Amino acid dipepetide frequency for Corynebacterium phage PeteyPab

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.263AlaAla: 10.263 ± 1.142
0.3AlaCys: 0.3 ± 0.103
5.007AlaAsp: 5.007 ± 0.506
6.859AlaGlu: 6.859 ± 0.503
2.603AlaPhe: 2.603 ± 0.337
6.759AlaGly: 6.759 ± 0.617
1.302AlaHis: 1.302 ± 0.335
5.257AlaIle: 5.257 ± 0.607
5.707AlaLys: 5.707 ± 0.615
7.71AlaLeu: 7.71 ± 0.99
2.153AlaMet: 2.153 ± 0.308
3.054AlaAsn: 3.054 ± 0.426
3.404AlaPro: 3.404 ± 0.421
3.705AlaGln: 3.705 ± 0.485
4.105AlaArg: 4.105 ± 0.496
5.858AlaSer: 5.858 ± 0.66
3.805AlaThr: 3.805 ± 0.544
5.858AlaVal: 5.858 ± 0.644
1.252AlaTrp: 1.252 ± 0.258
3.605AlaTyr: 3.605 ± 0.42
0.0AlaXaa: 0.0 ± 0.0
Cys
0.401CysAla: 0.401 ± 0.19
0.05CysCys: 0.05 ± 0.055
0.501CysAsp: 0.501 ± 0.156
0.501CysGlu: 0.501 ± 0.22
0.1CysPhe: 0.1 ± 0.071
0.401CysGly: 0.401 ± 0.137
0.1CysHis: 0.1 ± 0.079
0.2CysIle: 0.2 ± 0.104
0.15CysLys: 0.15 ± 0.092
0.501CysLeu: 0.501 ± 0.162
0.25CysMet: 0.25 ± 0.109
0.35CysAsn: 0.35 ± 0.112
0.2CysPro: 0.2 ± 0.132
0.15CysGln: 0.15 ± 0.082
0.451CysArg: 0.451 ± 0.154
0.801CysSer: 0.801 ± 0.219
0.2CysThr: 0.2 ± 0.097
0.551CysVal: 0.551 ± 0.165
0.1CysTrp: 0.1 ± 0.064
0.3CysTyr: 0.3 ± 0.112
0.0CysXaa: 0.0 ± 0.0
Asp
4.856AspAla: 4.856 ± 0.519
0.501AspCys: 0.501 ± 0.169
4.806AspAsp: 4.806 ± 0.544
6.208AspGlu: 6.208 ± 0.59
3.404AspPhe: 3.404 ± 0.379
5.607AspGly: 5.607 ± 0.606
1.352AspHis: 1.352 ± 0.206
3.555AspIle: 3.555 ± 0.415
3.104AspLys: 3.104 ± 0.346
6.208AspLeu: 6.208 ± 0.452
2.453AspMet: 2.453 ± 0.366
2.503AspAsn: 2.503 ± 0.297
4.105AspPro: 4.105 ± 0.464
2.303AspGln: 2.303 ± 0.284
3.905AspArg: 3.905 ± 0.437
4.055AspSer: 4.055 ± 0.339
3.505AspThr: 3.505 ± 0.384
3.404AspVal: 3.404 ± 0.47
1.001AspTrp: 1.001 ± 0.189
2.253AspTyr: 2.253 ± 0.323
0.0AspXaa: 0.0 ± 0.0
Glu
7.76GluAla: 7.76 ± 0.719
0.3GluCys: 0.3 ± 0.117
5.858GluAsp: 5.858 ± 0.733
6.709GluGlu: 6.709 ± 0.576
3.004GluPhe: 3.004 ± 0.414
5.908GluGly: 5.908 ± 0.509
0.951GluHis: 0.951 ± 0.203
6.058GluIle: 6.058 ± 0.668
3.605GluLys: 3.605 ± 0.471
6.108GluLeu: 6.108 ± 0.582
1.802GluMet: 1.802 ± 0.32
2.553GluAsn: 2.553 ± 0.417
2.804GluPro: 2.804 ± 0.316
2.453GluGln: 2.453 ± 0.346
4.856GluArg: 4.856 ± 0.684
4.005GluSer: 4.005 ± 0.404
4.806GluThr: 4.806 ± 0.493
6.008GluVal: 6.008 ± 0.744
1.202GluTrp: 1.202 ± 0.241
2.653GluTyr: 2.653 ± 0.392
0.0GluXaa: 0.0 ± 0.0
Phe
2.754PheAla: 2.754 ± 0.296
0.15PheCys: 0.15 ± 0.075
3.605PheAsp: 3.605 ± 0.458
3.204PheGlu: 3.204 ± 0.44
1.602PhePhe: 1.602 ± 0.311
2.954PheGly: 2.954 ± 0.464
0.751PheHis: 0.751 ± 0.196
1.552PheIle: 1.552 ± 0.245
1.402PheLys: 1.402 ± 0.281
2.904PheLeu: 2.904 ± 0.401
1.151PheMet: 1.151 ± 0.241
1.602PheAsn: 1.602 ± 0.258
1.202PhePro: 1.202 ± 0.265
1.402PheGln: 1.402 ± 0.198
2.603PheArg: 2.603 ± 0.31
3.505PheSer: 3.505 ± 0.528
2.253PheThr: 2.253 ± 0.329
2.103PheVal: 2.103 ± 0.364
0.401PheTrp: 0.401 ± 0.124
1.252PheTyr: 1.252 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
4.906GlyAla: 4.906 ± 0.919
0.401GlyCys: 0.401 ± 0.177
6.058GlyAsp: 6.058 ± 0.642
4.556GlyGlu: 4.556 ± 0.435
3.104GlyPhe: 3.104 ± 0.457
5.858GlyGly: 5.858 ± 0.883
1.151GlyHis: 1.151 ± 0.304
4.906GlyIle: 4.906 ± 0.527
3.655GlyLys: 3.655 ± 0.47
6.258GlyLeu: 6.258 ± 1.107
2.103GlyMet: 2.103 ± 0.309
3.454GlyAsn: 3.454 ± 0.426
2.904GlyPro: 2.904 ± 0.407
1.852GlyGln: 1.852 ± 0.331
4.656GlyArg: 4.656 ± 0.516
4.356GlySer: 4.356 ± 0.357
4.055GlyThr: 4.055 ± 0.491
5.207GlyVal: 5.207 ± 0.638
1.452GlyTrp: 1.452 ± 0.242
2.954GlyTyr: 2.954 ± 0.586
0.0GlyXaa: 0.0 ± 0.0
His
1.502HisAla: 1.502 ± 0.233
0.1HisCys: 0.1 ± 0.084
1.001HisAsp: 1.001 ± 0.279
0.851HisGlu: 0.851 ± 0.223
0.601HisPhe: 0.601 ± 0.192
1.252HisGly: 1.252 ± 0.207
0.551HisHis: 0.551 ± 0.196
1.252HisIle: 1.252 ± 0.274
1.051HisLys: 1.051 ± 0.266
0.901HisLeu: 0.901 ± 0.234
0.25HisMet: 0.25 ± 0.099
0.451HisAsn: 0.451 ± 0.147
1.402HisPro: 1.402 ± 0.243
0.501HisGln: 0.501 ± 0.152
0.851HisArg: 0.851 ± 0.257
0.901HisSer: 0.901 ± 0.258
1.202HisThr: 1.202 ± 0.275
1.151HisVal: 1.151 ± 0.27
0.25HisTrp: 0.25 ± 0.096
0.951HisTyr: 0.951 ± 0.227
0.0HisXaa: 0.0 ± 0.0
Ile
5.457IleAla: 5.457 ± 0.448
0.35IleCys: 0.35 ± 0.138
4.906IleAsp: 4.906 ± 0.464
4.756IleGlu: 4.756 ± 0.614
2.153IlePhe: 2.153 ± 0.364
3.655IleGly: 3.655 ± 0.553
1.402IleHis: 1.402 ± 0.304
3.104IleIle: 3.104 ± 0.384
3.505IleLys: 3.505 ± 0.36
3.655IleLeu: 3.655 ± 0.481
1.001IleMet: 1.001 ± 0.238
2.503IleAsn: 2.503 ± 0.281
2.603IlePro: 2.603 ± 0.265
1.852IleGln: 1.852 ± 0.314
2.704IleArg: 2.704 ± 0.411
4.406IleSer: 4.406 ± 0.449
3.154IleThr: 3.154 ± 0.501
4.506IleVal: 4.506 ± 0.445
0.901IleTrp: 0.901 ± 0.183
1.602IleTyr: 1.602 ± 0.327
0.0IleXaa: 0.0 ± 0.0
Lys
5.858LysAla: 5.858 ± 0.578
0.25LysCys: 0.25 ± 0.141
3.104LysAsp: 3.104 ± 0.389
4.306LysGlu: 4.306 ± 0.498
2.203LysPhe: 2.203 ± 0.32
3.354LysGly: 3.354 ± 0.46
1.051LysHis: 1.051 ± 0.205
3.304LysIle: 3.304 ± 0.309
2.804LysLys: 2.804 ± 0.52
2.804LysLeu: 2.804 ± 0.4
1.402LysMet: 1.402 ± 0.247
2.203LysAsn: 2.203 ± 0.387
1.302LysPro: 1.302 ± 0.233
1.652LysGln: 1.652 ± 0.375
2.854LysArg: 2.854 ± 0.378
2.754LysSer: 2.754 ± 0.403
3.404LysThr: 3.404 ± 0.479
4.105LysVal: 4.105 ± 0.456
1.252LysTrp: 1.252 ± 0.284
1.252LysTyr: 1.252 ± 0.298
0.0LysXaa: 0.0 ± 0.0
Leu
7.31LeuAla: 7.31 ± 0.732
0.701LeuCys: 0.701 ± 0.192
5.307LeuAsp: 5.307 ± 0.489
6.458LeuGlu: 6.458 ± 0.623
3.454LeuPhe: 3.454 ± 0.444
5.607LeuGly: 5.607 ± 0.685
0.901LeuHis: 0.901 ± 0.2
3.655LeuIle: 3.655 ± 0.506
3.855LeuLys: 3.855 ± 0.417
4.806LeuLeu: 4.806 ± 0.568
2.103LeuMet: 2.103 ± 0.417
3.454LeuAsn: 3.454 ± 0.394
3.905LeuPro: 3.905 ± 0.384
2.403LeuGln: 2.403 ± 0.364
5.357LeuArg: 5.357 ± 0.532
5.207LeuSer: 5.207 ± 0.46
5.858LeuThr: 5.858 ± 0.534
5.157LeuVal: 5.157 ± 0.609
1.101LeuTrp: 1.101 ± 0.245
1.852LeuTyr: 1.852 ± 0.293
0.0LeuXaa: 0.0 ± 0.0
Met
2.453MetAla: 2.453 ± 0.331
0.05MetCys: 0.05 ± 0.05
1.602MetAsp: 1.602 ± 0.372
2.103MetGlu: 2.103 ± 0.29
0.751MetPhe: 0.751 ± 0.184
1.502MetGly: 1.502 ± 0.367
0.15MetHis: 0.15 ± 0.078
1.552MetIle: 1.552 ± 0.224
1.151MetLys: 1.151 ± 0.214
2.153MetLeu: 2.153 ± 0.382
0.751MetMet: 0.751 ± 0.223
1.202MetAsn: 1.202 ± 0.208
1.452MetPro: 1.452 ± 0.294
1.151MetGln: 1.151 ± 0.268
1.452MetArg: 1.452 ± 0.299
2.353MetSer: 2.353 ± 0.32
1.802MetThr: 1.802 ± 0.254
1.252MetVal: 1.252 ± 0.285
0.451MetTrp: 0.451 ± 0.148
0.701MetTyr: 0.701 ± 0.178
0.0MetXaa: 0.0 ± 0.0
Asn
3.855AsnAla: 3.855 ± 0.473
0.3AsnCys: 0.3 ± 0.124
2.653AsnAsp: 2.653 ± 0.377
2.503AsnGlu: 2.503 ± 0.405
1.352AsnPhe: 1.352 ± 0.233
3.855AsnGly: 3.855 ± 0.36
0.851AsnHis: 0.851 ± 0.248
2.253AsnIle: 2.253 ± 0.34
2.103AsnLys: 2.103 ± 0.256
4.406AsnLeu: 4.406 ± 0.487
0.651AsnMet: 0.651 ± 0.175
2.653AsnAsn: 2.653 ± 0.401
2.754AsnPro: 2.754 ± 0.358
1.202AsnGln: 1.202 ± 0.284
2.353AsnArg: 2.353 ± 0.31
1.502AsnSer: 1.502 ± 0.291
2.303AsnThr: 2.303 ± 0.369
2.603AsnVal: 2.603 ± 0.289
0.801AsnTrp: 0.801 ± 0.173
1.502AsnTyr: 1.502 ± 0.274
0.0AsnXaa: 0.0 ± 0.0
Pro
3.404ProAla: 3.404 ± 0.344
0.3ProCys: 0.3 ± 0.138
3.304ProAsp: 3.304 ± 0.368
3.905ProGlu: 3.905 ± 0.47
1.702ProPhe: 1.702 ± 0.262
3.154ProGly: 3.154 ± 0.418
0.801ProHis: 0.801 ± 0.194
2.203ProIle: 2.203 ± 0.442
2.203ProLys: 2.203 ± 0.305
2.954ProLeu: 2.954 ± 0.458
1.302ProMet: 1.302 ± 0.251
1.752ProAsn: 1.752 ± 0.334
2.203ProPro: 2.203 ± 0.366
1.101ProGln: 1.101 ± 0.217
2.353ProArg: 2.353 ± 0.392
3.054ProSer: 3.054 ± 0.41
3.404ProThr: 3.404 ± 0.534
2.653ProVal: 2.653 ± 0.374
0.35ProTrp: 0.35 ± 0.151
1.652ProTyr: 1.652 ± 0.365
0.0ProXaa: 0.0 ± 0.0
Gln
3.655GlnAla: 3.655 ± 0.449
0.1GlnCys: 0.1 ± 0.093
1.552GlnAsp: 1.552 ± 0.304
2.503GlnGlu: 2.503 ± 0.433
0.851GlnPhe: 0.851 ± 0.209
1.902GlnGly: 1.902 ± 0.327
0.501GlnHis: 0.501 ± 0.162
2.203GlnIle: 2.203 ± 0.321
1.752GlnLys: 1.752 ± 0.346
2.303GlnLeu: 2.303 ± 0.308
1.001GlnMet: 1.001 ± 0.185
1.101GlnAsn: 1.101 ± 0.173
1.302GlnPro: 1.302 ± 0.269
0.851GlnGln: 0.851 ± 0.213
2.253GlnArg: 2.253 ± 0.342
2.053GlnSer: 2.053 ± 0.308
1.402GlnThr: 1.402 ± 0.257
2.103GlnVal: 2.103 ± 0.328
0.601GlnTrp: 0.601 ± 0.151
0.951GlnTyr: 0.951 ± 0.195
0.0GlnXaa: 0.0 ± 0.0
Arg
4.756ArgAla: 4.756 ± 0.514
0.451ArgCys: 0.451 ± 0.166
4.506ArgAsp: 4.506 ± 0.413
4.556ArgGlu: 4.556 ± 0.455
2.303ArgPhe: 2.303 ± 0.284
3.855ArgGly: 3.855 ± 0.402
1.452ArgHis: 1.452 ± 0.281
2.553ArgIle: 2.553 ± 0.335
4.005ArgLys: 4.005 ± 0.424
4.806ArgLeu: 4.806 ± 0.559
2.053ArgMet: 2.053 ± 0.315
2.754ArgAsn: 2.754 ± 0.437
1.802ArgPro: 1.802 ± 0.289
2.053ArgGln: 2.053 ± 0.299
3.755ArgArg: 3.755 ± 0.547
3.605ArgSer: 3.605 ± 0.384
2.303ArgThr: 2.303 ± 0.311
4.105ArgVal: 4.105 ± 0.475
1.151ArgTrp: 1.151 ± 0.307
2.203ArgTyr: 2.203 ± 0.295
0.0ArgXaa: 0.0 ± 0.0
Ser
5.307SerAla: 5.307 ± 0.626
0.601SerCys: 0.601 ± 0.272
4.256SerAsp: 4.256 ± 0.475
5.357SerGlu: 5.357 ± 0.483
2.203SerPhe: 2.203 ± 0.341
5.207SerGly: 5.207 ± 0.717
0.951SerHis: 0.951 ± 0.237
4.205SerIle: 4.205 ± 0.548
3.154SerLys: 3.154 ± 0.361
5.357SerLeu: 5.357 ± 0.522
1.252SerMet: 1.252 ± 0.307
3.004SerAsn: 3.004 ± 0.487
2.603SerPro: 2.603 ± 0.371
1.902SerGln: 1.902 ± 0.34
3.905SerArg: 3.905 ± 0.399
4.005SerSer: 4.005 ± 0.377
3.154SerThr: 3.154 ± 0.394
4.556SerVal: 4.556 ± 0.534
1.051SerTrp: 1.051 ± 0.187
2.153SerTyr: 2.153 ± 0.383
0.0SerXaa: 0.0 ± 0.0
Thr
4.606ThrAla: 4.606 ± 0.454
0.401ThrCys: 0.401 ± 0.16
2.303ThrAsp: 2.303 ± 0.33
3.605ThrGlu: 3.605 ± 0.366
2.904ThrPhe: 2.904 ± 0.405
4.606ThrGly: 4.606 ± 0.415
0.901ThrHis: 0.901 ± 0.205
3.705ThrIle: 3.705 ± 0.421
2.403ThrLys: 2.403 ± 0.359
4.606ThrLeu: 4.606 ± 0.576
1.452ThrMet: 1.452 ± 0.24
2.754ThrAsn: 2.754 ± 0.296
3.304ThrPro: 3.304 ± 0.388
1.151ThrGln: 1.151 ± 0.241
3.705ThrArg: 3.705 ± 0.416
4.105ThrSer: 4.105 ± 0.419
2.754ThrThr: 2.754 ± 0.402
3.454ThrVal: 3.454 ± 0.43
0.701ThrTrp: 0.701 ± 0.177
1.953ThrTyr: 1.953 ± 0.345
0.0ThrXaa: 0.0 ± 0.0
Val
5.557ValAla: 5.557 ± 0.534
0.35ValCys: 0.35 ± 0.18
4.806ValAsp: 4.806 ± 0.423
6.158ValGlu: 6.158 ± 0.813
2.653ValPhe: 2.653 ± 0.361
4.556ValGly: 4.556 ± 0.581
1.101ValHis: 1.101 ± 0.234
4.256ValIle: 4.256 ± 0.445
3.304ValLys: 3.304 ± 0.363
5.707ValLeu: 5.707 ± 0.603
1.902ValMet: 1.902 ± 0.219
3.004ValAsn: 3.004 ± 0.425
2.203ValPro: 2.203 ± 0.325
1.402ValGln: 1.402 ± 0.22
3.805ValArg: 3.805 ± 0.456
4.856ValSer: 4.856 ± 0.647
3.905ValThr: 3.905 ± 0.52
4.956ValVal: 4.956 ± 0.474
1.101ValTrp: 1.101 ± 0.191
2.053ValTyr: 2.053 ± 0.384
0.0ValXaa: 0.0 ± 0.0
Trp
1.302TrpAla: 1.302 ± 0.268
0.25TrpCys: 0.25 ± 0.099
1.402TrpAsp: 1.402 ± 0.258
1.602TrpGlu: 1.602 ± 0.268
0.451TrpPhe: 0.451 ± 0.158
1.202TrpGly: 1.202 ± 0.237
0.1TrpHis: 0.1 ± 0.066
0.851TrpIle: 0.851 ± 0.173
0.801TrpLys: 0.801 ± 0.176
1.151TrpLeu: 1.151 ± 0.32
0.501TrpMet: 0.501 ± 0.148
0.801TrpAsn: 0.801 ± 0.207
0.801TrpPro: 0.801 ± 0.209
0.751TrpGln: 0.751 ± 0.23
0.501TrpArg: 0.501 ± 0.144
0.701TrpSer: 0.701 ± 0.179
0.601TrpThr: 0.601 ± 0.154
1.652TrpVal: 1.652 ± 0.285
0.35TrpTrp: 0.35 ± 0.111
0.551TrpTyr: 0.551 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.603TyrAla: 2.603 ± 0.317
0.35TyrCys: 0.35 ± 0.146
2.553TyrAsp: 2.553 ± 0.359
2.704TyrGlu: 2.704 ± 0.429
0.951TyrPhe: 0.951 ± 0.192
2.653TyrGly: 2.653 ± 0.324
0.651TyrHis: 0.651 ± 0.198
1.552TyrIle: 1.552 ± 0.261
1.552TyrLys: 1.552 ± 0.246
3.154TyrLeu: 3.154 ± 0.428
0.451TyrMet: 0.451 ± 0.155
1.302TyrAsn: 1.302 ± 0.277
1.502TyrPro: 1.502 ± 0.328
1.101TyrGln: 1.101 ± 0.254
2.603TyrArg: 2.603 ± 0.42
2.103TyrSer: 2.103 ± 0.363
1.502TyrThr: 1.502 ± 0.324
2.253TyrVal: 2.253 ± 0.394
0.851TyrTrp: 0.851 ± 0.169
1.552TyrTyr: 1.552 ± 0.302
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 91 proteins (19975 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski