Amino acid dipepetide frequency for Etheostoma fonticola aquareovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.697AlaAla: 10.697 ± 1.142
1.289AlaCys: 1.289 ± 0.445
5.413AlaAsp: 5.413 ± 0.747
2.835AlaGlu: 2.835 ± 0.607
3.866AlaPhe: 3.866 ± 0.531
5.8AlaGly: 5.8 ± 0.941
2.449AlaHis: 2.449 ± 0.5
5.8AlaIle: 5.8 ± 0.873
2.449AlaLys: 2.449 ± 0.781
8.12AlaLeu: 8.12 ± 0.864
2.835AlaMet: 2.835 ± 0.863
3.866AlaAsn: 3.866 ± 0.696
6.573AlaPro: 6.573 ± 0.991
3.609AlaGln: 3.609 ± 0.916
6.315AlaArg: 6.315 ± 0.717
8.506AlaSer: 8.506 ± 1.11
7.991AlaThr: 7.991 ± 1.068
6.831AlaVal: 6.831 ± 0.736
1.289AlaTrp: 1.289 ± 0.403
3.609AlaTyr: 3.609 ± 0.535
0.0AlaXaa: 0.0 ± 0.0
Cys
1.289CysAla: 1.289 ± 0.442
0.902CysCys: 0.902 ± 0.806
0.902CysAsp: 0.902 ± 0.306
0.644CysGlu: 0.644 ± 0.429
0.258CysPhe: 0.258 ± 0.164
1.031CysGly: 1.031 ± 0.262
0.773CysHis: 0.773 ± 0.306
0.516CysIle: 0.516 ± 0.239
0.258CysLys: 0.258 ± 0.209
1.031CysLeu: 1.031 ± 0.32
0.0CysMet: 0.0 ± 0.0
0.129CysAsn: 0.129 ± 0.133
0.902CysPro: 0.902 ± 0.334
1.031CysGln: 1.031 ± 0.275
0.258CysArg: 0.258 ± 0.203
0.129CysSer: 0.129 ± 0.139
0.773CysThr: 0.773 ± 0.368
0.516CysVal: 0.516 ± 0.264
0.258CysTrp: 0.258 ± 0.207
0.387CysTyr: 0.387 ± 0.324
0.0CysXaa: 0.0 ± 0.0
Asp
6.444AspAla: 6.444 ± 1.053
0.387AspCys: 0.387 ± 0.163
3.222AspAsp: 3.222 ± 0.499
1.16AspGlu: 1.16 ± 0.39
1.547AspPhe: 1.547 ± 0.576
3.866AspGly: 3.866 ± 0.592
1.031AspHis: 1.031 ± 0.243
2.32AspIle: 2.32 ± 0.606
0.902AspLys: 0.902 ± 0.406
6.831AspLeu: 6.831 ± 1.011
1.031AspMet: 1.031 ± 0.299
1.933AspAsn: 1.933 ± 0.307
5.929AspPro: 5.929 ± 0.723
1.547AspGln: 1.547 ± 0.41
2.449AspArg: 2.449 ± 0.604
3.866AspSer: 3.866 ± 0.836
2.835AspThr: 2.835 ± 0.505
4.898AspVal: 4.898 ± 0.525
1.031AspTrp: 1.031 ± 0.356
2.062AspTyr: 2.062 ± 0.598
0.0AspXaa: 0.0 ± 0.0
Glu
3.222GluAla: 3.222 ± 0.669
0.387GluCys: 0.387 ± 0.2
1.16GluAsp: 1.16 ± 0.339
0.902GluGlu: 0.902 ± 0.436
0.902GluPhe: 0.902 ± 0.387
1.675GluGly: 1.675 ± 0.372
1.031GluHis: 1.031 ± 0.345
1.547GluIle: 1.547 ± 0.579
0.387GluLys: 0.387 ± 0.233
3.995GluLeu: 3.995 ± 0.808
1.418GluMet: 1.418 ± 0.469
0.902GluAsn: 0.902 ± 0.364
2.32GluPro: 2.32 ± 0.601
0.773GluGln: 0.773 ± 0.453
1.804GluArg: 1.804 ± 0.281
1.547GluSer: 1.547 ± 0.639
2.449GluThr: 2.449 ± 0.764
3.222GluVal: 3.222 ± 0.655
0.387GluTrp: 0.387 ± 0.228
1.031GluTyr: 1.031 ± 0.616
0.0GluXaa: 0.0 ± 0.0
Phe
2.707PheAla: 2.707 ± 0.672
0.129PheCys: 0.129 ± 0.147
2.449PheAsp: 2.449 ± 0.376
0.773PheGlu: 0.773 ± 0.394
1.031PhePhe: 1.031 ± 0.313
2.062PheGly: 2.062 ± 0.449
0.387PheHis: 0.387 ± 0.288
2.32PheIle: 2.32 ± 0.437
1.16PheLys: 1.16 ± 0.299
3.866PheLeu: 3.866 ± 0.885
0.773PheMet: 0.773 ± 0.279
1.289PheAsn: 1.289 ± 0.284
2.578PhePro: 2.578 ± 0.509
1.418PheGln: 1.418 ± 0.308
1.418PheArg: 1.418 ± 0.216
3.222PheSer: 3.222 ± 0.521
2.062PheThr: 2.062 ± 0.405
2.191PheVal: 2.191 ± 0.467
0.387PheTrp: 0.387 ± 0.279
1.418PheTyr: 1.418 ± 0.39
0.0PheXaa: 0.0 ± 0.0
Gly
5.8GlyAla: 5.8 ± 0.562
0.644GlyCys: 0.644 ± 0.3
2.964GlyAsp: 2.964 ± 0.543
1.16GlyGlu: 1.16 ± 0.32
3.222GlyPhe: 3.222 ± 0.372
2.964GlyGly: 2.964 ± 0.596
1.031GlyHis: 1.031 ± 0.408
2.32GlyIle: 2.32 ± 0.518
1.933GlyLys: 1.933 ± 0.54
5.8GlyLeu: 5.8 ± 0.677
1.289GlyMet: 1.289 ± 0.384
2.449GlyAsn: 2.449 ± 0.714
3.738GlyPro: 3.738 ± 0.584
1.933GlyGln: 1.933 ± 0.439
3.866GlyArg: 3.866 ± 0.557
4.511GlySer: 4.511 ± 0.69
2.449GlyThr: 2.449 ± 0.558
5.542GlyVal: 5.542 ± 0.691
0.644GlyTrp: 0.644 ± 0.289
1.547GlyTyr: 1.547 ± 0.384
0.0GlyXaa: 0.0 ± 0.0
His
2.32HisAla: 2.32 ± 0.456
0.129HisCys: 0.129 ± 0.138
0.644HisAsp: 0.644 ± 0.315
1.16HisGlu: 1.16 ± 0.429
0.258HisPhe: 0.258 ± 0.129
1.418HisGly: 1.418 ± 0.404
0.387HisHis: 0.387 ± 0.283
1.16HisIle: 1.16 ± 0.401
0.258HisLys: 0.258 ± 0.185
2.578HisLeu: 2.578 ± 0.576
0.773HisMet: 0.773 ± 0.321
0.644HisAsn: 0.644 ± 0.218
1.804HisPro: 1.804 ± 0.632
0.773HisGln: 0.773 ± 0.276
1.031HisArg: 1.031 ± 0.315
1.547HisSer: 1.547 ± 0.731
1.418HisThr: 1.418 ± 0.435
3.093HisVal: 3.093 ± 0.615
0.644HisTrp: 0.644 ± 0.192
0.516HisTyr: 0.516 ± 0.218
0.0HisXaa: 0.0 ± 0.0
Ile
5.671IleAla: 5.671 ± 0.777
0.773IleCys: 0.773 ± 0.247
3.351IleAsp: 3.351 ± 0.439
1.547IleGlu: 1.547 ± 0.501
1.289IlePhe: 1.289 ± 0.427
1.418IleGly: 1.418 ± 0.373
1.289IleHis: 1.289 ± 0.657
1.804IleIle: 1.804 ± 0.339
1.031IleLys: 1.031 ± 0.329
4.253IleLeu: 4.253 ± 0.66
1.418IleMet: 1.418 ± 0.458
2.449IleAsn: 2.449 ± 0.338
4.898IlePro: 4.898 ± 1.086
2.191IleGln: 2.191 ± 0.355
2.191IleArg: 2.191 ± 0.445
3.866IleSer: 3.866 ± 0.656
3.866IleThr: 3.866 ± 0.718
4.253IleVal: 4.253 ± 0.738
1.031IleTrp: 1.031 ± 0.34
0.773IleTyr: 0.773 ± 0.271
0.0IleXaa: 0.0 ± 0.0
Lys
1.933LysAla: 1.933 ± 0.543
0.129LysCys: 0.129 ± 0.106
1.804LysAsp: 1.804 ± 0.54
0.516LysGlu: 0.516 ± 0.148
0.387LysPhe: 0.387 ± 0.189
1.418LysGly: 1.418 ± 0.406
0.516LysHis: 0.516 ± 0.202
1.031LysIle: 1.031 ± 0.283
0.387LysLys: 0.387 ± 0.192
2.062LysLeu: 2.062 ± 0.913
0.516LysMet: 0.516 ± 0.189
0.644LysAsn: 0.644 ± 0.344
2.062LysPro: 2.062 ± 0.387
0.516LysGln: 0.516 ± 0.297
1.289LysArg: 1.289 ± 0.361
2.062LysSer: 2.062 ± 0.572
1.418LysThr: 1.418 ± 0.312
2.062LysVal: 2.062 ± 0.657
0.773LysTrp: 0.773 ± 0.349
1.031LysTyr: 1.031 ± 0.301
0.0LysXaa: 0.0 ± 0.0
Leu
10.439LeuAla: 10.439 ± 0.677
1.547LeuCys: 1.547 ± 0.565
5.929LeuAsp: 5.929 ± 0.713
3.609LeuGlu: 3.609 ± 0.815
2.578LeuPhe: 2.578 ± 0.336
4.769LeuGly: 4.769 ± 0.526
2.191LeuHis: 2.191 ± 0.565
4.511LeuIle: 4.511 ± 0.687
3.609LeuLys: 3.609 ± 0.486
10.311LeuLeu: 10.311 ± 1.459
2.707LeuMet: 2.707 ± 0.729
4.64LeuAsn: 4.64 ± 1.046
6.573LeuPro: 6.573 ± 0.794
3.351LeuGln: 3.351 ± 0.436
6.315LeuArg: 6.315 ± 0.693
9.022LeuSer: 9.022 ± 1.106
9.795LeuThr: 9.795 ± 1.036
5.155LeuVal: 5.155 ± 0.859
1.031LeuTrp: 1.031 ± 0.388
3.738LeuTyr: 3.738 ± 0.607
0.0LeuXaa: 0.0 ± 0.0
Met
1.933MetAla: 1.933 ± 0.417
0.258MetCys: 0.258 ± 0.131
0.902MetAsp: 0.902 ± 0.376
1.547MetGlu: 1.547 ± 0.532
1.031MetPhe: 1.031 ± 0.384
1.675MetGly: 1.675 ± 0.447
0.387MetHis: 0.387 ± 0.159
1.675MetIle: 1.675 ± 0.419
0.387MetLys: 0.387 ± 0.21
2.32MetLeu: 2.32 ± 0.664
0.773MetMet: 0.773 ± 0.324
1.289MetAsn: 1.289 ± 0.429
1.16MetPro: 1.16 ± 0.277
0.773MetGln: 0.773 ± 0.289
0.902MetArg: 0.902 ± 0.288
2.449MetSer: 2.449 ± 0.568
1.933MetThr: 1.933 ± 0.398
1.418MetVal: 1.418 ± 0.488
0.387MetTrp: 0.387 ± 0.301
0.644MetTyr: 0.644 ± 0.207
0.0MetXaa: 0.0 ± 0.0
Asn
4.124AsnAla: 4.124 ± 0.71
0.387AsnCys: 0.387 ± 0.198
1.804AsnAsp: 1.804 ± 0.419
1.16AsnGlu: 1.16 ± 0.487
0.644AsnPhe: 0.644 ± 0.229
2.964AsnGly: 2.964 ± 0.62
0.644AsnHis: 0.644 ± 0.26
1.804AsnIle: 1.804 ± 0.527
1.289AsnLys: 1.289 ± 0.24
3.093AsnLeu: 3.093 ± 0.574
0.516AsnMet: 0.516 ± 0.298
1.933AsnAsn: 1.933 ± 0.608
4.382AsnPro: 4.382 ± 0.789
2.578AsnGln: 2.578 ± 0.603
2.32AsnArg: 2.32 ± 0.375
2.449AsnSer: 2.449 ± 0.689
2.191AsnThr: 2.191 ± 0.647
3.609AsnVal: 3.609 ± 0.79
0.644AsnTrp: 0.644 ± 0.301
1.031AsnTyr: 1.031 ± 0.338
0.0AsnXaa: 0.0 ± 0.0
Pro
9.28ProAla: 9.28 ± 1.534
0.902ProCys: 0.902 ± 0.669
3.48ProAsp: 3.48 ± 0.702
3.48ProGlu: 3.48 ± 0.88
3.48ProPhe: 3.48 ± 0.842
3.866ProGly: 3.866 ± 0.714
2.191ProHis: 2.191 ± 0.498
4.64ProIle: 4.64 ± 0.463
0.773ProLys: 0.773 ± 0.443
8.893ProLeu: 8.893 ± 0.856
1.16ProMet: 1.16 ± 0.469
3.093ProAsn: 3.093 ± 0.491
7.733ProPro: 7.733 ± 2.526
2.707ProGln: 2.707 ± 0.426
4.253ProArg: 4.253 ± 1.175
6.96ProSer: 6.96 ± 0.897
7.089ProThr: 7.089 ± 0.761
5.671ProVal: 5.671 ± 0.88
0.902ProTrp: 0.902 ± 0.457
1.675ProTyr: 1.675 ± 0.413
0.0ProXaa: 0.0 ± 0.0
Gln
3.351GlnAla: 3.351 ± 0.605
0.644GlnCys: 0.644 ± 0.289
2.191GlnAsp: 2.191 ± 0.631
0.644GlnGlu: 0.644 ± 0.312
1.933GlnPhe: 1.933 ± 0.438
1.418GlnGly: 1.418 ± 0.424
1.031GlnHis: 1.031 ± 0.302
2.062GlnIle: 2.062 ± 0.468
0.387GlnLys: 0.387 ± 0.195
4.64GlnLeu: 4.64 ± 0.987
0.387GlnMet: 0.387 ± 0.161
0.902GlnAsn: 0.902 ± 0.52
3.351GlnPro: 3.351 ± 0.522
0.773GlnGln: 0.773 ± 0.258
3.222GlnArg: 3.222 ± 0.546
2.707GlnSer: 2.707 ± 0.618
3.222GlnThr: 3.222 ± 0.595
3.351GlnVal: 3.351 ± 0.625
0.516GlnTrp: 0.516 ± 0.199
1.418GlnTyr: 1.418 ± 0.348
0.0GlnXaa: 0.0 ± 0.0
Arg
5.413ArgAla: 5.413 ± 0.634
0.644ArgCys: 0.644 ± 0.312
3.48ArgAsp: 3.48 ± 0.749
1.933ArgGlu: 1.933 ± 0.328
1.804ArgPhe: 1.804 ± 0.48
3.609ArgGly: 3.609 ± 0.54
1.16ArgHis: 1.16 ± 0.483
2.835ArgIle: 2.835 ± 0.718
0.387ArgLys: 0.387 ± 0.177
7.733ArgLeu: 7.733 ± 1.009
1.675ArgMet: 1.675 ± 0.21
2.32ArgAsn: 2.32 ± 0.416
4.124ArgPro: 4.124 ± 0.83
2.449ArgGln: 2.449 ± 0.521
3.609ArgArg: 3.609 ± 0.815
4.511ArgSer: 4.511 ± 0.685
3.48ArgThr: 3.48 ± 0.486
4.124ArgVal: 4.124 ± 0.621
1.16ArgTrp: 1.16 ± 0.304
1.547ArgTyr: 1.547 ± 0.482
0.0ArgXaa: 0.0 ± 0.0
Ser
8.893SerAla: 8.893 ± 1.45
0.773SerCys: 0.773 ± 0.403
3.609SerAsp: 3.609 ± 0.769
1.804SerGlu: 1.804 ± 0.535
3.093SerPhe: 3.093 ± 0.656
5.155SerGly: 5.155 ± 0.714
1.031SerHis: 1.031 ± 0.441
3.866SerIle: 3.866 ± 0.558
1.804SerLys: 1.804 ± 0.407
7.991SerLeu: 7.991 ± 1.086
2.062SerMet: 2.062 ± 0.353
2.062SerAsn: 2.062 ± 0.447
5.671SerPro: 5.671 ± 0.762
2.578SerGln: 2.578 ± 0.511
5.026SerArg: 5.026 ± 0.489
7.217SerSer: 7.217 ± 1.391
6.831SerThr: 6.831 ± 1.087
5.929SerVal: 5.929 ± 0.785
1.418SerTrp: 1.418 ± 0.42
2.062SerTyr: 2.062 ± 0.401
0.0SerXaa: 0.0 ± 0.0
Thr
6.057ThrAla: 6.057 ± 0.846
0.516ThrCys: 0.516 ± 0.281
4.382ThrAsp: 4.382 ± 0.876
2.449ThrGlu: 2.449 ± 0.344
3.093ThrPhe: 3.093 ± 0.602
3.609ThrGly: 3.609 ± 0.495
1.418ThrHis: 1.418 ± 0.425
3.222ThrIle: 3.222 ± 0.612
2.062ThrLys: 2.062 ± 0.584
7.475ThrLeu: 7.475 ± 1.037
1.804ThrMet: 1.804 ± 0.361
2.449ThrAsn: 2.449 ± 0.487
6.444ThrPro: 6.444 ± 0.68
3.351ThrGln: 3.351 ± 0.427
3.866ThrArg: 3.866 ± 0.71
6.702ThrSer: 6.702 ± 0.771
5.413ThrThr: 5.413 ± 0.755
6.444ThrVal: 6.444 ± 0.547
0.902ThrTrp: 0.902 ± 0.377
2.191ThrTyr: 2.191 ± 0.598
0.0ThrXaa: 0.0 ± 0.0
Val
7.346ValAla: 7.346 ± 1.145
1.16ValCys: 1.16 ± 0.346
4.253ValAsp: 4.253 ± 0.618
2.707ValGlu: 2.707 ± 0.393
2.062ValPhe: 2.062 ± 0.544
4.382ValGly: 4.382 ± 0.63
1.933ValHis: 1.933 ± 0.868
2.707ValIle: 2.707 ± 0.637
1.547ValLys: 1.547 ± 0.479
6.315ValLeu: 6.315 ± 0.955
1.804ValMet: 1.804 ± 0.36
4.64ValAsn: 4.64 ± 0.926
7.475ValPro: 7.475 ± 0.762
3.866ValGln: 3.866 ± 0.603
4.511ValArg: 4.511 ± 0.533
4.64ValSer: 4.64 ± 0.604
6.444ValThr: 6.444 ± 0.771
5.155ValVal: 5.155 ± 0.625
1.547ValTrp: 1.547 ± 0.452
2.062ValTyr: 2.062 ± 0.611
0.0ValXaa: 0.0 ± 0.0
Trp
1.289TrpAla: 1.289 ± 0.37
0.129TrpCys: 0.129 ± 0.138
1.031TrpAsp: 1.031 ± 0.454
0.644TrpGlu: 0.644 ± 0.387
0.516TrpPhe: 0.516 ± 0.337
0.516TrpGly: 0.516 ± 0.328
0.516TrpHis: 0.516 ± 0.264
0.902TrpIle: 0.902 ± 0.283
0.644TrpLys: 0.644 ± 0.299
2.062TrpLeu: 2.062 ± 0.406
0.258TrpMet: 0.258 ± 0.212
0.387TrpAsn: 0.387 ± 0.201
1.418TrpPro: 1.418 ± 0.505
0.773TrpGln: 0.773 ± 0.357
1.289TrpArg: 1.289 ± 0.482
1.031TrpSer: 1.031 ± 0.427
0.902TrpThr: 0.902 ± 0.391
0.644TrpVal: 0.644 ± 0.333
0.387TrpTrp: 0.387 ± 0.239
0.258TrpTyr: 0.258 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.933TyrAla: 1.933 ± 0.543
0.258TyrCys: 0.258 ± 0.131
2.32TyrAsp: 2.32 ± 0.703
0.516TyrGlu: 0.516 ± 0.193
0.644TyrPhe: 0.644 ± 0.309
2.191TyrGly: 2.191 ± 0.412
1.16TyrHis: 1.16 ± 0.362
2.32TyrIle: 2.32 ± 0.627
0.902TyrLys: 0.902 ± 0.373
2.449TyrLeu: 2.449 ± 0.58
0.516TyrMet: 0.516 ± 0.187
1.547TyrAsn: 1.547 ± 0.376
3.093TyrPro: 3.093 ± 0.439
1.16TyrGln: 1.16 ± 0.439
2.062TyrArg: 2.062 ± 0.381
1.933TyrSer: 1.933 ± 0.37
1.289TyrThr: 1.289 ± 0.477
2.449TyrVal: 2.449 ± 0.534
0.258TyrTrp: 0.258 ± 0.212
0.129TyrTyr: 0.129 ± 0.138
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (7760 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski