Amino acid dipepetide frequency for Candidatus Syntrophoarchaeum caldarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.723AlaAla: 5.723 ± 0.147	1.077AlaCys: 1.077 ± 0.054	4.182AlaAsp: 4.182 ± 0.097	4.907AlaGlu: 4.907 ± 0.109	2.897AlaPhe: 2.897 ± 0.08	6.099AlaGly: 6.099 ± 0.14	1.316AlaHis: 1.316 ± 0.047	6.671AlaIle: 6.671 ± 0.12	4.168AlaLys: 4.168 ± 0.098	6.801AlaLeu: 6.801 ± 0.148	2.047AlaMet: 2.047 ± 0.072	2.254AlaAsn: 2.254 ± 0.063	2.219AlaPro: 2.219 ± 0.073	1.216AlaGln: 1.216 ± 0.052	3.763AlaArg: 3.763 ± 0.094	4.662AlaSer: 4.662 ± 0.089	3.866AlaThr: 3.866 ± 0.117	5.637AlaVal: 5.637 ± 0.123	0.621AlaTrp: 0.621 ± 0.036	2.145AlaTyr: 2.145 ± 0.066	0.002AlaXaa: 0.002 ± 0.002
Cys	0.758CysAla: 0.758 ± 0.041	0.215CysCys: 0.215 ± 0.026	0.785CysAsp: 0.785 ± 0.037	1.005CysGlu: 1.005 ± 0.051	0.39CysPhe: 0.39 ± 0.027	1.506CysGly: 1.506 ± 0.063	0.396CysHis: 0.396 ± 0.056	0.942CysIle: 0.942 ± 0.05	0.562CysLys: 0.562 ± 0.037	0.727CysLeu: 0.727 ± 0.034	0.345CysMet: 0.345 ± 0.025	0.482CysAsn: 0.482 ± 0.034	0.768CysPro: 0.768 ± 0.046	0.219CysGln: 0.219 ± 0.023	0.668CysArg: 0.668 ± 0.037	0.721CysSer: 0.721 ± 0.036	0.693CysThr: 0.693 ± 0.039	0.785CysVal: 0.785 ± 0.037	0.086CysTrp: 0.086 ± 0.014	0.409CysTyr: 0.409 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	5.069AspAla: 5.069 ± 0.105	0.725AspCys: 0.725 ± 0.037	3.559AspAsp: 3.559 ± 0.105	5.939AspGlu: 5.939 ± 0.126	2.27AspPhe: 2.27 ± 0.085	4.852AspGly: 4.852 ± 0.129	1.14AspHis: 1.14 ± 0.047	5.057AspIle: 5.057 ± 0.094	2.856AspLys: 2.856 ± 0.078	6.967AspLeu: 6.967 ± 0.106	1.508AspMet: 1.508 ± 0.059	1.606AspAsn: 1.606 ± 0.066	3.31AspPro: 3.31 ± 0.083	1.105AspGln: 1.105 ± 0.047	3.32AspArg: 3.32 ± 0.084	2.605AspSer: 2.605 ± 0.081	2.864AspThr: 2.864 ± 0.094	4.67AspVal: 4.67 ± 0.111	0.642AspTrp: 0.642 ± 0.038	1.986AspTyr: 1.986 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.625GluAla: 5.625 ± 0.11	0.778GluCys: 0.778 ± 0.043	4.742GluAsp: 4.742 ± 0.099	7.239GluGlu: 7.239 ± 0.149	2.999GluPhe: 2.999 ± 0.081	5.416GluGly: 5.416 ± 0.105	1.365GluHis: 1.365 ± 0.052	7.856GluIle: 7.856 ± 0.14	5.398GluLys: 5.398 ± 0.118	7.821GluLeu: 7.821 ± 0.166	2.376GluMet: 2.376 ± 0.071	3.016GluAsn: 3.016 ± 0.087	2.266GluPro: 2.266 ± 0.067	1.373GluGln: 1.373 ± 0.056	5.065GluArg: 5.065 ± 0.119	3.676GluSer: 3.676 ± 0.086	3.453GluThr: 3.453 ± 0.092	6.432GluVal: 6.432 ± 0.117	0.776GluTrp: 0.776 ± 0.044	2.523GluTyr: 2.523 ± 0.082	0.0GluXaa: 0.0 ± 0.0
Phe	2.781PheAla: 2.781 ± 0.08	0.458PheCys: 0.458 ± 0.028	2.993PheAsp: 2.993 ± 0.089	3.271PheGlu: 3.271 ± 0.089	1.589PhePhe: 1.589 ± 0.071	3.206PheGly: 3.206 ± 0.084	0.642PheHis: 0.642 ± 0.032	3.101PheIle: 3.101 ± 0.091	2.066PheLys: 2.066 ± 0.063	3.663PheLeu: 3.663 ± 0.106	1.022PheMet: 1.022 ± 0.045	1.469PheAsn: 1.469 ± 0.054	1.33PhePro: 1.33 ± 0.058	0.672PheGln: 0.672 ± 0.039	2.002PheArg: 2.002 ± 0.064	2.239PheSer: 2.239 ± 0.067	2.202PheThr: 2.202 ± 0.079	2.701PheVal: 2.701 ± 0.082	0.317PheTrp: 0.317 ± 0.028	1.346PheTyr: 1.346 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	5.459GlyAla: 5.459 ± 0.125	1.271GlyCys: 1.271 ± 0.059	4.673GlyAsp: 4.673 ± 0.143	5.759GlyGlu: 5.759 ± 0.119	3.267GlyPhe: 3.267 ± 0.1	6.229GlyGly: 6.229 ± 0.12	1.248GlyHis: 1.248 ± 0.051	7.429GlyIle: 7.429 ± 0.143	4.795GlyLys: 4.795 ± 0.103	6.19GlyLeu: 6.19 ± 0.129	2.421GlyMet: 2.421 ± 0.075	2.45GlyAsn: 2.45 ± 0.083	1.69GlyPro: 1.69 ± 0.061	1.058GlyGln: 1.058 ± 0.049	3.876GlyArg: 3.876 ± 0.104	4.722GlySer: 4.722 ± 0.117	3.865GlyThr: 3.865 ± 0.115	6.662GlyVal: 6.662 ± 0.136	0.877GlyTrp: 0.877 ± 0.042	2.967GlyTyr: 2.967 ± 0.091	0.0GlyXaa: 0.0 ± 0.0
His	1.387HisAla: 1.387 ± 0.052	0.272HisCys: 0.272 ± 0.025	1.087HisAsp: 1.087 ± 0.041	1.16HisGlu: 1.16 ± 0.048	0.686HisPhe: 0.686 ± 0.034	1.504HisGly: 1.504 ± 0.062	0.46HisHis: 0.46 ± 0.035	1.465HisIle: 1.465 ± 0.052	0.707HisLys: 0.707 ± 0.035	1.82HisLeu: 1.82 ± 0.06	0.329HisMet: 0.329 ± 0.027	0.611HisAsn: 0.611 ± 0.039	1.187HisPro: 1.187 ± 0.056	0.405HisGln: 0.405 ± 0.029	1.06HisArg: 1.06 ± 0.052	0.934HisSer: 0.934 ± 0.043	0.981HisThr: 0.981 ± 0.042	1.038HisVal: 1.038 ± 0.044	0.137HisTrp: 0.137 ± 0.015	0.537HisTyr: 0.537 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	7.016IleAla: 7.016 ± 0.142	0.97IleCys: 0.97 ± 0.047	5.79IleAsp: 5.79 ± 0.112	7.905IleGlu: 7.905 ± 0.132	3.604IlePhe: 3.604 ± 0.089	6.475IleGly: 6.475 ± 0.123	1.41IleHis: 1.41 ± 0.055	6.246IleIle: 6.246 ± 0.142	4.936IleLys: 4.936 ± 0.103	8.232IleLeu: 8.232 ± 0.166	1.822IleMet: 1.822 ± 0.065	2.985IleAsn: 2.985 ± 0.078	3.874IlePro: 3.874 ± 0.091	1.733IleGln: 1.733 ± 0.056	4.564IleArg: 4.564 ± 0.11	5.355IleSer: 5.355 ± 0.101	4.981IleThr: 4.981 ± 0.106	5.684IleVal: 5.684 ± 0.107	0.654IleTrp: 0.654 ± 0.038	2.703IleTyr: 2.703 ± 0.079	0.0IleXaa: 0.0 ± 0.0
Lys	3.722LysAla: 3.722 ± 0.096	0.57LysCys: 0.57 ± 0.036	3.445LysAsp: 3.445 ± 0.088	5.243LysGlu: 5.243 ± 0.116	1.808LysPhe: 1.808 ± 0.066	3.98LysGly: 3.98 ± 0.101	0.995LysHis: 0.995 ± 0.044	5.428LysIle: 5.428 ± 0.104	4.568LysLys: 4.568 ± 0.122	5.112LysLeu: 5.112 ± 0.1	1.618LysMet: 1.618 ± 0.066	2.493LysAsn: 2.493 ± 0.074	2.135LysPro: 2.135 ± 0.069	1.295LysGln: 1.295 ± 0.055	3.857LysArg: 3.857 ± 0.108	3.069LysSer: 3.069 ± 0.078	2.856LysThr: 2.856 ± 0.082	4.166LysVal: 4.166 ± 0.089	0.531LysTrp: 0.531 ± 0.033	1.769LysTyr: 1.769 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	6.595LeuAla: 6.595 ± 0.131	0.981LeuCys: 0.981 ± 0.053	6.162LeuAsp: 6.162 ± 0.121	7.275LeuGlu: 7.275 ± 0.133	3.751LeuPhe: 3.751 ± 0.116	6.626LeuGly: 6.626 ± 0.123	1.545LeuHis: 1.545 ± 0.052	7.684LeuIle: 7.684 ± 0.159	6.734LeuLys: 6.734 ± 0.15	9.018LeuLeu: 9.018 ± 0.179	2.497LeuMet: 2.497 ± 0.072	3.618LeuAsn: 3.618 ± 0.094	3.706LeuPro: 3.706 ± 0.09	1.831LeuGln: 1.831 ± 0.066	4.944LeuArg: 4.944 ± 0.101	6.109LeuSer: 6.109 ± 0.127	4.905LeuThr: 4.905 ± 0.099	5.847LeuVal: 5.847 ± 0.135	0.662LeuTrp: 0.662 ± 0.039	2.632LeuTyr: 2.632 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	1.98MetAla: 1.98 ± 0.067	0.243MetCys: 0.243 ± 0.024	1.598MetAsp: 1.598 ± 0.054	1.912MetGlu: 1.912 ± 0.066	0.58MetPhe: 0.58 ± 0.035	2.078MetGly: 2.078 ± 0.058	0.519MetHis: 0.519 ± 0.03	2.521MetIle: 2.521 ± 0.063	1.98MetLys: 1.98 ± 0.066	2.335MetLeu: 2.335 ± 0.072	0.901MetMet: 0.901 ± 0.04	1.091MetAsn: 1.091 ± 0.047	1.066MetPro: 1.066 ± 0.052	0.731MetGln: 0.731 ± 0.039	1.837MetArg: 1.837 ± 0.06	1.306MetSer: 1.306 ± 0.05	1.34MetThr: 1.34 ± 0.055	1.986MetVal: 1.986 ± 0.066	0.18MetTrp: 0.18 ± 0.018	0.613MetTyr: 0.613 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	2.589AsnAla: 2.589 ± 0.07	0.462AsnCys: 0.462 ± 0.034	1.741AsnAsp: 1.741 ± 0.065	2.507AsnGlu: 2.507 ± 0.089	1.516AsnPhe: 1.516 ± 0.062	2.576AsnGly: 2.576 ± 0.104	0.605AsnHis: 0.605 ± 0.037	3.171AsnIle: 3.171 ± 0.086	1.622AsnLys: 1.622 ± 0.061	3.667AsnLeu: 3.667 ± 0.09	0.766AsnMet: 0.766 ± 0.043	1.348AsnAsn: 1.348 ± 0.139	2.137AsnPro: 2.137 ± 0.063	0.776AsnGln: 0.776 ± 0.041	2.019AsnArg: 2.019 ± 0.063	1.731AsnSer: 1.731 ± 0.081	1.853AsnThr: 1.853 ± 0.088	2.501AsnVal: 2.501 ± 0.082	0.378AsnTrp: 0.378 ± 0.029	1.169AsnTyr: 1.169 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	2.795ProAla: 2.795 ± 0.08	0.452ProCys: 0.452 ± 0.028	2.891ProAsp: 2.891 ± 0.072	3.778ProGlu: 3.778 ± 0.08	1.688ProPhe: 1.688 ± 0.063	2.834ProGly: 2.834 ± 0.093	0.797ProHis: 0.797 ± 0.04	2.897ProIle: 2.897 ± 0.08	1.673ProLys: 1.673 ± 0.052	3.598ProLeu: 3.598 ± 0.097	0.807ProMet: 0.807 ± 0.042	1.144ProAsn: 1.144 ± 0.05	1.767ProPro: 1.767 ± 0.068	0.942ProGln: 0.942 ± 0.046	1.632ProArg: 1.632 ± 0.059	2.401ProSer: 2.401 ± 0.076	2.041ProThr: 2.041 ± 0.077	3.214ProVal: 3.214 ± 0.074	0.36ProTrp: 0.36 ± 0.027	1.424ProTyr: 1.424 ± 0.055	0.0ProXaa: 0.0 ± 0.0
Gln	1.291GlnAla: 1.291 ± 0.053	0.215GlnCys: 0.215 ± 0.02	1.052GlnAsp: 1.052 ± 0.046	1.397GlnGlu: 1.397 ± 0.055	0.736GlnPhe: 0.736 ± 0.043	1.23GlnGly: 1.23 ± 0.043	0.388GlnHis: 0.388 ± 0.03	1.9GlnIle: 1.9 ± 0.061	1.408GlnLys: 1.408 ± 0.054	1.684GlnLeu: 1.684 ± 0.058	0.688GlnMet: 0.688 ± 0.038	0.807GlnAsn: 0.807 ± 0.039	0.578GlnPro: 0.578 ± 0.033	0.572GlnGln: 0.572 ± 0.034	1.291GlnArg: 1.291 ± 0.059	1.009GlnSer: 1.009 ± 0.034	1.024GlnThr: 1.024 ± 0.049	1.291GlnVal: 1.291 ± 0.052	0.174GlnTrp: 0.174 ± 0.019	0.637GlnTyr: 0.637 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.635ArgAla: 3.635 ± 0.095	0.768ArgCys: 0.768 ± 0.044	3.465ArgAsp: 3.465 ± 0.088	4.858ArgGlu: 4.858 ± 0.105	2.258ArgPhe: 2.258 ± 0.08	3.98ArgGly: 3.98 ± 0.111	0.809ArgHis: 0.809 ± 0.045	5.046ArgIle: 5.046 ± 0.121	3.218ArgLys: 3.218 ± 0.09	4.885ArgLeu: 4.885 ± 0.099	1.827ArgMet: 1.827 ± 0.064	1.747ArgAsn: 1.747 ± 0.059	1.373ArgPro: 1.373 ± 0.054	1.06ArgGln: 1.06 ± 0.051	3.561ArgArg: 3.561 ± 0.105	3.447ArgSer: 3.447 ± 0.089	2.417ArgThr: 2.417 ± 0.071	4.117ArgVal: 4.117 ± 0.094	0.682ArgTrp: 0.682 ± 0.035	2.102ArgTyr: 2.102 ± 0.074	0.0ArgXaa: 0.0 ± 0.0
Ser	3.87SerAla: 3.87 ± 0.093	0.725SerCys: 0.725 ± 0.043	3.604SerAsp: 3.604 ± 0.103	4.233SerGlu: 4.233 ± 0.095	2.495SerPhe: 2.495 ± 0.073	5.269SerGly: 5.269 ± 0.116	1.105SerHis: 1.105 ± 0.047	4.828SerIle: 4.828 ± 0.104	3.097SerLys: 3.097 ± 0.085	4.822SerLeu: 4.822 ± 0.111	1.532SerMet: 1.532 ± 0.055	1.992SerAsn: 1.992 ± 0.095	2.403SerPro: 2.403 ± 0.072	1.087SerGln: 1.087 ± 0.047	3.195SerArg: 3.195 ± 0.098	3.702SerSer: 3.702 ± 0.125	3.118SerThr: 3.118 ± 0.1	3.923SerVal: 3.923 ± 0.079	0.615SerTrp: 0.615 ± 0.037	1.876SerTyr: 1.876 ± 0.072	0.002SerXaa: 0.002 ± 0.002
Thr	3.986ThrAla: 3.986 ± 0.11	0.642ThrCys: 0.642 ± 0.041	3.02ThrAsp: 3.02 ± 0.098	3.181ThrGlu: 3.181 ± 0.099	2.104ThrPhe: 2.104 ± 0.076	4.748ThrGly: 4.748 ± 0.112	0.956ThrHis: 0.956 ± 0.043	4.603ThrIle: 4.603 ± 0.122	2.337ThrLys: 2.337 ± 0.071	4.924ThrLeu: 4.924 ± 0.111	1.222ThrMet: 1.222 ± 0.058	1.577ThrAsn: 1.577 ± 0.077	2.864ThrPro: 2.864 ± 0.087	1.052ThrGln: 1.052 ± 0.042	2.384ThrArg: 2.384 ± 0.065	3.181ThrSer: 3.181 ± 0.101	3.093ThrThr: 3.093 ± 0.11	4.045ThrVal: 4.045 ± 0.124	0.435ThrTrp: 0.435 ± 0.035	1.606ThrTyr: 1.606 ± 0.061	0.002ThrXaa: 0.002 ± 0.002
Val	5.269ValAla: 5.269 ± 0.1	1.058ValCys: 1.058 ± 0.056	4.722ValAsp: 4.722 ± 0.102	5.731ValGlu: 5.731 ± 0.11	2.674ValPhe: 2.674 ± 0.074	5.038ValGly: 5.038 ± 0.112	1.136ValHis: 1.136 ± 0.046	6.795ValIle: 6.795 ± 0.147	4.652ValLys: 4.652 ± 0.105	6.64ValLeu: 6.64 ± 0.114	2.012ValMet: 2.012 ± 0.052	2.631ValAsn: 2.631 ± 0.1	2.685ValPro: 2.685 ± 0.072	1.224ValGln: 1.224 ± 0.05	3.735ValArg: 3.735 ± 0.102	4.154ValSer: 4.154 ± 0.093	4.233ValThr: 4.233 ± 0.109	5.806ValVal: 5.806 ± 0.133	0.588ValTrp: 0.588 ± 0.033	2.254ValTyr: 2.254 ± 0.071	0.0ValXaa: 0.0 ± 0.0
Trp	0.501TrpAla: 0.501 ± 0.033	0.123TrpCys: 0.123 ± 0.015	0.621TrpAsp: 0.621 ± 0.04	0.676TrpGlu: 0.676 ± 0.038	0.355TrpPhe: 0.355 ± 0.03	0.686TrpGly: 0.686 ± 0.04	0.182TrpHis: 0.182 ± 0.019	0.877TrpIle: 0.877 ± 0.041	0.576TrpLys: 0.576 ± 0.038	0.815TrpLeu: 0.815 ± 0.043	0.333TrpMet: 0.333 ± 0.025	0.519TrpAsn: 0.519 ± 0.047	0.182TrpPro: 0.182 ± 0.022	0.272TrpGln: 0.272 ± 0.025	0.515TrpArg: 0.515 ± 0.033	0.525TrpSer: 0.525 ± 0.035	0.368TrpThr: 0.368 ± 0.03	0.652TrpVal: 0.652 ± 0.039	0.139TrpTrp: 0.139 ± 0.017	0.321TrpTyr: 0.321 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.219TyrAla: 2.219 ± 0.069	0.456TyrCys: 0.456 ± 0.031	1.916TyrAsp: 1.916 ± 0.068	2.223TyrGlu: 2.223 ± 0.065	1.404TyrPhe: 1.404 ± 0.061	2.574TyrGly: 2.574 ± 0.077	0.752TyrHis: 0.752 ± 0.039	2.423TyrIle: 2.423 ± 0.07	1.304TyrLys: 1.304 ± 0.056	3.402TyrLeu: 3.402 ± 0.091	0.723TyrMet: 0.723 ± 0.034	1.295TyrAsn: 1.295 ± 0.065	1.596TyrPro: 1.596 ± 0.058	0.748TyrGln: 0.748 ± 0.043	1.968TyrArg: 1.968 ± 0.069	1.943TyrSer: 1.943 ± 0.084	1.808TyrThr: 1.808 ± 0.067	1.878TyrVal: 1.878 ± 0.057	0.384TyrTrp: 0.384 ± 0.03	1.261TyrTyr: 1.261 ± 0.068	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.002	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.836XaaXaa: 0.836 ± 0.617

Statistics based on 1784 proteins (510543 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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