Amino acid dipepetide frequency for Vibrio caribbeanicus ATCC BAA-2122

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.2AlaAla: 6.2 ± 0.092	0.869AlaCys: 0.869 ± 0.026	3.865AlaAsp: 3.865 ± 0.059	4.794AlaGlu: 4.794 ± 0.071	3.232AlaPhe: 3.232 ± 0.06	5.23AlaGly: 5.23 ± 0.069	1.569AlaHis: 1.569 ± 0.038	5.643AlaIle: 5.643 ± 0.066	4.718AlaLys: 4.718 ± 0.073	8.853AlaLeu: 8.853 ± 0.108	2.39AlaMet: 2.39 ± 0.047	3.258AlaAsn: 3.258 ± 0.057	2.451AlaPro: 2.451 ± 0.054	3.385AlaGln: 3.385 ± 0.054	3.392AlaArg: 3.392 ± 0.054	5.39AlaSer: 5.39 ± 0.076	4.003AlaThr: 4.003 ± 0.07	4.914AlaVal: 4.914 ± 0.074	0.808AlaTrp: 0.808 ± 0.029	2.184AlaTyr: 2.184 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.742CysAla: 0.742 ± 0.023	0.162CysCys: 0.162 ± 0.012	0.634CysAsp: 0.634 ± 0.025	0.615CysGlu: 0.615 ± 0.023	0.535CysPhe: 0.535 ± 0.021	0.868CysGly: 0.868 ± 0.026	0.348CysHis: 0.348 ± 0.016	0.655CysIle: 0.655 ± 0.026	0.454CysLys: 0.454 ± 0.019	1.126CysLeu: 1.126 ± 0.034	0.209CysMet: 0.209 ± 0.013	0.404CysAsn: 0.404 ± 0.02	0.437CysPro: 0.437 ± 0.022	0.481CysGln: 0.481 ± 0.019	0.455CysArg: 0.455 ± 0.018	0.833CysSer: 0.833 ± 0.024	0.484CysThr: 0.484 ± 0.022	0.677CysVal: 0.677 ± 0.024	0.136CysTrp: 0.136 ± 0.011	0.36CysTyr: 0.36 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.892AspAla: 3.892 ± 0.054	0.536AspCys: 0.536 ± 0.021	2.966AspAsp: 2.966 ± 0.066	3.66AspGlu: 3.66 ± 0.066	2.54AspPhe: 2.54 ± 0.049	3.583AspGly: 3.583 ± 0.074	1.128AspHis: 1.128 ± 0.03	4.448AspIle: 4.448 ± 0.06	3.529AspLys: 3.529 ± 0.058	5.274AspLeu: 5.274 ± 0.071	1.46AspMet: 1.46 ± 0.032	2.632AspAsn: 2.632 ± 0.047	1.928AspPro: 1.928 ± 0.044	2.007AspGln: 2.007 ± 0.043	2.229AspArg: 2.229 ± 0.05	3.637AspSer: 3.637 ± 0.063	2.844AspThr: 2.844 ± 0.051	3.797AspVal: 3.797 ± 0.057	0.933AspTrp: 0.933 ± 0.031	2.092AspTyr: 2.092 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.687GluAla: 4.687 ± 0.066	0.566GluCys: 0.566 ± 0.024	2.814GluAsp: 2.814 ± 0.057	3.838GluGlu: 3.838 ± 0.074	2.455GluPhe: 2.455 ± 0.053	3.551GluGly: 3.551 ± 0.059	1.671GluHis: 1.671 ± 0.036	4.05GluIle: 4.05 ± 0.07	4.269GluLys: 4.269 ± 0.064	7.071GluLeu: 7.071 ± 0.084	1.695GluMet: 1.695 ± 0.038	2.909GluAsn: 2.909 ± 0.047	2.1GluPro: 2.1 ± 0.048	3.873GluGln: 3.873 ± 0.065	3.357GluArg: 3.357 ± 0.056	4.244GluSer: 4.244 ± 0.064	3.161GluThr: 3.161 ± 0.049	4.454GluVal: 4.454 ± 0.058	0.78GluTrp: 0.78 ± 0.026	1.907GluTyr: 1.907 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.297PheAla: 3.297 ± 0.054	0.602PheCys: 0.602 ± 0.024	2.833PheAsp: 2.833 ± 0.051	2.717PheGlu: 2.717 ± 0.045	1.908PhePhe: 1.908 ± 0.048	3.082PheGly: 3.082 ± 0.062	0.874PheHis: 0.874 ± 0.028	2.993PheIle: 2.993 ± 0.054	2.188PheLys: 2.188 ± 0.045	3.71PheLeu: 3.71 ± 0.054	0.984PheMet: 0.984 ± 0.031	2.379PheAsn: 2.379 ± 0.062	1.442PhePro: 1.442 ± 0.033	1.354PheGln: 1.354 ± 0.031	1.538PheArg: 1.538 ± 0.037	3.838PheSer: 3.838 ± 0.061	2.327PheThr: 2.327 ± 0.051	2.745PheVal: 2.745 ± 0.05	0.586PheTrp: 0.586 ± 0.025	1.45PheTyr: 1.45 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.026GlyAla: 5.026 ± 0.076	0.838GlyCys: 0.838 ± 0.025	3.602GlyAsp: 3.602 ± 0.072	4.234GlyGlu: 4.234 ± 0.06	3.216GlyPhe: 3.216 ± 0.055	4.606GlyGly: 4.606 ± 0.077	1.556GlyHis: 1.556 ± 0.038	4.701GlyIle: 4.701 ± 0.067	3.995GlyLys: 3.995 ± 0.053	6.659GlyLeu: 6.659 ± 0.086	1.863GlyMet: 1.863 ± 0.044	2.786GlyAsn: 2.786 ± 0.06	1.555GlyPro: 1.555 ± 0.036	2.899GlyGln: 2.899 ± 0.05	3.01GlyArg: 3.01 ± 0.052	4.215GlySer: 4.215 ± 0.06	3.295GlyThr: 3.295 ± 0.047	4.788GlyVal: 4.788 ± 0.063	0.901GlyTrp: 0.901 ± 0.029	2.519GlyTyr: 2.519 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.495HisAla: 1.495 ± 0.035	0.349HisCys: 0.349 ± 0.016	1.112HisAsp: 1.112 ± 0.032	1.155HisGlu: 1.155 ± 0.029	1.161HisPhe: 1.161 ± 0.028	1.415HisGly: 1.415 ± 0.034	0.733HisHis: 0.733 ± 0.029	1.554HisIle: 1.554 ± 0.035	1.077HisLys: 1.077 ± 0.028	2.3HisLeu: 2.3 ± 0.047	0.491HisMet: 0.491 ± 0.02	0.962HisAsn: 0.962 ± 0.031	1.08HisPro: 1.08 ± 0.029	1.263HisGln: 1.263 ± 0.034	1.025HisArg: 1.025 ± 0.032	1.661HisSer: 1.661 ± 0.035	1.101HisThr: 1.101 ± 0.031	1.252HisVal: 1.252 ± 0.032	0.355HisTrp: 0.355 ± 0.016	0.938HisTyr: 0.938 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.027IleAla: 6.027 ± 0.079	0.752IleCys: 0.752 ± 0.026	4.532IleAsp: 4.532 ± 0.068	5.355IleGlu: 5.355 ± 0.068	2.629IlePhe: 2.629 ± 0.054	4.906IleGly: 4.906 ± 0.063	1.353IleHis: 1.353 ± 0.034	4.153IleIle: 4.153 ± 0.064	3.727IleLys: 3.727 ± 0.05	5.632IleLeu: 5.632 ± 0.073	1.371IleMet: 1.371 ± 0.036	3.336IleAsn: 3.336 ± 0.052	2.775IlePro: 2.775 ± 0.046	2.491IleGln: 2.491 ± 0.047	2.99IleArg: 2.99 ± 0.044	5.285IleSer: 5.285 ± 0.074	3.827IleThr: 3.827 ± 0.049	4.221IleVal: 4.221 ± 0.066	0.643IleTrp: 0.643 ± 0.023	1.87IleTyr: 1.87 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.605LysAla: 4.605 ± 0.068	0.355LysCys: 0.355 ± 0.016	2.908LysAsp: 2.908 ± 0.054	3.733LysGlu: 3.733 ± 0.06	1.738LysPhe: 1.738 ± 0.034	3.632LysGly: 3.632 ± 0.058	1.365LysHis: 1.365 ± 0.033	3.5LysIle: 3.5 ± 0.06	3.484LysLys: 3.484 ± 0.065	5.827LysLeu: 5.827 ± 0.072	1.497LysMet: 1.497 ± 0.036	2.64LysAsn: 2.64 ± 0.048	2.307LysPro: 2.307 ± 0.045	2.96LysGln: 2.96 ± 0.054	2.814LysArg: 2.814 ± 0.053	3.706LysSer: 3.706 ± 0.052	3.061LysThr: 3.061 ± 0.05	4.292LysVal: 4.292 ± 0.059	0.612LysTrp: 0.612 ± 0.02	1.641LysTyr: 1.641 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	8.72LeuAla: 8.72 ± 0.092	1.16LeuCys: 1.16 ± 0.034	5.869LeuAsp: 5.869 ± 0.064	6.428LeuGlu: 6.428 ± 0.086	4.426LeuPhe: 4.426 ± 0.067	6.841LeuGly: 6.841 ± 0.082	1.901LeuHis: 1.901 ± 0.043	6.715LeuIle: 6.715 ± 0.088	5.757LeuLys: 5.757 ± 0.067	10.016LeuLeu: 10.016 ± 0.13	2.655LeuMet: 2.655 ± 0.047	4.927LeuAsn: 4.927 ± 0.065	4.468LeuPro: 4.468 ± 0.068	3.317LeuGln: 3.317 ± 0.061	4.201LeuArg: 4.201 ± 0.06	8.781LeuSer: 8.781 ± 0.096	5.863LeuThr: 5.863 ± 0.07	6.927LeuVal: 6.927 ± 0.083	1.061LeuTrp: 1.061 ± 0.032	2.631LeuTyr: 2.631 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.229MetAla: 2.229 ± 0.046	0.218MetCys: 0.218 ± 0.015	1.196MetAsp: 1.196 ± 0.032	1.28MetGlu: 1.28 ± 0.034	1.112MetPhe: 1.112 ± 0.048	1.723MetGly: 1.723 ± 0.035	0.465MetHis: 0.465 ± 0.02	1.589MetIle: 1.589 ± 0.035	1.598MetLys: 1.598 ± 0.034	2.688MetLeu: 2.688 ± 0.044	0.746MetMet: 0.746 ± 0.024	1.189MetAsn: 1.189 ± 0.031	1.1MetPro: 1.1 ± 0.034	1.016MetGln: 1.016 ± 0.028	1.226MetArg: 1.226 ± 0.032	2.059MetSer: 2.059 ± 0.044	1.598MetThr: 1.598 ± 0.033	1.81MetVal: 1.81 ± 0.041	0.214MetTrp: 0.214 ± 0.013	0.533MetTyr: 0.533 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.239AsnAla: 3.239 ± 0.057	0.43AsnCys: 0.43 ± 0.019	2.521AsnAsp: 2.521 ± 0.054	2.594AsnGlu: 2.594 ± 0.051	1.759AsnPhe: 1.759 ± 0.041	2.949AsnGly: 2.949 ± 0.05	1.141AsnHis: 1.141 ± 0.036	3.408AsnIle: 3.408 ± 0.06	2.545AsnLys: 2.545 ± 0.045	4.35AsnLeu: 4.35 ± 0.06	1.126AsnMet: 1.126 ± 0.026	2.175AsnAsn: 2.175 ± 0.048	2.008AsnPro: 2.008 ± 0.034	2.559AsnGln: 2.559 ± 0.062	2.026AsnArg: 2.026 ± 0.038	2.949AsnSer: 2.949 ± 0.054	2.419AsnThr: 2.419 ± 0.053	2.926AsnVal: 2.926 ± 0.056	0.683AsnTrp: 0.683 ± 0.029	1.523AsnTyr: 1.523 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.407ProAla: 2.407 ± 0.046	0.348ProCys: 0.348 ± 0.016	2.164ProAsp: 2.164 ± 0.045	2.964ProGlu: 2.964 ± 0.06	1.736ProPhe: 1.736 ± 0.037	2.044ProGly: 2.044 ± 0.043	0.853ProHis: 0.853 ± 0.026	2.914ProIle: 2.914 ± 0.057	2.112ProLys: 2.112 ± 0.043	3.853ProLeu: 3.853 ± 0.06	0.94ProMet: 0.94 ± 0.025	1.805ProAsn: 1.805 ± 0.042	1.068ProPro: 1.068 ± 0.033	1.573ProGln: 1.573 ± 0.032	1.262ProArg: 1.262 ± 0.033	2.879ProSer: 2.879 ± 0.049	2.1ProThr: 2.1 ± 0.04	2.653ProVal: 2.653 ± 0.045	0.48ProTrp: 0.48 ± 0.021	1.222ProTyr: 1.222 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.763GlnAla: 3.763 ± 0.056	0.428GlnCys: 0.428 ± 0.019	2.186GlnAsp: 2.186 ± 0.047	2.48GlnGlu: 2.48 ± 0.049	1.803GlnPhe: 1.803 ± 0.041	2.837GlnGly: 2.837 ± 0.05	1.14GlnHis: 1.14 ± 0.031	2.796GlnIle: 2.796 ± 0.049	2.388GlnLys: 2.388 ± 0.045	4.845GlnLeu: 4.845 ± 0.076	1.088GlnMet: 1.088 ± 0.028	1.861GlnAsn: 1.861 ± 0.043	1.719GlnPro: 1.719 ± 0.043	2.446GlnGln: 2.446 ± 0.064	2.275GlnArg: 2.275 ± 0.045	3.09GlnSer: 3.09 ± 0.049	2.254GlnThr: 2.254 ± 0.043	2.993GlnVal: 2.993 ± 0.058	0.628GlnTrp: 0.628 ± 0.023	1.498GlnTyr: 1.498 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.25ArgAla: 3.25 ± 0.053	0.477ArgCys: 0.477 ± 0.019	2.49ArgAsp: 2.49 ± 0.047	3.02ArgGlu: 3.02 ± 0.054	2.202ArgPhe: 2.202 ± 0.048	2.554ArgGly: 2.554 ± 0.048	1.051ArgHis: 1.051 ± 0.033	2.881ArgIle: 2.881 ± 0.051	2.435ArgLys: 2.435 ± 0.047	4.891ArgLeu: 4.891 ± 0.08	1.118ArgMet: 1.118 ± 0.031	1.943ArgAsn: 1.943 ± 0.036	1.525ArgPro: 1.525 ± 0.035	2.123ArgGln: 2.123 ± 0.047	2.226ArgArg: 2.226 ± 0.049	2.88ArgSer: 2.88 ± 0.05	2.032ArgThr: 2.032 ± 0.043	3.157ArgVal: 3.157 ± 0.052	0.57ArgTrp: 0.57 ± 0.024	1.767ArgTyr: 1.767 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.252SerAla: 5.252 ± 0.065	0.687SerCys: 0.687 ± 0.025	4.169SerAsp: 4.169 ± 0.061	4.694SerGlu: 4.694 ± 0.065	3.282SerPhe: 3.282 ± 0.056	5.371SerGly: 5.371 ± 0.071	1.673SerHis: 1.673 ± 0.036	5.165SerIle: 5.165 ± 0.079	3.827SerLys: 3.827 ± 0.062	7.76SerLeu: 7.76 ± 0.084	1.901SerMet: 1.901 ± 0.033	3.202SerAsn: 3.202 ± 0.057	2.628SerPro: 2.628 ± 0.046	3.349SerGln: 3.349 ± 0.052	3.086SerArg: 3.086 ± 0.045	5.297SerSer: 5.297 ± 0.073	3.671SerThr: 3.671 ± 0.066	4.892SerVal: 4.892 ± 0.069	0.869SerTrp: 0.869 ± 0.03	2.296SerTyr: 2.296 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.876ThrAla: 3.876 ± 0.061	0.516ThrCys: 0.516 ± 0.023	2.725ThrAsp: 2.725 ± 0.051	3.189ThrGlu: 3.189 ± 0.049	2.217ThrPhe: 2.217 ± 0.039	3.787ThrGly: 3.787 ± 0.056	1.276ThrHis: 1.276 ± 0.032	3.569ThrIle: 3.569 ± 0.058	2.751ThrLys: 2.751 ± 0.044	6.208ThrLeu: 6.208 ± 0.084	1.193ThrMet: 1.193 ± 0.031	2.158ThrAsn: 2.158 ± 0.047	2.505ThrPro: 2.505 ± 0.048	2.405ThrGln: 2.405 ± 0.045	2.157ThrArg: 2.157 ± 0.044	3.877ThrSer: 3.877 ± 0.072	2.898ThrThr: 2.898 ± 0.05	3.614ThrVal: 3.614 ± 0.055	0.571ThrTrp: 0.571 ± 0.023	1.519ThrTyr: 1.519 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.554ValAla: 5.554 ± 0.067	0.74ValCys: 0.74 ± 0.023	4.032ValAsp: 4.032 ± 0.061	4.627ValGlu: 4.627 ± 0.07	2.783ValPhe: 2.783 ± 0.052	4.512ValGly: 4.512 ± 0.065	1.23ValHis: 1.23 ± 0.031	4.69ValIle: 4.69 ± 0.065	3.798ValLys: 3.798 ± 0.054	6.496ValLeu: 6.496 ± 0.071	1.864ValMet: 1.864 ± 0.045	3.021ValAsn: 3.021 ± 0.048	2.444ValPro: 2.444 ± 0.046	2.084ValGln: 2.084 ± 0.042	2.915ValArg: 2.915 ± 0.047	5.341ValSer: 5.341 ± 0.071	4.03ValThr: 4.03 ± 0.065	5.116ValVal: 5.116 ± 0.074	0.761ValTrp: 0.761 ± 0.027	1.822ValTyr: 1.822 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.748TrpAla: 0.748 ± 0.024	0.173TrpCys: 0.173 ± 0.012	0.729TrpAsp: 0.729 ± 0.037	0.548TrpGlu: 0.548 ± 0.021	0.631TrpPhe: 0.631 ± 0.024	0.726TrpGly: 0.726 ± 0.027	0.328TrpHis: 0.328 ± 0.018	0.66TrpIle: 0.66 ± 0.026	0.574TrpLys: 0.574 ± 0.022	1.662TrpLeu: 1.662 ± 0.041	0.329TrpMet: 0.329 ± 0.018	0.536TrpAsn: 0.536 ± 0.024	0.453TrpPro: 0.453 ± 0.019	0.865TrpGln: 0.865 ± 0.027	0.63TrpArg: 0.63 ± 0.026	0.852TrpSer: 0.852 ± 0.028	0.461TrpThr: 0.461 ± 0.02	0.78TrpVal: 0.78 ± 0.028	0.171TrpTrp: 0.171 ± 0.011	0.398TrpTyr: 0.398 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.14TyrAla: 2.14 ± 0.043	0.407TyrCys: 0.407 ± 0.019	1.77TyrAsp: 1.77 ± 0.044	1.526TyrGlu: 1.526 ± 0.039	1.484TyrPhe: 1.484 ± 0.034	2.047TyrGly: 2.047 ± 0.041	0.824TyrHis: 0.824 ± 0.024	1.789TyrIle: 1.789 ± 0.041	1.451TyrLys: 1.451 ± 0.036	3.445TyrLeu: 3.445 ± 0.06	0.666TyrMet: 0.666 ± 0.024	1.207TyrAsn: 1.207 ± 0.035	1.38TyrPro: 1.38 ± 0.034	2.068TyrGln: 2.068 ± 0.045	1.782TyrArg: 1.782 ± 0.045	2.256TyrSer: 2.256 ± 0.047	1.582TyrThr: 1.582 ± 0.039	1.851TyrVal: 1.851 ± 0.042	0.493TyrTrp: 0.493 ± 0.019	1.092TyrTyr: 1.092 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4023 proteins (1268750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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