Amino acid dipepetide frequency for Actinomyces massiliensis F0489

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.915AlaAla: 19.915 ± 0.203	1.219AlaCys: 1.219 ± 0.035	8.544AlaAsp: 8.544 ± 0.117	8.011AlaGlu: 8.011 ± 0.13	3.134AlaPhe: 3.134 ± 0.056	13.022AlaGly: 13.022 ± 0.131	2.611AlaHis: 2.611 ± 0.055	4.962AlaIle: 4.962 ± 0.073	2.194AlaLys: 2.194 ± 0.066	14.374AlaLeu: 14.374 ± 0.158	2.994AlaMet: 2.994 ± 0.053	2.01AlaAsn: 2.01 ± 0.05	7.394AlaPro: 7.394 ± 0.111	4.055AlaGln: 4.055 ± 0.079	9.976AlaArg: 9.976 ± 0.132	8.286AlaSer: 8.286 ± 0.096	7.014AlaThr: 7.014 ± 0.104	11.977AlaVal: 11.977 ± 0.129	2.108AlaTrp: 2.108 ± 0.052	2.282AlaTyr: 2.282 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.103CysAla: 1.103 ± 0.033	0.108CysCys: 0.108 ± 0.012	0.437CysAsp: 0.437 ± 0.024	0.409CysGlu: 0.409 ± 0.02	0.217CysPhe: 0.217 ± 0.015	0.831CysGly: 0.831 ± 0.032	0.149CysHis: 0.149 ± 0.013	0.27CysIle: 0.27 ± 0.017	0.091CysLys: 0.091 ± 0.009	0.87CysLeu: 0.87 ± 0.03	0.134CysMet: 0.134 ± 0.012	0.127CysAsn: 0.127 ± 0.01	0.444CysPro: 0.444 ± 0.025	0.205CysGln: 0.205 ± 0.013	0.58CysArg: 0.58 ± 0.026	0.482CysSer: 0.482 ± 0.025	0.49CysThr: 0.49 ± 0.022	0.605CysVal: 0.605 ± 0.022	0.114CysTrp: 0.114 ± 0.01	0.179CysTyr: 0.179 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.318AspAla: 8.318 ± 0.102	0.399AspCys: 0.399 ± 0.022	4.373AspAsp: 4.373 ± 0.083	3.941AspGlu: 3.941 ± 0.071	1.429AspPhe: 1.429 ± 0.041	6.081AspGly: 6.081 ± 0.096	1.302AspHis: 1.302 ± 0.036	2.262AspIle: 2.262 ± 0.05	1.144AspLys: 1.144 ± 0.043	6.171AspLeu: 6.171 ± 0.088	1.012AspMet: 1.012 ± 0.032	1.018AspAsn: 1.018 ± 0.03	4.226AspPro: 4.226 ± 0.078	1.616AspGln: 1.616 ± 0.045	4.164AspArg: 4.164 ± 0.076	3.78AspSer: 3.78 ± 0.076	2.882AspThr: 2.882 ± 0.061	5.088AspVal: 5.088 ± 0.074	0.81AspTrp: 0.81 ± 0.034	1.31AspTyr: 1.31 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.842GluAla: 7.842 ± 0.12	0.354GluCys: 0.354 ± 0.018	3.321GluAsp: 3.321 ± 0.063	3.363GluGlu: 3.363 ± 0.067	1.15GluPhe: 1.15 ± 0.031	4.286GluGly: 4.286 ± 0.07	1.421GluHis: 1.421 ± 0.043	2.517GluIle: 2.517 ± 0.058	1.231GluLys: 1.231 ± 0.041	5.941GluLeu: 5.941 ± 0.099	1.027GluMet: 1.027 ± 0.033	1.162GluAsn: 1.162 ± 0.039	3.313GluPro: 3.313 ± 0.064	2.082GluGln: 2.082 ± 0.049	5.051GluArg: 5.051 ± 0.079	3.124GluSer: 3.124 ± 0.066	2.881GluThr: 2.881 ± 0.058	4.511GluVal: 4.511 ± 0.067	0.616GluTrp: 0.616 ± 0.024	0.978GluTyr: 0.978 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.009PheAla: 3.009 ± 0.06	0.206PheCys: 0.206 ± 0.017	1.712PheAsp: 1.712 ± 0.05	1.264PheGlu: 1.264 ± 0.04	0.87PhePhe: 0.87 ± 0.029	2.368PheGly: 2.368 ± 0.055	0.521PheHis: 0.521 ± 0.026	1.152PheIle: 1.152 ± 0.042	0.469PheLys: 0.469 ± 0.022	2.427PheLeu: 2.427 ± 0.062	0.481PheMet: 0.481 ± 0.025	0.567PheAsn: 0.567 ± 0.024	1.175PhePro: 1.175 ± 0.036	0.591PheGln: 0.591 ± 0.024	1.353PheArg: 1.353 ± 0.037	1.717PheSer: 1.717 ± 0.045	1.763PheThr: 1.763 ± 0.052	2.037PheVal: 2.037 ± 0.048	0.391PheTrp: 0.391 ± 0.022	0.621PheTyr: 0.621 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.924GlyAla: 11.924 ± 0.141	0.755GlyCys: 0.755 ± 0.029	4.704GlyAsp: 4.704 ± 0.082	4.803GlyGlu: 4.803 ± 0.068	2.449GlyPhe: 2.449 ± 0.051	7.854GlyGly: 7.854 ± 0.113	1.812GlyHis: 1.812 ± 0.046	3.937GlyIle: 3.937 ± 0.069	1.953GlyLys: 1.953 ± 0.046	9.285GlyLeu: 9.285 ± 0.103	2.182GlyMet: 2.182 ± 0.047	1.579GlyAsn: 1.579 ± 0.047	4.46GlyPro: 4.46 ± 0.073	2.718GlyGln: 2.718 ± 0.056	7.181GlyArg: 7.181 ± 0.089	6.106GlySer: 6.106 ± 0.083	5.726GlyThr: 5.726 ± 0.086	7.304GlyVal: 7.304 ± 0.099	1.572GlyTrp: 1.572 ± 0.038	2.06GlyTyr: 2.06 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.393HisAla: 2.393 ± 0.047	0.175HisCys: 0.175 ± 0.013	1.365HisAsp: 1.365 ± 0.033	1.148HisGlu: 1.148 ± 0.032	0.446HisPhe: 0.446 ± 0.021	1.876HisGly: 1.876 ± 0.047	0.539HisHis: 0.539 ± 0.025	0.691HisIle: 0.691 ± 0.026	0.311HisLys: 0.311 ± 0.019	2.231HisLeu: 2.231 ± 0.048	0.404HisMet: 0.404 ± 0.019	0.416HisAsn: 0.416 ± 0.02	1.496HisPro: 1.496 ± 0.039	0.54HisGln: 0.54 ± 0.025	1.738HisArg: 1.738 ± 0.05	1.124HisSer: 1.124 ± 0.033	0.947HisThr: 0.947 ± 0.03	1.64HisVal: 1.64 ± 0.041	0.318HisTrp: 0.318 ± 0.015	0.453HisTyr: 0.453 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.811IleAla: 5.811 ± 0.091	0.341IleCys: 0.341 ± 0.017	3.124IleAsp: 3.124 ± 0.068	2.562IleGlu: 2.562 ± 0.057	0.971IlePhe: 0.971 ± 0.033	4.173IleGly: 4.173 ± 0.069	0.727IleHis: 0.727 ± 0.029	1.876IleIle: 1.876 ± 0.051	0.826IleLys: 0.826 ± 0.031	3.654IleLeu: 3.654 ± 0.068	0.843IleMet: 0.843 ± 0.029	0.951IleAsn: 0.951 ± 0.034	2.187IlePro: 2.187 ± 0.056	0.882IleGln: 0.882 ± 0.029	2.319IleArg: 2.319 ± 0.051	2.448IleSer: 2.448 ± 0.056	2.78IleThr: 2.78 ± 0.06	3.77IleVal: 3.77 ± 0.07	0.483IleTrp: 0.483 ± 0.024	0.666IleTyr: 0.666 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.484LysAla: 2.484 ± 0.058	0.094LysCys: 0.094 ± 0.009	1.278LysAsp: 1.278 ± 0.044	1.156LysGlu: 1.156 ± 0.042	0.36LysPhe: 0.36 ± 0.022	1.629LysGly: 1.629 ± 0.045	0.398LysHis: 0.398 ± 0.02	0.85LysIle: 0.85 ± 0.032	0.712LysLys: 0.712 ± 0.034	1.317LysLeu: 1.317 ± 0.037	0.383LysMet: 0.383 ± 0.025	0.543LysAsn: 0.543 ± 0.024	1.006LysPro: 1.006 ± 0.033	0.611LysGln: 0.611 ± 0.027	1.486LysArg: 1.486 ± 0.044	1.061LysSer: 1.061 ± 0.031	1.251LysThr: 1.251 ± 0.038	1.457LysVal: 1.457 ± 0.041	0.201LysTrp: 0.201 ± 0.014	0.376LysTyr: 0.376 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.521LeuAla: 14.521 ± 0.152	0.759LeuCys: 0.759 ± 0.029	6.441LeuAsp: 6.441 ± 0.096	4.937LeuGlu: 4.937 ± 0.076	2.303LeuPhe: 2.303 ± 0.054	8.994LeuGly: 8.994 ± 0.099	1.954LeuHis: 1.954 ± 0.043	4.306LeuIle: 4.306 ± 0.084	1.707LeuLys: 1.707 ± 0.052	10.35LeuLeu: 10.35 ± 0.149	2.12LeuMet: 2.12 ± 0.055	1.818LeuAsn: 1.818 ± 0.049	5.707LeuPro: 5.707 ± 0.078	1.976LeuGln: 1.976 ± 0.04	7.397LeuArg: 7.397 ± 0.087	6.212LeuSer: 6.212 ± 0.083	6.932LeuThr: 6.932 ± 0.091	8.803LeuVal: 8.803 ± 0.099	1.191LeuTrp: 1.191 ± 0.037	1.553LeuTyr: 1.553 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.625MetAla: 2.625 ± 0.053	0.168MetCys: 0.168 ± 0.013	1.016MetAsp: 1.016 ± 0.032	0.877MetGlu: 0.877 ± 0.031	0.478MetPhe: 0.478 ± 0.026	1.677MetGly: 1.677 ± 0.04	0.361MetHis: 0.361 ± 0.02	0.991MetIle: 0.991 ± 0.029	0.402MetLys: 0.402 ± 0.021	2.072MetLeu: 2.072 ± 0.05	0.421MetMet: 0.421 ± 0.025	0.532MetAsn: 0.532 ± 0.024	1.379MetPro: 1.379 ± 0.04	0.438MetGln: 0.438 ± 0.021	1.773MetArg: 1.773 ± 0.04	1.876MetSer: 1.876 ± 0.051	1.917MetThr: 1.917 ± 0.044	1.598MetVal: 1.598 ± 0.037	0.264MetTrp: 0.264 ± 0.017	0.307MetTyr: 0.307 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.446AsnAla: 2.446 ± 0.061	0.131AsnCys: 0.131 ± 0.012	1.134AsnAsp: 1.134 ± 0.042	0.969AsnGlu: 0.969 ± 0.032	0.412AsnPhe: 0.412 ± 0.021	1.786AsnGly: 1.786 ± 0.048	0.412AsnHis: 0.412 ± 0.021	0.802AsnIle: 0.802 ± 0.031	0.398AsnLys: 0.398 ± 0.022	1.887AsnLeu: 1.887 ± 0.049	0.324AsnMet: 0.324 ± 0.017	0.467AsnAsn: 0.467 ± 0.024	1.364AsnPro: 1.364 ± 0.037	0.538AsnGln: 0.538 ± 0.026	1.373AsnArg: 1.373 ± 0.035	1.051AsnSer: 1.051 ± 0.039	1.092AsnThr: 1.092 ± 0.039	1.368AsnVal: 1.368 ± 0.04	0.275AsnTrp: 0.275 ± 0.016	0.39AsnTyr: 0.39 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	8.038ProAla: 8.038 ± 0.113	0.316ProCys: 0.316 ± 0.019	4.3ProAsp: 4.3 ± 0.077	4.102ProGlu: 4.102 ± 0.07	1.36ProPhe: 1.36 ± 0.044	5.763ProGly: 5.763 ± 0.093	1.167ProHis: 1.167 ± 0.032	1.907ProIle: 1.907 ± 0.045	0.876ProLys: 0.876 ± 0.033	4.643ProLeu: 4.643 ± 0.075	1.079ProMet: 1.079 ± 0.029	0.936ProAsn: 0.936 ± 0.029	2.589ProPro: 2.589 ± 0.063	1.764ProGln: 1.764 ± 0.047	3.589ProArg: 3.589 ± 0.069	3.871ProSer: 3.871 ± 0.075	3.672ProThr: 3.672 ± 0.08	4.862ProVal: 4.862 ± 0.08	0.895ProTrp: 0.895 ± 0.034	0.977ProTyr: 0.977 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.888GlnAla: 3.888 ± 0.075	0.204GlnCys: 0.204 ± 0.015	1.495GlnAsp: 1.495 ± 0.045	1.567GlnGlu: 1.567 ± 0.046	0.559GlnPhe: 0.559 ± 0.022	2.178GlnGly: 2.178 ± 0.042	0.531GlnHis: 0.531 ± 0.024	1.302GlnIle: 1.302 ± 0.04	0.572GlnLys: 0.572 ± 0.024	2.422GlnLeu: 2.422 ± 0.054	0.692GlnMet: 0.692 ± 0.026	0.517GlnAsn: 0.517 ± 0.025	1.523GlnPro: 1.523 ± 0.049	0.954GlnGln: 0.954 ± 0.043	2.241GlnArg: 2.241 ± 0.057	1.485GlnSer: 1.485 ± 0.041	1.507GlnThr: 1.507 ± 0.042	2.568GlnVal: 2.568 ± 0.052	0.534GlnTrp: 0.534 ± 0.024	0.537GlnTyr: 0.537 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.834ArgAla: 9.834 ± 0.139	0.556ArgCys: 0.556 ± 0.021	3.866ArgAsp: 3.866 ± 0.07	4.326ArgGlu: 4.326 ± 0.074	2.014ArgPhe: 2.014 ± 0.047	5.382ArgGly: 5.382 ± 0.089	1.735ArgHis: 1.735 ± 0.041	3.307ArgIle: 3.307 ± 0.057	1.431ArgLys: 1.431 ± 0.038	8.131ArgLeu: 8.131 ± 0.105	1.865ArgMet: 1.865 ± 0.048	1.341ArgAsn: 1.341 ± 0.046	4.161ArgPro: 4.161 ± 0.076	2.106ArgGln: 2.106 ± 0.053	7.851ArgArg: 7.851 ± 0.105	4.855ArgSer: 4.855 ± 0.082	4.751ArgThr: 4.751 ± 0.075	5.569ArgVal: 5.569 ± 0.093	1.199ArgTrp: 1.199 ± 0.034	1.571ArgTyr: 1.571 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	8.871SerAla: 8.871 ± 0.115	0.454SerCys: 0.454 ± 0.026	3.399SerAsp: 3.399 ± 0.069	3.074SerGlu: 3.074 ± 0.064	1.718SerPhe: 1.718 ± 0.048	6.476SerGly: 6.476 ± 0.083	1.169SerHis: 1.169 ± 0.037	2.314SerIle: 2.314 ± 0.052	1.19SerLys: 1.19 ± 0.042	5.726SerLeu: 5.726 ± 0.079	1.512SerMet: 1.512 ± 0.046	1.118SerAsn: 1.118 ± 0.033	3.971SerPro: 3.971 ± 0.072	1.882SerGln: 1.882 ± 0.044	4.663SerArg: 4.663 ± 0.084	4.892SerSer: 4.892 ± 0.1	4.374SerThr: 4.374 ± 0.083	4.608SerVal: 4.608 ± 0.061	1.047SerTrp: 1.047 ± 0.031	1.237SerTyr: 1.237 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	8.65ThrAla: 8.65 ± 0.125	0.544ThrCys: 0.544 ± 0.024	3.779ThrAsp: 3.779 ± 0.076	2.923ThrGlu: 2.923 ± 0.055	1.601ThrPhe: 1.601 ± 0.044	6.255ThrGly: 6.255 ± 0.079	1.168ThrHis: 1.168 ± 0.035	2.76ThrIle: 2.76 ± 0.055	0.996ThrLys: 0.996 ± 0.037	5.431ThrLeu: 5.431 ± 0.081	1.221ThrMet: 1.221 ± 0.036	1.141ThrAsn: 1.141 ± 0.034	3.855ThrPro: 3.855 ± 0.075	1.496ThrGln: 1.496 ± 0.037	4.069ThrArg: 4.069 ± 0.072	3.933ThrSer: 3.933 ± 0.069	4.354ThrThr: 4.354 ± 0.072	5.389ThrVal: 5.389 ± 0.085	1.07ThrTrp: 1.07 ± 0.039	1.277ThrTyr: 1.277 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	10.35ValAla: 10.35 ± 0.121	0.752ValCys: 0.752 ± 0.032	5.032ValAsp: 5.032 ± 0.08	4.816ValGlu: 4.816 ± 0.076	2.162ValPhe: 2.162 ± 0.048	6.909ValGly: 6.909 ± 0.102	1.642ValHis: 1.642 ± 0.042	3.868ValIle: 3.868 ± 0.068	1.457ValLys: 1.457 ± 0.036	9.402ValLeu: 9.402 ± 0.113	1.753ValMet: 1.753 ± 0.042	1.573ValAsn: 1.573 ± 0.039	4.784ValPro: 4.784 ± 0.076	1.855ValGln: 1.855 ± 0.046	6.203ValArg: 6.203 ± 0.086	5.278ValSer: 5.278 ± 0.069	5.403ValThr: 5.403 ± 0.081	8.542ValVal: 8.542 ± 0.123	1.094ValTrp: 1.094 ± 0.039	1.366ValTyr: 1.366 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.752TrpAla: 1.752 ± 0.042	0.157TrpCys: 0.157 ± 0.014	0.807TrpAsp: 0.807 ± 0.03	0.764TrpGlu: 0.764 ± 0.027	0.471TrpPhe: 0.471 ± 0.022	1.053TrpGly: 1.053 ± 0.036	0.283TrpHis: 0.283 ± 0.019	0.658TrpIle: 0.658 ± 0.025	0.32TrpLys: 0.32 ± 0.02	1.606TrpLeu: 1.606 ± 0.04	0.378TrpMet: 0.378 ± 0.018	0.402TrpAsn: 0.402 ± 0.023	0.685TrpPro: 0.685 ± 0.028	0.439TrpGln: 0.439 ± 0.022	1.316TrpArg: 1.316 ± 0.041	0.96TrpSer: 0.96 ± 0.034	1.035TrpThr: 1.035 ± 0.039	1.072TrpVal: 1.072 ± 0.038	0.388TrpTrp: 0.388 ± 0.019	0.305TrpTyr: 0.305 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.31TyrAla: 2.31 ± 0.05	0.154TyrCys: 0.154 ± 0.013	1.2TyrAsp: 1.2 ± 0.036	1.16TyrGlu: 1.16 ± 0.036	0.589TyrPhe: 0.589 ± 0.029	1.771TyrGly: 1.771 ± 0.044	0.347TyrHis: 0.347 ± 0.019	0.662TyrIle: 0.662 ± 0.03	0.374TyrLys: 0.374 ± 0.021	2.041TyrLeu: 2.041 ± 0.05	0.345TyrMet: 0.345 ± 0.02	0.401TyrAsn: 0.401 ± 0.021	0.988TyrPro: 0.988 ± 0.035	0.528TyrGln: 0.528 ± 0.025	1.526TyrArg: 1.526 ± 0.039	1.153TyrSer: 1.153 ± 0.04	1.142TyrThr: 1.142 ± 0.035	1.472TyrVal: 1.472 ± 0.044	0.282TyrTrp: 0.282 ± 0.019	0.466TyrTyr: 0.466 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3129 proteins (984542 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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