Amino acid dipepetide frequency for Ferruginivarius sediminum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.841AlaAla: 16.841 ± 0.189	1.234AlaCys: 1.234 ± 0.032	6.969AlaAsp: 6.969 ± 0.101	8.841AlaGlu: 8.841 ± 0.105	4.244AlaPhe: 4.244 ± 0.058	11.603AlaGly: 11.603 ± 0.114	2.238AlaHis: 2.238 ± 0.044	5.453AlaIle: 5.453 ± 0.076	3.473AlaLys: 3.473 ± 0.056	12.539AlaLeu: 12.539 ± 0.119	3.352AlaMet: 3.352 ± 0.054	2.814AlaAsn: 2.814 ± 0.054	5.099AlaPro: 5.099 ± 0.064	3.706AlaGln: 3.706 ± 0.061	9.787AlaArg: 9.787 ± 0.123	5.531AlaSer: 5.531 ± 0.102	5.552AlaThr: 5.552 ± 0.092	9.495AlaVal: 9.495 ± 0.116	1.611AlaTrp: 1.611 ± 0.038	2.68AlaTyr: 2.68 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.044CysAla: 1.044 ± 0.031	0.115CysCys: 0.115 ± 0.01	0.602CysAsp: 0.602 ± 0.025	0.558CysGlu: 0.558 ± 0.022	0.318CysPhe: 0.318 ± 0.018	1.0CysGly: 1.0 ± 0.037	0.297CysHis: 0.297 ± 0.019	0.377CysIle: 0.377 ± 0.016	0.198CysLys: 0.198 ± 0.011	0.865CysLeu: 0.865 ± 0.027	0.189CysMet: 0.189 ± 0.013	0.245CysAsn: 0.245 ± 0.017	0.54CysPro: 0.54 ± 0.025	0.265CysGln: 0.265 ± 0.015	0.808CysArg: 0.808 ± 0.027	0.42CysSer: 0.42 ± 0.019	0.403CysThr: 0.403 ± 0.019	0.629CysVal: 0.629 ± 0.028	0.121CysTrp: 0.121 ± 0.012	0.241CysTyr: 0.241 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.05AspAla: 7.05 ± 0.114	0.516AspCys: 0.516 ± 0.021	3.529AspAsp: 3.529 ± 0.068	4.042AspGlu: 4.042 ± 0.062	2.14AspPhe: 2.14 ± 0.043	5.868AspGly: 5.868 ± 0.119	1.184AspHis: 1.184 ± 0.033	3.057AspIle: 3.057 ± 0.051	1.681AspLys: 1.681 ± 0.04	6.126AspLeu: 6.126 ± 0.087	1.339AspMet: 1.339 ± 0.037	1.374AspAsn: 1.374 ± 0.041	3.629AspPro: 3.629 ± 0.058	1.506AspGln: 1.506 ± 0.036	4.443AspArg: 4.443 ± 0.063	2.739AspSer: 2.739 ± 0.059	2.907AspThr: 2.907 ± 0.067	4.541AspVal: 4.541 ± 0.075	0.999AspTrp: 0.999 ± 0.028	1.531AspTyr: 1.531 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.593GluAla: 8.593 ± 0.097	0.412GluCys: 0.412 ± 0.02	3.441GluAsp: 3.441 ± 0.053	4.071GluGlu: 4.071 ± 0.081	1.706GluPhe: 1.706 ± 0.04	5.05GluGly: 5.05 ± 0.063	1.401GluHis: 1.401 ± 0.036	3.343GluIle: 3.343 ± 0.049	2.138GluLys: 2.138 ± 0.05	6.287GluLeu: 6.287 ± 0.09	1.778GluMet: 1.778 ± 0.044	1.66GluAsn: 1.66 ± 0.042	3.103GluPro: 3.103 ± 0.056	2.417GluGln: 2.417 ± 0.057	6.053GluArg: 6.053 ± 0.079	3.127GluSer: 3.127 ± 0.05	3.922GluThr: 3.922 ± 0.06	4.927GluVal: 4.927 ± 0.065	0.698GluTrp: 0.698 ± 0.024	1.07GluTyr: 1.07 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.286PheAla: 4.286 ± 0.071	0.404PheCys: 0.404 ± 0.021	2.593PheAsp: 2.593 ± 0.054	2.194PheGlu: 2.194 ± 0.042	1.282PhePhe: 1.282 ± 0.039	3.301PheGly: 3.301 ± 0.052	0.782PheHis: 0.782 ± 0.027	1.333PheIle: 1.333 ± 0.037	0.865PheLys: 0.865 ± 0.027	3.161PheLeu: 3.161 ± 0.06	0.75PheMet: 0.75 ± 0.027	0.984PheAsn: 0.984 ± 0.026	1.504PhePro: 1.504 ± 0.037	1.053PheGln: 1.053 ± 0.029	2.229PheArg: 2.229 ± 0.042	1.755PheSer: 1.755 ± 0.041	1.797PheThr: 1.797 ± 0.032	2.711PheVal: 2.711 ± 0.05	0.473PheTrp: 0.473 ± 0.02	0.831PheTyr: 0.831 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.268GlyAla: 9.268 ± 0.119	0.925GlyCys: 0.925 ± 0.028	5.091GlyAsp: 5.091 ± 0.114	6.225GlyGlu: 6.225 ± 0.076	3.417GlyPhe: 3.417 ± 0.06	8.252GlyGly: 8.252 ± 0.145	2.113GlyHis: 2.113 ± 0.048	4.248GlyIle: 4.248 ± 0.064	2.993GlyLys: 2.993 ± 0.064	8.935GlyLeu: 8.935 ± 0.085	2.434GlyMet: 2.434 ± 0.05	2.266GlyAsn: 2.266 ± 0.056	3.612GlyPro: 3.612 ± 0.064	3.033GlyGln: 3.033 ± 0.052	6.961GlyArg: 6.961 ± 0.076	4.249GlySer: 4.249 ± 0.076	4.665GlyThr: 4.665 ± 0.074	6.614GlyVal: 6.614 ± 0.076	1.392GlyTrp: 1.392 ± 0.037	2.419GlyTyr: 2.419 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.452HisAla: 2.452 ± 0.05	0.293HisCys: 0.293 ± 0.014	1.31HisAsp: 1.31 ± 0.029	1.299HisGlu: 1.299 ± 0.03	0.764HisPhe: 0.764 ± 0.023	2.16HisGly: 2.16 ± 0.038	0.577HisHis: 0.577 ± 0.02	0.966HisIle: 0.966 ± 0.028	0.517HisLys: 0.517 ± 0.022	2.203HisLeu: 2.203 ± 0.051	0.452HisMet: 0.452 ± 0.018	0.509HisAsn: 0.509 ± 0.02	1.444HisPro: 1.444 ± 0.037	0.546HisGln: 0.546 ± 0.021	1.663HisArg: 1.663 ± 0.046	0.879HisSer: 0.879 ± 0.025	0.902HisThr: 0.902 ± 0.03	1.645HisVal: 1.645 ± 0.039	0.329HisTrp: 0.329 ± 0.018	0.587HisTyr: 0.587 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.031IleAla: 6.031 ± 0.079	0.478IleCys: 0.478 ± 0.02	3.315IleAsp: 3.315 ± 0.055	3.287IleGlu: 3.287 ± 0.056	1.493IlePhe: 1.493 ± 0.037	4.291IleGly: 4.291 ± 0.065	0.877IleHis: 0.877 ± 0.023	1.553IleIle: 1.553 ± 0.04	1.142IleLys: 1.142 ± 0.033	4.054IleLeu: 4.054 ± 0.063	0.837IleMet: 0.837 ± 0.03	1.114IleAsn: 1.114 ± 0.031	2.2IlePro: 2.2 ± 0.042	1.162IleGln: 1.162 ± 0.032	2.912IleArg: 2.912 ± 0.047	2.299IleSer: 2.299 ± 0.045	2.145IleThr: 2.145 ± 0.038	3.921IleVal: 3.921 ± 0.06	0.566IleTrp: 0.566 ± 0.022	1.095IleTyr: 1.095 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.772LysAla: 3.772 ± 0.067	0.165LysCys: 0.165 ± 0.013	1.564LysAsp: 1.564 ± 0.043	1.56LysGlu: 1.56 ± 0.042	0.698LysPhe: 0.698 ± 0.024	2.299LysGly: 2.299 ± 0.05	0.624LysHis: 0.624 ± 0.02	1.183LysIle: 1.183 ± 0.037	0.969LysLys: 0.969 ± 0.034	2.986LysLeu: 2.986 ± 0.052	0.649LysMet: 0.649 ± 0.025	0.666LysAsn: 0.666 ± 0.024	1.774LysPro: 1.774 ± 0.041	1.057LysGln: 1.057 ± 0.037	2.382LysArg: 2.382 ± 0.054	1.496LysSer: 1.496 ± 0.035	1.613LysThr: 1.613 ± 0.039	2.357LysVal: 2.357 ± 0.05	0.297LysTrp: 0.297 ± 0.015	0.579LysTyr: 0.579 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.672LeuAla: 13.672 ± 0.13	0.924LeuCys: 0.924 ± 0.028	6.54LeuAsp: 6.54 ± 0.092	6.076LeuGlu: 6.076 ± 0.089	3.221LeuPhe: 3.221 ± 0.061	8.658LeuGly: 8.658 ± 0.096	2.076LeuHis: 2.076 ± 0.039	4.233LeuIle: 4.233 ± 0.071	2.933LeuLys: 2.933 ± 0.057	9.595LeuLeu: 9.595 ± 0.138	2.198LeuMet: 2.198 ± 0.046	2.543LeuAsn: 2.543 ± 0.04	5.505LeuPro: 5.505 ± 0.078	2.953LeuGln: 2.953 ± 0.052	7.986LeuArg: 7.986 ± 0.1	6.095LeuSer: 6.095 ± 0.076	5.202LeuThr: 5.202 ± 0.07	7.089LeuVal: 7.089 ± 0.093	1.187LeuTrp: 1.187 ± 0.033	2.078LeuTyr: 2.078 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.151MetAla: 3.151 ± 0.053	0.167MetCys: 0.167 ± 0.013	1.149MetAsp: 1.149 ± 0.031	1.267MetGlu: 1.267 ± 0.033	0.671MetPhe: 0.671 ± 0.023	1.816MetGly: 1.816 ± 0.052	0.496MetHis: 0.496 ± 0.018	1.052MetIle: 1.052 ± 0.027	0.762MetLys: 0.762 ± 0.029	2.491MetLeu: 2.491 ± 0.056	0.592MetMet: 0.592 ± 0.027	0.718MetAsn: 0.718 ± 0.022	1.459MetPro: 1.459 ± 0.04	0.872MetGln: 0.872 ± 0.027	1.857MetArg: 1.857 ± 0.044	1.487MetSer: 1.487 ± 0.038	1.721MetThr: 1.721 ± 0.035	1.612MetVal: 1.612 ± 0.045	0.24MetTrp: 0.24 ± 0.014	0.383MetTyr: 0.383 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.092AsnAla: 3.092 ± 0.056	0.253AsnCys: 0.253 ± 0.016	1.437AsnAsp: 1.437 ± 0.04	1.32AsnGlu: 1.32 ± 0.031	0.855AsnPhe: 0.855 ± 0.029	2.334AsnGly: 2.334 ± 0.054	0.476AsnHis: 0.476 ± 0.019	1.166AsnIle: 1.166 ± 0.032	0.614AsnLys: 0.614 ± 0.026	2.504AsnLeu: 2.504 ± 0.044	0.564AsnMet: 0.564 ± 0.021	0.635AsnAsn: 0.635 ± 0.025	1.79AsnPro: 1.79 ± 0.048	0.685AsnGln: 0.685 ± 0.029	1.788AsnArg: 1.788 ± 0.039	1.03AsnSer: 1.03 ± 0.028	1.194AsnThr: 1.194 ± 0.037	2.026AsnVal: 2.026 ± 0.04	0.373AsnTrp: 0.373 ± 0.019	0.621AsnTyr: 0.621 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.111ProAla: 6.111 ± 0.076	0.405ProCys: 0.405 ± 0.03	3.92ProAsp: 3.92 ± 0.064	4.226ProGlu: 4.226 ± 0.062	1.854ProPhe: 1.854 ± 0.044	4.905ProGly: 4.905 ± 0.065	1.08ProHis: 1.08 ± 0.029	2.012ProIle: 2.012 ± 0.038	1.482ProLys: 1.482 ± 0.042	4.605ProLeu: 4.605 ± 0.076	1.139ProMet: 1.139 ± 0.029	1.207ProAsn: 1.207 ± 0.035	2.693ProPro: 2.693 ± 0.059	1.57ProGln: 1.57 ± 0.041	3.421ProArg: 3.421 ± 0.058	2.468ProSer: 2.468 ± 0.047	2.301ProThr: 2.301 ± 0.044	4.161ProVal: 4.161 ± 0.059	0.742ProTrp: 0.742 ± 0.025	1.245ProTyr: 1.245 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.341GlnAla: 4.341 ± 0.069	0.213GlnCys: 0.213 ± 0.014	1.698GlnAsp: 1.698 ± 0.044	1.828GlnGlu: 1.828 ± 0.036	0.907GlnPhe: 0.907 ± 0.031	2.63GlnGly: 2.63 ± 0.059	0.695GlnHis: 0.695 ± 0.022	1.428GlnIle: 1.428 ± 0.033	0.836GlnLys: 0.836 ± 0.03	2.853GlnLeu: 2.853 ± 0.053	0.808GlnMet: 0.808 ± 0.025	0.692GlnAsn: 0.692 ± 0.023	1.877GlnPro: 1.877 ± 0.039	1.358GlnGln: 1.358 ± 0.04	2.841GlnArg: 2.841 ± 0.05	1.533GlnSer: 1.533 ± 0.034	1.582GlnThr: 1.582 ± 0.043	2.491GlnVal: 2.491 ± 0.048	0.373GlnTrp: 0.373 ± 0.018	0.6GlnTyr: 0.6 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.534ArgAla: 8.534 ± 0.097	0.651ArgCys: 0.651 ± 0.023	4.598ArgAsp: 4.598 ± 0.061	5.37ArgGlu: 5.37 ± 0.083	2.893ArgPhe: 2.893 ± 0.052	5.57ArgGly: 5.57 ± 0.062	2.078ArgHis: 2.078 ± 0.045	4.007ArgIle: 4.007 ± 0.064	2.539ArgLys: 2.539 ± 0.062	8.946ArgLeu: 8.946 ± 0.107	1.934ArgMet: 1.934 ± 0.049	1.933ArgAsn: 1.933 ± 0.039	3.918ArgPro: 3.918 ± 0.057	3.041ArgGln: 3.041 ± 0.059	7.447ArgArg: 7.447 ± 0.11	3.155ArgSer: 3.155 ± 0.053	3.551ArgThr: 3.551 ± 0.06	5.588ArgVal: 5.588 ± 0.079	1.02ArgTrp: 1.02 ± 0.028	1.875ArgTyr: 1.875 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.503SerAla: 5.503 ± 0.085	0.415SerCys: 0.415 ± 0.017	2.984SerAsp: 2.984 ± 0.073	3.13SerGlu: 3.13 ± 0.051	1.896SerPhe: 1.896 ± 0.044	5.264SerGly: 5.264 ± 0.092	1.012SerHis: 1.012 ± 0.028	2.13SerIle: 2.13 ± 0.043	1.315SerLys: 1.315 ± 0.036	4.895SerLeu: 4.895 ± 0.074	1.145SerMet: 1.145 ± 0.032	1.26SerAsn: 1.26 ± 0.035	2.501SerPro: 2.501 ± 0.049	1.533SerGln: 1.533 ± 0.033	3.62SerArg: 3.62 ± 0.062	2.27SerSer: 2.27 ± 0.054	2.266SerThr: 2.266 ± 0.046	3.714SerVal: 3.714 ± 0.055	0.685SerTrp: 0.685 ± 0.023	1.244SerTyr: 1.244 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.128ThrAla: 6.128 ± 0.1	0.481ThrCys: 0.481 ± 0.019	2.571ThrAsp: 2.571 ± 0.054	2.55ThrGlu: 2.55 ± 0.047	1.902ThrPhe: 1.902 ± 0.042	5.072ThrGly: 5.072 ± 0.087	0.982ThrHis: 0.982 ± 0.029	2.313ThrIle: 2.313 ± 0.046	1.182ThrLys: 1.182 ± 0.029	5.611ThrLeu: 5.611 ± 0.082	1.104ThrMet: 1.104 ± 0.031	1.161ThrAsn: 1.161 ± 0.03	3.102ThrPro: 3.102 ± 0.054	1.404ThrGln: 1.404 ± 0.034	3.478ThrArg: 3.478 ± 0.057	2.499ThrSer: 2.499 ± 0.044	2.595ThrThr: 2.595 ± 0.049	4.557ThrVal: 4.557 ± 0.077	0.694ThrTrp: 0.694 ± 0.025	1.198ThrTyr: 1.198 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.468ValAla: 9.468 ± 0.106	0.775ValCys: 0.775 ± 0.029	4.683ValAsp: 4.683 ± 0.072	5.371ValGlu: 5.371 ± 0.069	2.738ValPhe: 2.738 ± 0.049	5.951ValGly: 5.951 ± 0.08	1.599ValHis: 1.599 ± 0.034	3.445ValIle: 3.445 ± 0.062	2.067ValLys: 2.067 ± 0.044	7.903ValLeu: 7.903 ± 0.087	1.893ValMet: 1.893 ± 0.041	1.959ValAsn: 1.959 ± 0.035	3.895ValPro: 3.895 ± 0.058	2.155ValGln: 2.155 ± 0.049	5.599ValArg: 5.599 ± 0.067	3.988ValSer: 3.988 ± 0.067	4.393ValThr: 4.393 ± 0.068	6.473ValVal: 6.473 ± 0.079	0.934ValTrp: 0.934 ± 0.03	1.71ValTyr: 1.71 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.243TrpAla: 1.243 ± 0.03	0.146TrpCys: 0.146 ± 0.011	0.687TrpAsp: 0.687 ± 0.026	0.612TrpGlu: 0.612 ± 0.022	0.462TrpPhe: 0.462 ± 0.022	0.9TrpGly: 0.9 ± 0.031	0.355TrpHis: 0.355 ± 0.016	0.559TrpIle: 0.559 ± 0.026	0.373TrpLys: 0.373 ± 0.018	1.742TrpLeu: 1.742 ± 0.044	0.332TrpMet: 0.332 ± 0.017	0.394TrpAsn: 0.394 ± 0.018	0.753TrpPro: 0.753 ± 0.027	0.594TrpGln: 0.594 ± 0.018	1.375TrpArg: 1.375 ± 0.031	0.734TrpSer: 0.734 ± 0.03	0.724TrpThr: 0.724 ± 0.034	0.82TrpVal: 0.82 ± 0.026	0.234TrpTrp: 0.234 ± 0.015	0.318TrpTyr: 0.318 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.483TyrAla: 2.483 ± 0.049	0.264TyrCys: 0.264 ± 0.014	1.521TyrAsp: 1.521 ± 0.036	1.375TyrGlu: 1.375 ± 0.036	0.829TyrPhe: 0.829 ± 0.027	2.188TyrGly: 2.188 ± 0.043	0.552TyrHis: 0.552 ± 0.021	0.913TyrIle: 0.913 ± 0.028	0.609TyrLys: 0.609 ± 0.024	2.461TyrLeu: 2.461 ± 0.05	0.471TyrMet: 0.471 ± 0.021	0.623TyrAsn: 0.623 ± 0.024	1.147TyrPro: 1.147 ± 0.028	0.673TyrGln: 0.673 ± 0.026	1.999TyrArg: 1.999 ± 0.043	1.028TyrSer: 1.028 ± 0.026	1.15TyrThr: 1.15 ± 0.032	1.627TyrVal: 1.627 ± 0.038	0.388TyrTrp: 0.388 ± 0.017	0.656TyrTyr: 0.656 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3868 proteins (1237093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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