Amino acid dipepetide frequency for Lewinellaceae bacterium SD302

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.521AlaAla: 7.521 ± 0.09	0.812AlaCys: 0.812 ± 0.031	5.125AlaAsp: 5.125 ± 0.065	5.341AlaGlu: 5.341 ± 0.071	3.399AlaPhe: 3.399 ± 0.055	7.114AlaGly: 7.114 ± 0.087	1.241AlaHis: 1.241 ± 0.031	4.7AlaIle: 4.7 ± 0.06	3.414AlaLys: 3.414 ± 0.064	6.976AlaLeu: 6.976 ± 0.089	1.686AlaMet: 1.686 ± 0.036	3.587AlaAsn: 3.587 ± 0.055	3.034AlaPro: 3.034 ± 0.056	2.764AlaGln: 2.764 ± 0.046	3.823AlaArg: 3.823 ± 0.062	4.424AlaSer: 4.424 ± 0.052	5.189AlaThr: 5.189 ± 0.088	4.786AlaVal: 4.786 ± 0.062	0.835AlaTrp: 0.835 ± 0.026	2.792AlaTyr: 2.792 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.699CysAla: 0.699 ± 0.027	0.147CysCys: 0.147 ± 0.013	0.699CysAsp: 0.699 ± 0.04	0.589CysGlu: 0.589 ± 0.027	0.537CysPhe: 0.537 ± 0.028	0.909CysGly: 0.909 ± 0.039	0.204CysHis: 0.204 ± 0.013	0.481CysIle: 0.481 ± 0.015	0.274CysLys: 0.274 ± 0.013	0.915CysLeu: 0.915 ± 0.025	0.153CysMet: 0.153 ± 0.011	0.496CysAsn: 0.496 ± 0.025	0.571CysPro: 0.571 ± 0.038	0.375CysGln: 0.375 ± 0.017	0.45CysArg: 0.45 ± 0.02	0.739CysSer: 0.739 ± 0.036	0.584CysThr: 0.584 ± 0.033	0.574CysVal: 0.574 ± 0.026	0.126CysTrp: 0.126 ± 0.01	0.333CysTyr: 0.333 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.584AspAla: 4.584 ± 0.092	0.78AspCys: 0.78 ± 0.04	3.834AspAsp: 3.834 ± 0.111	4.272AspGlu: 4.272 ± 0.052	3.613AspPhe: 3.613 ± 0.062	5.703AspGly: 5.703 ± 0.135	1.18AspHis: 1.18 ± 0.031	3.484AspIle: 3.484 ± 0.062	2.311AspLys: 2.311 ± 0.052	6.529AspLeu: 6.529 ± 0.078	1.078AspMet: 1.078 ± 0.028	3.059AspAsn: 3.059 ± 0.068	3.112AspPro: 3.112 ± 0.061	2.392AspGln: 2.392 ± 0.038	3.406AspArg: 3.406 ± 0.055	3.331AspSer: 3.331 ± 0.054	3.147AspThr: 3.147 ± 0.08	3.843AspVal: 3.843 ± 0.068	0.969AspTrp: 0.969 ± 0.027	2.834AspTyr: 2.834 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.299GluAla: 5.299 ± 0.085	0.483GluCys: 0.483 ± 0.023	3.943GluAsp: 3.943 ± 0.068	4.687GluGlu: 4.687 ± 0.078	2.672GluPhe: 2.672 ± 0.043	4.225GluGly: 4.225 ± 0.061	1.018GluHis: 1.018 ± 0.029	4.379GluIle: 4.379 ± 0.062	3.327GluLys: 3.327 ± 0.068	7.437GluLeu: 7.437 ± 0.089	1.631GluMet: 1.631 ± 0.035	3.268GluAsn: 3.268 ± 0.046	2.321GluPro: 2.321 ± 0.042	2.681GluGln: 2.681 ± 0.049	3.669GluArg: 3.669 ± 0.061	3.274GluSer: 3.274 ± 0.048	3.238GluThr: 3.238 ± 0.052	4.731GluVal: 4.731 ± 0.052	0.85GluTrp: 0.85 ± 0.027	2.172GluTyr: 2.172 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.444PheAla: 3.444 ± 0.053	0.485PheCys: 0.485 ± 0.017	3.248PheAsp: 3.248 ± 0.059	2.784PheGlu: 2.784 ± 0.04	2.3PhePhe: 2.3 ± 0.044	3.888PheGly: 3.888 ± 0.057	0.768PheHis: 0.768 ± 0.025	2.604PheIle: 2.604 ± 0.044	1.721PheLys: 1.721 ± 0.042	4.419PheLeu: 4.419 ± 0.065	0.834PheMet: 0.834 ± 0.023	2.457PheAsn: 2.457 ± 0.051	1.914PhePro: 1.914 ± 0.038	1.609PheGln: 1.609 ± 0.032	2.403PheArg: 2.403 ± 0.053	3.652PheSer: 3.652 ± 0.058	3.272PheThr: 3.272 ± 0.06	2.954PheVal: 2.954 ± 0.049	0.579PheTrp: 0.579 ± 0.021	1.798PheTyr: 1.798 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.115GlyAla: 5.115 ± 0.069	1.085GlyCys: 1.085 ± 0.053	4.749GlyAsp: 4.749 ± 0.097	5.039GlyGlu: 5.039 ± 0.063	3.638GlyPhe: 3.638 ± 0.052	6.514GlyGly: 6.514 ± 0.139	1.31GlyHis: 1.31 ± 0.034	4.654GlyIle: 4.654 ± 0.064	3.751GlyLys: 3.751 ± 0.082	7.369GlyLeu: 7.369 ± 0.079	1.825GlyMet: 1.825 ± 0.04	3.97GlyAsn: 3.97 ± 0.084	2.608GlyPro: 2.608 ± 0.051	3.151GlyGln: 3.151 ± 0.052	3.959GlyArg: 3.959 ± 0.065	4.923GlySer: 4.923 ± 0.071	4.619GlyThr: 4.619 ± 0.083	4.869GlyVal: 4.869 ± 0.064	1.005GlyTrp: 1.005 ± 0.029	2.829GlyTyr: 2.829 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.14HisAla: 1.14 ± 0.032	0.227HisCys: 0.227 ± 0.013	0.961HisAsp: 0.961 ± 0.027	0.996HisGlu: 0.996 ± 0.031	1.009HisPhe: 1.009 ± 0.027	1.179HisGly: 1.179 ± 0.033	0.505HisHis: 0.505 ± 0.022	0.829HisIle: 0.829 ± 0.024	0.576HisLys: 0.576 ± 0.019	2.027HisLeu: 2.027 ± 0.043	0.255HisMet: 0.255 ± 0.012	0.666HisAsn: 0.666 ± 0.025	1.173HisPro: 1.173 ± 0.031	0.696HisGln: 0.696 ± 0.023	1.092HisArg: 1.092 ± 0.03	0.909HisSer: 0.909 ± 0.026	0.82HisThr: 0.82 ± 0.024	0.941HisVal: 0.941 ± 0.024	0.281HisTrp: 0.281 ± 0.014	0.887HisTyr: 0.887 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.62IleAla: 4.62 ± 0.066	0.705IleCys: 0.705 ± 0.024	4.408IleAsp: 4.408 ± 0.064	4.076IleGlu: 4.076 ± 0.062	2.725IlePhe: 2.725 ± 0.052	4.607IleGly: 4.607 ± 0.071	1.088IleHis: 1.088 ± 0.029	3.643IleIle: 3.643 ± 0.062	2.505IleLys: 2.505 ± 0.05	5.286IleLeu: 5.286 ± 0.073	1.137IleMet: 1.137 ± 0.03	3.106IleAsn: 3.106 ± 0.048	2.636IlePro: 2.636 ± 0.047	1.944IleGln: 1.944 ± 0.038	3.043IleArg: 3.043 ± 0.047	4.196IleSer: 4.196 ± 0.06	3.911IleThr: 3.911 ± 0.081	3.864IleVal: 3.864 ± 0.054	0.657IleTrp: 0.657 ± 0.019	2.251IleTyr: 2.251 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.424LysAla: 3.424 ± 0.071	0.211LysCys: 0.211 ± 0.013	2.264LysAsp: 2.264 ± 0.051	2.91LysGlu: 2.91 ± 0.057	1.571LysPhe: 1.571 ± 0.036	2.665LysGly: 2.665 ± 0.056	0.725LysHis: 0.725 ± 0.025	2.916LysIle: 2.916 ± 0.059	2.586LysLys: 2.586 ± 0.069	4.417LysLeu: 4.417 ± 0.081	1.252LysMet: 1.252 ± 0.034	1.897LysAsn: 1.897 ± 0.041	1.673LysPro: 1.673 ± 0.039	1.571LysGln: 1.571 ± 0.043	2.359LysArg: 2.359 ± 0.051	2.511LysSer: 2.511 ± 0.051	2.359LysThr: 2.359 ± 0.05	3.029LysVal: 3.029 ± 0.055	0.483LysTrp: 0.483 ± 0.02	1.511LysTyr: 1.511 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	8.523LeuAla: 8.523 ± 0.091	0.844LeuCys: 0.844 ± 0.024	6.185LeuAsp: 6.185 ± 0.069	6.418LeuGlu: 6.418 ± 0.073	4.5LeuPhe: 4.5 ± 0.066	6.723LeuGly: 6.723 ± 0.076	1.678LeuHis: 1.678 ± 0.038	5.842LeuIle: 5.842 ± 0.066	4.385LeuLys: 4.385 ± 0.079	10.832LeuLeu: 10.832 ± 0.139	1.866LeuMet: 1.866 ± 0.039	4.898LeuAsn: 4.898 ± 0.065	5.13LeuPro: 5.13 ± 0.066	3.316LeuGln: 3.316 ± 0.05	5.728LeuArg: 5.728 ± 0.084	6.991LeuSer: 6.991 ± 0.078	6.11LeuThr: 6.11 ± 0.09	6.121LeuVal: 6.121 ± 0.067	0.951LeuTrp: 0.951 ± 0.028	3.217LeuTyr: 3.217 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.776MetAla: 1.776 ± 0.042	0.115MetCys: 0.115 ± 0.009	1.276MetAsp: 1.276 ± 0.031	1.197MetGlu: 1.197 ± 0.03	0.604MetPhe: 0.604 ± 0.02	1.453MetGly: 1.453 ± 0.032	0.378MetHis: 0.378 ± 0.016	1.333MetIle: 1.333 ± 0.027	1.155MetLys: 1.155 ± 0.031	1.987MetLeu: 1.987 ± 0.037	0.507MetMet: 0.507 ± 0.018	0.995MetAsn: 0.995 ± 0.025	1.028MetPro: 1.028 ± 0.027	0.805MetGln: 0.805 ± 0.023	1.125MetArg: 1.125 ± 0.025	1.291MetSer: 1.291 ± 0.03	1.245MetThr: 1.245 ± 0.031	1.342MetVal: 1.342 ± 0.027	0.15MetTrp: 0.15 ± 0.01	0.513MetTyr: 0.513 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.33AsnAla: 3.33 ± 0.052	0.653AsnCys: 0.653 ± 0.043	3.188AsnAsp: 3.188 ± 0.058	2.955AsnGlu: 2.955 ± 0.051	2.457AsnPhe: 2.457 ± 0.042	4.552AsnGly: 4.552 ± 0.086	0.792AsnHis: 0.792 ± 0.022	2.734AsnIle: 2.734 ± 0.049	1.697AsnLys: 1.697 ± 0.036	4.542AsnLeu: 4.542 ± 0.057	0.842AsnMet: 0.842 ± 0.019	2.516AsnAsn: 2.516 ± 0.055	2.688AsnPro: 2.688 ± 0.05	1.834AsnGln: 1.834 ± 0.037	2.441AsnArg: 2.441 ± 0.046	2.858AsnSer: 2.858 ± 0.047	2.652AsnThr: 2.652 ± 0.054	3.02AsnVal: 3.02 ± 0.046	0.82AsnTrp: 0.82 ± 0.026	2.185AsnTyr: 2.185 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.069ProAla: 4.069 ± 0.063	0.329ProCys: 0.329 ± 0.023	3.354ProAsp: 3.354 ± 0.063	3.638ProGlu: 3.638 ± 0.049	2.042ProPhe: 2.042 ± 0.042	3.702ProGly: 3.702 ± 0.064	0.701ProHis: 0.701 ± 0.022	2.404ProIle: 2.404 ± 0.042	1.591ProLys: 1.591 ± 0.036	3.922ProLeu: 3.922 ± 0.051	0.736ProMet: 0.736 ± 0.019	2.275ProAsn: 2.275 ± 0.043	1.907ProPro: 1.907 ± 0.068	1.429ProGln: 1.429 ± 0.031	1.683ProArg: 1.683 ± 0.035	2.382ProSer: 2.382 ± 0.045	2.72ProThr: 2.72 ± 0.05	3.365ProVal: 3.365 ± 0.049	0.468ProTrp: 0.468 ± 0.017	1.482ProTyr: 1.482 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.776GlnAla: 2.776 ± 0.04	0.235GlnCys: 0.235 ± 0.014	1.997GlnAsp: 1.997 ± 0.039	2.307GlnGlu: 2.307 ± 0.04	1.597GlnPhe: 1.597 ± 0.037	2.263GlnGly: 2.263 ± 0.047	0.647GlnHis: 0.647 ± 0.022	2.142GlnIle: 2.142 ± 0.037	1.484GlnLys: 1.484 ± 0.037	4.658GlnLeu: 4.658 ± 0.069	0.836GlnMet: 0.836 ± 0.025	1.593GlnAsn: 1.593 ± 0.032	1.658GlnPro: 1.658 ± 0.032	1.816GlnGln: 1.816 ± 0.043	2.218GlnArg: 2.218 ± 0.044	2.261GlnSer: 2.261 ± 0.041	2.045GlnThr: 2.045 ± 0.037	2.389GlnVal: 2.389 ± 0.043	0.437GlnTrp: 0.437 ± 0.017	1.251GlnTyr: 1.251 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.606ArgAla: 3.606 ± 0.061	0.359ArgCys: 0.359 ± 0.016	2.809ArgAsp: 2.809 ± 0.051	3.455ArgGlu: 3.455 ± 0.064	2.669ArgPhe: 2.669 ± 0.049	3.03ArgGly: 3.03 ± 0.055	1.015ArgHis: 1.015 ± 0.028	3.59ArgIle: 3.59 ± 0.048	2.821ArgLys: 2.821 ± 0.057	5.597ArgLeu: 5.597 ± 0.085	1.356ArgMet: 1.356 ± 0.032	2.551ArgAsn: 2.551 ± 0.043	2.23ArgPro: 2.23 ± 0.042	2.226ArgGln: 2.226 ± 0.046	3.199ArgArg: 3.199 ± 0.059	3.178ArgSer: 3.178 ± 0.049	2.482ArgThr: 2.482 ± 0.039	3.177ArgVal: 3.177 ± 0.049	0.715ArgTrp: 0.715 ± 0.024	2.281ArgTyr: 2.281 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.648SerAla: 4.648 ± 0.059	0.757SerCys: 0.757 ± 0.032	3.592SerAsp: 3.592 ± 0.062	3.495SerGlu: 3.495 ± 0.049	3.164SerPhe: 3.164 ± 0.043	5.646SerGly: 5.646 ± 0.077	0.893SerHis: 0.893 ± 0.027	4.075SerIle: 4.075 ± 0.059	2.401SerLys: 2.401 ± 0.049	6.365SerLeu: 6.365 ± 0.071	1.197SerMet: 1.197 ± 0.028	2.899SerAsn: 2.899 ± 0.049	2.863SerPro: 2.863 ± 0.048	2.043SerGln: 2.043 ± 0.037	2.93SerArg: 2.93 ± 0.054	4.115SerSer: 4.115 ± 0.063	3.566SerThr: 3.566 ± 0.053	4.166SerVal: 4.166 ± 0.065	0.896SerTrp: 0.896 ± 0.027	2.354SerTyr: 2.354 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.914ThrAla: 4.914 ± 0.083	0.524ThrCys: 0.524 ± 0.029	4.218ThrAsp: 4.218 ± 0.099	3.665ThrGlu: 3.665 ± 0.051	2.928ThrPhe: 2.928 ± 0.059	4.867ThrGly: 4.867 ± 0.073	0.911ThrHis: 0.911 ± 0.025	4.135ThrIle: 4.135 ± 0.088	1.926ThrLys: 1.926 ± 0.042	5.68ThrLeu: 5.68 ± 0.085	0.974ThrMet: 0.974 ± 0.027	2.666ThrAsn: 2.666 ± 0.049	2.874ThrPro: 2.874 ± 0.059	1.662ThrGln: 1.662 ± 0.038	2.253ThrArg: 2.253 ± 0.045	3.45ThrSer: 3.45 ± 0.052	3.793ThrThr: 3.793 ± 0.081	4.659ThrVal: 4.659 ± 0.114	0.52ThrTrp: 0.52 ± 0.021	2.422ThrTyr: 2.422 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.556ValAla: 5.556 ± 0.069	0.616ValCys: 0.616 ± 0.025	4.449ValAsp: 4.449 ± 0.055	4.38ValGlu: 4.38 ± 0.058	3.056ValPhe: 3.056 ± 0.049	4.357ValGly: 4.357 ± 0.064	1.095ValHis: 1.095 ± 0.031	4.244ValIle: 4.244 ± 0.057	2.637ValLys: 2.637 ± 0.048	5.771ValLeu: 5.771 ± 0.064	1.313ValMet: 1.313 ± 0.031	3.503ValAsn: 3.503 ± 0.057	2.662ValPro: 2.662 ± 0.045	1.983ValGln: 1.983 ± 0.036	3.214ValArg: 3.214 ± 0.059	4.516ValSer: 4.516 ± 0.061	4.4ValThr: 4.4 ± 0.118	4.602ValVal: 4.602 ± 0.066	0.715ValTrp: 0.715 ± 0.025	2.382ValTyr: 2.382 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.778TrpAla: 0.778 ± 0.026	0.111TrpCys: 0.111 ± 0.009	0.659TrpAsp: 0.659 ± 0.023	0.721TrpGlu: 0.721 ± 0.022	0.52TrpPhe: 0.52 ± 0.02	0.815TrpGly: 0.815 ± 0.024	0.23TrpHis: 0.23 ± 0.013	0.617TrpIle: 0.617 ± 0.021	0.56TrpLys: 0.56 ± 0.021	1.423TrpLeu: 1.423 ± 0.037	0.311TrpMet: 0.311 ± 0.015	0.621TrpAsn: 0.621 ± 0.02	0.442TrpPro: 0.442 ± 0.016	0.589TrpGln: 0.589 ± 0.019	0.78TrpArg: 0.78 ± 0.027	0.886TrpSer: 0.886 ± 0.032	0.733TrpThr: 0.733 ± 0.024	0.713TrpVal: 0.713 ± 0.023	0.256TrpTrp: 0.256 ± 0.015	0.447TrpTyr: 0.447 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.741TyrAla: 2.741 ± 0.042	0.376TyrCys: 0.376 ± 0.019	2.504TyrAsp: 2.504 ± 0.044	2.382TyrGlu: 2.382 ± 0.038	2.132TyrPhe: 2.132 ± 0.046	2.772TyrGly: 2.772 ± 0.05	0.787TyrHis: 0.787 ± 0.025	1.601TyrIle: 1.601 ± 0.03	1.212TyrLys: 1.212 ± 0.035	4.106TyrLeu: 4.106 ± 0.055	0.483TyrMet: 0.483 ± 0.018	1.732TyrAsn: 1.732 ± 0.042	1.674TyrPro: 1.674 ± 0.038	1.725TyrGln: 1.725 ± 0.034	2.571TyrArg: 2.571 ± 0.046	2.181TyrSer: 2.181 ± 0.041	2.155TyrThr: 2.155 ± 0.054	2.308TyrVal: 2.308 ± 0.04	0.502TyrTrp: 0.502 ± 0.019	1.639TyrTyr: 1.639 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4052 proteins (1596819 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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