Amino acid dipepetide frequency for Acinetobacter phage vB_AbaM_B09_Aci05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.028AlaAla: 4.028 ± 0.426
0.726AlaCys: 0.726 ± 0.138
3.466AlaAsp: 3.466 ± 0.424
4.127AlaGlu: 4.127 ± 0.398
2.641AlaPhe: 2.641 ± 0.293
3.83AlaGly: 3.83 ± 0.374
0.825AlaHis: 0.825 ± 0.188
4.49AlaIle: 4.49 ± 0.561
5.183AlaLys: 5.183 ± 0.429
6.471AlaLeu: 6.471 ± 0.484
2.047AlaMet: 2.047 ± 0.233
3.202AlaAsn: 3.202 ± 0.598
1.519AlaPro: 1.519 ± 0.197
2.245AlaGln: 2.245 ± 0.327
2.74AlaArg: 2.74 ± 0.3
3.863AlaSer: 3.863 ± 0.514
3.334AlaThr: 3.334 ± 0.338
3.367AlaVal: 3.367 ± 0.309
0.627AlaTrp: 0.627 ± 0.138
2.344AlaTyr: 2.344 ± 0.263
0.0AlaXaa: 0.0 ± 0.0
Cys
0.561CysAla: 0.561 ± 0.126
0.165CysCys: 0.165 ± 0.07
0.693CysAsp: 0.693 ± 0.14
1.089CysGlu: 1.089 ± 0.208
0.528CysPhe: 0.528 ± 0.147
1.155CysGly: 1.155 ± 0.207
0.528CysHis: 0.528 ± 0.145
0.957CysIle: 0.957 ± 0.182
1.023CysLys: 1.023 ± 0.209
0.924CysLeu: 0.924 ± 0.17
0.264CysMet: 0.264 ± 0.083
0.627CysAsn: 0.627 ± 0.134
0.33CysPro: 0.33 ± 0.111
0.396CysGln: 0.396 ± 0.111
0.693CysArg: 0.693 ± 0.177
0.528CysSer: 0.528 ± 0.143
0.66CysThr: 0.66 ± 0.152
0.561CysVal: 0.561 ± 0.132
0.099CysTrp: 0.099 ± 0.052
0.792CysTyr: 0.792 ± 0.17
0.0CysXaa: 0.0 ± 0.0
Asp
3.764AspAla: 3.764 ± 0.367
0.693AspCys: 0.693 ± 0.184
4.853AspAsp: 4.853 ± 0.5
4.919AspGlu: 4.919 ± 0.525
3.4AspPhe: 3.4 ± 0.297
5.018AspGly: 5.018 ± 0.433
1.023AspHis: 1.023 ± 0.19
4.16AspIle: 4.16 ± 0.348
4.259AspLys: 4.259 ± 0.372
5.877AspLeu: 5.877 ± 0.402
1.948AspMet: 1.948 ± 0.263
3.4AspAsn: 3.4 ± 0.354
2.806AspPro: 2.806 ± 0.378
2.08AspGln: 2.08 ± 0.261
2.278AspArg: 2.278 ± 0.291
4.061AspSer: 4.061 ± 0.384
2.74AspThr: 2.74 ± 0.234
5.414AspVal: 5.414 ± 0.47
1.122AspTrp: 1.122 ± 0.208
2.641AspTyr: 2.641 ± 0.305
0.0AspXaa: 0.0 ± 0.0
Glu
5.051GluAla: 5.051 ± 0.456
1.354GluCys: 1.354 ± 0.248
5.414GluAsp: 5.414 ± 0.444
5.612GluGlu: 5.612 ± 0.535
3.533GluPhe: 3.533 ± 0.428
4.094GluGly: 4.094 ± 0.413
1.717GluHis: 1.717 ± 0.256
4.886GluIle: 4.886 ± 0.35
5.084GluLys: 5.084 ± 0.431
6.273GluLeu: 6.273 ± 0.439
2.212GluMet: 2.212 ± 0.321
3.599GluAsn: 3.599 ± 0.366
1.552GluPro: 1.552 ± 0.255
2.674GluGln: 2.674 ± 0.259
3.004GluArg: 3.004 ± 0.287
3.764GluSer: 3.764 ± 0.404
3.169GluThr: 3.169 ± 0.326
5.513GluVal: 5.513 ± 0.496
1.354GluTrp: 1.354 ± 0.18
3.301GluTyr: 3.301 ± 0.296
0.0GluXaa: 0.0 ± 0.0
Phe
2.344PheAla: 2.344 ± 0.328
0.495PheCys: 0.495 ± 0.13
3.334PheAsp: 3.334 ± 0.267
3.334PheGlu: 3.334 ± 0.362
1.089PhePhe: 1.089 ± 0.181
3.4PheGly: 3.4 ± 0.336
0.957PheHis: 0.957 ± 0.181
3.004PheIle: 3.004 ± 0.315
3.929PheLys: 3.929 ± 0.376
2.839PheLeu: 2.839 ± 0.331
1.75PheMet: 1.75 ± 0.272
2.146PheAsn: 2.146 ± 0.256
1.618PhePro: 1.618 ± 0.217
1.42PheGln: 1.42 ± 0.181
1.849PheArg: 1.849 ± 0.24
3.433PheSer: 3.433 ± 0.362
2.179PheThr: 2.179 ± 0.265
2.509PheVal: 2.509 ± 0.246
0.429PheTrp: 0.429 ± 0.111
1.981PheTyr: 1.981 ± 0.272
0.0PheXaa: 0.0 ± 0.0
Gly
3.466GlyAla: 3.466 ± 0.29
1.122GlyCys: 1.122 ± 0.195
4.688GlyAsp: 4.688 ± 0.456
4.457GlyGlu: 4.457 ± 0.351
3.268GlyPhe: 3.268 ± 0.396
4.82GlyGly: 4.82 ± 0.392
1.189GlyHis: 1.189 ± 0.211
4.655GlyIle: 4.655 ± 0.374
5.348GlyLys: 5.348 ± 0.408
5.315GlyLeu: 5.315 ± 0.452
1.684GlyMet: 1.684 ± 0.238
3.301GlyAsn: 3.301 ± 0.35
0.825GlyPro: 0.825 ± 0.159
2.311GlyGln: 2.311 ± 0.344
2.905GlyArg: 2.905 ± 0.324
4.391GlySer: 4.391 ± 0.393
4.391GlyThr: 4.391 ± 0.44
4.787GlyVal: 4.787 ± 0.435
1.354GlyTrp: 1.354 ± 0.196
3.103GlyTyr: 3.103 ± 0.298
0.0GlyXaa: 0.0 ± 0.0
His
0.957HisAla: 0.957 ± 0.177
0.165HisCys: 0.165 ± 0.077
1.354HisAsp: 1.354 ± 0.266
1.089HisGlu: 1.089 ± 0.246
0.99HisPhe: 0.99 ± 0.182
1.75HisGly: 1.75 ± 0.22
0.594HisHis: 0.594 ± 0.147
1.387HisIle: 1.387 ± 0.227
1.387HisLys: 1.387 ± 0.228
1.783HisLeu: 1.783 ± 0.286
0.693HisMet: 0.693 ± 0.147
1.222HisAsn: 1.222 ± 0.245
0.561HisPro: 0.561 ± 0.135
0.495HisGln: 0.495 ± 0.12
1.122HisArg: 1.122 ± 0.228
1.387HisSer: 1.387 ± 0.199
0.858HisThr: 0.858 ± 0.16
1.486HisVal: 1.486 ± 0.242
0.462HisTrp: 0.462 ± 0.125
0.429HisTyr: 0.429 ± 0.113
0.0HisXaa: 0.0 ± 0.0
Ile
4.028IleAla: 4.028 ± 0.403
0.726IleCys: 0.726 ± 0.146
5.678IleAsp: 5.678 ± 0.414
5.678IleGlu: 5.678 ± 0.396
2.377IlePhe: 2.377 ± 0.287
3.962IleGly: 3.962 ± 0.386
1.387IleHis: 1.387 ± 0.201
3.533IleIle: 3.533 ± 0.352
5.348IleLys: 5.348 ± 0.383
4.754IleLeu: 4.754 ± 0.39
1.288IleMet: 1.288 ± 0.21
3.533IleAsn: 3.533 ± 0.322
2.377IlePro: 2.377 ± 0.228
2.707IleGln: 2.707 ± 0.337
2.707IleArg: 2.707 ± 0.272
4.094IleSer: 4.094 ± 0.438
3.797IleThr: 3.797 ± 0.449
4.127IleVal: 4.127 ± 0.389
0.726IleTrp: 0.726 ± 0.149
2.377IleTyr: 2.377 ± 0.258
0.0IleXaa: 0.0 ± 0.0
Lys
6.471LysAla: 6.471 ± 0.642
0.924LysCys: 0.924 ± 0.201
4.721LysAsp: 4.721 ± 0.413
4.919LysGlu: 4.919 ± 0.418
3.5LysPhe: 3.5 ± 0.386
4.82LysGly: 4.82 ± 0.41
2.245LysHis: 2.245 ± 0.29
4.919LysIle: 4.919 ± 0.42
5.612LysLys: 5.612 ± 0.541
6.867LysLeu: 6.867 ± 0.416
2.278LysMet: 2.278 ± 0.299
3.334LysAsn: 3.334 ± 0.299
2.08LysPro: 2.08 ± 0.304
2.905LysGln: 2.905 ± 0.373
3.235LysArg: 3.235 ± 0.358
5.15LysSer: 5.15 ± 0.354
3.929LysThr: 3.929 ± 0.357
6.669LysVal: 6.669 ± 0.456
0.99LysTrp: 0.99 ± 0.147
3.863LysTyr: 3.863 ± 0.369
0.0LysXaa: 0.0 ± 0.0
Leu
5.249LeuAla: 5.249 ± 0.476
0.891LeuCys: 0.891 ± 0.197
5.315LeuAsp: 5.315 ± 0.393
6.372LeuGlu: 6.372 ± 0.531
3.169LeuPhe: 3.169 ± 0.382
5.018LeuGly: 5.018 ± 0.382
1.288LeuHis: 1.288 ± 0.231
4.688LeuIle: 4.688 ± 0.384
6.339LeuLys: 6.339 ± 0.446
5.777LeuLeu: 5.777 ± 0.465
1.915LeuMet: 1.915 ± 0.235
5.216LeuAsn: 5.216 ± 0.435
2.278LeuPro: 2.278 ± 0.297
2.608LeuGln: 2.608 ± 0.302
3.599LeuArg: 3.599 ± 0.359
5.711LeuSer: 5.711 ± 0.463
5.216LeuThr: 5.216 ± 0.483
5.414LeuVal: 5.414 ± 0.423
0.759LeuTrp: 0.759 ± 0.169
2.806LeuTyr: 2.806 ± 0.319
0.0LeuXaa: 0.0 ± 0.0
Met
1.651MetAla: 1.651 ± 0.216
0.264MetCys: 0.264 ± 0.084
1.717MetAsp: 1.717 ± 0.244
2.212MetGlu: 2.212 ± 0.295
0.924MetPhe: 0.924 ± 0.162
1.453MetGly: 1.453 ± 0.246
0.264MetHis: 0.264 ± 0.09
2.047MetIle: 2.047 ± 0.276
2.905MetLys: 2.905 ± 0.334
1.948MetLeu: 1.948 ± 0.241
0.594MetMet: 0.594 ± 0.141
1.519MetAsn: 1.519 ± 0.215
0.825MetPro: 0.825 ± 0.157
0.66MetGln: 0.66 ± 0.153
1.122MetArg: 1.122 ± 0.179
2.278MetSer: 2.278 ± 0.347
1.453MetThr: 1.453 ± 0.227
1.585MetVal: 1.585 ± 0.194
0.297MetTrp: 0.297 ± 0.095
1.155MetTyr: 1.155 ± 0.225
0.0MetXaa: 0.0 ± 0.0
Asn
3.235AsnAla: 3.235 ± 0.6
0.759AsnCys: 0.759 ± 0.19
2.971AsnAsp: 2.971 ± 0.26
2.971AsnGlu: 2.971 ± 0.307
2.41AsnPhe: 2.41 ± 0.279
4.622AsnGly: 4.622 ± 0.405
0.792AsnHis: 0.792 ± 0.151
4.061AsnIle: 4.061 ± 0.326
3.797AsnLys: 3.797 ± 0.414
3.995AsnLeu: 3.995 ± 0.359
1.288AsnMet: 1.288 ± 0.189
2.41AsnAsn: 2.41 ± 0.348
2.08AsnPro: 2.08 ± 0.272
1.684AsnGln: 1.684 ± 0.239
2.047AsnArg: 2.047 ± 0.258
3.301AsnSer: 3.301 ± 0.399
2.872AsnThr: 2.872 ± 0.291
3.566AsnVal: 3.566 ± 0.392
0.561AsnTrp: 0.561 ± 0.141
2.146AsnTyr: 2.146 ± 0.32
0.0AsnXaa: 0.0 ± 0.0
Pro
1.42ProAla: 1.42 ± 0.194
0.264ProCys: 0.264 ± 0.099
2.113ProAsp: 2.113 ± 0.346
2.542ProGlu: 2.542 ± 0.39
1.189ProPhe: 1.189 ± 0.177
0.0ProGly: 0.0 ± 0.0
0.66ProHis: 0.66 ± 0.132
1.783ProIle: 1.783 ± 0.268
2.641ProLys: 2.641 ± 0.279
1.981ProLeu: 1.981 ± 0.247
0.858ProMet: 0.858 ± 0.193
1.981ProAsn: 1.981 ± 0.312
1.222ProPro: 1.222 ± 0.24
0.924ProGln: 0.924 ± 0.164
1.155ProArg: 1.155 ± 0.244
2.047ProSer: 2.047 ± 0.272
1.915ProThr: 1.915 ± 0.208
2.344ProVal: 2.344 ± 0.277
0.231ProTrp: 0.231 ± 0.076
1.717ProTyr: 1.717 ± 0.262
0.0ProXaa: 0.0 ± 0.0
Gln
3.004GlnAla: 3.004 ± 0.487
0.33GlnCys: 0.33 ± 0.122
1.948GlnAsp: 1.948 ± 0.231
2.905GlnGlu: 2.905 ± 0.248
1.519GlnPhe: 1.519 ± 0.21
2.74GlnGly: 2.74 ± 0.353
0.726GlnHis: 0.726 ± 0.178
2.047GlnIle: 2.047 ± 0.233
1.948GlnLys: 1.948 ± 0.265
3.037GlnLeu: 3.037 ± 0.301
1.387GlnMet: 1.387 ± 0.255
1.486GlnAsn: 1.486 ± 0.262
0.726GlnPro: 0.726 ± 0.153
0.99GlnGln: 0.99 ± 0.205
2.212GlnArg: 2.212 ± 0.283
1.717GlnSer: 1.717 ± 0.309
1.684GlnThr: 1.684 ± 0.264
2.179GlnVal: 2.179 ± 0.263
0.561GlnTrp: 0.561 ± 0.139
1.486GlnTyr: 1.486 ± 0.199
0.0GlnXaa: 0.0 ± 0.0
Arg
1.915ArgAla: 1.915 ± 0.308
0.561ArgCys: 0.561 ± 0.138
3.037ArgAsp: 3.037 ± 0.328
3.334ArgGlu: 3.334 ± 0.301
2.311ArgPhe: 2.311 ± 0.292
3.004ArgGly: 3.004 ± 0.284
0.957ArgHis: 0.957 ± 0.184
3.533ArgIle: 3.533 ± 0.34
3.665ArgLys: 3.665 ± 0.376
3.268ArgLeu: 3.268 ± 0.328
0.924ArgMet: 0.924 ± 0.199
2.245ArgAsn: 2.245 ± 0.328
1.056ArgPro: 1.056 ± 0.161
1.519ArgGln: 1.519 ± 0.2
2.311ArgArg: 2.311 ± 0.285
2.212ArgSer: 2.212 ± 0.312
1.981ArgThr: 1.981 ± 0.268
3.599ArgVal: 3.599 ± 0.299
0.627ArgTrp: 0.627 ± 0.139
1.816ArgTyr: 1.816 ± 0.265
0.0ArgXaa: 0.0 ± 0.0
Ser
3.797SerAla: 3.797 ± 0.577
0.792SerCys: 0.792 ± 0.178
3.533SerAsp: 3.533 ± 0.321
4.721SerGlu: 4.721 ± 0.399
2.542SerPhe: 2.542 ± 0.272
5.447SerGly: 5.447 ± 0.462
1.222SerHis: 1.222 ± 0.202
3.797SerIle: 3.797 ± 0.363
5.414SerLys: 5.414 ± 0.371
4.49SerLeu: 4.49 ± 0.377
1.222SerMet: 1.222 ± 0.199
3.103SerAsn: 3.103 ± 0.339
1.849SerPro: 1.849 ± 0.288
2.542SerGln: 2.542 ± 0.344
2.542SerArg: 2.542 ± 0.33
4.292SerSer: 4.292 ± 0.634
3.202SerThr: 3.202 ± 0.378
4.622SerVal: 4.622 ± 0.446
0.924SerTrp: 0.924 ± 0.152
3.037SerTyr: 3.037 ± 0.281
0.0SerXaa: 0.0 ± 0.0
Thr
3.334ThrAla: 3.334 ± 0.424
0.627ThrCys: 0.627 ± 0.144
2.938ThrAsp: 2.938 ± 0.317
3.566ThrGlu: 3.566 ± 0.34
2.773ThrPhe: 2.773 ± 0.321
4.391ThrGly: 4.391 ± 0.399
1.255ThrHis: 1.255 ± 0.204
3.731ThrIle: 3.731 ± 0.352
4.16ThrLys: 4.16 ± 0.438
4.424ThrLeu: 4.424 ± 0.396
1.122ThrMet: 1.122 ± 0.176
2.344ThrAsn: 2.344 ± 0.337
1.948ThrPro: 1.948 ± 0.253
1.849ThrGln: 1.849 ± 0.244
2.476ThrArg: 2.476 ± 0.281
3.202ThrSer: 3.202 ± 0.374
3.103ThrThr: 3.103 ± 0.333
3.5ThrVal: 3.5 ± 0.405
0.858ThrTrp: 0.858 ± 0.146
2.377ThrTyr: 2.377 ± 0.341
0.0ThrXaa: 0.0 ± 0.0
Val
3.83ValAla: 3.83 ± 0.328
0.792ValCys: 0.792 ± 0.156
4.589ValAsp: 4.589 ± 0.475
5.315ValGlu: 5.315 ± 0.397
3.136ValPhe: 3.136 ± 0.303
4.49ValGly: 4.49 ± 0.46
1.222ValHis: 1.222 ± 0.186
4.127ValIle: 4.127 ± 0.376
6.405ValLys: 6.405 ± 0.488
5.381ValLeu: 5.381 ± 0.435
1.849ValMet: 1.849 ± 0.245
4.391ValAsn: 4.391 ± 0.375
1.783ValPro: 1.783 ± 0.234
2.212ValGln: 2.212 ± 0.304
3.202ValArg: 3.202 ± 0.286
4.226ValSer: 4.226 ± 0.32
4.193ValThr: 4.193 ± 0.439
5.645ValVal: 5.645 ± 0.543
1.089ValTrp: 1.089 ± 0.169
2.938ValTyr: 2.938 ± 0.306
0.0ValXaa: 0.0 ± 0.0
Trp
0.66TrpAla: 0.66 ± 0.152
0.297TrpCys: 0.297 ± 0.092
1.023TrpAsp: 1.023 ± 0.196
1.023TrpGlu: 1.023 ± 0.2
0.825TrpPhe: 0.825 ± 0.15
0.561TrpGly: 0.561 ± 0.137
0.297TrpHis: 0.297 ± 0.095
1.023TrpIle: 1.023 ± 0.197
1.222TrpLys: 1.222 ± 0.237
1.089TrpLeu: 1.089 ± 0.183
0.528TrpMet: 0.528 ± 0.11
0.495TrpAsn: 0.495 ± 0.118
0.198TrpPro: 0.198 ± 0.083
0.396TrpGln: 0.396 ± 0.095
0.627TrpArg: 0.627 ± 0.155
0.858TrpSer: 0.858 ± 0.149
0.924TrpThr: 0.924 ± 0.152
0.99TrpVal: 0.99 ± 0.192
0.132TrpTrp: 0.132 ± 0.06
0.825TrpTyr: 0.825 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.311TyrAla: 2.311 ± 0.261
0.627TyrCys: 0.627 ± 0.151
3.07TyrAsp: 3.07 ± 0.388
2.971TyrGlu: 2.971 ± 0.249
1.915TyrPhe: 1.915 ± 0.248
2.806TyrGly: 2.806 ± 0.255
1.023TyrHis: 1.023 ± 0.186
2.41TyrIle: 2.41 ± 0.311
3.764TyrLys: 3.764 ± 0.316
3.136TyrLeu: 3.136 ± 0.305
0.99TyrMet: 0.99 ± 0.173
2.014TyrAsn: 2.014 ± 0.242
1.354TyrPro: 1.354 ± 0.259
2.014TyrGln: 2.014 ± 0.299
2.047TyrArg: 2.047 ± 0.247
2.575TyrSer: 2.575 ± 0.3
2.377TyrThr: 2.377 ± 0.296
2.938TyrVal: 2.938 ± 0.29
0.792TyrTrp: 0.792 ± 0.15
1.915TyrTyr: 1.915 ± 0.321
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 160 proteins (30291 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski