Amino acid dipepetide frequency for Roseovarius sp. A46

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.778AlaAla: 17.778 ± 0.192	1.26AlaCys: 1.26 ± 0.036	7.058AlaAsp: 7.058 ± 0.086	8.593AlaGlu: 8.593 ± 0.125	4.036AlaPhe: 4.036 ± 0.069	11.473AlaGly: 11.473 ± 0.125	2.677AlaHis: 2.677 ± 0.053	5.693AlaIle: 5.693 ± 0.076	2.995AlaLys: 2.995 ± 0.066	14.597AlaLeu: 14.597 ± 0.175	3.827AlaMet: 3.827 ± 0.067	2.46AlaAsn: 2.46 ± 0.052	6.454AlaPro: 6.454 ± 0.107	4.512AlaGln: 4.512 ± 0.072	11.457AlaArg: 11.457 ± 0.147	4.866AlaSer: 4.866 ± 0.069	6.263AlaThr: 6.263 ± 0.083	8.737AlaVal: 8.737 ± 0.105	1.519AlaTrp: 1.519 ± 0.04	2.488AlaTyr: 2.488 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.232CysAla: 1.232 ± 0.038	0.121CysCys: 0.121 ± 0.012	0.71CysAsp: 0.71 ± 0.028	0.478CysGlu: 0.478 ± 0.02	0.322CysPhe: 0.322 ± 0.016	1.011CysGly: 1.011 ± 0.032	0.331CysHis: 0.331 ± 0.02	0.402CysIle: 0.402 ± 0.022	0.198CysLys: 0.198 ± 0.015	0.918CysLeu: 0.918 ± 0.03	0.159CysMet: 0.159 ± 0.012	0.219CysAsn: 0.219 ± 0.015	0.553CysPro: 0.553 ± 0.024	0.216CysGln: 0.216 ± 0.014	0.631CysArg: 0.631 ± 0.028	0.405CysSer: 0.405 ± 0.023	0.461CysThr: 0.461 ± 0.024	0.66CysVal: 0.66 ± 0.026	0.119CysTrp: 0.119 ± 0.012	0.214CysTyr: 0.214 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.671AspAla: 7.671 ± 0.11	0.543AspCys: 0.543 ± 0.023	3.419AspAsp: 3.419 ± 0.085	3.707AspGlu: 3.707 ± 0.066	2.207AspPhe: 2.207 ± 0.043	5.59AspGly: 5.59 ± 0.073	1.418AspHis: 1.418 ± 0.04	3.183AspIle: 3.183 ± 0.051	1.477AspLys: 1.477 ± 0.037	6.48AspLeu: 6.48 ± 0.092	1.757AspMet: 1.757 ± 0.044	1.179AspAsn: 1.179 ± 0.036	3.713AspPro: 3.713 ± 0.062	1.541AspGln: 1.541 ± 0.035	4.693AspArg: 4.693 ± 0.069	2.062AspSer: 2.062 ± 0.044	3.173AspThr: 3.173 ± 0.058	4.135AspVal: 4.135 ± 0.07	1.194AspTrp: 1.194 ± 0.037	1.47AspTyr: 1.47 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.836GluAla: 8.836 ± 0.116	0.422GluCys: 0.422 ± 0.021	3.268GluAsp: 3.268 ± 0.058	3.808GluGlu: 3.808 ± 0.075	1.8GluPhe: 1.8 ± 0.042	5.393GluGly: 5.393 ± 0.08	1.176GluHis: 1.176 ± 0.034	3.855GluIle: 3.855 ± 0.059	1.929GluLys: 1.929 ± 0.057	4.432GluLeu: 4.432 ± 0.074	2.067GluMet: 2.067 ± 0.052	1.61GluAsn: 1.61 ± 0.044	2.63GluPro: 2.63 ± 0.051	1.679GluGln: 1.679 ± 0.048	4.826GluArg: 4.826 ± 0.08	2.279GluSer: 2.279 ± 0.043	4.174GluThr: 4.174 ± 0.071	4.69GluVal: 4.69 ± 0.074	0.733GluTrp: 0.733 ± 0.026	1.053GluTyr: 1.053 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.413PheAla: 4.413 ± 0.071	0.439PheCys: 0.439 ± 0.02	2.808PheAsp: 2.808 ± 0.053	2.113PheGlu: 2.113 ± 0.046	1.387PhePhe: 1.387 ± 0.036	3.589PheGly: 3.589 ± 0.059	0.781PheHis: 0.781 ± 0.031	1.559PheIle: 1.559 ± 0.04	0.752PheLys: 0.752 ± 0.029	3.262PheLeu: 3.262 ± 0.071	0.807PheMet: 0.807 ± 0.026	0.961PheAsn: 0.961 ± 0.036	1.464PhePro: 1.464 ± 0.037	0.908PheGln: 0.908 ± 0.028	2.168PheArg: 2.168 ± 0.05	1.931PheSer: 1.931 ± 0.047	1.991PheThr: 1.991 ± 0.043	2.614PheVal: 2.614 ± 0.052	0.551PheTrp: 0.551 ± 0.025	0.881PheTyr: 0.881 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.981GlyAla: 10.981 ± 0.119	0.939GlyCys: 0.939 ± 0.033	5.075GlyAsp: 5.075 ± 0.08	5.079GlyGlu: 5.079 ± 0.071	3.61GlyPhe: 3.61 ± 0.062	8.089GlyGly: 8.089 ± 0.106	2.289GlyHis: 2.289 ± 0.048	4.41GlyIle: 4.41 ± 0.069	2.743GlyLys: 2.743 ± 0.061	9.559GlyLeu: 9.559 ± 0.104	2.89GlyMet: 2.89 ± 0.055	2.03GlyAsn: 2.03 ± 0.058	3.93GlyPro: 3.93 ± 0.061	3.004GlyGln: 3.004 ± 0.059	6.766GlyArg: 6.766 ± 0.088	3.868GlySer: 3.868 ± 0.068	4.833GlyThr: 4.833 ± 0.071	6.602GlyVal: 6.602 ± 0.089	1.617GlyTrp: 1.617 ± 0.044	2.438GlyTyr: 2.438 ± 0.048	0.001GlyXaa: 0.001 ± 0.001
His	2.772HisAla: 2.772 ± 0.063	0.255HisCys: 0.255 ± 0.016	1.43HisAsp: 1.43 ± 0.043	1.244HisGlu: 1.244 ± 0.035	0.833HisPhe: 0.833 ± 0.028	2.134HisGly: 2.134 ± 0.048	0.624HisHis: 0.624 ± 0.027	0.926HisIle: 0.926 ± 0.032	0.504HisLys: 0.504 ± 0.021	2.311HisLeu: 2.311 ± 0.046	0.56HisMet: 0.56 ± 0.021	0.453HisAsn: 0.453 ± 0.021	1.472HisPro: 1.472 ± 0.042	0.514HisGln: 0.514 ± 0.021	1.516HisArg: 1.516 ± 0.037	0.88HisSer: 0.88 ± 0.029	0.824HisThr: 0.824 ± 0.032	1.761HisVal: 1.761 ± 0.043	0.373HisTrp: 0.373 ± 0.021	0.582HisTyr: 0.582 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.861IleAla: 6.861 ± 0.091	0.595IleCys: 0.595 ± 0.024	3.347IleAsp: 3.347 ± 0.062	3.563IleGlu: 3.563 ± 0.063	1.672IlePhe: 1.672 ± 0.054	4.717IleGly: 4.717 ± 0.068	0.932IleHis: 0.932 ± 0.035	2.008IleIle: 2.008 ± 0.05	1.212IleLys: 1.212 ± 0.04	4.593IleLeu: 4.593 ± 0.069	1.077IleMet: 1.077 ± 0.035	1.241IleAsn: 1.241 ± 0.037	2.248IlePro: 2.248 ± 0.054	0.948IleGln: 0.948 ± 0.033	3.239IleArg: 3.239 ± 0.067	2.55IleSer: 2.55 ± 0.056	2.839IleThr: 2.839 ± 0.059	3.704IleVal: 3.704 ± 0.061	0.629IleTrp: 0.629 ± 0.029	1.103IleTyr: 1.103 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.14LysAla: 3.14 ± 0.072	0.175LysCys: 0.175 ± 0.013	1.361LysAsp: 1.361 ± 0.044	1.33LysGlu: 1.33 ± 0.046	0.825LysPhe: 0.825 ± 0.029	2.396LysGly: 2.396 ± 0.055	0.53LysHis: 0.53 ± 0.025	1.331LysIle: 1.331 ± 0.046	0.965LysLys: 0.965 ± 0.029	2.383LysLeu: 2.383 ± 0.053	0.748LysMet: 0.748 ± 0.026	0.619LysAsn: 0.619 ± 0.027	1.605LysPro: 1.605 ± 0.044	0.723LysGln: 0.723 ± 0.027	2.057LysArg: 2.057 ± 0.049	1.533LysSer: 1.533 ± 0.041	1.697LysThr: 1.697 ± 0.046	1.93LysVal: 1.93 ± 0.05	0.364LysTrp: 0.364 ± 0.021	0.583LysTyr: 0.583 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.761LeuAla: 13.761 ± 0.158	1.029LeuCys: 1.029 ± 0.035	6.57LeuAsp: 6.57 ± 0.088	5.163LeuGlu: 5.163 ± 0.07	3.361LeuPhe: 3.361 ± 0.066	8.783LeuGly: 8.783 ± 0.113	2.024LeuHis: 2.024 ± 0.047	4.759LeuIle: 4.759 ± 0.067	2.671LeuLys: 2.671 ± 0.063	8.662LeuLeu: 8.662 ± 0.135	2.772LeuMet: 2.772 ± 0.049	2.3LeuAsn: 2.3 ± 0.047	5.511LeuPro: 5.511 ± 0.068	2.276LeuGln: 2.276 ± 0.054	8.005LeuArg: 8.005 ± 0.102	6.17LeuSer: 6.17 ± 0.072	5.574LeuThr: 5.574 ± 0.076	7.275LeuVal: 7.275 ± 0.104	1.39LeuTrp: 1.39 ± 0.041	2.046LeuTyr: 2.046 ± 0.044	0.001LeuXaa: 0.001 ± 0.001
Met	3.736MetAla: 3.736 ± 0.062	0.216MetCys: 0.216 ± 0.015	1.36MetAsp: 1.36 ± 0.036	1.421MetGlu: 1.421 ± 0.038	0.79MetPhe: 0.79 ± 0.027	2.356MetGly: 2.356 ± 0.053	0.507MetHis: 0.507 ± 0.025	1.531MetIle: 1.531 ± 0.039	0.896MetLys: 0.896 ± 0.028	2.611MetLeu: 2.611 ± 0.047	0.754MetMet: 0.754 ± 0.029	0.752MetAsn: 0.752 ± 0.029	1.572MetPro: 1.572 ± 0.04	0.952MetGln: 0.952 ± 0.026	2.198MetArg: 2.198 ± 0.046	1.742MetSer: 1.742 ± 0.04	2.106MetThr: 2.106 ± 0.041	1.967MetVal: 1.967 ± 0.044	0.261MetTrp: 0.261 ± 0.017	0.328MetTyr: 0.328 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.954AsnAla: 2.954 ± 0.058	0.248AsnCys: 0.248 ± 0.014	1.257AsnAsp: 1.257 ± 0.036	1.114AsnGlu: 1.114 ± 0.034	0.847AsnPhe: 0.847 ± 0.029	2.029AsnGly: 2.029 ± 0.046	0.479AsnHis: 0.479 ± 0.019	1.251AsnIle: 1.251 ± 0.038	0.56AsnLys: 0.56 ± 0.026	2.338AsnLeu: 2.338 ± 0.052	0.605AsnMet: 0.605 ± 0.027	0.596AsnAsn: 0.596 ± 0.028	1.713AsnPro: 1.713 ± 0.041	0.551AsnGln: 0.551 ± 0.025	1.667AsnArg: 1.667 ± 0.042	0.957AsnSer: 0.957 ± 0.041	1.226AsnThr: 1.226 ± 0.04	1.714AsnVal: 1.714 ± 0.038	0.366AsnTrp: 0.366 ± 0.019	0.606AsnTyr: 0.606 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.858ProAla: 5.858 ± 0.097	0.4ProCys: 0.4 ± 0.021	4.203ProAsp: 4.203 ± 0.08	4.437ProGlu: 4.437 ± 0.077	1.892ProPhe: 1.892 ± 0.042	5.226ProGly: 5.226 ± 0.07	1.158ProHis: 1.158 ± 0.04	1.953ProIle: 1.953 ± 0.044	1.31ProLys: 1.31 ± 0.043	4.806ProLeu: 4.806 ± 0.075	1.281ProMet: 1.281 ± 0.037	1.146ProAsn: 1.146 ± 0.034	2.588ProPro: 2.588 ± 0.065	1.547ProGln: 1.547 ± 0.039	3.423ProArg: 3.423 ± 0.063	2.194ProSer: 2.194 ± 0.043	2.247ProThr: 2.247 ± 0.048	4.521ProVal: 4.521 ± 0.064	0.681ProTrp: 0.681 ± 0.028	1.154ProTyr: 1.154 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.904GlnAla: 3.904 ± 0.072	0.207GlnCys: 0.207 ± 0.014	1.524GlnAsp: 1.524 ± 0.038	1.639GlnGlu: 1.639 ± 0.039	0.996GlnPhe: 0.996 ± 0.033	2.613GlnGly: 2.613 ± 0.053	0.552GlnHis: 0.552 ± 0.023	1.574GlnIle: 1.574 ± 0.04	0.888GlnLys: 0.888 ± 0.026	2.29GlnLeu: 2.29 ± 0.051	1.002GlnMet: 1.002 ± 0.037	0.674GlnAsn: 0.674 ± 0.028	1.436GlnPro: 1.436 ± 0.035	0.912GlnGln: 0.912 ± 0.034	1.983GlnArg: 1.983 ± 0.04	1.496GlnSer: 1.496 ± 0.041	1.551GlnThr: 1.551 ± 0.038	2.313GlnVal: 2.313 ± 0.045	0.375GlnTrp: 0.375 ± 0.019	0.541GlnTyr: 0.541 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	10.114ArgAla: 10.114 ± 0.12	0.523ArgCys: 0.523 ± 0.024	4.893ArgAsp: 4.893 ± 0.074	4.563ArgGlu: 4.563 ± 0.07	2.851ArgPhe: 2.851 ± 0.049	5.651ArgGly: 5.651 ± 0.08	1.907ArgHis: 1.907 ± 0.046	4.11ArgIle: 4.11 ± 0.059	2.136ArgLys: 2.136 ± 0.051	8.581ArgLeu: 8.581 ± 0.113	2.142ArgMet: 2.142 ± 0.04	1.688ArgAsn: 1.688 ± 0.04	3.653ArgPro: 3.653 ± 0.074	2.255ArgGln: 2.255 ± 0.047	6.148ArgArg: 6.148 ± 0.109	3.048ArgSer: 3.048 ± 0.056	3.169ArgThr: 3.169 ± 0.06	5.49ArgVal: 5.49 ± 0.083	1.027ArgTrp: 1.027 ± 0.032	1.677ArgTyr: 1.677 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.258SerAla: 5.258 ± 0.074	0.421SerCys: 0.421 ± 0.02	3.029SerAsp: 3.029 ± 0.056	2.721SerGlu: 2.721 ± 0.051	1.879SerPhe: 1.879 ± 0.048	5.182SerGly: 5.182 ± 0.074	1.043SerHis: 1.043 ± 0.033	2.143SerIle: 2.143 ± 0.047	1.101SerLys: 1.101 ± 0.037	4.61SerLeu: 4.61 ± 0.067	1.193SerMet: 1.193 ± 0.034	1.134SerAsn: 1.134 ± 0.035	2.368SerPro: 2.368 ± 0.043	1.266SerGln: 1.266 ± 0.036	3.106SerArg: 3.106 ± 0.056	2.096SerSer: 2.096 ± 0.057	2.235SerThr: 2.235 ± 0.055	3.598SerVal: 3.598 ± 0.061	0.587SerTrp: 0.587 ± 0.023	1.175SerTyr: 1.175 ± 0.037	0.001SerXaa: 0.001 ± 0.001
Thr	6.201ThrAla: 6.201 ± 0.096	0.509ThrCys: 0.509 ± 0.026	3.136ThrAsp: 3.136 ± 0.062	3.121ThrGlu: 3.121 ± 0.051	1.789ThrPhe: 1.789 ± 0.041	5.826ThrGly: 5.826 ± 0.088	1.177ThrHis: 1.177 ± 0.037	2.477ThrIle: 2.477 ± 0.051	1.195ThrLys: 1.195 ± 0.042	6.055ThrLeu: 6.055 ± 0.088	1.247ThrMet: 1.247 ± 0.038	1.152ThrAsn: 1.152 ± 0.035	3.427ThrPro: 3.427 ± 0.056	1.406ThrGln: 1.406 ± 0.034	3.926ThrArg: 3.926 ± 0.065	2.352ThrSer: 2.352 ± 0.051	2.75ThrThr: 2.75 ± 0.065	4.165ThrVal: 4.165 ± 0.071	0.723ThrTrp: 0.723 ± 0.027	1.187ThrTyr: 1.187 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.413ValAla: 9.413 ± 0.103	0.671ValCys: 0.671 ± 0.024	3.894ValAsp: 3.894 ± 0.06	4.544ValGlu: 4.544 ± 0.071	2.801ValPhe: 2.801 ± 0.05	5.426ValGly: 5.426 ± 0.084	1.428ValHis: 1.428 ± 0.038	4.321ValIle: 4.321 ± 0.071	1.847ValLys: 1.847 ± 0.049	7.709ValLeu: 7.709 ± 0.099	2.295ValMet: 2.295 ± 0.048	1.912ValAsn: 1.912 ± 0.041	3.815ValPro: 3.815 ± 0.063	2.008ValGln: 2.008 ± 0.046	4.827ValArg: 4.827 ± 0.067	3.904ValSer: 3.904 ± 0.067	4.914ValThr: 4.914 ± 0.062	5.688ValVal: 5.688 ± 0.082	1.015ValTrp: 1.015 ± 0.029	1.472ValTyr: 1.472 ± 0.042	0.001ValXaa: 0.001 ± 0.001
Trp	1.402TrpAla: 1.402 ± 0.04	0.151TrpCys: 0.151 ± 0.012	0.721TrpAsp: 0.721 ± 0.027	0.713TrpGlu: 0.713 ± 0.026	0.596TrpPhe: 0.596 ± 0.026	1.097TrpGly: 1.097 ± 0.033	0.357TrpHis: 0.357 ± 0.02	0.685TrpIle: 0.685 ± 0.026	0.396TrpLys: 0.396 ± 0.02	1.7TrpLeu: 1.7 ± 0.04	0.388TrpMet: 0.388 ± 0.019	0.388TrpAsn: 0.388 ± 0.019	0.769TrpPro: 0.769 ± 0.031	0.649TrpGln: 0.649 ± 0.026	1.299TrpArg: 1.299 ± 0.039	0.734TrpSer: 0.734 ± 0.027	0.703TrpThr: 0.703 ± 0.023	0.868TrpVal: 0.868 ± 0.032	0.216TrpTrp: 0.216 ± 0.015	0.266TrpTyr: 0.266 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.047	0.237TyrCys: 0.237 ± 0.015	1.544TyrAsp: 1.544 ± 0.041	1.309TyrGlu: 1.309 ± 0.042	0.887TyrPhe: 0.887 ± 0.032	2.17TyrGly: 2.17 ± 0.049	0.578TyrHis: 0.578 ± 0.026	0.907TyrIle: 0.907 ± 0.03	0.52TyrLys: 0.52 ± 0.022	2.209TyrLeu: 2.209 ± 0.055	0.488TyrMet: 0.488 ± 0.022	0.565TyrAsn: 0.565 ± 0.025	1.103TyrPro: 1.103 ± 0.027	0.602TyrGln: 0.602 ± 0.025	1.688TyrArg: 1.688 ± 0.046	1.076TyrSer: 1.076 ± 0.031	1.089TyrThr: 1.089 ± 0.036	1.473TyrVal: 1.473 ± 0.041	0.356TyrTrp: 0.356 ± 0.017	0.556TyrTyr: 0.556 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3369 proteins (1039432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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