPro: 0.496 ± 0.006
0.457TrpGln: 0.457 ± 0.006
0.81TrpArg: 0.81 ± 0.008
0.995TrpSer: 0.995 ± 0.01
0.642TrpThr: 0.642 ± 0.008
0.801TrpVal: 0.801 ± 0.008
0.237TrpTrp: 0.237 ± 0.004
0.334TrpTyr: 0.334 ± 0.005
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.742TyrAla: 1.742 ± 0.014
0.641TyrCys: 0.641 ± 0.007
1.481TyrAsp: 1.481 ± 0.011
1.531TyrGlu: 1.531 ± 0.012
1.293TyrPhe: 1.293 ± 0.011
2.089TyrGly: 2.089 ± 0.017
0.721TyrHis: 0.721 ± 0.009
1.401TyrIle: 1.401 ± 0.011
1.509TyrLys: 1.509 ± 0.013
2.711TyrLeu: 2.711 ± 0.016
0.722TyrMet: 0.722 ± 0.008
1.267TyrAsn: 1.267 ± 0.011
1.253TyrPro: 1.253 ± 0.011
0.962TyrGln: 0.962 ± 0.008
1.471TyrArg: 1.471 ± 0.01
2.342TyrSer: 2.342 ± 0.015
1.282TyrThr: 1.282 ± 0.01
1.704TyrVal: 1.704 ± 0.012
0.402TyrTrp: 0.402 ± 0.005
0.935TyrTyr: 0.935 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 29803 proteins (13053624 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski