Amino acid dipepetide frequency for Phascolarctobacterium faecium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.175AlaAla: 11.175 ± 0.217	1.203AlaCys: 1.203 ± 0.049	5.178AlaAsp: 5.178 ± 0.095	6.566AlaGlu: 6.566 ± 0.114	3.41AlaPhe: 3.41 ± 0.083	7.61AlaGly: 7.61 ± 0.136	1.411AlaHis: 1.411 ± 0.048	5.434AlaIle: 5.434 ± 0.097	5.419AlaLys: 5.419 ± 0.099	8.863AlaLeu: 8.863 ± 0.114	2.686AlaMet: 2.686 ± 0.068	3.026AlaAsn: 3.026 ± 0.069	2.544AlaPro: 2.544 ± 0.075	3.027AlaGln: 3.027 ± 0.075	3.585AlaArg: 3.585 ± 0.067	4.26AlaSer: 4.26 ± 0.081	3.832AlaThr: 3.832 ± 0.084	8.039AlaVal: 8.039 ± 0.137	0.724AlaTrp: 0.724 ± 0.037	2.79AlaTyr: 2.79 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	1.091CysAla: 1.091 ± 0.041	0.299CysCys: 0.299 ± 0.023	0.7CysAsp: 0.7 ± 0.035	0.77CysGlu: 0.77 ± 0.036	0.514CysPhe: 0.514 ± 0.025	1.556CysGly: 1.556 ± 0.058	0.269CysHis: 0.269 ± 0.022	0.877CysIle: 0.877 ± 0.039	0.687CysLys: 0.687 ± 0.037	1.317CysLeu: 1.317 ± 0.041	0.314CysMet: 0.314 ± 0.022	0.492CysAsn: 0.492 ± 0.026	0.669CysPro: 0.669 ± 0.043	0.381CysGln: 0.381 ± 0.022	0.777CysArg: 0.777 ± 0.037	0.94CysSer: 0.94 ± 0.035	0.593CysThr: 0.593 ± 0.029	0.855CysVal: 0.855 ± 0.037	0.128CysTrp: 0.128 ± 0.013	0.466CysTyr: 0.466 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.254AspAla: 4.254 ± 0.091	0.697AspCys: 0.697 ± 0.033	2.63AspAsp: 2.63 ± 0.071	3.536AspGlu: 3.536 ± 0.075	2.495AspPhe: 2.495 ± 0.061	3.957AspGly: 3.957 ± 0.082	0.786AspHis: 0.786 ± 0.031	4.412AspIle: 4.412 ± 0.073	3.669AspLys: 3.669 ± 0.066	4.851AspLeu: 4.851 ± 0.098	1.523AspMet: 1.523 ± 0.041	2.398AspAsn: 2.398 ± 0.065	1.886AspPro: 1.886 ± 0.056	1.196AspGln: 1.196 ± 0.04	2.23AspArg: 2.23 ± 0.055	2.662AspSer: 2.662 ± 0.067	2.702AspThr: 2.702 ± 0.07	3.96AspVal: 3.96 ± 0.081	0.548AspTrp: 0.548 ± 0.03	2.231AspTyr: 2.231 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	6.235GluAla: 6.235 ± 0.109	0.73GluCys: 0.73 ± 0.036	2.989GluAsp: 2.989 ± 0.068	4.669GluGlu: 4.669 ± 0.103	2.381GluPhe: 2.381 ± 0.057	3.8GluGly: 3.8 ± 0.094	1.353GluHis: 1.353 ± 0.043	5.007GluIle: 5.007 ± 0.089	5.125GluLys: 5.125 ± 0.096	7.195GluLeu: 7.195 ± 0.114	2.05GluMet: 2.05 ± 0.06	3.105GluAsn: 3.105 ± 0.072	1.828GluPro: 1.828 ± 0.051	2.925GluGln: 2.925 ± 0.073	3.373GluArg: 3.373 ± 0.07	2.518GluSer: 2.518 ± 0.064	3.088GluThr: 3.088 ± 0.063	4.329GluVal: 4.329 ± 0.069	0.557GluTrp: 0.557 ± 0.027	2.318GluTyr: 2.318 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.606PheAla: 3.606 ± 0.076	0.704PheCys: 0.704 ± 0.029	2.439PheAsp: 2.439 ± 0.059	2.1PheGlu: 2.1 ± 0.062	1.915PhePhe: 1.915 ± 0.077	3.251PheGly: 3.251 ± 0.074	0.612PheHis: 0.612 ± 0.032	3.009PheIle: 3.009 ± 0.077	2.267PheLys: 2.267 ± 0.054	3.903PheLeu: 3.903 ± 0.09	1.18PheMet: 1.18 ± 0.038	1.719PheAsn: 1.719 ± 0.054	1.271PhePro: 1.271 ± 0.043	0.975PheGln: 0.975 ± 0.041	1.34PheArg: 1.34 ± 0.046	2.643PheSer: 2.643 ± 0.063	2.364PheThr: 2.364 ± 0.063	2.747PheVal: 2.747 ± 0.078	0.468PheTrp: 0.468 ± 0.026	1.422PheTyr: 1.422 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	6.167GlyAla: 6.167 ± 0.109	1.274GlyCys: 1.274 ± 0.043	3.704GlyAsp: 3.704 ± 0.087	4.427GlyGlu: 4.427 ± 0.085	3.099GlyPhe: 3.099 ± 0.061	6.046GlyGly: 6.046 ± 0.144	1.408GlyHis: 1.408 ± 0.046	6.219GlyIle: 6.219 ± 0.118	5.256GlyLys: 5.256 ± 0.085	7.07GlyLeu: 7.07 ± 0.112	2.503GlyMet: 2.503 ± 0.06	2.905GlyAsn: 2.905 ± 0.092	1.641GlyPro: 1.641 ± 0.049	2.241GlyGln: 2.241 ± 0.058	3.623GlyArg: 3.623 ± 0.077	4.863GlySer: 4.863 ± 0.116	4.336GlyThr: 4.336 ± 0.101	5.554GlyVal: 5.554 ± 0.095	0.777GlyTrp: 0.777 ± 0.037	3.019GlyTyr: 3.019 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	1.284HisAla: 1.284 ± 0.042	0.289HisCys: 0.289 ± 0.021	0.988HisAsp: 0.988 ± 0.039	1.035HisGlu: 1.035 ± 0.037	0.705HisPhe: 0.705 ± 0.03	1.477HisGly: 1.477 ± 0.044	0.35HisHis: 0.35 ± 0.026	1.227HisIle: 1.227 ± 0.046	1.028HisLys: 1.028 ± 0.043	1.713HisLeu: 1.713 ± 0.058	0.476HisMet: 0.476 ± 0.026	0.805HisAsn: 0.805 ± 0.033	0.851HisPro: 0.851 ± 0.038	0.573HisGln: 0.573 ± 0.031	0.772HisArg: 0.772 ± 0.037	0.844HisSer: 0.844 ± 0.036	0.91HisThr: 0.91 ± 0.036	1.074HisVal: 1.074 ± 0.039	0.181HisTrp: 0.181 ± 0.017	0.684HisTyr: 0.684 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.52IleAla: 6.52 ± 0.108	1.078IleCys: 1.078 ± 0.034	4.204IleAsp: 4.204 ± 0.072	4.293IleGlu: 4.293 ± 0.085	2.809IlePhe: 2.809 ± 0.078	5.508IleGly: 5.508 ± 0.104	1.011IleHis: 1.011 ± 0.041	5.169IleIle: 5.169 ± 0.111	4.365IleLys: 4.365 ± 0.082	6.521IleLeu: 6.521 ± 0.121	1.848IleMet: 1.848 ± 0.052	3.187IleAsn: 3.187 ± 0.09	2.856IlePro: 2.856 ± 0.079	1.588IleGln: 1.588 ± 0.049	2.822IleArg: 2.822 ± 0.074	4.227IleSer: 4.227 ± 0.089	4.162IleThr: 4.162 ± 0.08	5.413IleVal: 5.413 ± 0.096	0.574IleTrp: 0.574 ± 0.033	2.24IleTyr: 2.24 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	5.365LysAla: 5.365 ± 0.106	0.643LysCys: 0.643 ± 0.034	3.122LysAsp: 3.122 ± 0.071	4.538LysGlu: 4.538 ± 0.095	2.131LysPhe: 2.131 ± 0.059	3.682LysGly: 3.682 ± 0.066	1.035LysHis: 1.035 ± 0.041	4.964LysIle: 4.964 ± 0.086	4.542LysLys: 4.542 ± 0.085	5.98LysLeu: 5.98 ± 0.105	2.444LysMet: 2.444 ± 0.061	3.497LysAsn: 3.497 ± 0.072	2.07LysPro: 2.07 ± 0.056	2.404LysGln: 2.404 ± 0.069	2.708LysArg: 2.708 ± 0.069	2.822LysSer: 2.822 ± 0.069	3.553LysThr: 3.553 ± 0.075	4.61LysVal: 4.61 ± 0.088	0.528LysTrp: 0.528 ± 0.029	2.354LysTyr: 2.354 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	9.684LeuAla: 9.684 ± 0.145	1.349LeuCys: 1.349 ± 0.053	5.123LeuAsp: 5.123 ± 0.082	6.562LeuGlu: 6.562 ± 0.127	3.677LeuPhe: 3.677 ± 0.093	7.33LeuGly: 7.33 ± 0.115	1.85LeuHis: 1.85 ± 0.057	5.642LeuIle: 5.642 ± 0.118	5.722LeuLys: 5.722 ± 0.094	11.079LeuLeu: 11.079 ± 0.183	2.575LeuMet: 2.575 ± 0.063	3.88LeuAsn: 3.88 ± 0.088	4.628LeuPro: 4.628 ± 0.096	4.309LeuGln: 4.309 ± 0.091	4.694LeuArg: 4.694 ± 0.078	5.774LeuSer: 5.774 ± 0.103	5.659LeuThr: 5.659 ± 0.097	6.495LeuVal: 6.495 ± 0.106	0.864LeuTrp: 0.864 ± 0.039	3.0LeuTyr: 3.0 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	2.632MetAla: 2.632 ± 0.066	0.282MetCys: 0.282 ± 0.022	1.514MetAsp: 1.514 ± 0.045	2.011MetGlu: 2.011 ± 0.059	1.051MetPhe: 1.051 ± 0.045	2.037MetGly: 2.037 ± 0.062	0.445MetHis: 0.445 ± 0.027	1.781MetIle: 1.781 ± 0.051	1.861MetLys: 1.861 ± 0.049	3.118MetLeu: 3.118 ± 0.079	0.871MetMet: 0.871 ± 0.044	1.274MetAsn: 1.274 ± 0.047	1.25MetPro: 1.25 ± 0.043	1.329MetGln: 1.329 ± 0.039	1.476MetArg: 1.476 ± 0.046	1.746MetSer: 1.746 ± 0.052	1.732MetThr: 1.732 ± 0.046	1.864MetVal: 1.864 ± 0.053	0.207MetTrp: 0.207 ± 0.016	0.815MetTyr: 0.815 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.35AsnAla: 3.35 ± 0.084	0.602AsnCys: 0.602 ± 0.031	2.27AsnAsp: 2.27 ± 0.063	2.325AsnGlu: 2.325 ± 0.066	1.789AsnPhe: 1.789 ± 0.054	3.435AsnGly: 3.435 ± 0.108	0.586AsnHis: 0.586 ± 0.03	3.747AsnIle: 3.747 ± 0.078	3.007AsnLys: 3.007 ± 0.072	3.849AsnLeu: 3.849 ± 0.083	1.218AsnMet: 1.218 ± 0.044	2.169AsnAsn: 2.169 ± 0.081	1.799AsnPro: 1.799 ± 0.05	1.06AsnGln: 1.06 ± 0.044	1.553AsnArg: 1.553 ± 0.046	2.323AsnSer: 2.323 ± 0.07	2.23AsnThr: 2.23 ± 0.072	3.037AsnVal: 3.037 ± 0.068	0.439AsnTrp: 0.439 ± 0.027	1.719AsnTyr: 1.719 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	3.095ProAla: 3.095 ± 0.077	0.426ProCys: 0.426 ± 0.027	2.013ProAsp: 2.013 ± 0.057	3.117ProGlu: 3.117 ± 0.074	1.489ProPhe: 1.489 ± 0.05	2.666ProGly: 2.666 ± 0.069	0.708ProHis: 0.708 ± 0.03	2.015ProIle: 2.015 ± 0.055	1.884ProLys: 1.884 ± 0.048	3.586ProLeu: 3.586 ± 0.081	0.969ProMet: 0.969 ± 0.042	1.3ProAsn: 1.3 ± 0.049	1.044ProPro: 1.044 ± 0.037	1.581ProGln: 1.581 ± 0.054	1.28ProArg: 1.28 ± 0.042	1.653ProSer: 1.653 ± 0.048	1.621ProThr: 1.621 ± 0.046	3.23ProVal: 3.23 ± 0.066	0.393ProTrp: 0.393 ± 0.023	1.313ProTyr: 1.313 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.233GlnAla: 3.233 ± 0.074	0.314GlnCys: 0.314 ± 0.025	1.47GlnAsp: 1.47 ± 0.048	2.558GlnGlu: 2.558 ± 0.07	1.058GlnPhe: 1.058 ± 0.039	2.325GlnGly: 2.325 ± 0.074	0.665GlnHis: 0.665 ± 0.03	2.349GlnIle: 2.349 ± 0.062	2.542GlnLys: 2.542 ± 0.069	3.466GlnLeu: 3.466 ± 0.078	1.104GlnMet: 1.104 ± 0.039	1.532GlnAsn: 1.532 ± 0.045	1.155GlnPro: 1.155 ± 0.045	1.997GlnGln: 1.997 ± 0.072	1.759GlnArg: 1.759 ± 0.06	1.658GlnSer: 1.658 ± 0.058	1.814GlnThr: 1.814 ± 0.05	2.226GlnVal: 2.226 ± 0.06	0.276GlnTrp: 0.276 ± 0.019	1.163GlnTyr: 1.163 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	3.014ArgAla: 3.014 ± 0.069	0.55ArgCys: 0.55 ± 0.027	2.08ArgAsp: 2.08 ± 0.053	3.135ArgGlu: 3.135 ± 0.074	1.874ArgPhe: 1.874 ± 0.05	2.729ArgGly: 2.729 ± 0.066	0.845ArgHis: 0.845 ± 0.035	3.255ArgIle: 3.255 ± 0.068	2.725ArgLys: 2.725 ± 0.068	4.712ArgLeu: 4.712 ± 0.095	1.294ArgMet: 1.294 ± 0.05	1.951ArgAsn: 1.951 ± 0.058	1.55ArgPro: 1.55 ± 0.055	2.025ArgGln: 2.025 ± 0.055	2.45ArgArg: 2.45 ± 0.076	2.522ArgSer: 2.522 ± 0.063	2.133ArgThr: 2.133 ± 0.066	2.871ArgVal: 2.871 ± 0.072	0.436ArgTrp: 0.436 ± 0.025	1.811ArgTyr: 1.811 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	4.522SerAla: 4.522 ± 0.095	0.834SerCys: 0.834 ± 0.037	2.941SerAsp: 2.941 ± 0.07	3.43SerGlu: 3.43 ± 0.073	2.326SerPhe: 2.326 ± 0.06	5.315SerGly: 5.315 ± 0.114	0.924SerHis: 0.924 ± 0.033	3.641SerIle: 3.641 ± 0.073	3.223SerLys: 3.223 ± 0.075	5.27SerLeu: 5.27 ± 0.088	1.562SerMet: 1.562 ± 0.05	2.25SerAsn: 2.25 ± 0.075	1.585SerPro: 1.585 ± 0.049	1.53SerGln: 1.53 ± 0.047	2.345SerArg: 2.345 ± 0.06	3.265SerSer: 3.265 ± 0.087	2.57SerThr: 2.57 ± 0.075	4.12SerVal: 4.12 ± 0.08	0.582SerTrp: 0.582 ± 0.025	1.929SerTyr: 1.929 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	5.567ThrAla: 5.567 ± 0.089	0.595ThrCys: 0.595 ± 0.027	2.878ThrAsp: 2.878 ± 0.069	3.314ThrGlu: 3.314 ± 0.074	2.041ThrPhe: 2.041 ± 0.059	4.709ThrGly: 4.709 ± 0.097	0.962ThrHis: 0.962 ± 0.036	3.654ThrIle: 3.654 ± 0.079	2.709ThrLys: 2.709 ± 0.075	5.169ThrLeu: 5.169 ± 0.095	1.435ThrMet: 1.435 ± 0.048	1.985ThrAsn: 1.985 ± 0.066	2.24ThrPro: 2.24 ± 0.057	1.402ThrGln: 1.402 ± 0.05	1.846ThrArg: 1.846 ± 0.042	2.647ThrSer: 2.647 ± 0.059	2.678ThrThr: 2.678 ± 0.071	4.7ThrVal: 4.7 ± 0.081	0.453ThrTrp: 0.453 ± 0.024	1.676ThrTyr: 1.676 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	6.51ValAla: 6.51 ± 0.114	1.134ValCys: 1.134 ± 0.038	3.764ValAsp: 3.764 ± 0.079	4.523ValGlu: 4.523 ± 0.081	3.065ValPhe: 3.065 ± 0.075	5.157ValGly: 5.157 ± 0.099	1.18ValHis: 1.18 ± 0.046	5.349ValIle: 5.349 ± 0.1	4.487ValLys: 4.487 ± 0.097	7.494ValLeu: 7.494 ± 0.116	2.053ValMet: 2.053 ± 0.06	3.014ValAsn: 3.014 ± 0.072	2.906ValPro: 2.906 ± 0.067	2.231ValGln: 2.231 ± 0.056	3.18ValArg: 3.18 ± 0.071	4.216ValSer: 4.216 ± 0.08	4.392ValThr: 4.392 ± 0.076	5.555ValVal: 5.555 ± 0.102	0.638ValTrp: 0.638 ± 0.032	2.57ValTyr: 2.57 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.609TrpAla: 0.609 ± 0.028	0.125TrpCys: 0.125 ± 0.013	0.466TrpAsp: 0.466 ± 0.027	0.569TrpGlu: 0.569 ± 0.03	0.464TrpPhe: 0.464 ± 0.029	0.632TrpGly: 0.632 ± 0.035	0.226TrpHis: 0.226 ± 0.019	0.475TrpIle: 0.475 ± 0.028	0.462TrpLys: 0.462 ± 0.027	1.182TrpLeu: 1.182 ± 0.044	0.286TrpMet: 0.286 ± 0.021	0.415TrpAsn: 0.415 ± 0.029	0.327TrpPro: 0.327 ± 0.024	0.655TrpGln: 0.655 ± 0.032	0.5TrpArg: 0.5 ± 0.026	0.512TrpSer: 0.512 ± 0.029	0.415TrpThr: 0.415 ± 0.021	0.505TrpVal: 0.505 ± 0.025	0.118TrpTrp: 0.118 ± 0.013	0.353TrpTyr: 0.353 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.869TyrAla: 2.869 ± 0.067	0.569TyrCys: 0.569 ± 0.028	2.152TyrAsp: 2.152 ± 0.061	2.097TyrGlu: 2.097 ± 0.052	1.641TyrPhe: 1.641 ± 0.055	2.911TyrGly: 2.911 ± 0.077	0.639TyrHis: 0.639 ± 0.032	2.168TyrIle: 2.168 ± 0.06	2.01TyrLys: 2.01 ± 0.057	3.556TyrLeu: 3.556 ± 0.07	0.9TyrMet: 0.9 ± 0.036	1.605TyrAsn: 1.605 ± 0.06	1.281TyrPro: 1.281 ± 0.045	1.235TyrGln: 1.235 ± 0.038	1.654TyrArg: 1.654 ± 0.05	2.069TyrSer: 2.069 ± 0.067	1.877TyrThr: 1.877 ± 0.05	2.237TyrVal: 2.237 ± 0.05	0.402TyrTrp: 0.402 ± 0.026	1.483TyrTyr: 1.483 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2228 proteins (694653 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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