Amino acid dipepetide frequency for Rhodovulum sp. ES.010

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.496AlaAla: 20.496 ± 0.228
1.226AlaCys: 1.226 ± 0.04
7.535AlaAsp: 7.535 ± 0.094
9.833AlaGlu: 9.833 ± 0.13
4.538AlaPhe: 4.538 ± 0.07
12.364AlaGly: 12.364 ± 0.144
2.584AlaHis: 2.584 ± 0.052
5.746AlaIle: 5.746 ± 0.079
3.028AlaLys: 3.028 ± 0.056
15.767AlaLeu: 15.767 ± 0.167
3.899AlaMet: 3.899 ± 0.076
2.444AlaAsn: 2.444 ± 0.047
7.272AlaPro: 7.272 ± 0.124
4.075AlaGln: 4.075 ± 0.06
11.569AlaArg: 11.569 ± 0.126
5.056AlaSer: 5.056 ± 0.072
6.199AlaThr: 6.199 ± 0.078
9.231AlaVal: 9.231 ± 0.107
1.724AlaTrp: 1.724 ± 0.044
2.605AlaTyr: 2.605 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.188CysAla: 1.188 ± 0.036
0.116CysCys: 0.116 ± 0.011
0.594CysAsp: 0.594 ± 0.027
0.458CysGlu: 0.458 ± 0.02
0.274CysPhe: 0.274 ± 0.017
0.918CysGly: 0.918 ± 0.029
0.266CysHis: 0.266 ± 0.017
0.379CysIle: 0.379 ± 0.018
0.17CysLys: 0.17 ± 0.012
0.875CysLeu: 0.875 ± 0.026
0.146CysMet: 0.146 ± 0.011
0.175CysAsn: 0.175 ± 0.013
0.57CysPro: 0.57 ± 0.024
0.22CysGln: 0.22 ± 0.017
0.649CysArg: 0.649 ± 0.025
0.378CysSer: 0.378 ± 0.017
0.431CysThr: 0.431 ± 0.023
0.616CysVal: 0.616 ± 0.022
0.125CysTrp: 0.125 ± 0.01
0.219CysTyr: 0.219 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.734AspAla: 7.734 ± 0.112
0.528AspCys: 0.528 ± 0.021
3.219AspAsp: 3.219 ± 0.065
3.758AspGlu: 3.758 ± 0.062
2.227AspPhe: 2.227 ± 0.045
5.549AspGly: 5.549 ± 0.084
1.308AspHis: 1.308 ± 0.032
2.85AspIle: 2.85 ± 0.05
1.319AspLys: 1.319 ± 0.04
6.526AspLeu: 6.526 ± 0.091
1.544AspMet: 1.544 ± 0.039
1.039AspAsn: 1.039 ± 0.034
3.965AspPro: 3.965 ± 0.073
1.514AspGln: 1.514 ± 0.034
5.15AspArg: 5.15 ± 0.072
2.076AspSer: 2.076 ± 0.048
2.729AspThr: 2.729 ± 0.046
3.878AspVal: 3.878 ± 0.05
1.221AspTrp: 1.221 ± 0.032
1.526AspTyr: 1.526 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
9.398GluAla: 9.398 ± 0.116
0.375GluCys: 0.375 ± 0.016
3.532GluAsp: 3.532 ± 0.063
3.902GluGlu: 3.902 ± 0.081
1.814GluPhe: 1.814 ± 0.042
5.431GluGly: 5.431 ± 0.07
1.097GluHis: 1.097 ± 0.035
3.808GluIle: 3.808 ± 0.064
1.958GluLys: 1.958 ± 0.048
5.139GluLeu: 5.139 ± 0.085
1.923GluMet: 1.923 ± 0.044
1.57GluAsn: 1.57 ± 0.036
2.712GluPro: 2.712 ± 0.055
1.635GluGln: 1.635 ± 0.046
4.972GluArg: 4.972 ± 0.072
2.329GluSer: 2.329 ± 0.049
4.28GluThr: 4.28 ± 0.065
4.623GluVal: 4.623 ± 0.066
0.652GluTrp: 0.652 ± 0.024
0.956GluTyr: 0.956 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.54PheAla: 4.54 ± 0.066
0.385PheCys: 0.385 ± 0.017
2.736PheAsp: 2.736 ± 0.053
2.193PheGlu: 2.193 ± 0.044
1.398PhePhe: 1.398 ± 0.043
3.704PheGly: 3.704 ± 0.066
0.774PheHis: 0.774 ± 0.026
1.366PheIle: 1.366 ± 0.043
0.752PheLys: 0.752 ± 0.026
3.482PheLeu: 3.482 ± 0.069
0.752PheMet: 0.752 ± 0.027
0.846PheAsn: 0.846 ± 0.026
1.566PhePro: 1.566 ± 0.038
0.91PheGln: 0.91 ± 0.031
2.408PheArg: 2.408 ± 0.05
1.832PheSer: 1.832 ± 0.044
2.019PheThr: 2.019 ± 0.046
2.679PheVal: 2.679 ± 0.056
0.532PheTrp: 0.532 ± 0.023
0.855PheTyr: 0.855 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
11.644GlyAla: 11.644 ± 0.136
0.906GlyCys: 0.906 ± 0.031
4.793GlyAsp: 4.793 ± 0.079
5.182GlyGlu: 5.182 ± 0.073
3.651GlyPhe: 3.651 ± 0.058
7.916GlyGly: 7.916 ± 0.106
2.019GlyHis: 2.019 ± 0.049
4.071GlyIle: 4.071 ± 0.067
2.635GlyLys: 2.635 ± 0.06
10.104GlyLeu: 10.104 ± 0.127
2.58GlyMet: 2.58 ± 0.053
1.782GlyAsn: 1.782 ± 0.049
4.404GlyPro: 4.404 ± 0.07
2.955GlyGln: 2.955 ± 0.047
7.199GlyArg: 7.199 ± 0.088
3.814GlySer: 3.814 ± 0.077
4.762GlyThr: 4.762 ± 0.064
6.569GlyVal: 6.569 ± 0.072
1.589GlyTrp: 1.589 ± 0.047
2.177GlyTyr: 2.177 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.589HisAla: 2.589 ± 0.058
0.209HisCys: 0.209 ± 0.012
1.26HisAsp: 1.26 ± 0.039
1.103HisGlu: 1.103 ± 0.033
0.775HisPhe: 0.775 ± 0.029
2.041HisGly: 2.041 ± 0.052
0.485HisHis: 0.485 ± 0.023
0.809HisIle: 0.809 ± 0.031
0.403HisLys: 0.403 ± 0.019
2.12HisLeu: 2.12 ± 0.046
0.515HisMet: 0.515 ± 0.023
0.39HisAsn: 0.39 ± 0.018
1.408HisPro: 1.408 ± 0.038
0.449HisGln: 0.449 ± 0.021
1.563HisArg: 1.563 ± 0.038
0.806HisSer: 0.806 ± 0.028
0.744HisThr: 0.744 ± 0.029
1.624HisVal: 1.624 ± 0.044
0.34HisTrp: 0.34 ± 0.02
0.528HisTyr: 0.528 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.837IleAla: 6.837 ± 0.08
0.504IleCys: 0.504 ± 0.021
3.21IleAsp: 3.21 ± 0.051
3.342IleGlu: 3.342 ± 0.062
1.459IlePhe: 1.459 ± 0.04
4.564IleGly: 4.564 ± 0.064
0.825IleHis: 0.825 ± 0.029
1.486IleIle: 1.486 ± 0.041
0.992IleLys: 0.992 ± 0.034
4.295IleLeu: 4.295 ± 0.075
0.847IleMet: 0.847 ± 0.029
0.985IleAsn: 0.985 ± 0.03
2.181IlePro: 2.181 ± 0.041
0.932IleGln: 0.932 ± 0.03
3.243IleArg: 3.243 ± 0.053
2.335IleSer: 2.335 ± 0.049
2.267IleThr: 2.267 ± 0.047
3.668IleVal: 3.668 ± 0.063
0.592IleTrp: 0.592 ± 0.021
0.976IleTyr: 0.976 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
3.427LysAla: 3.427 ± 0.063
0.17LysCys: 0.17 ± 0.011
1.42LysAsp: 1.42 ± 0.039
1.275LysGlu: 1.275 ± 0.039
0.662LysPhe: 0.662 ± 0.025
2.267LysGly: 2.267 ± 0.051
0.511LysHis: 0.511 ± 0.02
1.206LysIle: 1.206 ± 0.032
0.916LysLys: 0.916 ± 0.036
2.43LysLeu: 2.43 ± 0.057
0.644LysMet: 0.644 ± 0.025
0.577LysAsn: 0.577 ± 0.025
1.539LysPro: 1.539 ± 0.038
0.644LysGln: 0.644 ± 0.022
2.062LysArg: 2.062 ± 0.047
1.425LysSer: 1.425 ± 0.035
1.599LysThr: 1.599 ± 0.043
1.941LysVal: 1.941 ± 0.051
0.316LysTrp: 0.316 ± 0.018
0.535LysTyr: 0.535 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
15.144LeuAla: 15.144 ± 0.164
0.969LeuCys: 0.969 ± 0.032
6.541LeuAsp: 6.541 ± 0.074
5.513LeuGlu: 5.513 ± 0.075
3.626LeuPhe: 3.626 ± 0.073
9.218LeuGly: 9.218 ± 0.101
1.909LeuHis: 1.909 ± 0.046
4.674LeuIle: 4.674 ± 0.077
2.801LeuLys: 2.801 ± 0.057
8.941LeuLeu: 8.941 ± 0.137
2.563LeuMet: 2.563 ± 0.05
2.233LeuAsn: 2.233 ± 0.049
5.776LeuPro: 5.776 ± 0.075
2.447LeuGln: 2.447 ± 0.049
7.581LeuArg: 7.581 ± 0.087
6.081LeuSer: 6.081 ± 0.082
5.775LeuThr: 5.775 ± 0.076
7.543LeuVal: 7.543 ± 0.105
1.365LeuTrp: 1.365 ± 0.042
1.973LeuTyr: 1.973 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
3.603MetAla: 3.603 ± 0.071
0.159MetCys: 0.159 ± 0.012
1.237MetAsp: 1.237 ± 0.036
1.425MetGlu: 1.425 ± 0.033
0.738MetPhe: 0.738 ± 0.027
2.28MetGly: 2.28 ± 0.049
0.453MetHis: 0.453 ± 0.021
1.302MetIle: 1.302 ± 0.04
0.864MetLys: 0.864 ± 0.029
2.48MetLeu: 2.48 ± 0.046
0.659MetMet: 0.659 ± 0.025
0.699MetAsn: 0.699 ± 0.025
1.516MetPro: 1.516 ± 0.038
0.841MetGln: 0.841 ± 0.026
1.977MetArg: 1.977 ± 0.043
1.515MetSer: 1.515 ± 0.043
1.878MetThr: 1.878 ± 0.044
1.791MetVal: 1.791 ± 0.038
0.218MetTrp: 0.218 ± 0.014
0.297MetTyr: 0.297 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.864AsnAla: 2.864 ± 0.055
0.221AsnCys: 0.221 ± 0.016
1.096AsnAsp: 1.096 ± 0.033
1.013AsnGlu: 1.013 ± 0.027
0.714AsnPhe: 0.714 ± 0.026
1.98AsnGly: 1.98 ± 0.053
0.394AsnHis: 0.394 ± 0.018
1.033AsnIle: 1.033 ± 0.033
0.443AsnLys: 0.443 ± 0.023
2.143AsnLeu: 2.143 ± 0.042
0.549AsnMet: 0.549 ± 0.026
0.449AsnAsn: 0.449 ± 0.021
1.643AsnPro: 1.643 ± 0.042
0.476AsnGln: 0.476 ± 0.019
1.694AsnArg: 1.694 ± 0.039
0.845AsnSer: 0.845 ± 0.03
1.005AsnThr: 1.005 ± 0.027
1.646AsnVal: 1.646 ± 0.039
0.352AsnTrp: 0.352 ± 0.019
0.523AsnTyr: 0.523 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.257ProAla: 7.257 ± 0.119
0.406ProCys: 0.406 ± 0.02
4.327ProAsp: 4.327 ± 0.078
4.618ProGlu: 4.618 ± 0.07
1.959ProPhe: 1.959 ± 0.041
5.457ProGly: 5.457 ± 0.076
1.108ProHis: 1.108 ± 0.034
1.976ProIle: 1.976 ± 0.04
1.351ProLys: 1.351 ± 0.031
4.94ProLeu: 4.94 ± 0.062
1.31ProMet: 1.31 ± 0.034
1.062ProAsn: 1.062 ± 0.033
2.994ProPro: 2.994 ± 0.073
1.479ProGln: 1.479 ± 0.034
3.632ProArg: 3.632 ± 0.07
2.242ProSer: 2.242 ± 0.043
2.311ProThr: 2.311 ± 0.047
4.536ProVal: 4.536 ± 0.065
0.744ProTrp: 0.744 ± 0.029
1.142ProTyr: 1.142 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.795GlnAla: 3.795 ± 0.061
0.181GlnCys: 0.181 ± 0.013
1.454GlnAsp: 1.454 ± 0.038
1.44GlnGlu: 1.44 ± 0.037
0.874GlnPhe: 0.874 ± 0.03
2.364GlnGly: 2.364 ± 0.046
0.451GlnHis: 0.451 ± 0.023
1.53GlnIle: 1.53 ± 0.038
0.877GlnLys: 0.877 ± 0.03
2.322GlnLeu: 2.322 ± 0.049
0.832GlnMet: 0.832 ± 0.026
0.644GlnAsn: 0.644 ± 0.027
1.488GlnPro: 1.488 ± 0.035
0.85GlnGln: 0.85 ± 0.043
2.068GlnArg: 2.068 ± 0.047
1.395GlnSer: 1.395 ± 0.037
1.517GlnThr: 1.517 ± 0.036
2.219GlnVal: 2.219 ± 0.046
0.339GlnTrp: 0.339 ± 0.019
0.498GlnTyr: 0.498 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
10.512ArgAla: 10.512 ± 0.115
0.548ArgCys: 0.548 ± 0.024
4.528ArgAsp: 4.528 ± 0.073
4.468ArgGlu: 4.468 ± 0.071
3.047ArgPhe: 3.047 ± 0.051
5.584ArgGly: 5.584 ± 0.076
1.826ArgHis: 1.826 ± 0.046
3.874ArgIle: 3.874 ± 0.059
2.17ArgLys: 2.17 ± 0.054
9.024ArgLeu: 9.024 ± 0.1
2.171ArgMet: 2.171 ± 0.046
1.641ArgAsn: 1.641 ± 0.038
4.415ArgPro: 4.415 ± 0.068
2.224ArgGln: 2.224 ± 0.047
6.573ArgArg: 6.573 ± 0.105
3.071ArgSer: 3.071 ± 0.047
3.328ArgThr: 3.328 ± 0.066
5.544ArgVal: 5.544 ± 0.07
1.028ArgTrp: 1.028 ± 0.03
1.621ArgTyr: 1.621 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.531SerAla: 5.531 ± 0.082
0.371SerCys: 0.371 ± 0.021
2.82SerAsp: 2.82 ± 0.049
2.643SerGlu: 2.643 ± 0.058
1.968SerPhe: 1.968 ± 0.049
4.88SerGly: 4.88 ± 0.076
0.948SerHis: 0.948 ± 0.032
1.923SerIle: 1.923 ± 0.049
1.064SerLys: 1.064 ± 0.036
4.349SerLeu: 4.349 ± 0.065
1.096SerMet: 1.096 ± 0.029
0.964SerAsn: 0.964 ± 0.027
2.414SerPro: 2.414 ± 0.05
1.273SerGln: 1.273 ± 0.038
3.22SerArg: 3.22 ± 0.055
2.036SerSer: 2.036 ± 0.051
2.17SerThr: 2.17 ± 0.046
3.379SerVal: 3.379 ± 0.059
0.623SerTrp: 0.623 ± 0.024
1.084SerTyr: 1.084 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.389ThrAla: 6.389 ± 0.091
0.502ThrCys: 0.502 ± 0.02
2.962ThrAsp: 2.962 ± 0.051
3.037ThrGlu: 3.037 ± 0.051
1.783ThrPhe: 1.783 ± 0.038
5.526ThrGly: 5.526 ± 0.076
1.073ThrHis: 1.073 ± 0.032
2.282ThrIle: 2.282 ± 0.049
1.081ThrLys: 1.081 ± 0.034
6.061ThrLeu: 6.061 ± 0.075
1.152ThrMet: 1.152 ± 0.03
1.059ThrAsn: 1.059 ± 0.029
3.359ThrPro: 3.359 ± 0.049
1.291ThrGln: 1.291 ± 0.034
3.847ThrArg: 3.847 ± 0.059
2.118ThrSer: 2.118 ± 0.047
2.51ThrThr: 2.51 ± 0.058
4.207ThrVal: 4.207 ± 0.07
0.704ThrTrp: 0.704 ± 0.03
1.122ThrTyr: 1.122 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
10.054ValAla: 10.054 ± 0.1
0.636ValCys: 0.636 ± 0.025
4.1ValAsp: 4.1 ± 0.06
4.914ValGlu: 4.914 ± 0.069
2.857ValPhe: 2.857 ± 0.059
5.524ValGly: 5.524 ± 0.075
1.333ValHis: 1.333 ± 0.033
3.784ValIle: 3.784 ± 0.063
1.88ValLys: 1.88 ± 0.052
7.841ValLeu: 7.841 ± 0.096
1.901ValMet: 1.901 ± 0.049
1.679ValAsn: 1.679 ± 0.043
3.875ValPro: 3.875 ± 0.059
1.82ValGln: 1.82 ± 0.042
4.876ValArg: 4.876 ± 0.067
3.769ValSer: 3.769 ± 0.062
4.721ValThr: 4.721 ± 0.063
5.847ValVal: 5.847 ± 0.084
0.986ValTrp: 0.986 ± 0.03
1.509ValTyr: 1.509 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.588TrpAla: 1.588 ± 0.043
0.138TrpCys: 0.138 ± 0.012
0.748TrpAsp: 0.748 ± 0.027
0.708TrpGlu: 0.708 ± 0.027
0.528TrpPhe: 0.528 ± 0.022
1.068TrpGly: 1.068 ± 0.032
0.327TrpHis: 0.327 ± 0.016
0.633TrpIle: 0.633 ± 0.025
0.401TrpLys: 0.401 ± 0.019
1.703TrpLeu: 1.703 ± 0.041
0.371TrpMet: 0.371 ± 0.018
0.34TrpAsn: 0.34 ± 0.019
0.741TrpPro: 0.741 ± 0.028
0.553TrpGln: 0.553 ± 0.023
1.268TrpArg: 1.268 ± 0.033
0.704TrpSer: 0.704 ± 0.028
0.785TrpThr: 0.785 ± 0.032
0.916TrpVal: 0.916 ± 0.032
0.218TrpTrp: 0.218 ± 0.015
0.26TrpTyr: 0.26 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.602TyrAla: 2.602 ± 0.051
0.217TyrCys: 0.217 ± 0.014
1.548TyrAsp: 1.548 ± 0.041
1.278TyrGlu: 1.278 ± 0.037
0.836TyrPhe: 0.836 ± 0.031
2.118TyrGly: 2.118 ± 0.044
0.475TyrHis: 0.475 ± 0.021
0.807TyrIle: 0.807 ± 0.025
0.461TyrLys: 0.461 ± 0.022
2.131TyrLeu: 2.131 ± 0.041
0.475TyrMet: 0.475 ± 0.02
0.504TyrAsn: 0.504 ± 0.024
1.018TyrPro: 1.018 ± 0.031
0.553TyrGln: 0.553 ± 0.024
1.645TyrArg: 1.645 ± 0.036
0.927TyrSer: 0.927 ± 0.033
1.034TyrThr: 1.034 ± 0.032
1.448TyrVal: 1.448 ± 0.038
0.329TyrTrp: 0.329 ± 0.018
0.525TyrTyr: 0.525 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3606 proteins (1120362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski