Amino acid dipepetide frequency for Desulfitobacterium hafniense (strain Y51)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.05AlaAla: 8.05 ± 0.092	1.056AlaCys: 1.056 ± 0.031	4.033AlaAsp: 4.033 ± 0.056	5.878AlaGlu: 5.878 ± 0.069	3.181AlaPhe: 3.181 ± 0.053	6.95AlaGly: 6.95 ± 0.09	1.453AlaHis: 1.453 ± 0.029	5.309AlaIle: 5.309 ± 0.069	4.754AlaLys: 4.754 ± 0.066	9.217AlaLeu: 9.217 ± 0.099	2.319AlaMet: 2.319 ± 0.04	2.694AlaAsn: 2.694 ± 0.043	2.652AlaPro: 2.652 ± 0.049	3.542AlaGln: 3.542 ± 0.054	3.673AlaArg: 3.673 ± 0.052	4.017AlaSer: 4.017 ± 0.053	3.627AlaThr: 3.627 ± 0.083	6.209AlaVal: 6.209 ± 0.07	0.864AlaTrp: 0.864 ± 0.025	2.562AlaTyr: 2.562 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.885CysAla: 0.885 ± 0.024	0.214CysCys: 0.214 ± 0.014	0.528CysAsp: 0.528 ± 0.018	0.62CysGlu: 0.62 ± 0.02	0.52CysPhe: 0.52 ± 0.018	1.194CysGly: 1.194 ± 0.033	0.325CysHis: 0.325 ± 0.017	0.721CysIle: 0.721 ± 0.02	0.507CysLys: 0.507 ± 0.019	1.207CysLeu: 1.207 ± 0.031	0.284CysMet: 0.284 ± 0.014	0.408CysAsn: 0.408 ± 0.017	0.736CysPro: 0.736 ± 0.027	0.479CysGln: 0.479 ± 0.019	0.661CysArg: 0.661 ± 0.022	0.795CysSer: 0.795 ± 0.024	0.632CysThr: 0.632 ± 0.019	0.704CysVal: 0.704 ± 0.023	0.136CysTrp: 0.136 ± 0.009	0.377CysTyr: 0.377 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.346AspAla: 3.346 ± 0.051	0.566AspCys: 0.566 ± 0.021	2.014AspAsp: 2.014 ± 0.039	3.515AspGlu: 3.515 ± 0.048	2.359AspPhe: 2.359 ± 0.037	3.391AspGly: 3.391 ± 0.068	0.989AspHis: 0.989 ± 0.028	3.72AspIle: 3.72 ± 0.053	2.717AspLys: 2.717 ± 0.037	5.119AspLeu: 5.119 ± 0.065	1.378AspMet: 1.378 ± 0.03	1.687AspAsn: 1.687 ± 0.04	2.297AspPro: 2.297 ± 0.045	1.86AspGln: 1.86 ± 0.037	2.347AspArg: 2.347 ± 0.039	2.67AspSer: 2.67 ± 0.04	2.362AspThr: 2.362 ± 0.04	3.131AspVal: 3.131 ± 0.044	0.662AspTrp: 0.662 ± 0.021	2.214AspTyr: 2.214 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.649GluAla: 5.649 ± 0.065	0.6GluCys: 0.6 ± 0.019	3.427GluAsp: 3.427 ± 0.056	6.284GluGlu: 6.284 ± 0.087	2.578GluPhe: 2.578 ± 0.049	4.869GluGly: 4.869 ± 0.054	1.378GluHis: 1.378 ± 0.033	5.229GluIle: 5.229 ± 0.061	5.244GluLys: 5.244 ± 0.065	7.244GluLeu: 7.244 ± 0.077	1.944GluMet: 1.944 ± 0.036	2.873GluAsn: 2.873 ± 0.05	2.22GluPro: 2.22 ± 0.037	3.227GluGln: 3.227 ± 0.051	3.773GluArg: 3.773 ± 0.065	3.332GluSer: 3.332 ± 0.05	3.214GluThr: 3.214 ± 0.044	4.788GluVal: 4.788 ± 0.063	0.758GluTrp: 0.758 ± 0.027	2.181GluTyr: 2.181 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.324PheAla: 3.324 ± 0.055	0.57PheCys: 0.57 ± 0.019	1.995PheAsp: 1.995 ± 0.034	2.222PheGlu: 2.222 ± 0.042	1.928PhePhe: 1.928 ± 0.041	3.072PheGly: 3.072 ± 0.047	0.755PheHis: 0.755 ± 0.02	2.885PheIle: 2.885 ± 0.046	2.006PheLys: 2.006 ± 0.043	4.44PheLeu: 4.44 ± 0.064	1.081PheMet: 1.081 ± 0.028	1.52PheAsn: 1.52 ± 0.032	1.696PhePro: 1.696 ± 0.035	1.455PheGln: 1.455 ± 0.031	1.762PheArg: 1.762 ± 0.036	2.875PheSer: 2.875 ± 0.042	2.266PheThr: 2.266 ± 0.039	2.625PheVal: 2.625 ± 0.048	0.539PheTrp: 0.539 ± 0.02	1.545PheTyr: 1.545 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.82GlyAla: 5.82 ± 0.097	1.197GlyCys: 1.197 ± 0.031	3.414GlyAsp: 3.414 ± 0.057	5.168GlyGlu: 5.168 ± 0.061	3.279GlyPhe: 3.279 ± 0.05	5.725GlyGly: 5.725 ± 0.094	1.408GlyHis: 1.408 ± 0.031	6.242GlyIle: 6.242 ± 0.075	5.181GlyLys: 5.181 ± 0.059	7.508GlyLeu: 7.508 ± 0.075	2.417GlyMet: 2.417 ± 0.046	2.791GlyAsn: 2.791 ± 0.049	2.004GlyPro: 2.004 ± 0.046	2.831GlyGln: 2.831 ± 0.039	3.567GlyArg: 3.567 ± 0.052	4.416GlySer: 4.416 ± 0.068	4.301GlyThr: 4.301 ± 0.074	5.591GlyVal: 5.591 ± 0.062	0.932GlyTrp: 0.932 ± 0.029	3.021GlyTyr: 3.021 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.209HisAla: 1.209 ± 0.027	0.339HisCys: 0.339 ± 0.015	0.954HisAsp: 0.954 ± 0.023	1.18HisGlu: 1.18 ± 0.031	0.853HisPhe: 0.853 ± 0.023	1.464HisGly: 1.464 ± 0.035	0.555HisHis: 0.555 ± 0.022	1.248HisIle: 1.248 ± 0.026	0.97HisLys: 0.97 ± 0.027	2.011HisLeu: 2.011 ± 0.04	0.448HisMet: 0.448 ± 0.018	0.731HisAsn: 0.731 ± 0.02	1.191HisPro: 1.191 ± 0.029	0.77HisGln: 0.77 ± 0.023	0.955HisArg: 0.955 ± 0.025	1.209HisSer: 1.209 ± 0.033	0.998HisThr: 0.998 ± 0.028	1.06HisVal: 1.06 ± 0.028	0.265HisTrp: 0.265 ± 0.013	0.882HisTyr: 0.882 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.171IleAla: 6.171 ± 0.072	0.863IleCys: 0.863 ± 0.026	3.487IleAsp: 3.487 ± 0.052	4.424IleGlu: 4.424 ± 0.049	2.772IlePhe: 2.772 ± 0.052	5.268IleGly: 5.268 ± 0.068	1.363IleHis: 1.363 ± 0.031	4.836IleIle: 4.836 ± 0.068	3.75IleLys: 3.75 ± 0.048	7.487IleLeu: 7.487 ± 0.093	1.829IleMet: 1.829 ± 0.038	2.776IleAsn: 2.776 ± 0.043	3.482IlePro: 3.482 ± 0.049	2.53IleGln: 2.53 ± 0.04	3.421IleArg: 3.421 ± 0.051	4.425IleSer: 4.425 ± 0.058	3.79IleThr: 3.79 ± 0.057	4.635IleVal: 4.635 ± 0.065	0.632IleTrp: 0.632 ± 0.021	2.224IleTyr: 2.224 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	5.081LysAla: 5.081 ± 0.06	0.488LysCys: 0.488 ± 0.019	3.285LysAsp: 3.285 ± 0.048	5.151LysGlu: 5.151 ± 0.065	1.68LysPhe: 1.68 ± 0.033	4.337LysGly: 4.337 ± 0.059	1.003LysHis: 1.003 ± 0.024	4.158LysIle: 4.158 ± 0.049	3.906LysLys: 3.906 ± 0.05	5.164LysLeu: 5.164 ± 0.061	1.633LysMet: 1.633 ± 0.03	2.509LysAsn: 2.509 ± 0.043	2.169LysPro: 2.169 ± 0.039	2.068LysGln: 2.068 ± 0.04	2.815LysArg: 2.815 ± 0.053	3.058LysSer: 3.058 ± 0.048	3.174LysThr: 3.174 ± 0.05	4.317LysVal: 4.317 ± 0.053	0.547LysTrp: 0.547 ± 0.02	1.815LysTyr: 1.815 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	9.57LeuAla: 9.57 ± 0.087	1.228LeuCys: 1.228 ± 0.031	4.902LeuAsp: 4.902 ± 0.059	6.953LeuGlu: 6.953 ± 0.082	4.317LeuPhe: 4.317 ± 0.067	7.879LeuGly: 7.879 ± 0.09	1.825LeuHis: 1.825 ± 0.036	6.833LeuIle: 6.833 ± 0.091	6.362LeuLys: 6.362 ± 0.069	10.799LeuLeu: 10.799 ± 0.12	2.704LeuMet: 2.704 ± 0.043	4.107LeuAsn: 4.107 ± 0.049	4.722LeuPro: 4.722 ± 0.057	3.785LeuGln: 3.785 ± 0.055	4.904LeuArg: 4.904 ± 0.062	6.828LeuSer: 6.828 ± 0.079	5.865LeuThr: 5.865 ± 0.066	6.554LeuVal: 6.554 ± 0.074	1.119LeuTrp: 1.119 ± 0.029	3.118LeuTyr: 3.118 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.519MetAla: 2.519 ± 0.04	0.244MetCys: 0.244 ± 0.013	1.477MetAsp: 1.477 ± 0.03	1.995MetGlu: 1.995 ± 0.035	0.902MetPhe: 0.902 ± 0.025	2.251MetGly: 2.251 ± 0.044	0.455MetHis: 0.455 ± 0.016	1.934MetIle: 1.934 ± 0.037	1.846MetLys: 1.846 ± 0.035	2.601MetLeu: 2.601 ± 0.042	0.882MetMet: 0.882 ± 0.029	1.237MetAsn: 1.237 ± 0.032	1.09MetPro: 1.09 ± 0.026	0.879MetGln: 0.879 ± 0.024	1.167MetArg: 1.167 ± 0.027	1.684MetSer: 1.684 ± 0.032	1.52MetThr: 1.52 ± 0.032	1.853MetVal: 1.853 ± 0.036	0.192MetTrp: 0.192 ± 0.012	0.6MetTyr: 0.6 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.602AsnAla: 2.602 ± 0.043	0.495AsnCys: 0.495 ± 0.021	1.56AsnAsp: 1.56 ± 0.035	2.215AsnGlu: 2.215 ± 0.043	1.445AsnPhe: 1.445 ± 0.029	2.668AsnGly: 2.668 ± 0.049	0.832AsnHis: 0.832 ± 0.024	2.701AsnIle: 2.701 ± 0.039	2.054AsnLys: 2.054 ± 0.04	4.038AsnLeu: 4.038 ± 0.06	0.968AsnMet: 0.968 ± 0.027	1.474AsnAsn: 1.474 ± 0.035	2.45AsnPro: 2.45 ± 0.038	1.603AsnGln: 1.603 ± 0.035	1.973AsnArg: 1.973 ± 0.028	2.335AsnSer: 2.335 ± 0.043	2.053AsnThr: 2.053 ± 0.036	2.247AsnVal: 2.247 ± 0.042	0.435AsnTrp: 0.435 ± 0.017	1.551AsnTyr: 1.551 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.369ProAla: 3.369 ± 0.05	0.425ProCys: 0.425 ± 0.016	2.322ProAsp: 2.322 ± 0.047	3.688ProGlu: 3.688 ± 0.055	1.697ProPhe: 1.697 ± 0.037	3.212ProGly: 3.212 ± 0.051	0.906ProHis: 0.906 ± 0.026	2.442ProIle: 2.442 ± 0.043	2.009ProLys: 2.009 ± 0.031	4.213ProLeu: 4.213 ± 0.058	1.021ProMet: 1.021 ± 0.027	1.436ProAsn: 1.436 ± 0.035	1.473ProPro: 1.473 ± 0.037	1.85ProGln: 1.85 ± 0.039	1.64ProArg: 1.64 ± 0.03	2.319ProSer: 2.319 ± 0.045	1.99ProThr: 1.99 ± 0.037	3.296ProVal: 3.296 ± 0.05	0.557ProTrp: 0.557 ± 0.019	1.537ProTyr: 1.537 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.527GlnAla: 3.527 ± 0.055	0.369GlnCys: 0.369 ± 0.016	1.934GlnAsp: 1.934 ± 0.037	3.492GlnGlu: 3.492 ± 0.048	1.249GlnPhe: 1.249 ± 0.024	3.267GlnGly: 3.267 ± 0.052	0.67GlnHis: 0.67 ± 0.023	2.68GlnIle: 2.68 ± 0.045	2.504GlnLys: 2.504 ± 0.043	3.6GlnLeu: 3.6 ± 0.045	1.041GlnMet: 1.041 ± 0.027	1.488GlnAsn: 1.488 ± 0.029	1.409GlnPro: 1.409 ± 0.034	1.51GlnGln: 1.51 ± 0.038	2.084GlnArg: 2.084 ± 0.04	2.073GlnSer: 2.073 ± 0.038	1.913GlnThr: 1.913 ± 0.037	2.691GlnVal: 2.691 ± 0.044	0.512GlnTrp: 0.512 ± 0.019	1.194GlnTyr: 1.194 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.084ArgAla: 3.084 ± 0.046	0.569ArgCys: 0.569 ± 0.02	2.212ArgAsp: 2.212 ± 0.039	3.998ArgGlu: 3.998 ± 0.064	2.043ArgPhe: 2.043 ± 0.039	3.013ArgGly: 3.013 ± 0.04	0.939ArgHis: 0.939 ± 0.025	3.682ArgIle: 3.682 ± 0.049	3.071ArgLys: 3.071 ± 0.044	5.139ArgLeu: 5.139 ± 0.06	1.372ArgMet: 1.372 ± 0.035	1.845ArgAsn: 1.845 ± 0.034	1.729ArgPro: 1.729 ± 0.044	2.155ArgGln: 2.155 ± 0.038	2.682ArgArg: 2.682 ± 0.054	2.587ArgSer: 2.587 ± 0.042	2.354ArgThr: 2.354 ± 0.04	3.164ArgVal: 3.164 ± 0.047	0.568ArgTrp: 0.568 ± 0.018	1.788ArgTyr: 1.788 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.532SerAla: 4.532 ± 0.058	0.733SerCys: 0.733 ± 0.027	2.505SerAsp: 2.505 ± 0.044	3.427SerGlu: 3.427 ± 0.048	2.725SerPhe: 2.725 ± 0.044	5.088SerGly: 5.088 ± 0.069	1.2SerHis: 1.2 ± 0.029	3.94SerIle: 3.94 ± 0.059	2.875SerLys: 2.875 ± 0.041	6.584SerLeu: 6.584 ± 0.069	1.663SerMet: 1.663 ± 0.034	1.956SerAsn: 1.956 ± 0.041	2.56SerPro: 2.56 ± 0.041	2.374SerGln: 2.374 ± 0.042	2.892SerArg: 2.892 ± 0.043	3.795SerSer: 3.795 ± 0.057	2.847SerThr: 2.847 ± 0.05	3.79SerVal: 3.79 ± 0.05	0.76SerTrp: 0.76 ± 0.021	1.978SerTyr: 1.978 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.487ThrAla: 4.487 ± 0.068	0.53ThrCys: 0.53 ± 0.019	2.405ThrAsp: 2.405 ± 0.043	3.118ThrGlu: 3.118 ± 0.044	1.998ThrPhe: 1.998 ± 0.037	4.673ThrGly: 4.673 ± 0.126	1.081ThrHis: 1.081 ± 0.027	3.68ThrIle: 3.68 ± 0.055	2.537ThrLys: 2.537 ± 0.046	5.637ThrLeu: 5.637 ± 0.072	1.44ThrMet: 1.44 ± 0.027	1.733ThrAsn: 1.733 ± 0.038	2.651ThrPro: 2.651 ± 0.049	1.855ThrGln: 1.855 ± 0.031	2.113ThrArg: 2.113 ± 0.038	2.829ThrSer: 2.829 ± 0.043	2.7ThrThr: 2.7 ± 0.044	3.976ThrVal: 3.976 ± 0.062	0.578ThrTrp: 0.578 ± 0.02	1.663ThrTyr: 1.663 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	5.421ValAla: 5.421 ± 0.066	0.851ValCys: 0.851 ± 0.025	3.466ValAsp: 3.466 ± 0.051	4.49ValGlu: 4.49 ± 0.059	3.088ValPhe: 3.088 ± 0.051	4.849ValGly: 4.849 ± 0.059	1.189ValHis: 1.189 ± 0.03	5.06ValIle: 5.06 ± 0.061	3.871ValLys: 3.871 ± 0.056	7.43ValLeu: 7.43 ± 0.071	1.911ValMet: 1.911 ± 0.035	2.625ValAsn: 2.625 ± 0.047	2.778ValPro: 2.778 ± 0.043	2.405ValGln: 2.405 ± 0.039	3.077ValArg: 3.077 ± 0.053	4.252ValSer: 4.252 ± 0.048	3.693ValThr: 3.693 ± 0.055	4.956ValVal: 4.956 ± 0.064	0.724ValTrp: 0.724 ± 0.023	2.19ValTyr: 2.19 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.826TrpAla: 0.826 ± 0.021	0.121TrpCys: 0.121 ± 0.008	0.621TrpAsp: 0.621 ± 0.018	0.833TrpGlu: 0.833 ± 0.025	0.417TrpPhe: 0.417 ± 0.017	0.935TrpGly: 0.935 ± 0.027	0.235TrpHis: 0.235 ± 0.012	0.695TrpIle: 0.695 ± 0.023	0.564TrpLys: 0.564 ± 0.017	1.307TrpLeu: 1.307 ± 0.034	0.278TrpMet: 0.278 ± 0.013	0.477TrpAsn: 0.477 ± 0.018	0.43TrpPro: 0.43 ± 0.016	0.592TrpGln: 0.592 ± 0.018	0.58TrpArg: 0.58 ± 0.021	0.65TrpSer: 0.65 ± 0.018	0.528TrpThr: 0.528 ± 0.019	0.761TrpVal: 0.761 ± 0.025	0.157TrpTrp: 0.157 ± 0.01	0.33TrpTyr: 0.33 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.567TyrAla: 2.567 ± 0.039	0.474TyrCys: 0.474 ± 0.02	1.8TyrAsp: 1.8 ± 0.035	2.163TyrGlu: 2.163 ± 0.038	1.532TyrPhe: 1.532 ± 0.033	2.712TyrGly: 2.712 ± 0.037	0.731TyrHis: 0.731 ± 0.024	2.167TyrIle: 2.167 ± 0.039	1.628TyrLys: 1.628 ± 0.032	3.63TyrLeu: 3.63 ± 0.053	0.713TyrMet: 0.713 ± 0.021	1.333TyrAsn: 1.333 ± 0.032	1.663TyrPro: 1.663 ± 0.032	1.437TyrGln: 1.437 ± 0.033	1.91TyrArg: 1.91 ± 0.033	2.076TyrSer: 2.076 ± 0.038	1.856TyrThr: 1.856 ± 0.038	1.979TyrVal: 1.979 ± 0.037	0.399TyrTrp: 0.399 ± 0.016	1.34TyrTyr: 1.34 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5014 proteins (1600940 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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