Amino acid dipepetide frequency for Streptococcus phage Javan132

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.624AlaAla: 3.624 ± 1.162
0.473AlaCys: 0.473 ± 0.2
4.412AlaAsp: 4.412 ± 0.63
5.199AlaGlu: 5.199 ± 0.71
1.418AlaPhe: 1.418 ± 0.3
3.624AlaGly: 3.624 ± 0.787
0.709AlaHis: 0.709 ± 0.256
4.648AlaIle: 4.648 ± 0.681
6.696AlaLys: 6.696 ± 0.766
6.46AlaLeu: 6.46 ± 1.054
2.521AlaMet: 2.521 ± 0.537
3.545AlaAsn: 3.545 ± 0.608
1.182AlaPro: 1.182 ± 0.29
3.23AlaGln: 3.23 ± 0.681
2.757AlaArg: 2.757 ± 0.417
4.805AlaSer: 4.805 ± 0.689
3.703AlaThr: 3.703 ± 0.78
5.593AlaVal: 5.593 ± 0.93
0.945AlaTrp: 0.945 ± 0.305
2.836AlaTyr: 2.836 ± 0.474
0.0AlaXaa: 0.0 ± 0.0
Cys
0.236CysAla: 0.236 ± 0.126
0.0CysCys: 0.0 ± 0.0
0.079CysAsp: 0.079 ± 0.072
0.788CysGlu: 0.788 ± 0.248
0.315CysPhe: 0.315 ± 0.143
0.709CysGly: 0.709 ± 0.29
0.079CysHis: 0.079 ± 0.087
0.236CysIle: 0.236 ± 0.128
0.394CysLys: 0.394 ± 0.191
0.63CysLeu: 0.63 ± 0.279
0.0CysMet: 0.0 ± 0.0
0.315CysAsn: 0.315 ± 0.161
0.0CysPro: 0.0 ± 0.0
0.079CysGln: 0.079 ± 0.073
0.315CysArg: 0.315 ± 0.159
0.158CysSer: 0.158 ± 0.11
0.158CysThr: 0.158 ± 0.116
0.63CysVal: 0.63 ± 0.229
0.079CysTrp: 0.079 ± 0.085
0.394CysTyr: 0.394 ± 0.175
0.0CysXaa: 0.0 ± 0.0
Asp
3.387AspAla: 3.387 ± 0.56
0.63AspCys: 0.63 ± 0.236
4.412AspAsp: 4.412 ± 0.606
4.175AspGlu: 4.175 ± 0.676
3.624AspPhe: 3.624 ± 0.52
4.963AspGly: 4.963 ± 0.906
0.945AspHis: 0.945 ± 0.279
4.569AspIle: 4.569 ± 0.711
6.775AspLys: 6.775 ± 0.588
6.775AspLeu: 6.775 ± 0.841
1.339AspMet: 1.339 ± 0.267
4.254AspAsn: 4.254 ± 0.604
1.891AspPro: 1.891 ± 0.359
1.26AspGln: 1.26 ± 0.321
2.285AspArg: 2.285 ± 0.424
3.703AspSer: 3.703 ± 0.592
3.072AspThr: 3.072 ± 0.519
3.545AspVal: 3.545 ± 0.519
0.63AspTrp: 0.63 ± 0.235
3.624AspTyr: 3.624 ± 0.662
0.0AspXaa: 0.0 ± 0.0
Glu
5.278GluAla: 5.278 ± 0.779
0.158GluCys: 0.158 ± 0.117
2.915GluAsp: 2.915 ± 0.582
5.987GluGlu: 5.987 ± 0.966
3.151GluPhe: 3.151 ± 0.494
2.285GluGly: 2.285 ± 0.61
1.024GluHis: 1.024 ± 0.33
7.248GluIle: 7.248 ± 0.812
6.145GluLys: 6.145 ± 0.793
7.799GluLeu: 7.799 ± 0.912
1.733GluMet: 1.733 ± 0.307
3.624GluAsn: 3.624 ± 0.666
2.206GluPro: 2.206 ± 0.517
3.387GluGln: 3.387 ± 0.623
3.624GluArg: 3.624 ± 0.494
4.333GluSer: 4.333 ± 0.643
4.884GluThr: 4.884 ± 0.639
4.805GluVal: 4.805 ± 1.036
1.103GluTrp: 1.103 ± 0.272
2.521GluTyr: 2.521 ± 0.439
0.0GluXaa: 0.0 ± 0.0
Phe
2.521PheAla: 2.521 ± 0.443
0.315PheCys: 0.315 ± 0.168
2.915PheAsp: 2.915 ± 0.468
3.781PheGlu: 3.781 ± 0.525
1.182PhePhe: 1.182 ± 0.332
2.757PheGly: 2.757 ± 0.446
0.315PheHis: 0.315 ± 0.132
2.442PheIle: 2.442 ± 0.503
3.466PheLys: 3.466 ± 0.502
2.442PheLeu: 2.442 ± 0.455
0.945PheMet: 0.945 ± 0.301
2.836PheAsn: 2.836 ± 0.454
0.63PhePro: 0.63 ± 0.172
0.945PheGln: 0.945 ± 0.277
1.812PheArg: 1.812 ± 0.394
2.442PheSer: 2.442 ± 0.421
2.363PheThr: 2.363 ± 0.378
1.891PheVal: 1.891 ± 0.393
0.236PheTrp: 0.236 ± 0.131
1.26PheTyr: 1.26 ± 0.301
0.0PheXaa: 0.0 ± 0.0
Gly
3.703GlyAla: 3.703 ± 0.634
0.394GlyCys: 0.394 ± 0.173
4.096GlyAsp: 4.096 ± 0.788
3.939GlyGlu: 3.939 ± 0.487
2.285GlyPhe: 2.285 ± 0.505
4.49GlyGly: 4.49 ± 0.636
0.945GlyHis: 0.945 ± 0.218
4.412GlyIle: 4.412 ± 0.51
6.066GlyLys: 6.066 ± 0.761
5.751GlyLeu: 5.751 ± 0.84
1.812GlyMet: 1.812 ± 0.37
3.624GlyAsn: 3.624 ± 0.52
0.867GlyPro: 0.867 ± 0.297
2.678GlyGln: 2.678 ± 0.435
2.915GlyArg: 2.915 ± 0.426
2.836GlySer: 2.836 ± 0.497
2.915GlyThr: 2.915 ± 0.441
4.569GlyVal: 4.569 ± 0.616
1.103GlyTrp: 1.103 ± 0.287
2.994GlyTyr: 2.994 ± 0.575
0.0GlyXaa: 0.0 ± 0.0
His
0.867HisAla: 0.867 ± 0.291
0.158HisCys: 0.158 ± 0.117
1.182HisAsp: 1.182 ± 0.349
0.788HisGlu: 0.788 ± 0.229
0.473HisPhe: 0.473 ± 0.226
0.945HisGly: 0.945 ± 0.288
0.079HisHis: 0.079 ± 0.079
0.788HisIle: 0.788 ± 0.259
1.182HisLys: 1.182 ± 0.285
0.63HisLeu: 0.63 ± 0.215
0.079HisMet: 0.079 ± 0.076
0.945HisAsn: 0.945 ± 0.337
0.473HisPro: 0.473 ± 0.15
0.551HisGln: 0.551 ± 0.192
1.024HisArg: 1.024 ± 0.328
0.867HisSer: 0.867 ± 0.29
0.788HisThr: 0.788 ± 0.267
0.788HisVal: 0.788 ± 0.229
0.158HisTrp: 0.158 ± 0.116
0.63HisTyr: 0.63 ± 0.26
0.0HisXaa: 0.0 ± 0.0
Ile
5.436IleAla: 5.436 ± 0.613
0.473IleCys: 0.473 ± 0.218
5.042IleAsp: 5.042 ± 0.722
5.751IleGlu: 5.751 ± 0.689
2.442IlePhe: 2.442 ± 0.399
3.939IleGly: 3.939 ± 0.58
1.26IleHis: 1.26 ± 0.414
3.151IleIle: 3.151 ± 0.552
8.272IleLys: 8.272 ± 0.888
6.302IleLeu: 6.302 ± 0.756
1.024IleMet: 1.024 ± 0.278
4.648IleAsn: 4.648 ± 0.71
2.678IlePro: 2.678 ± 0.562
1.812IleGln: 1.812 ± 0.363
2.6IleArg: 2.6 ± 0.422
4.254IleSer: 4.254 ± 0.492
4.805IleThr: 4.805 ± 0.685
3.86IleVal: 3.86 ± 0.522
0.63IleTrp: 0.63 ± 0.196
2.127IleTyr: 2.127 ± 0.468
0.0IleXaa: 0.0 ± 0.0
Lys
7.326LysAla: 7.326 ± 0.98
0.473LysCys: 0.473 ± 0.184
5.121LysAsp: 5.121 ± 0.702
7.641LysGlu: 7.641 ± 0.932
3.23LysPhe: 3.23 ± 0.413
6.066LysGly: 6.066 ± 1.086
1.26LysHis: 1.26 ± 0.376
6.539LysIle: 6.539 ± 1.016
7.878LysLys: 7.878 ± 0.873
7.484LysLeu: 7.484 ± 0.947
2.442LysMet: 2.442 ± 0.426
4.963LysAsn: 4.963 ± 0.648
2.442LysPro: 2.442 ± 0.491
5.042LysGln: 5.042 ± 0.64
4.018LysArg: 4.018 ± 0.712
5.278LysSer: 5.278 ± 0.6
5.987LysThr: 5.987 ± 0.692
5.593LysVal: 5.593 ± 0.789
0.867LysTrp: 0.867 ± 0.24
3.466LysTyr: 3.466 ± 0.648
0.0LysXaa: 0.0 ± 0.0
Leu
6.381LeuAla: 6.381 ± 1.041
0.394LeuCys: 0.394 ± 0.171
6.302LeuAsp: 6.302 ± 0.652
7.484LeuGlu: 7.484 ± 0.8
2.915LeuPhe: 2.915 ± 0.557
5.514LeuGly: 5.514 ± 0.801
0.788LeuHis: 0.788 ± 0.24
6.223LeuIle: 6.223 ± 0.853
9.532LeuLys: 9.532 ± 0.911
6.932LeuLeu: 6.932 ± 0.775
2.206LeuMet: 2.206 ± 0.443
5.357LeuAsn: 5.357 ± 0.593
2.915LeuPro: 2.915 ± 0.508
3.703LeuGln: 3.703 ± 0.564
3.387LeuArg: 3.387 ± 0.412
5.987LeuSer: 5.987 ± 0.993
5.83LeuThr: 5.83 ± 0.581
4.175LeuVal: 4.175 ± 0.599
0.236LeuTrp: 0.236 ± 0.14
2.6LeuTyr: 2.6 ± 0.483
0.0LeuXaa: 0.0 ± 0.0
Met
2.285MetAla: 2.285 ± 0.542
0.079MetCys: 0.079 ± 0.072
1.497MetAsp: 1.497 ± 0.434
1.103MetGlu: 1.103 ± 0.304
0.788MetPhe: 0.788 ± 0.229
1.418MetGly: 1.418 ± 0.3
0.158MetHis: 0.158 ± 0.096
2.363MetIle: 2.363 ± 0.439
1.497MetLys: 1.497 ± 0.318
2.285MetLeu: 2.285 ± 0.477
0.394MetMet: 0.394 ± 0.171
1.339MetAsn: 1.339 ± 0.348
0.709MetPro: 0.709 ± 0.225
0.945MetGln: 0.945 ± 0.267
1.182MetArg: 1.182 ± 0.256
1.654MetSer: 1.654 ± 0.495
2.127MetThr: 2.127 ± 0.446
1.182MetVal: 1.182 ± 0.278
0.236MetTrp: 0.236 ± 0.147
0.315MetTyr: 0.315 ± 0.207
0.0MetXaa: 0.0 ± 0.0
Asn
3.387AsnAla: 3.387 ± 0.637
0.236AsnCys: 0.236 ± 0.194
4.018AsnAsp: 4.018 ± 0.587
3.86AsnGlu: 3.86 ± 0.681
2.442AsnPhe: 2.442 ± 0.346
4.884AsnGly: 4.884 ± 0.532
0.709AsnHis: 0.709 ± 0.225
4.096AsnIle: 4.096 ± 0.693
5.593AsnLys: 5.593 ± 0.797
5.199AsnLeu: 5.199 ± 0.599
1.339AsnMet: 1.339 ± 0.334
4.096AsnAsn: 4.096 ± 0.584
1.969AsnPro: 1.969 ± 0.391
2.285AsnGln: 2.285 ± 0.538
2.994AsnArg: 2.994 ± 0.509
3.309AsnSer: 3.309 ± 0.686
2.757AsnThr: 2.757 ± 0.443
3.072AsnVal: 3.072 ± 0.499
1.103AsnTrp: 1.103 ± 0.271
1.812AsnTyr: 1.812 ± 0.296
0.0AsnXaa: 0.0 ± 0.0
Pro
1.497ProAla: 1.497 ± 0.424
0.158ProCys: 0.158 ± 0.128
1.812ProAsp: 1.812 ± 0.356
1.969ProGlu: 1.969 ± 0.44
0.867ProPhe: 0.867 ± 0.228
0.709ProGly: 0.709 ± 0.249
0.473ProHis: 0.473 ± 0.17
1.733ProIle: 1.733 ± 0.332
3.466ProLys: 3.466 ± 0.663
2.363ProLeu: 2.363 ± 0.517
0.315ProMet: 0.315 ± 0.131
1.182ProAsn: 1.182 ± 0.356
0.551ProPro: 0.551 ± 0.223
2.048ProGln: 2.048 ± 0.425
0.709ProArg: 0.709 ± 0.242
1.497ProSer: 1.497 ± 0.307
1.812ProThr: 1.812 ± 0.291
2.127ProVal: 2.127 ± 0.512
0.236ProTrp: 0.236 ± 0.121
1.182ProTyr: 1.182 ± 0.336
0.0ProXaa: 0.0 ± 0.0
Gln
2.442GlnAla: 2.442 ± 0.446
0.158GlnCys: 0.158 ± 0.118
1.576GlnAsp: 1.576 ± 0.33
3.151GlnGlu: 3.151 ± 0.507
1.576GlnPhe: 1.576 ± 0.286
1.654GlnGly: 1.654 ± 0.265
0.709GlnHis: 0.709 ± 0.229
3.387GlnIle: 3.387 ± 0.479
2.836GlnLys: 2.836 ± 0.418
4.175GlnLeu: 4.175 ± 0.566
1.418GlnMet: 1.418 ± 0.371
2.757GlnAsn: 2.757 ± 0.535
0.788GlnPro: 0.788 ± 0.221
1.654GlnGln: 1.654 ± 0.468
1.891GlnArg: 1.891 ± 0.341
4.018GlnSer: 4.018 ± 0.681
2.206GlnThr: 2.206 ± 0.48
1.891GlnVal: 1.891 ± 0.429
1.024GlnTrp: 1.024 ± 0.279
1.418GlnTyr: 1.418 ± 0.391
0.0GlnXaa: 0.0 ± 0.0
Arg
3.151ArgAla: 3.151 ± 0.506
0.079ArgCys: 0.079 ± 0.09
2.915ArgAsp: 2.915 ± 0.552
3.23ArgGlu: 3.23 ± 0.627
1.576ArgPhe: 1.576 ± 0.276
3.151ArgGly: 3.151 ± 0.443
0.945ArgHis: 0.945 ± 0.269
3.23ArgIle: 3.23 ± 0.56
4.096ArgLys: 4.096 ± 0.584
3.781ArgLeu: 3.781 ± 0.572
0.63ArgMet: 0.63 ± 0.216
2.521ArgAsn: 2.521 ± 0.474
0.473ArgPro: 0.473 ± 0.185
2.048ArgGln: 2.048 ± 0.4
1.812ArgArg: 1.812 ± 0.414
1.497ArgSer: 1.497 ± 0.292
2.521ArgThr: 2.521 ± 0.575
2.048ArgVal: 2.048 ± 0.489
0.473ArgTrp: 0.473 ± 0.205
1.969ArgTyr: 1.969 ± 0.463
0.0ArgXaa: 0.0 ± 0.0
Ser
4.49SerAla: 4.49 ± 0.97
0.315SerCys: 0.315 ± 0.171
5.751SerAsp: 5.751 ± 0.575
4.175SerGlu: 4.175 ± 0.523
2.442SerPhe: 2.442 ± 0.449
4.727SerGly: 4.727 ± 0.629
0.788SerHis: 0.788 ± 0.254
4.175SerIle: 4.175 ± 0.645
5.357SerLys: 5.357 ± 0.657
4.412SerLeu: 4.412 ± 0.523
1.497SerMet: 1.497 ± 0.311
3.703SerAsn: 3.703 ± 0.824
1.418SerPro: 1.418 ± 0.366
2.678SerGln: 2.678 ± 0.406
1.969SerArg: 1.969 ± 0.407
3.545SerSer: 3.545 ± 0.436
2.757SerThr: 2.757 ± 0.538
3.466SerVal: 3.466 ± 0.535
0.63SerTrp: 0.63 ± 0.307
2.994SerTyr: 2.994 ± 0.552
0.0SerXaa: 0.0 ± 0.0
Thr
4.648ThrAla: 4.648 ± 0.892
0.315ThrCys: 0.315 ± 0.149
3.781ThrAsp: 3.781 ± 0.472
3.86ThrGlu: 3.86 ± 0.699
2.285ThrPhe: 2.285 ± 0.394
4.963ThrGly: 4.963 ± 0.577
0.551ThrHis: 0.551 ± 0.234
4.333ThrIle: 4.333 ± 0.491
4.805ThrLys: 4.805 ± 0.635
5.199ThrLeu: 5.199 ± 0.615
1.654ThrMet: 1.654 ± 0.45
2.915ThrAsn: 2.915 ± 0.473
2.363ThrPro: 2.363 ± 0.498
2.285ThrGln: 2.285 ± 0.354
1.891ThrArg: 1.891 ± 0.413
4.096ThrSer: 4.096 ± 0.521
3.466ThrThr: 3.466 ± 0.519
3.86ThrVal: 3.86 ± 0.606
0.473ThrTrp: 0.473 ± 0.155
1.576ThrTyr: 1.576 ± 0.343
0.0ThrXaa: 0.0 ± 0.0
Val
4.569ValAla: 4.569 ± 0.922
0.158ValCys: 0.158 ± 0.096
4.727ValAsp: 4.727 ± 0.728
4.805ValGlu: 4.805 ± 0.643
2.521ValPhe: 2.521 ± 0.4
3.23ValGly: 3.23 ± 0.462
0.709ValHis: 0.709 ± 0.262
3.545ValIle: 3.545 ± 0.522
4.884ValLys: 4.884 ± 0.741
6.223ValLeu: 6.223 ± 0.691
1.103ValMet: 1.103 ± 0.336
3.545ValAsn: 3.545 ± 0.595
1.182ValPro: 1.182 ± 0.221
1.418ValGln: 1.418 ± 0.308
2.442ValArg: 2.442 ± 0.506
4.805ValSer: 4.805 ± 0.628
4.412ValThr: 4.412 ± 0.606
3.309ValVal: 3.309 ± 0.496
0.473ValTrp: 0.473 ± 0.197
1.024ValTyr: 1.024 ± 0.337
0.0ValXaa: 0.0 ± 0.0
Trp
0.394TrpAla: 0.394 ± 0.171
0.158TrpCys: 0.158 ± 0.125
0.709TrpAsp: 0.709 ± 0.245
0.709TrpGlu: 0.709 ± 0.214
0.394TrpPhe: 0.394 ± 0.182
0.788TrpGly: 0.788 ± 0.249
0.158TrpHis: 0.158 ± 0.118
1.182TrpIle: 1.182 ± 0.37
0.945TrpLys: 0.945 ± 0.28
1.182TrpLeu: 1.182 ± 0.327
0.158TrpMet: 0.158 ± 0.111
0.709TrpAsn: 0.709 ± 0.251
0.394TrpPro: 0.394 ± 0.181
0.551TrpGln: 0.551 ± 0.19
0.788TrpArg: 0.788 ± 0.274
0.551TrpSer: 0.551 ± 0.205
0.473TrpThr: 0.473 ± 0.255
0.551TrpVal: 0.551 ± 0.222
0.0TrpTrp: 0.0 ± 0.0
0.394TrpTyr: 0.394 ± 0.182
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.757TyrAla: 2.757 ± 0.411
0.473TyrCys: 0.473 ± 0.195
2.678TyrAsp: 2.678 ± 0.49
1.812TyrGlu: 1.812 ± 0.374
1.576TyrPhe: 1.576 ± 0.435
1.576TyrGly: 1.576 ± 0.302
0.788TyrHis: 0.788 ± 0.265
2.206TyrIle: 2.206 ± 0.532
3.23TyrLys: 3.23 ± 0.518
2.836TyrLeu: 2.836 ± 0.41
0.867TyrMet: 0.867 ± 0.284
2.285TyrAsn: 2.285 ± 0.506
1.576TyrPro: 1.576 ± 0.443
2.127TyrGln: 2.127 ± 0.43
1.733TyrArg: 1.733 ± 0.36
1.654TyrSer: 1.654 ± 0.388
2.285TyrThr: 2.285 ± 0.464
2.127TyrVal: 2.127 ± 0.387
0.551TyrTrp: 0.551 ± 0.238
1.891TyrTyr: 1.891 ± 0.368
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (12695 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski