Amino acid dipepetide frequency for Pseudomicrostroma glucosiphilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.697AlaAla: 13.697 ± 0.465	0.929AlaCys: 0.929 ± 0.018	4.764AlaAsp: 4.764 ± 0.038	6.015AlaGlu: 6.015 ± 0.053	3.025AlaPhe: 3.025 ± 0.033	8.12AlaGly: 8.12 ± 0.061	2.041AlaHis: 2.041 ± 0.029	3.789AlaIle: 3.789 ± 0.038	4.479AlaLys: 4.479 ± 0.041	8.973AlaLeu: 8.973 ± 0.071	1.973AlaMet: 1.973 ± 0.026	2.848AlaAsn: 2.848 ± 0.032	6.256AlaPro: 6.256 ± 0.054	4.211AlaGln: 4.211 ± 0.042	6.329AlaArg: 6.329 ± 0.051	11.782AlaSer: 11.782 ± 0.4	6.225AlaThr: 6.225 ± 0.064	5.512AlaVal: 5.512 ± 0.071	1.142AlaTrp: 1.142 ± 0.02	2.004AlaTyr: 2.004 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.798CysAla: 0.798 ± 0.015	0.197CysCys: 0.197 ± 0.008	0.498CysAsp: 0.498 ± 0.013	0.504CysGlu: 0.504 ± 0.012	0.415CysPhe: 0.415 ± 0.011	0.727CysGly: 0.727 ± 0.017	0.264CysHis: 0.264 ± 0.01	0.513CysIle: 0.513 ± 0.013	0.419CysLys: 0.419 ± 0.013	1.083CysLeu: 1.083 ± 0.019	0.177CysMet: 0.177 ± 0.007	0.285CysAsn: 0.285 ± 0.009	0.577CysPro: 0.577 ± 0.016	0.366CysGln: 0.366 ± 0.011	0.625CysArg: 0.625 ± 0.016	0.856CysSer: 0.856 ± 0.018	0.571CysThr: 0.571 ± 0.013	0.625CysVal: 0.625 ± 0.015	0.149CysTrp: 0.149 ± 0.006	0.273CysTyr: 0.273 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.364AspAla: 5.364 ± 0.048	0.513AspCys: 0.513 ± 0.014	4.336AspAsp: 4.336 ± 0.057	4.996AspGlu: 4.996 ± 0.054	1.823AspPhe: 1.823 ± 0.025	4.3AspGly: 4.3 ± 0.033	1.055AspHis: 1.055 ± 0.018	2.014AspIle: 2.014 ± 0.027	1.965AspLys: 1.965 ± 0.028	4.869AspLeu: 4.869 ± 0.044	0.918AspMet: 0.918 ± 0.017	1.253AspAsn: 1.253 ± 0.018	2.985AspPro: 2.985 ± 0.035	1.734AspGln: 1.734 ± 0.023	2.97AspArg: 2.97 ± 0.033	4.248AspSer: 4.248 ± 0.04	2.436AspThr: 2.436 ± 0.029	3.613AspVal: 3.613 ± 0.034	0.799AspTrp: 0.799 ± 0.016	1.242AspTyr: 1.242 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	6.867GluAla: 6.867 ± 0.065	0.498GluCys: 0.498 ± 0.015	4.582GluAsp: 4.582 ± 0.047	7.305GluGlu: 7.305 ± 0.084	1.256GluPhe: 1.256 ± 0.024	5.155GluGly: 5.155 ± 0.041	1.267GluHis: 1.267 ± 0.022	2.208GluIle: 2.208 ± 0.029	3.219GluLys: 3.219 ± 0.039	4.873GluLeu: 4.873 ± 0.047	1.386GluMet: 1.386 ± 0.021	1.396GluAsn: 1.396 ± 0.022	2.362GluPro: 2.362 ± 0.029	2.748GluGln: 2.748 ± 0.031	4.426GluArg: 4.426 ± 0.046	4.192GluSer: 4.192 ± 0.036	2.93GluThr: 2.93 ± 0.035	3.87GluVal: 3.87 ± 0.043	0.808GluTrp: 0.808 ± 0.019	1.246GluTyr: 1.246 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.948PheAla: 2.948 ± 0.031	0.421PheCys: 0.421 ± 0.011	1.919PheAsp: 1.919 ± 0.025	1.782PheGlu: 1.782 ± 0.025	1.259PhePhe: 1.259 ± 0.026	2.586PheGly: 2.586 ± 0.035	0.707PheHis: 0.707 ± 0.015	1.209PheIle: 1.209 ± 0.022	1.207PheLys: 1.207 ± 0.02	2.942PheLeu: 2.942 ± 0.037	0.527PheMet: 0.527 ± 0.014	0.965PheAsn: 0.965 ± 0.016	1.595PhePro: 1.595 ± 0.025	1.006PheGln: 1.006 ± 0.02	1.622PheArg: 1.622 ± 0.024	2.716PheSer: 2.716 ± 0.029	1.71PheThr: 1.71 ± 0.022	1.931PheVal: 1.931 ± 0.03	0.457PheTrp: 0.457 ± 0.012	0.819PheTyr: 0.819 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	7.562GlyAla: 7.562 ± 0.063	0.727GlyCys: 0.727 ± 0.018	3.911GlyAsp: 3.911 ± 0.039	4.83GlyGlu: 4.83 ± 0.046	2.268GlyPhe: 2.268 ± 0.03	8.824GlyGly: 8.824 ± 0.106	1.7GlyHis: 1.7 ± 0.024	2.823GlyIle: 2.823 ± 0.029	3.989GlyLys: 3.989 ± 0.041	6.232GlyLeu: 6.232 ± 0.046	1.604GlyMet: 1.604 ± 0.02	2.307GlyAsn: 2.307 ± 0.03	4.041GlyPro: 4.041 ± 0.044	3.207GlyGln: 3.207 ± 0.036	4.95GlyArg: 4.95 ± 0.044	8.113GlySer: 8.113 ± 0.077	4.284GlyThr: 4.284 ± 0.04	4.333GlyVal: 4.333 ± 0.037	1.066GlyTrp: 1.066 ± 0.017	1.782GlyTyr: 1.782 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.941HisAla: 1.941 ± 0.027	0.281HisCys: 0.281 ± 0.01	1.063HisAsp: 1.063 ± 0.02	1.092HisGlu: 1.092 ± 0.017	0.857HisPhe: 0.857 ± 0.018	1.516HisGly: 1.516 ± 0.023	0.858HisHis: 0.858 ± 0.021	0.937HisIle: 0.937 ± 0.015	0.783HisLys: 0.783 ± 0.015	2.467HisLeu: 2.467 ± 0.032	0.358HisMet: 0.358 ± 0.01	0.619HisAsn: 0.619 ± 0.012	1.661HisPro: 1.661 ± 0.026	1.012HisGln: 1.012 ± 0.021	1.593HisArg: 1.593 ± 0.023	2.089HisSer: 2.089 ± 0.03	1.233HisThr: 1.233 ± 0.021	1.189HisVal: 1.189 ± 0.018	0.286HisTrp: 0.286 ± 0.009	0.573HisTyr: 0.573 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.864IleAla: 3.864 ± 0.034	0.53IleCys: 0.53 ± 0.013	2.277IleAsp: 2.277 ± 0.027	2.36IleGlu: 2.36 ± 0.032	1.434IlePhe: 1.434 ± 0.023	2.679IleGly: 2.679 ± 0.034	0.845IleHis: 0.845 ± 0.016	1.634IleIle: 1.634 ± 0.027	1.775IleLys: 1.775 ± 0.029	3.606IleLeu: 3.606 ± 0.043	0.659IleMet: 0.659 ± 0.015	1.217IleAsn: 1.217 ± 0.022	2.267IlePro: 2.267 ± 0.028	1.314IleGln: 1.314 ± 0.02	2.301IleArg: 2.301 ± 0.03	3.199IleSer: 3.199 ± 0.03	2.003IleThr: 2.003 ± 0.028	2.615IleVal: 2.615 ± 0.031	0.531IleTrp: 0.531 ± 0.014	0.932IleTyr: 0.932 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.764LysAla: 4.764 ± 0.049	0.357LysCys: 0.357 ± 0.011	2.39LysAsp: 2.39 ± 0.033	3.29LysGlu: 3.29 ± 0.041	0.976LysPhe: 0.976 ± 0.021	3.597LysGly: 3.597 ± 0.039	0.873LysHis: 0.873 ± 0.019	1.706LysIle: 1.706 ± 0.022	3.159LysLys: 3.159 ± 0.054	3.51LysLeu: 3.51 ± 0.036	0.946LysMet: 0.946 ± 0.019	1.153LysAsn: 1.153 ± 0.021	2.175LysPro: 2.175 ± 0.029	1.697LysGln: 1.697 ± 0.025	3.542LysArg: 3.542 ± 0.035	3.418LysSer: 3.418 ± 0.033	2.493LysThr: 2.493 ± 0.031	2.752LysVal: 2.752 ± 0.033	0.581LysTrp: 0.581 ± 0.013	0.933LysTyr: 0.933 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	9.047LeuAla: 9.047 ± 0.06	1.083LeuCys: 1.083 ± 0.019	4.883LeuAsp: 4.883 ± 0.046	5.022LeuGlu: 5.022 ± 0.046	2.939LeuPhe: 2.939 ± 0.037	6.028LeuGly: 6.028 ± 0.04	2.107LeuHis: 2.107 ± 0.03	3.351LeuIle: 3.351 ± 0.037	3.796LeuLys: 3.796 ± 0.035	9.163LeuLeu: 9.163 ± 0.087	1.544LeuMet: 1.544 ± 0.023	2.636LeuAsn: 2.636 ± 0.033	6.361LeuPro: 6.361 ± 0.058	3.871LeuGln: 3.871 ± 0.034	6.062LeuArg: 6.062 ± 0.052	8.372LeuSer: 8.372 ± 0.054	4.873LeuThr: 4.873 ± 0.042	5.109LeuVal: 5.109 ± 0.046	1.045LeuTrp: 1.045 ± 0.019	1.99LeuTyr: 1.99 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.063MetAla: 2.063 ± 0.022	0.175MetCys: 0.175 ± 0.007	1.047MetAsp: 1.047 ± 0.015	1.087MetGlu: 1.087 ± 0.018	0.453MetPhe: 0.453 ± 0.011	1.439MetGly: 1.439 ± 0.025	0.354MetHis: 0.354 ± 0.009	0.742MetIle: 0.742 ± 0.018	0.807MetLys: 0.807 ± 0.016	1.671MetLeu: 1.671 ± 0.022	0.48MetMet: 0.48 ± 0.012	0.552MetAsn: 0.552 ± 0.011	1.187MetPro: 1.187 ± 0.019	0.748MetGln: 0.748 ± 0.017	1.226MetArg: 1.226 ± 0.019	1.86MetSer: 1.86 ± 0.024	1.201MetThr: 1.201 ± 0.021	1.024MetVal: 1.024 ± 0.018	0.19MetTrp: 0.19 ± 0.007	0.358MetTyr: 0.358 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.999AsnAla: 2.999 ± 0.03	0.27AsnCys: 0.27 ± 0.01	1.442AsnAsp: 1.442 ± 0.02	1.557AsnGlu: 1.557 ± 0.02	0.941AsnPhe: 0.941 ± 0.017	2.889AsnGly: 2.889 ± 0.04	0.587AsnHis: 0.587 ± 0.012	1.208AsnIle: 1.208 ± 0.022	1.142AsnLys: 1.142 ± 0.02	2.551AsnLeu: 2.551 ± 0.029	0.509AsnMet: 0.509 ± 0.013	0.905AsnAsn: 0.905 ± 0.019	1.734AsnPro: 1.734 ± 0.024	0.923AsnGln: 0.923 ± 0.017	1.654AsnArg: 1.654 ± 0.021	2.276AsnSer: 2.276 ± 0.029	1.551AsnThr: 1.551 ± 0.019	1.891AsnVal: 1.891 ± 0.026	0.371AsnTrp: 0.371 ± 0.011	0.646AsnTyr: 0.646 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.571ProAla: 6.571 ± 0.063	0.46ProCys: 0.46 ± 0.013	2.619ProAsp: 2.619 ± 0.033	3.068ProGlu: 3.068 ± 0.033	1.909ProPhe: 1.909 ± 0.026	3.981ProGly: 3.981 ± 0.04	1.509ProHis: 1.509 ± 0.023	2.171ProIle: 2.171 ± 0.027	2.098ProLys: 2.098 ± 0.03	5.496ProLeu: 5.496 ± 0.046	0.952ProMet: 0.952 ± 0.021	1.639ProAsn: 1.639 ± 0.025	6.054ProPro: 6.054 ± 0.086	2.402ProGln: 2.402 ± 0.033	3.841ProArg: 3.841 ± 0.037	8.185ProSer: 8.185 ± 0.083	4.171ProThr: 4.171 ± 0.04	3.251ProVal: 3.251 ± 0.03	0.626ProTrp: 0.626 ± 0.014	1.271ProTyr: 1.271 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	4.362GlnAla: 4.362 ± 0.044	0.338GlnCys: 0.338 ± 0.01	2.1GlnAsp: 2.1 ± 0.026	2.58GlnGlu: 2.58 ± 0.028	0.847GlnPhe: 0.847 ± 0.016	3.073GlnGly: 3.073 ± 0.034	1.137GlnHis: 1.137 ± 0.023	1.472GlnIle: 1.472 ± 0.021	1.653GlnLys: 1.653 ± 0.023	3.321GlnLeu: 3.321 ± 0.039	0.864GlnMet: 0.864 ± 0.018	1.052GlnAsn: 1.052 ± 0.019	2.485GlnPro: 2.485 ± 0.032	3.394GlnGln: 3.394 ± 0.09	3.117GlnArg: 3.117 ± 0.03	3.56GlnSer: 3.56 ± 0.041	2.207GlnThr: 2.207 ± 0.022	2.181GlnVal: 2.181 ± 0.027	0.512GlnTrp: 0.512 ± 0.013	0.884GlnTyr: 0.884 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	5.829ArgAla: 5.829 ± 0.049	0.668ArgCys: 0.668 ± 0.016	3.284ArgAsp: 3.284 ± 0.042	4.185ArgGlu: 4.185 ± 0.047	1.947ArgPhe: 1.947 ± 0.024	4.814ArgGly: 4.814 ± 0.048	1.478ArgHis: 1.478 ± 0.025	2.561ArgIle: 2.561 ± 0.031	3.509ArgLys: 3.509 ± 0.037	5.988ArgLeu: 5.988 ± 0.05	1.31ArgMet: 1.31 ± 0.019	1.915ArgAsn: 1.915 ± 0.025	4.02ArgPro: 4.02 ± 0.044	2.927ArgGln: 2.927 ± 0.034	6.104ArgArg: 6.104 ± 0.064	6.305ArgSer: 6.305 ± 0.062	3.459ArgThr: 3.459 ± 0.038	3.274ArgVal: 3.274 ± 0.03	0.829ArgTrp: 0.829 ± 0.016	1.466ArgTyr: 1.466 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	10.671SerAla: 10.671 ± 0.36	0.762SerCys: 0.762 ± 0.018	4.473SerAsp: 4.473 ± 0.041	4.441SerGlu: 4.441 ± 0.04	2.879SerPhe: 2.879 ± 0.03	7.684SerGly: 7.684 ± 0.07	2.313SerHis: 2.313 ± 0.028	3.54SerIle: 3.54 ± 0.034	3.858SerLys: 3.858 ± 0.039	8.588SerLeu: 8.588 ± 0.059	1.711SerMet: 1.711 ± 0.025	2.919SerAsn: 2.919 ± 0.032	6.876SerPro: 6.876 ± 0.081	3.856SerGln: 3.856 ± 0.037	6.375SerArg: 6.375 ± 0.063	16.019SerSer: 16.019 ± 0.196	7.159SerThr: 7.159 ± 0.079	4.886SerVal: 4.886 ± 0.09	0.984SerTrp: 0.984 ± 0.019	1.99SerTyr: 1.99 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	6.014ThrAla: 6.014 ± 0.054	0.551ThrCys: 0.551 ± 0.015	2.504ThrAsp: 2.504 ± 0.029	2.68ThrGlu: 2.68 ± 0.033	1.916ThrPhe: 1.916 ± 0.029	4.339ThrGly: 4.339 ± 0.041	1.204ThrHis: 1.204 ± 0.017	2.378ThrIle: 2.378 ± 0.029	2.218ThrLys: 2.218 ± 0.027	5.266ThrLeu: 5.266 ± 0.043	1.03ThrMet: 1.03 ± 0.018	1.59ThrAsn: 1.59 ± 0.023	4.423ThrPro: 4.423 ± 0.047	2.009ThrGln: 2.009 ± 0.025	3.285ThrArg: 3.285 ± 0.031	7.186ThrSer: 7.186 ± 0.08	4.086ThrThr: 4.086 ± 0.057	3.157ThrVal: 3.157 ± 0.037	0.673ThrTrp: 0.673 ± 0.015	1.244ThrTyr: 1.244 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.695ValAla: 5.695 ± 0.112	0.683ValCys: 0.683 ± 0.015	3.324ValAsp: 3.324 ± 0.033	3.797ValGlu: 3.797 ± 0.038	1.917ValPhe: 1.917 ± 0.028	4.26ValGly: 4.26 ± 0.034	1.238ValHis: 1.238 ± 0.019	2.285ValIle: 2.285 ± 0.029	2.737ValLys: 2.737 ± 0.034	5.238ValLeu: 5.238 ± 0.052	1.068ValMet: 1.068 ± 0.016	1.64ValAsn: 1.64 ± 0.022	3.445ValPro: 3.445 ± 0.037	2.274ValGln: 2.274 ± 0.024	3.59ValArg: 3.59 ± 0.033	4.702ValSer: 4.702 ± 0.05	3.106ValThr: 3.106 ± 0.04	3.793ValVal: 3.793 ± 0.037	0.786ValTrp: 0.786 ± 0.019	1.347ValTyr: 1.347 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.048TrpAla: 1.048 ± 0.019	0.17TrpCys: 0.17 ± 0.007	0.701TrpAsp: 0.701 ± 0.017	0.759TrpGlu: 0.759 ± 0.015	0.39TrpPhe: 0.39 ± 0.011	0.814TrpGly: 0.814 ± 0.018	0.272TrpHis: 0.272 ± 0.009	0.554TrpIle: 0.554 ± 0.013	0.653TrpLys: 0.653 ± 0.015	1.211TrpLeu: 1.211 ± 0.022	0.275TrpMet: 0.275 ± 0.008	0.441TrpAsn: 0.441 ± 0.012	0.551TrpPro: 0.551 ± 0.015	0.547TrpGln: 0.547 ± 0.012	0.874TrpArg: 0.874 ± 0.018	1.102TrpSer: 1.102 ± 0.02	0.779TrpThr: 0.779 ± 0.017	0.683TrpVal: 0.683 ± 0.016	0.234TrpTrp: 0.234 ± 0.008	0.32TrpTyr: 0.32 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.008TyrAla: 2.008 ± 0.031	0.309TyrCys: 0.309 ± 0.009	1.314TyrAsp: 1.314 ± 0.023	1.243TyrGlu: 1.243 ± 0.019	0.874TyrPhe: 0.874 ± 0.017	1.729TyrGly: 1.729 ± 0.024	0.598TyrHis: 0.598 ± 0.014	0.947TyrIle: 0.947 ± 0.02	0.845TyrLys: 0.845 ± 0.017	2.235TyrLeu: 2.235 ± 0.029	0.372TyrMet: 0.372 ± 0.011	0.713TyrAsn: 0.713 ± 0.014	1.22TyrPro: 1.22 ± 0.021	0.894TyrGln: 0.894 ± 0.019	1.387TyrArg: 1.387 ± 0.022	1.807TyrSer: 1.807 ± 0.023	1.277TyrThr: 1.277 ± 0.021	1.239TyrVal: 1.239 ± 0.02	0.307TyrTrp: 0.307 ± 0.01	0.644TyrTyr: 0.644 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 6679 proteins (3653858 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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