Amino acid dipepetide frequency for Paenibacillus hemerocallicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.827AlaAla: 9.827 ± 0.086	0.838AlaCys: 0.838 ± 0.019	5.163AlaAsp: 5.163 ± 0.047	6.1AlaGlu: 6.1 ± 0.059	3.521AlaPhe: 3.521 ± 0.038	7.597AlaGly: 7.597 ± 0.071	1.473AlaHis: 1.473 ± 0.022	5.326AlaIle: 5.326 ± 0.048	4.45AlaLys: 4.45 ± 0.041	8.349AlaLeu: 8.349 ± 0.067	2.406AlaMet: 2.406 ± 0.028	2.868AlaAsn: 2.868 ± 0.038	3.146AlaPro: 3.146 ± 0.044	2.61AlaGln: 2.61 ± 0.035	4.051AlaArg: 4.051 ± 0.049	5.447AlaSer: 5.447 ± 0.046	3.994AlaThr: 3.994 ± 0.073	6.886AlaVal: 6.886 ± 0.058	0.976AlaTrp: 0.976 ± 0.022	2.971AlaTyr: 2.971 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.59CysAla: 0.59 ± 0.014	0.144CysCys: 0.144 ± 0.008	0.462CysAsp: 0.462 ± 0.014	0.471CysGlu: 0.471 ± 0.012	0.35CysPhe: 0.35 ± 0.012	0.861CysGly: 0.861 ± 0.02	0.22CysHis: 0.22 ± 0.009	0.49CysIle: 0.49 ± 0.013	0.319CysLys: 0.319 ± 0.01	0.753CysLeu: 0.753 ± 0.018	0.232CysMet: 0.232 ± 0.009	0.267CysAsn: 0.267 ± 0.01	0.378CysPro: 0.378 ± 0.013	0.2CysGln: 0.2 ± 0.009	0.59CysArg: 0.59 ± 0.016	0.625CysSer: 0.625 ± 0.017	0.41CysThr: 0.41 ± 0.012	0.488CysVal: 0.488 ± 0.015	0.113CysTrp: 0.113 ± 0.006	0.315CysTyr: 0.315 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.355AspAla: 4.355 ± 0.046	0.462AspCys: 0.462 ± 0.013	2.705AspAsp: 2.705 ± 0.035	3.732AspGlu: 3.732 ± 0.039	2.079AspPhe: 2.079 ± 0.028	4.818AspGly: 4.818 ± 0.057	1.061AspHis: 1.061 ± 0.022	3.48AspIle: 3.48 ± 0.035	2.838AspLys: 2.838 ± 0.039	4.813AspLeu: 4.813 ± 0.043	1.517AspMet: 1.517 ± 0.025	1.862AspAsn: 1.862 ± 0.029	2.77AspPro: 2.77 ± 0.038	1.539AspGln: 1.539 ± 0.024	3.478AspArg: 3.478 ± 0.037	2.977AspSer: 2.977 ± 0.034	2.554AspThr: 2.554 ± 0.038	3.64AspVal: 3.64 ± 0.033	0.878AspTrp: 0.878 ± 0.019	2.115AspTyr: 2.115 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.353GluAla: 6.353 ± 0.058	0.436GluCys: 0.436 ± 0.013	2.632GluAsp: 2.632 ± 0.034	4.693GluGlu: 4.693 ± 0.053	2.033GluPhe: 2.033 ± 0.027	4.319GluGly: 4.319 ± 0.042	1.512GluHis: 1.512 ± 0.028	3.683GluIle: 3.683 ± 0.041	3.563GluLys: 3.563 ± 0.045	6.996GluLeu: 6.996 ± 0.058	1.827GluMet: 1.827 ± 0.024	2.065GluAsn: 2.065 ± 0.029	2.672GluPro: 2.672 ± 0.031	3.37GluGln: 3.37 ± 0.039	4.888GluArg: 4.888 ± 0.066	3.586GluSer: 3.586 ± 0.039	3.62GluThr: 3.62 ± 0.038	3.749GluVal: 3.749 ± 0.043	1.033GluTrp: 1.033 ± 0.02	1.921GluTyr: 1.921 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.596PheAla: 3.596 ± 0.037	0.364PheCys: 0.364 ± 0.011	2.539PheAsp: 2.539 ± 0.031	2.439PheGlu: 2.439 ± 0.03	1.64PhePhe: 1.64 ± 0.026	3.397PheGly: 3.397 ± 0.03	0.966PheHis: 0.966 ± 0.022	2.345PheIle: 2.345 ± 0.033	1.814PheLys: 1.814 ± 0.028	3.575PheLeu: 3.575 ± 0.041	1.006PheMet: 1.006 ± 0.021	1.394PheAsn: 1.394 ± 0.022	1.795PhePro: 1.795 ± 0.027	1.389PheGln: 1.389 ± 0.027	2.474PheArg: 2.474 ± 0.034	2.592PheSer: 2.592 ± 0.035	2.184PheThr: 2.184 ± 0.024	3.096PheVal: 3.096 ± 0.034	0.522PheTrp: 0.522 ± 0.014	1.574PheTyr: 1.574 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	6.343GlyAla: 6.343 ± 0.09	0.829GlyCys: 0.829 ± 0.018	3.831GlyAsp: 3.831 ± 0.044	4.842GlyGlu: 4.842 ± 0.041	3.258GlyPhe: 3.258 ± 0.033	6.194GlyGly: 6.194 ± 0.073	1.591GlyHis: 1.591 ± 0.025	5.359GlyIle: 5.359 ± 0.052	4.892GlyLys: 4.892 ± 0.047	7.177GlyLeu: 7.177 ± 0.06	2.428GlyMet: 2.428 ± 0.03	3.052GlyAsn: 3.052 ± 0.037	2.23GlyPro: 2.23 ± 0.035	2.834GlyGln: 2.834 ± 0.035	4.05GlyArg: 4.05 ± 0.044	5.189GlySer: 5.189 ± 0.062	5.029GlyThr: 5.029 ± 0.062	5.316GlyVal: 5.316 ± 0.051	1.213GlyTrp: 1.213 ± 0.024	3.028GlyTyr: 3.028 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.67HisAla: 1.67 ± 0.028	0.222HisCys: 0.222 ± 0.01	1.057HisAsp: 1.057 ± 0.021	1.162HisGlu: 1.162 ± 0.022	1.058HisPhe: 1.058 ± 0.022	1.54HisGly: 1.54 ± 0.024	0.584HisHis: 0.584 ± 0.019	1.376HisIle: 1.376 ± 0.024	0.817HisLys: 0.817 ± 0.02	2.055HisLeu: 2.055 ± 0.036	0.622HisMet: 0.622 ± 0.016	0.719HisAsn: 0.719 ± 0.016	1.289HisPro: 1.289 ± 0.024	0.625HisGln: 0.625 ± 0.016	1.271HisArg: 1.271 ± 0.024	1.161HisSer: 1.161 ± 0.021	1.083HisThr: 1.083 ± 0.02	1.469HisVal: 1.469 ± 0.023	0.325HisTrp: 0.325 ± 0.012	0.938HisTyr: 0.938 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.141IleAla: 6.141 ± 0.051	0.515IleCys: 0.515 ± 0.014	3.684IleAsp: 3.684 ± 0.042	3.941IleGlu: 3.941 ± 0.039	1.951IlePhe: 1.951 ± 0.03	5.451IleGly: 5.451 ± 0.049	1.327IleHis: 1.327 ± 0.024	2.92IleIle: 2.92 ± 0.037	2.393IleLys: 2.393 ± 0.035	4.439IleLeu: 4.439 ± 0.047	1.393IleMet: 1.393 ± 0.023	1.925IleAsn: 1.925 ± 0.029	3.085IlePro: 3.085 ± 0.039	1.99IleGln: 1.99 ± 0.029	4.479IleArg: 4.479 ± 0.041	3.698IleSer: 3.698 ± 0.037	3.103IleThr: 3.103 ± 0.034	5.324IleVal: 5.324 ± 0.048	0.656IleTrp: 0.656 ± 0.016	1.789IleTyr: 1.789 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.262LysAla: 4.262 ± 0.047	0.222LysCys: 0.222 ± 0.009	2.746LysAsp: 2.746 ± 0.044	3.82LysGlu: 3.82 ± 0.044	1.595LysPhe: 1.595 ± 0.027	3.404LysGly: 3.404 ± 0.036	1.146LysHis: 1.146 ± 0.018	2.62LysIle: 2.62 ± 0.035	2.895LysLys: 2.895 ± 0.039	5.254LysLeu: 5.254 ± 0.057	1.503LysMet: 1.503 ± 0.027	1.804LysAsn: 1.804 ± 0.033	2.478LysPro: 2.478 ± 0.032	2.314LysGln: 2.314 ± 0.03	3.147LysArg: 3.147 ± 0.034	2.871LysSer: 2.871 ± 0.033	2.851LysThr: 2.851 ± 0.037	3.078LysVal: 3.078 ± 0.041	0.718LysTrp: 0.718 ± 0.017	1.674LysTyr: 1.674 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	8.618LeuAla: 8.618 ± 0.075	0.881LeuCys: 0.881 ± 0.018	5.204LeuAsp: 5.204 ± 0.042	5.923LeuGlu: 5.923 ± 0.053	4.509LeuPhe: 4.509 ± 0.05	6.558LeuGly: 6.558 ± 0.05	2.164LeuHis: 2.164 ± 0.034	5.462LeuIle: 5.462 ± 0.049	4.715LeuLys: 4.715 ± 0.045	10.653LeuLeu: 10.653 ± 0.099	2.308LeuMet: 2.308 ± 0.034	3.628LeuAsn: 3.628 ± 0.038	4.589LeuPro: 4.589 ± 0.048	3.742LeuGln: 3.742 ± 0.032	5.488LeuArg: 5.488 ± 0.048	6.685LeuSer: 6.685 ± 0.052	5.278LeuThr: 5.278 ± 0.049	6.138LeuVal: 6.138 ± 0.053	1.047LeuTrp: 1.047 ± 0.019	3.39LeuTyr: 3.39 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.232MetAla: 2.232 ± 0.028	0.162MetCys: 0.162 ± 0.008	1.388MetAsp: 1.388 ± 0.025	1.852MetGlu: 1.852 ± 0.027	0.995MetPhe: 0.995 ± 0.022	1.598MetGly: 1.598 ± 0.024	0.523MetHis: 0.523 ± 0.013	1.699MetIle: 1.699 ± 0.025	1.813MetLys: 1.813 ± 0.025	2.876MetLeu: 2.876 ± 0.042	0.808MetMet: 0.808 ± 0.023	1.399MetAsn: 1.399 ± 0.022	1.252MetPro: 1.252 ± 0.023	0.983MetGln: 0.983 ± 0.019	1.523MetArg: 1.523 ± 0.024	1.785MetSer: 1.785 ± 0.025	1.775MetThr: 1.775 ± 0.027	1.534MetVal: 1.534 ± 0.025	0.252MetTrp: 0.252 ± 0.009	0.785MetTyr: 0.785 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.991AsnAla: 2.991 ± 0.038	0.295AsnCys: 0.295 ± 0.012	1.853AsnAsp: 1.853 ± 0.025	2.296AsnGlu: 2.296 ± 0.029	1.167AsnPhe: 1.167 ± 0.026	3.655AsnGly: 3.655 ± 0.044	0.714AsnHis: 0.714 ± 0.017	2.019AsnIle: 2.019 ± 0.031	2.008AsnLys: 2.008 ± 0.036	2.886AsnLeu: 2.886 ± 0.03	1.012AsnMet: 1.012 ± 0.021	1.418AsnAsn: 1.418 ± 0.032	2.013AsnPro: 2.013 ± 0.03	1.189AsnGln: 1.189 ± 0.021	2.486AsnArg: 2.486 ± 0.037	1.873AsnSer: 1.873 ± 0.03	1.938AsnThr: 1.938 ± 0.034	2.775AsnVal: 2.775 ± 0.036	0.592AsnTrp: 0.592 ± 0.016	1.276AsnTyr: 1.276 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	3.812ProAla: 3.812 ± 0.042	0.275ProCys: 0.275 ± 0.01	3.196ProAsp: 3.196 ± 0.04	3.43ProGlu: 3.43 ± 0.033	2.066ProPhe: 2.066 ± 0.03	3.657ProGly: 3.657 ± 0.039	1.025ProHis: 1.025 ± 0.021	2.584ProIle: 2.584 ± 0.035	1.857ProLys: 1.857 ± 0.026	4.101ProLeu: 4.101 ± 0.04	0.992ProMet: 0.992 ± 0.018	1.711ProAsn: 1.711 ± 0.026	1.537ProPro: 1.537 ± 0.028	1.36ProGln: 1.36 ± 0.022	1.692ProArg: 1.692 ± 0.028	2.728ProSer: 2.728 ± 0.038	2.066ProThr: 2.066 ± 0.025	3.622ProVal: 3.622 ± 0.042	0.538ProTrp: 0.538 ± 0.015	1.782ProTyr: 1.782 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.342GlnAla: 3.342 ± 0.039	0.205GlnCys: 0.205 ± 0.009	1.459GlnAsp: 1.459 ± 0.022	1.994GlnGlu: 1.994 ± 0.03	1.496GlnPhe: 1.496 ± 0.021	2.348GlnGly: 2.348 ± 0.028	0.7GlnHis: 0.7 ± 0.017	2.155GlnIle: 2.155 ± 0.029	1.628GlnLys: 1.628 ± 0.028	3.918GlnLeu: 3.918 ± 0.046	1.019GlnMet: 1.019 ± 0.019	1.223GlnAsn: 1.223 ± 0.022	1.587GlnPro: 1.587 ± 0.028	1.552GlnGln: 1.552 ± 0.027	1.813GlnArg: 1.813 ± 0.03	2.351GlnSer: 2.351 ± 0.029	2.087GlnThr: 2.087 ± 0.029	2.236GlnVal: 2.236 ± 0.03	0.556GlnTrp: 0.556 ± 0.015	1.401GlnTyr: 1.401 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	3.926ArgAla: 3.926 ± 0.045	0.473ArgCys: 0.473 ± 0.013	2.906ArgAsp: 2.906 ± 0.041	4.234ArgGlu: 4.234 ± 0.056	2.77ArgPhe: 2.77 ± 0.032	3.417ArgGly: 3.417 ± 0.039	1.355ArgHis: 1.355 ± 0.027	4.099ArgIle: 4.099 ± 0.045	3.222ArgLys: 3.222 ± 0.041	6.595ArgLeu: 6.595 ± 0.062	1.903ArgMet: 1.903 ± 0.027	2.312ArgAsn: 2.312 ± 0.033	2.057ArgPro: 2.057 ± 0.032	2.367ArgGln: 2.367 ± 0.032	3.367ArgArg: 3.367 ± 0.047	3.687ArgSer: 3.687 ± 0.043	3.197ArgThr: 3.197 ± 0.034	3.426ArgVal: 3.426 ± 0.042	0.834ArgTrp: 0.834 ± 0.018	2.121ArgTyr: 2.121 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.396SerAla: 5.396 ± 0.053	0.491SerCys: 0.491 ± 0.017	3.343SerAsp: 3.343 ± 0.033	3.608SerGlu: 3.608 ± 0.038	2.933SerPhe: 2.933 ± 0.034	6.063SerGly: 6.063 ± 0.064	1.214SerHis: 1.214 ± 0.024	3.881SerIle: 3.881 ± 0.039	2.855SerLys: 2.855 ± 0.038	6.087SerLeu: 6.087 ± 0.048	1.638SerMet: 1.638 ± 0.025	2.047SerAsn: 2.047 ± 0.032	2.811SerPro: 2.811 ± 0.036	1.743SerGln: 1.743 ± 0.027	3.585SerArg: 3.585 ± 0.041	4.037SerSer: 4.037 ± 0.047	3.011SerThr: 3.011 ± 0.039	4.695SerVal: 4.695 ± 0.05	0.82SerTrp: 0.82 ± 0.016	2.18SerTyr: 2.18 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	4.961ThrAla: 4.961 ± 0.057	0.333ThrCys: 0.333 ± 0.011	3.029ThrAsp: 3.029 ± 0.029	3.21ThrGlu: 3.21 ± 0.036	2.359ThrPhe: 2.359 ± 0.032	5.148ThrGly: 5.148 ± 0.126	0.979ThrHis: 0.979 ± 0.02	3.726ThrIle: 3.726 ± 0.045	2.302ThrLys: 2.302 ± 0.031	5.056ThrLeu: 5.056 ± 0.048	1.381ThrMet: 1.381 ± 0.023	1.971ThrAsn: 1.971 ± 0.032	2.609ThrPro: 2.609 ± 0.035	1.32ThrGln: 1.32 ± 0.022	2.403ThrArg: 2.403 ± 0.032	3.14ThrSer: 3.14 ± 0.037	2.794ThrThr: 2.794 ± 0.045	4.727ThrVal: 4.727 ± 0.048	0.706ThrTrp: 0.706 ± 0.016	1.887ThrTyr: 1.887 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	5.697ValAla: 5.697 ± 0.043	0.692ValCys: 0.692 ± 0.019	3.539ValAsp: 3.539 ± 0.039	4.153ValGlu: 4.153 ± 0.04	2.798ValPhe: 2.798 ± 0.033	4.747ValGly: 4.747 ± 0.046	1.545ValHis: 1.545 ± 0.029	4.181ValIle: 4.181 ± 0.037	3.553ValLys: 3.553 ± 0.039	6.915ValLeu: 6.915 ± 0.058	1.848ValMet: 1.848 ± 0.03	2.642ValAsn: 2.642 ± 0.038	3.433ValPro: 3.433 ± 0.038	2.578ValGln: 2.578 ± 0.031	4.294ValArg: 4.294 ± 0.048	4.936ValSer: 4.936 ± 0.043	4.406ValThr: 4.406 ± 0.068	4.963ValVal: 4.963 ± 0.043	0.929ValTrp: 0.929 ± 0.023	2.596ValTyr: 2.596 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.852TrpAla: 0.852 ± 0.02	0.099TrpCys: 0.099 ± 0.006	0.835TrpAsp: 0.835 ± 0.017	0.796TrpGlu: 0.796 ± 0.019	0.535TrpPhe: 0.535 ± 0.017	0.868TrpGly: 0.868 ± 0.02	0.307TrpHis: 0.307 ± 0.011	0.897TrpIle: 0.897 ± 0.019	0.844TrpLys: 0.844 ± 0.017	1.431TrpLeu: 1.431 ± 0.027	0.414TrpMet: 0.414 ± 0.012	0.717TrpAsn: 0.717 ± 0.019	0.441TrpPro: 0.441 ± 0.013	0.471TrpGln: 0.471 ± 0.014	0.764TrpArg: 0.764 ± 0.019	0.945TrpSer: 0.945 ± 0.022	0.797TrpThr: 0.797 ± 0.018	0.812TrpVal: 0.812 ± 0.02	0.172TrpTrp: 0.172 ± 0.009	0.429TrpTyr: 0.429 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.036TyrAla: 3.036 ± 0.033	0.34TyrCys: 0.34 ± 0.011	2.101TyrAsp: 2.101 ± 0.031	2.255TyrGlu: 2.255 ± 0.031	1.588TyrPhe: 1.588 ± 0.023	3.044TyrGly: 3.044 ± 0.037	0.632TyrHis: 0.632 ± 0.018	1.902TyrIle: 1.902 ± 0.027	1.625TyrLys: 1.625 ± 0.03	3.053TyrLeu: 3.053 ± 0.032	0.98TyrMet: 0.98 ± 0.019	1.431TyrAsn: 1.431 ± 0.021	1.86TyrPro: 1.86 ± 0.027	0.895TyrGln: 0.895 ± 0.02	2.423TyrArg: 2.423 ± 0.032	2.125TyrSer: 2.125 ± 0.032	1.866TyrThr: 1.866 ± 0.03	2.469TyrVal: 2.469 ± 0.034	0.544TyrTrp: 0.544 ± 0.017	1.495TyrTyr: 1.495 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 7848 proteins (2694558 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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