Amino acid dipepetide frequency for Salegentibacter echinorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.757AlaAla: 4.757 ± 0.086	0.524AlaCys: 0.524 ± 0.023	3.131AlaAsp: 3.131 ± 0.063	4.949AlaGlu: 4.949 ± 0.078	3.341AlaPhe: 3.341 ± 0.064	4.553AlaGly: 4.553 ± 0.066	1.156AlaHis: 1.156 ± 0.035	5.15AlaIle: 5.15 ± 0.076	5.043AlaLys: 5.043 ± 0.069	6.365AlaLeu: 6.365 ± 0.084	1.63AlaMet: 1.63 ± 0.039	3.44AlaAsn: 3.44 ± 0.057	1.979AlaPro: 1.979 ± 0.05	2.48AlaGln: 2.48 ± 0.05	2.433AlaArg: 2.433 ± 0.046	4.096AlaSer: 4.096 ± 0.065	3.388AlaThr: 3.388 ± 0.057	4.282AlaVal: 4.282 ± 0.054	0.674AlaTrp: 0.674 ± 0.023	2.611AlaTyr: 2.611 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.412CysAla: 0.412 ± 0.02	0.097CysCys: 0.097 ± 0.009	0.397CysAsp: 0.397 ± 0.019	0.465CysGlu: 0.465 ± 0.023	0.372CysPhe: 0.372 ± 0.017	0.574CysGly: 0.574 ± 0.024	0.146CysHis: 0.146 ± 0.012	0.489CysIle: 0.489 ± 0.022	0.446CysLys: 0.446 ± 0.022	0.587CysLeu: 0.587 ± 0.022	0.109CysMet: 0.109 ± 0.01	0.349CysAsn: 0.349 ± 0.017	0.283CysPro: 0.283 ± 0.018	0.189CysGln: 0.189 ± 0.013	0.227CysArg: 0.227 ± 0.015	0.485CysSer: 0.485 ± 0.021	0.335CysThr: 0.335 ± 0.016	0.38CysVal: 0.38 ± 0.018	0.059CysTrp: 0.059 ± 0.007	0.247CysTyr: 0.247 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.639AspAla: 3.639 ± 0.063	0.365AspCys: 0.365 ± 0.019	2.827AspAsp: 2.827 ± 0.062	4.089AspGlu: 4.089 ± 0.065	3.78AspPhe: 3.78 ± 0.061	3.464AspGly: 3.464 ± 0.074	0.992AspHis: 0.992 ± 0.036	4.129AspIle: 4.129 ± 0.063	4.311AspLys: 4.311 ± 0.06	5.293AspLeu: 5.293 ± 0.065	1.13AspMet: 1.13 ± 0.034	2.804AspAsn: 2.804 ± 0.059	1.792AspPro: 1.792 ± 0.043	1.479AspGln: 1.479 ± 0.037	2.096AspArg: 2.096 ± 0.045	3.112AspSer: 3.112 ± 0.057	2.48AspThr: 2.48 ± 0.05	3.204AspVal: 3.204 ± 0.053	0.747AspTrp: 0.747 ± 0.025	2.854AspTyr: 2.854 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.04GluAla: 5.04 ± 0.074	0.311GluCys: 0.311 ± 0.02	4.394GluAsp: 4.394 ± 0.073	6.644GluGlu: 6.644 ± 0.097	3.273GluPhe: 3.273 ± 0.059	4.059GluGly: 4.059 ± 0.064	1.249GluHis: 1.249 ± 0.039	6.416GluIle: 6.416 ± 0.075	7.057GluLys: 7.057 ± 0.119	6.693GluLeu: 6.693 ± 0.095	1.874GluMet: 1.874 ± 0.038	5.385GluAsn: 5.385 ± 0.078	1.79GluPro: 1.79 ± 0.04	2.426GluGln: 2.426 ± 0.046	2.88GluArg: 2.88 ± 0.059	3.328GluSer: 3.328 ± 0.057	3.776GluThr: 3.776 ± 0.064	4.788GluVal: 4.788 ± 0.064	0.658GluTrp: 0.658 ± 0.024	2.548GluTyr: 2.548 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.074PheAla: 3.074 ± 0.061	0.413PheCys: 0.413 ± 0.021	3.069PheAsp: 3.069 ± 0.057	3.563PheGlu: 3.563 ± 0.068	2.798PhePhe: 2.798 ± 0.056	3.524PheGly: 3.524 ± 0.061	0.855PheHis: 0.855 ± 0.027	3.958PheIle: 3.958 ± 0.074	4.045PheLys: 4.045 ± 0.071	5.035PheLeu: 5.035 ± 0.076	1.161PheMet: 1.161 ± 0.031	3.104PheAsn: 3.104 ± 0.073	1.827PhePro: 1.827 ± 0.044	1.761PheGln: 1.761 ± 0.044	1.821PheArg: 1.821 ± 0.042	4.016PheSer: 4.016 ± 0.065	2.823PheThr: 2.823 ± 0.053	2.757PheVal: 2.757 ± 0.051	0.61PheTrp: 0.61 ± 0.026	2.155PheTyr: 2.155 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.206GlyAla: 4.206 ± 0.073	0.501GlyCys: 0.501 ± 0.022	3.471GlyAsp: 3.471 ± 0.062	4.287GlyGlu: 4.287 ± 0.069	3.642GlyPhe: 3.642 ± 0.06	4.568GlyGly: 4.568 ± 0.084	1.125GlyHis: 1.125 ± 0.036	5.245GlyIle: 5.245 ± 0.07	5.346GlyLys: 5.346 ± 0.086	5.816GlyLeu: 5.816 ± 0.08	1.659GlyMet: 1.659 ± 0.041	3.574GlyAsn: 3.574 ± 0.066	1.358GlyPro: 1.358 ± 0.036	1.801GlyGln: 1.801 ± 0.041	2.284GlyArg: 2.284 ± 0.053	3.968GlySer: 3.968 ± 0.075	3.53GlyThr: 3.53 ± 0.067	4.276GlyVal: 4.276 ± 0.075	0.778GlyTrp: 0.778 ± 0.028	2.71GlyTyr: 2.71 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.914HisAla: 0.914 ± 0.028	0.175HisCys: 0.175 ± 0.014	0.773HisAsp: 0.773 ± 0.03	1.025HisGlu: 1.025 ± 0.033	1.141HisPhe: 1.141 ± 0.034	1.071HisGly: 1.071 ± 0.033	0.463HisHis: 0.463 ± 0.023	1.371HisIle: 1.371 ± 0.038	1.298HisLys: 1.298 ± 0.038	1.887HisLeu: 1.887 ± 0.046	0.257HisMet: 0.257 ± 0.016	0.931HisAsn: 0.931 ± 0.031	0.945HisPro: 0.945 ± 0.034	0.757HisGln: 0.757 ± 0.027	0.764HisArg: 0.764 ± 0.026	1.076HisSer: 1.076 ± 0.032	0.882HisThr: 0.882 ± 0.027	0.865HisVal: 0.865 ± 0.028	0.235HisTrp: 0.235 ± 0.013	0.827HisTyr: 0.827 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.552IleAla: 5.552 ± 0.069	0.559IleCys: 0.559 ± 0.022	4.524IleAsp: 4.524 ± 0.061	5.402IleGlu: 5.402 ± 0.082	3.77IlePhe: 3.77 ± 0.072	4.857IleGly: 4.857 ± 0.086	1.235IleHis: 1.235 ± 0.032	5.584IleIle: 5.584 ± 0.087	5.886IleLys: 5.886 ± 0.083	7.161IleLeu: 7.161 ± 0.093	1.369IleMet: 1.369 ± 0.037	4.332IleAsn: 4.332 ± 0.068	3.243IlePro: 3.243 ± 0.059	2.338IleGln: 2.338 ± 0.045	2.653IleArg: 2.653 ± 0.049	5.621IleSer: 5.621 ± 0.071	4.201IleThr: 4.201 ± 0.064	4.059IleVal: 4.059 ± 0.068	0.711IleTrp: 0.711 ± 0.029	2.731IleTyr: 2.731 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.384LysAla: 5.384 ± 0.077	0.292LysCys: 0.292 ± 0.016	5.053LysAsp: 5.053 ± 0.079	7.167LysGlu: 7.167 ± 0.108	3.059LysPhe: 3.059 ± 0.06	4.377LysGly: 4.377 ± 0.066	1.432LysHis: 1.432 ± 0.041	6.44LysIle: 6.44 ± 0.082	7.602LysLys: 7.602 ± 0.104	7.252LysLeu: 7.252 ± 0.094	2.123LysMet: 2.123 ± 0.045	5.437LysAsn: 5.437 ± 0.078	2.708LysPro: 2.708 ± 0.05	2.742LysGln: 2.742 ± 0.052	3.221LysArg: 3.221 ± 0.059	4.623LysSer: 4.623 ± 0.07	4.692LysThr: 4.692 ± 0.07	4.693LysVal: 4.693 ± 0.071	0.775LysTrp: 0.775 ± 0.026	3.003LysTyr: 3.003 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.206LeuAla: 6.206 ± 0.085	0.692LeuCys: 0.692 ± 0.027	5.19LeuAsp: 5.19 ± 0.067	7.145LeuGlu: 7.145 ± 0.084	4.803LeuPhe: 4.803 ± 0.074	5.999LeuGly: 5.999 ± 0.082	1.502LeuHis: 1.502 ± 0.041	6.936LeuIle: 6.936 ± 0.081	8.471LeuLys: 8.471 ± 0.102	8.819LeuLeu: 8.819 ± 0.111	2.067LeuMet: 2.067 ± 0.044	5.59LeuAsn: 5.59 ± 0.088	3.68LeuPro: 3.68 ± 0.051	3.57LeuGln: 3.57 ± 0.064	3.596LeuArg: 3.596 ± 0.061	6.674LeuSer: 6.674 ± 0.082	4.453LeuThr: 4.453 ± 0.067	5.312LeuVal: 5.312 ± 0.077	0.824LeuTrp: 0.824 ± 0.027	3.128LeuTyr: 3.128 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.716MetAla: 1.716 ± 0.039	0.116MetCys: 0.116 ± 0.01	1.238MetAsp: 1.238 ± 0.037	1.638MetGlu: 1.638 ± 0.04	0.839MetPhe: 0.839 ± 0.03	1.508MetGly: 1.508 ± 0.043	0.401MetHis: 0.401 ± 0.018	1.436MetIle: 1.436 ± 0.042	2.129MetLys: 2.129 ± 0.041	2.102MetLeu: 2.102 ± 0.041	0.593MetMet: 0.593 ± 0.024	1.261MetAsn: 1.261 ± 0.03	0.847MetPro: 0.847 ± 0.024	0.956MetGln: 0.956 ± 0.028	0.945MetArg: 0.945 ± 0.028	1.277MetSer: 1.277 ± 0.035	0.993MetThr: 0.993 ± 0.031	1.377MetVal: 1.377 ± 0.034	0.171MetTrp: 0.171 ± 0.012	0.654MetTyr: 0.654 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.728AsnAla: 3.728 ± 0.067	0.388AsnCys: 0.388 ± 0.022	2.859AsnAsp: 2.859 ± 0.059	3.865AsnGlu: 3.865 ± 0.063	3.423AsnPhe: 3.423 ± 0.064	3.552AsnGly: 3.552 ± 0.065	1.016AsnHis: 1.016 ± 0.032	4.571AsnIle: 4.571 ± 0.062	4.467AsnLys: 4.467 ± 0.068	5.772AsnLeu: 5.772 ± 0.074	1.212AsnMet: 1.212 ± 0.032	3.46AsnAsn: 3.46 ± 0.069	2.742AsnPro: 2.742 ± 0.047	1.985AsnGln: 1.985 ± 0.043	2.433AsnArg: 2.433 ± 0.051	3.632AsnSer: 3.632 ± 0.063	3.265AsnThr: 3.265 ± 0.06	3.046AsnVal: 3.046 ± 0.055	0.772AsnTrp: 0.772 ± 0.027	2.761AsnTyr: 2.761 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	2.149ProAla: 2.149 ± 0.045	0.197ProCys: 0.197 ± 0.012	1.964ProAsp: 1.964 ± 0.039	3.281ProGlu: 3.281 ± 0.057	1.782ProPhe: 1.782 ± 0.041	2.362ProGly: 2.362 ± 0.048	0.645ProHis: 0.645 ± 0.024	2.432ProIle: 2.432 ± 0.049	2.765ProLys: 2.765 ± 0.054	2.987ProLeu: 2.987 ± 0.055	0.711ProMet: 0.711 ± 0.028	2.089ProAsn: 2.089 ± 0.044	0.871ProPro: 0.871 ± 0.032	1.382ProGln: 1.382 ± 0.038	1.092ProArg: 1.092 ± 0.03	1.975ProSer: 1.975 ± 0.047	1.719ProThr: 1.719 ± 0.036	2.491ProVal: 2.491 ± 0.048	0.364ProTrp: 0.364 ± 0.017	1.377ProTyr: 1.377 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.093GlnAla: 2.093 ± 0.042	0.129GlnCys: 0.129 ± 0.012	1.813GlnAsp: 1.813 ± 0.044	2.789GlnGlu: 2.789 ± 0.047	1.62GlnPhe: 1.62 ± 0.036	1.838GlnGly: 1.838 ± 0.038	0.664GlnHis: 0.664 ± 0.025	2.492GlnIle: 2.492 ± 0.047	2.994GlnLys: 2.994 ± 0.052	3.572GlnLeu: 3.572 ± 0.061	0.812GlnMet: 0.812 ± 0.025	2.172GlnAsn: 2.172 ± 0.05	1.121GlnPro: 1.121 ± 0.033	1.629GlnGln: 1.629 ± 0.044	1.417GlnArg: 1.417 ± 0.03	1.727GlnSer: 1.727 ± 0.04	1.689GlnThr: 1.689 ± 0.037	2.08GlnVal: 2.08 ± 0.052	0.342GlnTrp: 0.342 ± 0.018	1.23GlnTyr: 1.23 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.271ArgAla: 2.271 ± 0.049	0.195ArgCys: 0.195 ± 0.012	2.069ArgAsp: 2.069 ± 0.04	3.038ArgGlu: 3.038 ± 0.057	2.089ArgPhe: 2.089 ± 0.039	2.184ArgGly: 2.184 ± 0.051	0.696ArgHis: 0.696 ± 0.027	3.068ArgIle: 3.068 ± 0.051	3.502ArgLys: 3.502 ± 0.058	3.562ArgLeu: 3.562 ± 0.061	0.924ArgMet: 0.924 ± 0.028	2.389ArgAsn: 2.389 ± 0.045	1.152ArgPro: 1.152 ± 0.034	1.246ArgGln: 1.246 ± 0.038	1.578ArgArg: 1.578 ± 0.043	2.147ArgSer: 2.147 ± 0.051	1.76ArgThr: 1.76 ± 0.041	2.153ArgVal: 2.153 ± 0.044	0.458ArgTrp: 0.458 ± 0.025	1.638ArgTyr: 1.638 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.837SerAla: 3.837 ± 0.06	0.585SerCys: 0.585 ± 0.025	2.96SerAsp: 2.96 ± 0.054	4.429SerGlu: 4.429 ± 0.055	3.751SerPhe: 3.751 ± 0.056	4.54SerGly: 4.54 ± 0.069	1.076SerHis: 1.076 ± 0.035	4.561SerIle: 4.561 ± 0.07	4.73SerLys: 4.73 ± 0.073	6.428SerLeu: 6.428 ± 0.087	1.225SerMet: 1.225 ± 0.033	3.459SerAsn: 3.459 ± 0.058	2.048SerPro: 2.048 ± 0.039	2.079SerGln: 2.079 ± 0.047	2.471SerArg: 2.471 ± 0.055	3.972SerSer: 3.972 ± 0.073	2.98SerThr: 2.98 ± 0.053	3.758SerVal: 3.758 ± 0.057	0.731SerTrp: 0.731 ± 0.027	2.671SerTyr: 2.671 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.779ThrAla: 3.779 ± 0.064	0.299ThrCys: 0.299 ± 0.017	2.767ThrAsp: 2.767 ± 0.049	3.479ThrGlu: 3.479 ± 0.058	2.527ThrPhe: 2.527 ± 0.047	4.187ThrGly: 4.187 ± 0.063	0.968ThrHis: 0.968 ± 0.032	3.776ThrIle: 3.776 ± 0.064	3.551ThrLys: 3.551 ± 0.052	4.529ThrLeu: 4.529 ± 0.073	0.913ThrMet: 0.913 ± 0.029	2.849ThrAsn: 2.849 ± 0.055	2.228ThrPro: 2.228 ± 0.041	1.69ThrGln: 1.69 ± 0.034	2.011ThrArg: 2.011 ± 0.042	3.29ThrSer: 3.29 ± 0.063	2.816ThrThr: 2.816 ± 0.063	3.097ThrVal: 3.097 ± 0.062	0.572ThrTrp: 0.572 ± 0.024	2.178ThrTyr: 2.178 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.147ValAla: 4.147 ± 0.058	0.43ValCys: 0.43 ± 0.019	3.251ValAsp: 3.251 ± 0.066	4.09ValGlu: 4.09 ± 0.062	3.239ValPhe: 3.239 ± 0.056	3.673ValGly: 3.673 ± 0.064	1.012ValHis: 1.012 ± 0.031	4.545ValIle: 4.545 ± 0.06	4.456ValLys: 4.456 ± 0.071	5.767ValLeu: 5.767 ± 0.073	1.404ValMet: 1.404 ± 0.043	3.289ValAsn: 3.289 ± 0.064	2.164ValPro: 2.164 ± 0.045	1.847ValGln: 1.847 ± 0.038	1.99ValArg: 1.99 ± 0.043	4.101ValSer: 4.101 ± 0.066	3.056ValThr: 3.056 ± 0.061	3.865ValVal: 3.865 ± 0.071	0.571ValTrp: 0.571 ± 0.026	2.197ValTyr: 2.197 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.639TrpAla: 0.639 ± 0.026	0.091TrpCys: 0.091 ± 0.009	0.659TrpAsp: 0.659 ± 0.026	0.784TrpGlu: 0.784 ± 0.029	0.593TrpPhe: 0.593 ± 0.028	0.643TrpGly: 0.643 ± 0.028	0.246TrpHis: 0.246 ± 0.016	0.74TrpIle: 0.74 ± 0.025	0.796TrpLys: 0.796 ± 0.03	1.083TrpLeu: 1.083 ± 0.035	0.312TrpMet: 0.312 ± 0.017	0.632TrpAsn: 0.632 ± 0.026	0.299TrpPro: 0.299 ± 0.018	0.452TrpGln: 0.452 ± 0.022	0.458TrpArg: 0.458 ± 0.022	0.607TrpSer: 0.607 ± 0.022	0.495TrpThr: 0.495 ± 0.022	0.591TrpVal: 0.591 ± 0.024	0.173TrpTrp: 0.173 ± 0.012	0.436TrpTyr: 0.436 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.439TyrAla: 2.439 ± 0.053	0.289TyrCys: 0.289 ± 0.016	2.176TyrAsp: 2.176 ± 0.047	2.461TyrGlu: 2.461 ± 0.046	2.529TyrPhe: 2.529 ± 0.05	2.61TyrGly: 2.61 ± 0.057	0.777TyrHis: 0.777 ± 0.026	2.45TyrIle: 2.45 ± 0.046	3.181TyrLys: 3.181 ± 0.059	3.946TyrLeu: 3.946 ± 0.061	0.71TyrMet: 0.71 ± 0.023	2.405TyrAsn: 2.405 ± 0.054	1.557TyrPro: 1.557 ± 0.041	1.411TyrGln: 1.411 ± 0.034	1.753TyrArg: 1.753 ± 0.04	2.565TyrSer: 2.565 ± 0.051	2.175TyrThr: 2.175 ± 0.043	2.021TyrVal: 2.021 ± 0.046	0.503TyrTrp: 0.503 ± 0.022	1.8TyrTyr: 1.8 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3479 proteins (1135832 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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