Amino acid dipepetide frequency for Pararhodobacter marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.987AlaAla: 17.987 ± 0.192	1.141AlaCys: 1.141 ± 0.028	6.799AlaAsp: 6.799 ± 0.061	8.636AlaGlu: 8.636 ± 0.098	4.515AlaPhe: 4.515 ± 0.062	11.553AlaGly: 11.553 ± 0.117	2.436AlaHis: 2.436 ± 0.044	5.837AlaIle: 5.837 ± 0.067	2.904AlaLys: 2.904 ± 0.047	16.372AlaLeu: 16.372 ± 0.166	4.291AlaMet: 4.291 ± 0.065	2.405AlaAsn: 2.405 ± 0.051	6.996AlaPro: 6.996 ± 0.093	5.119AlaGln: 5.119 ± 0.068	10.719AlaArg: 10.719 ± 0.12	5.895AlaSer: 5.895 ± 0.077	6.077AlaThr: 6.077 ± 0.077	8.772AlaVal: 8.772 ± 0.093	1.581AlaTrp: 1.581 ± 0.036	2.486AlaTyr: 2.486 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.185CysAla: 1.185 ± 0.03	0.11CysCys: 0.11 ± 0.01	0.603CysAsp: 0.603 ± 0.022	0.428CysGlu: 0.428 ± 0.019	0.309CysPhe: 0.309 ± 0.016	0.875CysGly: 0.875 ± 0.031	0.254CysHis: 0.254 ± 0.014	0.383CysIle: 0.383 ± 0.017	0.163CysLys: 0.163 ± 0.011	0.882CysLeu: 0.882 ± 0.026	0.155CysMet: 0.155 ± 0.01	0.207CysAsn: 0.207 ± 0.011	0.533CysPro: 0.533 ± 0.021	0.221CysGln: 0.221 ± 0.013	0.609CysArg: 0.609 ± 0.023	0.395CysSer: 0.395 ± 0.016	0.444CysThr: 0.444 ± 0.02	0.579CysVal: 0.579 ± 0.02	0.121CysTrp: 0.121 ± 0.009	0.224CysTyr: 0.224 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.692AspAla: 7.692 ± 0.077	0.556AspCys: 0.556 ± 0.02	3.297AspAsp: 3.297 ± 0.063	3.616AspGlu: 3.616 ± 0.055	2.347AspPhe: 2.347 ± 0.047	5.494AspGly: 5.494 ± 0.08	1.345AspHis: 1.345 ± 0.037	2.75AspIle: 2.75 ± 0.042	1.301AspLys: 1.301 ± 0.033	6.568AspLeu: 6.568 ± 0.069	1.567AspMet: 1.567 ± 0.037	1.098AspAsn: 1.098 ± 0.027	4.076AspPro: 4.076 ± 0.056	1.652AspGln: 1.652 ± 0.036	4.476AspArg: 4.476 ± 0.072	2.304AspSer: 2.304 ± 0.044	2.958AspThr: 2.958 ± 0.052	3.619AspVal: 3.619 ± 0.056	1.332AspTrp: 1.332 ± 0.033	1.417AspTyr: 1.417 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.745GluAla: 8.745 ± 0.114	0.393GluCys: 0.393 ± 0.017	3.267GluAsp: 3.267 ± 0.052	2.972GluGlu: 2.972 ± 0.061	1.519GluPhe: 1.519 ± 0.035	5.012GluGly: 5.012 ± 0.059	1.095GluHis: 1.095 ± 0.03	3.467GluIle: 3.467 ± 0.056	1.607GluLys: 1.607 ± 0.041	4.864GluLeu: 4.864 ± 0.073	1.733GluMet: 1.733 ± 0.034	1.436GluAsn: 1.436 ± 0.033	2.733GluPro: 2.733 ± 0.049	1.868GluGln: 1.868 ± 0.041	4.689GluArg: 4.689 ± 0.076	2.269GluSer: 2.269 ± 0.04	4.019GluThr: 4.019 ± 0.06	3.732GluVal: 3.732 ± 0.057	0.699GluTrp: 0.699 ± 0.023	0.979GluTyr: 0.979 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.479PheAla: 4.479 ± 0.062	0.388PheCys: 0.388 ± 0.019	2.762PheAsp: 2.762 ± 0.043	2.038PheGlu: 2.038 ± 0.04	1.291PhePhe: 1.291 ± 0.032	3.616PheGly: 3.616 ± 0.064	0.744PheHis: 0.744 ± 0.023	1.508PheIle: 1.508 ± 0.039	0.664PheLys: 0.664 ± 0.025	3.418PheLeu: 3.418 ± 0.056	0.785PheMet: 0.785 ± 0.026	0.936PheAsn: 0.936 ± 0.031	1.62PhePro: 1.62 ± 0.035	0.966PheGln: 0.966 ± 0.025	2.347PheArg: 2.347 ± 0.041	1.872PheSer: 1.872 ± 0.042	1.998PheThr: 1.998 ± 0.039	2.626PheVal: 2.626 ± 0.046	0.572PheTrp: 0.572 ± 0.021	0.772PheTyr: 0.772 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.248GlyAla: 11.248 ± 0.117	0.866GlyCys: 0.866 ± 0.026	4.848GlyAsp: 4.848 ± 0.063	4.715GlyGlu: 4.715 ± 0.059	3.76GlyPhe: 3.76 ± 0.057	7.763GlyGly: 7.763 ± 0.103	1.934GlyHis: 1.934 ± 0.042	4.5GlyIle: 4.5 ± 0.057	2.595GlyLys: 2.595 ± 0.048	9.742GlyLeu: 9.742 ± 0.103	2.726GlyMet: 2.726 ± 0.05	1.952GlyAsn: 1.952 ± 0.043	4.137GlyPro: 4.137 ± 0.056	3.157GlyGln: 3.157 ± 0.055	6.32GlyArg: 6.32 ± 0.075	4.097GlySer: 4.097 ± 0.056	4.84GlyThr: 4.84 ± 0.056	6.485GlyVal: 6.485 ± 0.078	1.647GlyTrp: 1.647 ± 0.037	2.303GlyTyr: 2.303 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.598HisAla: 2.598 ± 0.049	0.226HisCys: 0.226 ± 0.012	1.336HisAsp: 1.336 ± 0.033	1.075HisGlu: 1.075 ± 0.028	0.793HisPhe: 0.793 ± 0.028	1.974HisGly: 1.974 ± 0.044	0.574HisHis: 0.574 ± 0.024	0.813HisIle: 0.813 ± 0.024	0.447HisLys: 0.447 ± 0.02	2.099HisLeu: 2.099 ± 0.04	0.478HisMet: 0.478 ± 0.019	0.441HisAsn: 0.441 ± 0.02	1.53HisPro: 1.53 ± 0.037	0.547HisGln: 0.547 ± 0.019	1.493HisArg: 1.493 ± 0.038	0.895HisSer: 0.895 ± 0.026	0.741HisThr: 0.741 ± 0.024	1.524HisVal: 1.524 ± 0.038	0.355HisTrp: 0.355 ± 0.015	0.525HisTyr: 0.525 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.134IleAla: 7.134 ± 0.084	0.51IleCys: 0.51 ± 0.019	3.394IleAsp: 3.394 ± 0.055	3.347IleGlu: 3.347 ± 0.051	1.579IlePhe: 1.579 ± 0.039	4.628IleGly: 4.628 ± 0.07	0.934IleHis: 0.934 ± 0.026	1.773IleIle: 1.773 ± 0.046	0.978IleLys: 0.978 ± 0.028	4.738IleLeu: 4.738 ± 0.072	0.956IleMet: 0.956 ± 0.028	1.138IleAsn: 1.138 ± 0.033	2.313IlePro: 2.313 ± 0.04	1.045IleGln: 1.045 ± 0.029	3.428IleArg: 3.428 ± 0.05	2.383IleSer: 2.383 ± 0.052	2.714IleThr: 2.714 ± 0.047	3.716IleVal: 3.716 ± 0.061	0.696IleTrp: 0.696 ± 0.024	0.975IleTyr: 0.975 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.363LysAla: 3.363 ± 0.06	0.131LysCys: 0.131 ± 0.01	1.318LysAsp: 1.318 ± 0.038	1.101LysGlu: 1.101 ± 0.037	0.646LysPhe: 0.646 ± 0.024	2.286LysGly: 2.286 ± 0.048	0.47LysHis: 0.47 ± 0.019	1.265LysIle: 1.265 ± 0.033	0.829LysLys: 0.829 ± 0.036	2.323LysLeu: 2.323 ± 0.048	0.626LysMet: 0.626 ± 0.02	0.502LysAsn: 0.502 ± 0.023	1.581LysPro: 1.581 ± 0.04	0.637LysGln: 0.637 ± 0.023	1.92LysArg: 1.92 ± 0.038	1.325LysSer: 1.325 ± 0.034	1.494LysThr: 1.494 ± 0.038	1.768LysVal: 1.768 ± 0.04	0.242LysTrp: 0.242 ± 0.013	0.464LysTyr: 0.464 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.321LeuAla: 14.321 ± 0.161	0.984LeuCys: 0.984 ± 0.025	6.493LeuAsp: 6.493 ± 0.08	5.075LeuGlu: 5.075 ± 0.071	3.457LeuPhe: 3.457 ± 0.056	9.253LeuGly: 9.253 ± 0.097	1.97LeuHis: 1.97 ± 0.038	5.323LeuIle: 5.323 ± 0.078	2.818LeuLys: 2.818 ± 0.055	9.167LeuLeu: 9.167 ± 0.127	2.824LeuMet: 2.824 ± 0.048	2.486LeuAsn: 2.486 ± 0.043	6.156LeuPro: 6.156 ± 0.082	2.815LeuGln: 2.815 ± 0.049	7.904LeuArg: 7.904 ± 0.096	6.755LeuSer: 6.755 ± 0.07	6.1LeuThr: 6.1 ± 0.074	7.278LeuVal: 7.278 ± 0.096	1.434LeuTrp: 1.434 ± 0.036	1.959LeuTyr: 1.959 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.694MetAla: 3.694 ± 0.054	0.175MetCys: 0.175 ± 0.012	1.402MetAsp: 1.402 ± 0.031	1.314MetGlu: 1.314 ± 0.039	0.778MetPhe: 0.778 ± 0.027	2.325MetGly: 2.325 ± 0.041	0.46MetHis: 0.46 ± 0.019	1.507MetIle: 1.507 ± 0.03	0.854MetLys: 0.854 ± 0.026	2.818MetLeu: 2.818 ± 0.047	0.776MetMet: 0.776 ± 0.025	0.766MetAsn: 0.766 ± 0.023	1.663MetPro: 1.663 ± 0.032	0.939MetGln: 0.939 ± 0.027	2.061MetArg: 2.061 ± 0.04	1.64MetSer: 1.64 ± 0.033	2.096MetThr: 2.096 ± 0.043	1.928MetVal: 1.928 ± 0.038	0.23MetTrp: 0.23 ± 0.014	0.324MetTyr: 0.324 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.106AsnAla: 3.106 ± 0.05	0.225AsnCys: 0.225 ± 0.012	1.262AsnAsp: 1.262 ± 0.04	1.022AsnGlu: 1.022 ± 0.032	0.824AsnPhe: 0.824 ± 0.028	2.092AsnGly: 2.092 ± 0.042	0.48AsnHis: 0.48 ± 0.02	1.075AsnIle: 1.075 ± 0.036	0.477AsnLys: 0.477 ± 0.02	2.263AsnLeu: 2.263 ± 0.037	0.57AsnMet: 0.57 ± 0.022	0.576AsnAsn: 0.576 ± 0.028	1.767AsnPro: 1.767 ± 0.041	0.553AsnGln: 0.553 ± 0.023	1.67AsnArg: 1.67 ± 0.037	0.91AsnSer: 0.91 ± 0.027	1.185AsnThr: 1.185 ± 0.031	1.572AsnVal: 1.572 ± 0.038	0.38AsnTrp: 0.38 ± 0.015	0.55AsnTyr: 0.55 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.962ProAla: 6.962 ± 0.095	0.358ProCys: 0.358 ± 0.018	4.405ProAsp: 4.405 ± 0.065	4.48ProGlu: 4.48 ± 0.067	2.041ProPhe: 2.041 ± 0.037	5.546ProGly: 5.546 ± 0.077	1.143ProHis: 1.143 ± 0.028	2.036ProIle: 2.036 ± 0.041	1.277ProLys: 1.277 ± 0.037	5.193ProLeu: 5.193 ± 0.065	1.484ProMet: 1.484 ± 0.036	1.083ProAsn: 1.083 ± 0.032	2.66ProPro: 2.66 ± 0.053	1.768ProGln: 1.768 ± 0.036	3.61ProArg: 3.61 ± 0.056	2.472ProSer: 2.472 ± 0.049	2.235ProThr: 2.235 ± 0.038	4.898ProVal: 4.898 ± 0.065	0.754ProTrp: 0.754 ± 0.025	1.141ProTyr: 1.141 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.423GlnAla: 4.423 ± 0.065	0.21GlnCys: 0.21 ± 0.013	1.605GlnAsp: 1.605 ± 0.039	1.414GlnGlu: 1.414 ± 0.037	0.923GlnPhe: 0.923 ± 0.028	2.906GlnGly: 2.906 ± 0.052	0.625GlnHis: 0.625 ± 0.024	1.879GlnIle: 1.879 ± 0.034	0.804GlnLys: 0.804 ± 0.026	2.637GlnLeu: 2.637 ± 0.043	0.985GlnMet: 0.985 ± 0.028	0.795GlnAsn: 0.795 ± 0.024	1.849GlnPro: 1.849 ± 0.038	1.007GlnGln: 1.007 ± 0.028	2.403GlnArg: 2.403 ± 0.045	1.681GlnSer: 1.681 ± 0.039	1.691GlnThr: 1.691 ± 0.035	2.325GlnVal: 2.325 ± 0.048	0.37GlnTrp: 0.37 ± 0.017	0.509GlnTyr: 0.509 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.121ArgAla: 10.121 ± 0.12	0.513ArgCys: 0.513 ± 0.019	4.693ArgAsp: 4.693 ± 0.072	4.039ArgGlu: 4.039 ± 0.06	2.807ArgPhe: 2.807 ± 0.039	5.278ArgGly: 5.278 ± 0.062	1.756ArgHis: 1.756 ± 0.039	3.979ArgIle: 3.979 ± 0.058	1.948ArgLys: 1.948 ± 0.038	8.321ArgLeu: 8.321 ± 0.097	2.2ArgMet: 2.2 ± 0.043	1.776ArgAsn: 1.776 ± 0.04	3.926ArgPro: 3.926 ± 0.057	2.392ArgGln: 2.392 ± 0.043	5.833ArgArg: 5.833 ± 0.096	3.266ArgSer: 3.266 ± 0.057	3.069ArgThr: 3.069 ± 0.048	5.271ArgVal: 5.271 ± 0.066	1.114ArgTrp: 1.114 ± 0.03	1.612ArgTyr: 1.612 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.945SerAla: 5.945 ± 0.073	0.41SerCys: 0.41 ± 0.018	3.036SerAsp: 3.036 ± 0.046	2.647SerGlu: 2.647 ± 0.053	1.93SerPhe: 1.93 ± 0.041	5.175SerGly: 5.175 ± 0.07	0.985SerHis: 0.985 ± 0.033	2.164SerIle: 2.164 ± 0.045	1.075SerLys: 1.075 ± 0.028	5.001SerLeu: 5.001 ± 0.063	1.346SerMet: 1.346 ± 0.031	1.131SerAsn: 1.131 ± 0.033	2.608SerPro: 2.608 ± 0.041	1.465SerGln: 1.465 ± 0.031	3.296SerArg: 3.296 ± 0.052	2.215SerSer: 2.215 ± 0.053	2.364SerThr: 2.364 ± 0.041	3.966SerVal: 3.966 ± 0.062	0.696SerTrp: 0.696 ± 0.023	1.108SerTyr: 1.108 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.265ThrAla: 6.265 ± 0.075	0.473ThrCys: 0.473 ± 0.019	2.955ThrAsp: 2.955 ± 0.049	3.111ThrGlu: 3.111 ± 0.051	1.735ThrPhe: 1.735 ± 0.033	5.695ThrGly: 5.695 ± 0.072	1.052ThrHis: 1.052 ± 0.025	2.521ThrIle: 2.521 ± 0.045	1.119ThrLys: 1.119 ± 0.029	6.452ThrLeu: 6.452 ± 0.084	1.27ThrMet: 1.27 ± 0.03	1.124ThrAsn: 1.124 ± 0.028	3.648ThrPro: 3.648 ± 0.05	1.57ThrGln: 1.57 ± 0.04	3.903ThrArg: 3.903 ± 0.061	2.294ThrSer: 2.294 ± 0.04	2.602ThrThr: 2.602 ± 0.047	3.676ThrVal: 3.676 ± 0.055	0.65ThrTrp: 0.65 ± 0.025	1.137ThrTyr: 1.137 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.252ValAla: 9.252 ± 0.091	0.643ValCys: 0.643 ± 0.024	3.722ValAsp: 3.722 ± 0.054	4.285ValGlu: 4.285 ± 0.063	2.799ValPhe: 2.799 ± 0.049	5.092ValGly: 5.092 ± 0.077	1.338ValHis: 1.338 ± 0.036	4.051ValIle: 4.051 ± 0.055	1.628ValLys: 1.628 ± 0.037	7.726ValLeu: 7.726 ± 0.093	2.133ValMet: 2.133 ± 0.044	1.801ValAsn: 1.801 ± 0.042	3.926ValPro: 3.926 ± 0.061	2.085ValGln: 2.085 ± 0.039	4.348ValArg: 4.348 ± 0.056	4.059ValSer: 4.059 ± 0.051	4.818ValThr: 4.818 ± 0.06	5.656ValVal: 5.656 ± 0.085	0.979ValTrp: 0.979 ± 0.026	1.385ValTyr: 1.385 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.48TrpAla: 1.48 ± 0.042	0.135TrpCys: 0.135 ± 0.01	0.753TrpAsp: 0.753 ± 0.026	0.655TrpGlu: 0.655 ± 0.021	0.545TrpPhe: 0.545 ± 0.02	1.087TrpGly: 1.087 ± 0.033	0.364TrpHis: 0.364 ± 0.017	0.763TrpIle: 0.763 ± 0.027	0.372TrpLys: 0.372 ± 0.019	1.781TrpLeu: 1.781 ± 0.039	0.415TrpMet: 0.415 ± 0.018	0.416TrpAsn: 0.416 ± 0.019	0.768TrpPro: 0.768 ± 0.026	0.608TrpGln: 0.608 ± 0.024	1.296TrpArg: 1.296 ± 0.034	0.815TrpSer: 0.815 ± 0.025	0.778TrpThr: 0.778 ± 0.025	0.908TrpVal: 0.908 ± 0.024	0.24TrpTrp: 0.24 ± 0.013	0.281TrpTyr: 0.281 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.52TyrAla: 2.52 ± 0.043	0.234TyrCys: 0.234 ± 0.013	1.517TyrAsp: 1.517 ± 0.032	1.13TyrGlu: 1.13 ± 0.033	0.804TyrPhe: 0.804 ± 0.023	1.987TyrGly: 1.987 ± 0.042	0.504TyrHis: 0.504 ± 0.017	0.784TyrIle: 0.784 ± 0.024	0.431TyrLys: 0.431 ± 0.017	2.207TyrLeu: 2.207 ± 0.04	0.43TyrMet: 0.43 ± 0.016	0.489TyrAsn: 0.489 ± 0.017	1.06TyrPro: 1.06 ± 0.027	0.626TyrGln: 0.626 ± 0.026	1.588TyrArg: 1.588 ± 0.035	1.019TyrSer: 1.019 ± 0.031	1.03TyrThr: 1.03 ± 0.027	1.428TyrVal: 1.428 ± 0.029	0.365TyrTrp: 0.365 ± 0.017	0.528TyrTyr: 0.528 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4216 proteins (1328425 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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