Amino acid dipepetide frequency for Tilletiopsis washingtonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.277AlaAla: 25.277 ± 0.19	1.453AlaCys: 1.453 ± 0.026	6.213AlaAsp: 6.213 ± 0.046	7.682AlaGlu: 7.682 ± 0.057	3.434AlaPhe: 3.434 ± 0.038	10.047AlaGly: 10.047 ± 0.07	3.194AlaHis: 3.194 ± 0.038	3.295AlaIle: 3.295 ± 0.036	4.253AlaLys: 4.253 ± 0.047	12.404AlaLeu: 12.404 ± 0.09	2.371AlaMet: 2.371 ± 0.026	2.48AlaAsn: 2.48 ± 0.032	11.041AlaPro: 11.041 ± 0.104	5.792AlaGln: 5.792 ± 0.051	10.481AlaArg: 10.481 ± 0.086	13.494AlaSer: 13.494 ± 0.109	6.343AlaThr: 6.343 ± 0.042	7.038AlaVal: 7.038 ± 0.051	1.581AlaTrp: 1.581 ± 0.024	2.221AlaTyr: 2.221 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.505CysAla: 1.505 ± 0.029	0.307CysCys: 0.307 ± 0.013	0.561CysAsp: 0.561 ± 0.013	0.542CysGlu: 0.542 ± 0.014	0.406CysPhe: 0.406 ± 0.012	0.968CysGly: 0.968 ± 0.021	0.252CysHis: 0.252 ± 0.009	0.473CysIle: 0.473 ± 0.012	0.344CysLys: 0.344 ± 0.012	1.068CysLeu: 1.068 ± 0.017	0.232CysMet: 0.232 ± 0.008	0.255CysAsn: 0.255 ± 0.009	0.612CysPro: 0.612 ± 0.014	0.301CysGln: 0.301 ± 0.01	0.85CysArg: 0.85 ± 0.017	0.973CysSer: 0.973 ± 0.021	0.647CysThr: 0.647 ± 0.016	0.817CysVal: 0.817 ± 0.018	0.166CysTrp: 0.166 ± 0.007	0.237CysTyr: 0.237 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.152AspAla: 8.152 ± 0.056	0.477AspCys: 0.477 ± 0.014	4.323AspAsp: 4.323 ± 0.054	4.974AspGlu: 4.974 ± 0.051	1.618AspPhe: 1.618 ± 0.023	4.407AspGly: 4.407 ± 0.037	0.773AspHis: 0.773 ± 0.017	1.674AspIle: 1.674 ± 0.025	1.464AspLys: 1.464 ± 0.024	4.055AspLeu: 4.055 ± 0.041	0.975AspMet: 0.975 ± 0.02	0.924AspAsn: 0.924 ± 0.018	2.456AspPro: 2.456 ± 0.027	1.123AspGln: 1.123 ± 0.021	2.503AspArg: 2.503 ± 0.031	3.526AspSer: 3.526 ± 0.037	2.158AspThr: 2.158 ± 0.022	3.978AspVal: 3.978 ± 0.037	0.683AspTrp: 0.683 ± 0.014	1.016AspTyr: 1.016 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	8.016GluAla: 8.016 ± 0.06	0.523GluCys: 0.523 ± 0.013	3.301GluAsp: 3.301 ± 0.041	5.572GluGlu: 5.572 ± 0.064	1.188GluPhe: 1.188 ± 0.023	4.004GluGly: 4.004 ± 0.037	1.49GluHis: 1.49 ± 0.023	1.692GluIle: 1.692 ± 0.023	2.411GluLys: 2.411 ± 0.034	5.674GluLeu: 5.674 ± 0.048	1.307GluMet: 1.307 ± 0.022	1.075GluAsn: 1.075 ± 0.017	3.013GluPro: 3.013 ± 0.035	2.872GluGln: 2.872 ± 0.039	5.475GluArg: 5.475 ± 0.052	3.6GluSer: 3.6 ± 0.037	2.743GluThr: 2.743 ± 0.03	3.059GluVal: 3.059 ± 0.031	0.797GluTrp: 0.797 ± 0.017	1.067GluTyr: 1.067 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.573PheAla: 3.573 ± 0.033	0.403PheCys: 0.403 ± 0.012	1.822PheAsp: 1.822 ± 0.023	1.743PheGlu: 1.743 ± 0.022	1.142PhePhe: 1.142 ± 0.022	2.515PheGly: 2.515 ± 0.042	0.616PheHis: 0.616 ± 0.012	0.981PheIle: 0.981 ± 0.022	0.905PheLys: 0.905 ± 0.019	2.662PheLeu: 2.662 ± 0.032	0.534PheMet: 0.534 ± 0.013	0.789PheAsn: 0.789 ± 0.017	1.345PhePro: 1.345 ± 0.022	0.809PheGln: 0.809 ± 0.015	1.62PheArg: 1.62 ± 0.021	2.358PheSer: 2.358 ± 0.027	1.427PheThr: 1.427 ± 0.021	2.052PheVal: 2.052 ± 0.023	0.425PheTrp: 0.425 ± 0.013	0.705PheTyr: 0.705 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.488GlyAla: 10.488 ± 0.065	0.844GlyCys: 0.844 ± 0.018	3.648GlyAsp: 3.648 ± 0.032	4.143GlyGlu: 4.143 ± 0.035	2.186GlyPhe: 2.186 ± 0.032	7.545GlyGly: 7.545 ± 0.1	1.638GlyHis: 1.638 ± 0.024	2.487GlyIle: 2.487 ± 0.03	2.991GlyLys: 2.991 ± 0.038	6.047GlyLeu: 6.047 ± 0.052	1.608GlyMet: 1.608 ± 0.025	1.731GlyAsn: 1.731 ± 0.026	3.981GlyPro: 3.981 ± 0.04	2.44GlyGln: 2.44 ± 0.028	5.218GlyArg: 5.218 ± 0.044	7.294GlySer: 7.294 ± 0.069	4.074GlyThr: 4.074 ± 0.039	4.441GlyVal: 4.441 ± 0.042	1.062GlyTrp: 1.062 ± 0.018	1.505GlyTyr: 1.505 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	3.504HisAla: 3.504 ± 0.041	0.288HisCys: 0.288 ± 0.009	1.247HisAsp: 1.247 ± 0.019	1.321HisGlu: 1.321 ± 0.019	0.79HisPhe: 0.79 ± 0.015	1.873HisGly: 1.873 ± 0.023	0.722HisHis: 0.722 ± 0.021	0.842HisIle: 0.842 ± 0.014	0.637HisLys: 0.637 ± 0.014	2.414HisLeu: 2.414 ± 0.027	0.451HisMet: 0.451 ± 0.012	0.488HisAsn: 0.488 ± 0.013	1.465HisPro: 1.465 ± 0.022	0.755HisGln: 0.755 ± 0.017	1.6HisArg: 1.6 ± 0.025	1.907HisSer: 1.907 ± 0.028	1.18HisThr: 1.18 ± 0.02	1.602HisVal: 1.602 ± 0.019	0.277HisTrp: 0.277 ± 0.009	0.498HisTyr: 0.498 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.684IleAla: 3.684 ± 0.041	0.474IleCys: 0.474 ± 0.011	1.976IleAsp: 1.976 ± 0.025	1.999IleGlu: 1.999 ± 0.029	1.146IlePhe: 1.146 ± 0.023	2.234IleGly: 2.234 ± 0.027	0.634IleHis: 0.634 ± 0.014	1.221IleIle: 1.221 ± 0.023	1.214IleLys: 1.214 ± 0.021	2.692IleLeu: 2.692 ± 0.038	0.604IleMet: 0.604 ± 0.013	0.919IleAsn: 0.919 ± 0.021	1.518IlePro: 1.518 ± 0.021	0.869IleGln: 0.869 ± 0.016	1.817IleArg: 1.817 ± 0.024	2.406IleSer: 2.406 ± 0.028	1.56IleThr: 1.56 ± 0.023	2.292IleVal: 2.292 ± 0.027	0.399IleTrp: 0.399 ± 0.011	0.736IleTyr: 0.736 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.239LysAla: 4.239 ± 0.053	0.315LysCys: 0.315 ± 0.011	1.67LysAsp: 1.67 ± 0.027	2.307LysGlu: 2.307 ± 0.038	0.714LysPhe: 0.714 ± 0.016	2.482LysGly: 2.482 ± 0.03	0.82LysHis: 0.82 ± 0.018	1.099LysIle: 1.099 ± 0.018	2.098LysLys: 2.098 ± 0.041	2.991LysLeu: 2.991 ± 0.033	0.679LysMet: 0.679 ± 0.015	0.796LysAsn: 0.796 ± 0.016	1.929LysPro: 1.929 ± 0.026	1.36LysGln: 1.36 ± 0.021	3.146LysArg: 3.146 ± 0.04	2.216LysSer: 2.216 ± 0.028	1.786LysThr: 1.786 ± 0.027	1.834LysVal: 1.834 ± 0.029	0.405LysTrp: 0.405 ± 0.011	0.709LysTyr: 0.709 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	11.921LeuAla: 11.921 ± 0.074	1.277LeuCys: 1.277 ± 0.02	5.172LeuAsp: 5.172 ± 0.046	5.177LeuGlu: 5.177 ± 0.046	2.864LeuPhe: 2.864 ± 0.034	6.505LeuGly: 6.505 ± 0.048	2.407LeuHis: 2.407 ± 0.027	2.676LeuIle: 2.676 ± 0.033	2.84LeuLys: 2.84 ± 0.038	10.022LeuLeu: 10.022 ± 0.091	1.467LeuMet: 1.467 ± 0.023	2.085LeuAsn: 2.085 ± 0.031	6.575LeuPro: 6.575 ± 0.049	3.618LeuGln: 3.618 ± 0.042	7.73LeuArg: 7.73 ± 0.06	7.835LeuSer: 7.835 ± 0.064	4.047LeuThr: 4.047 ± 0.037	5.573LeuVal: 5.573 ± 0.054	1.028LeuTrp: 1.028 ± 0.018	1.809LeuTyr: 1.809 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.215MetAla: 2.215 ± 0.025	0.211MetCys: 0.211 ± 0.008	0.871MetAsp: 0.871 ± 0.017	0.86MetGlu: 0.86 ± 0.018	0.429MetPhe: 0.429 ± 0.011	1.324MetGly: 1.324 ± 0.027	0.501MetHis: 0.501 ± 0.012	0.514MetIle: 0.514 ± 0.012	0.54MetLys: 0.54 ± 0.013	1.94MetLeu: 1.94 ± 0.027	0.373MetMet: 0.373 ± 0.011	0.419MetAsn: 0.419 ± 0.011	1.563MetPro: 1.563 ± 0.024	0.92MetGln: 0.92 ± 0.018	1.719MetArg: 1.719 ± 0.023	1.788MetSer: 1.788 ± 0.023	0.945MetThr: 0.945 ± 0.015	0.835MetVal: 0.835 ± 0.017	0.216MetTrp: 0.216 ± 0.008	0.352MetTyr: 0.352 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.843AsnAla: 2.843 ± 0.033	0.22AsnCys: 0.22 ± 0.008	1.093AsnAsp: 1.093 ± 0.019	1.248AsnGlu: 1.248 ± 0.02	0.74AsnPhe: 0.74 ± 0.014	2.055AsnGly: 2.055 ± 0.033	0.408AsnHis: 0.408 ± 0.011	0.888AsnIle: 0.888 ± 0.018	0.781AsnLys: 0.781 ± 0.017	1.924AsnLeu: 1.924 ± 0.029	0.473AsnMet: 0.473 ± 0.013	0.597AsnAsn: 0.597 ± 0.016	1.262AsnPro: 1.262 ± 0.022	0.575AsnGln: 0.575 ± 0.013	1.197AsnArg: 1.197 ± 0.018	1.534AsnSer: 1.534 ± 0.023	1.114AsnThr: 1.114 ± 0.018	1.625AsnVal: 1.625 ± 0.027	0.299AsnTrp: 0.299 ± 0.01	0.513AsnTyr: 0.513 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.269ProAla: 10.269 ± 0.083	0.592ProCys: 0.592 ± 0.014	2.893ProAsp: 2.893 ± 0.033	3.257ProGlu: 3.257 ± 0.034	1.742ProPhe: 1.742 ± 0.026	4.638ProGly: 4.638 ± 0.044	1.748ProHis: 1.748 ± 0.027	1.612ProIle: 1.612 ± 0.023	1.814ProLys: 1.814 ± 0.028	5.999ProLeu: 5.999 ± 0.05	1.051ProMet: 1.051 ± 0.018	1.286ProAsn: 1.286 ± 0.021	7.076ProPro: 7.076 ± 0.107	2.796ProGln: 2.796 ± 0.037	5.267ProArg: 5.267 ± 0.051	7.449ProSer: 7.449 ± 0.08	3.667ProThr: 3.667 ± 0.033	3.397ProVal: 3.397 ± 0.036	0.671ProTrp: 0.671 ± 0.015	1.116ProTyr: 1.116 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	4.993GlnAla: 4.993 ± 0.053	0.352GlnCys: 0.352 ± 0.01	1.521GlnAsp: 1.521 ± 0.022	2.0GlnGlu: 2.0 ± 0.031	0.76GlnPhe: 0.76 ± 0.016	2.487GlnGly: 2.487 ± 0.034	1.318GlnHis: 1.318 ± 0.024	1.116GlnIle: 1.116 ± 0.018	1.161GlnLys: 1.161 ± 0.019	3.807GlnLeu: 3.807 ± 0.04	0.836GlnMet: 0.836 ± 0.019	0.776GlnAsn: 0.776 ± 0.017	2.857GlnPro: 2.857 ± 0.037	3.629GlnGln: 3.629 ± 0.123	3.728GlnArg: 3.728 ± 0.04	2.6GlnSer: 2.6 ± 0.028	1.881GlnThr: 1.881 ± 0.024	1.875GlnVal: 1.875 ± 0.025	0.452GlnTrp: 0.452 ± 0.011	0.715GlnTyr: 0.715 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	10.017ArgAla: 10.017 ± 0.075	1.067ArgCys: 1.067 ± 0.023	3.646ArgAsp: 3.646 ± 0.036	4.62ArgGlu: 4.62 ± 0.049	2.156ArgPhe: 2.156 ± 0.024	5.285ArgGly: 5.285 ± 0.054	1.886ArgHis: 1.886 ± 0.027	2.588ArgIle: 2.588 ± 0.029	3.016ArgLys: 3.016 ± 0.034	6.923ArgLeu: 6.923 ± 0.051	1.459ArgMet: 1.459 ± 0.021	1.644ArgAsn: 1.644 ± 0.023	4.811ArgPro: 4.811 ± 0.046	2.907ArgGln: 2.907 ± 0.032	8.474ArgArg: 8.474 ± 0.101	6.801ArgSer: 6.801 ± 0.065	4.018ArgThr: 4.018 ± 0.038	4.03ArgVal: 4.03 ± 0.038	0.992ArgTrp: 0.992 ± 0.018	1.324ArgTyr: 1.324 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	12.461SerAla: 12.461 ± 0.1	0.856SerCys: 0.856 ± 0.017	4.199SerAsp: 4.199 ± 0.041	3.91SerGlu: 3.91 ± 0.039	2.522SerPhe: 2.522 ± 0.026	7.035SerGly: 7.035 ± 0.062	1.987SerHis: 1.987 ± 0.027	2.614SerIle: 2.614 ± 0.026	2.596SerLys: 2.596 ± 0.031	7.674SerLeu: 7.674 ± 0.053	1.603SerMet: 1.603 ± 0.02	1.88SerAsn: 1.88 ± 0.023	6.577SerPro: 6.577 ± 0.088	2.804SerGln: 2.804 ± 0.034	6.259SerArg: 6.259 ± 0.061	12.363SerSer: 12.363 ± 0.148	5.316SerThr: 5.316 ± 0.058	4.564SerVal: 4.564 ± 0.04	0.944SerTrp: 0.944 ± 0.015	1.563SerTyr: 1.563 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	6.282ThrAla: 6.282 ± 0.042	0.615ThrCys: 0.615 ± 0.016	2.085ThrAsp: 2.085 ± 0.026	2.191ThrGlu: 2.191 ± 0.026	1.613ThrPhe: 1.613 ± 0.022	3.564ThrGly: 3.564 ± 0.042	1.288ThrHis: 1.288 ± 0.02	1.658ThrIle: 1.658 ± 0.026	1.466ThrLys: 1.466 ± 0.023	5.232ThrLeu: 5.232 ± 0.045	0.9ThrMet: 0.9 ± 0.016	1.053ThrAsn: 1.053 ± 0.017	4.626ThrPro: 4.626 ± 0.05	1.866ThrGln: 1.866 ± 0.027	3.524ThrArg: 3.524 ± 0.031	4.992ThrSer: 4.992 ± 0.048	2.915ThrThr: 2.915 ± 0.039	2.636ThrVal: 2.636 ± 0.033	0.671ThrTrp: 0.671 ± 0.014	1.064ThrTyr: 1.064 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	6.922ValAla: 6.922 ± 0.05	0.788ValCys: 0.788 ± 0.017	3.121ValAsp: 3.121 ± 0.034	3.525ValGlu: 3.525 ± 0.037	1.868ValPhe: 1.868 ± 0.027	3.98ValGly: 3.98 ± 0.036	1.389ValHis: 1.389 ± 0.021	1.856ValIle: 1.856 ± 0.025	1.995ValLys: 1.995 ± 0.028	5.955ValLeu: 5.955 ± 0.056	0.994ValMet: 0.994 ± 0.017	1.257ValAsn: 1.257 ± 0.022	4.107ValPro: 4.107 ± 0.034	2.272ValGln: 2.272 ± 0.029	4.663ValArg: 4.663 ± 0.032	4.246ValSer: 4.246 ± 0.042	2.631ValThr: 2.631 ± 0.031	4.092ValVal: 4.092 ± 0.041	0.785ValTrp: 0.785 ± 0.016	1.227ValTyr: 1.227 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.339TrpAla: 1.339 ± 0.02	0.184TrpCys: 0.184 ± 0.007	0.712TrpAsp: 0.712 ± 0.017	0.68TrpGlu: 0.68 ± 0.012	0.335TrpPhe: 0.335 ± 0.01	0.816TrpGly: 0.816 ± 0.018	0.338TrpHis: 0.338 ± 0.011	0.409TrpIle: 0.409 ± 0.011	0.434TrpLys: 0.434 ± 0.012	1.306TrpLeu: 1.306 ± 0.02	0.25TrpMet: 0.25 ± 0.009	0.372TrpAsn: 0.372 ± 0.011	0.596TrpPro: 0.596 ± 0.013	0.55TrpGln: 0.55 ± 0.011	1.171TrpArg: 1.171 ± 0.019	0.977TrpSer: 0.977 ± 0.018	0.757TrpThr: 0.757 ± 0.015	0.622TrpVal: 0.622 ± 0.013	0.226TrpTrp: 0.226 ± 0.008	0.272TrpTyr: 0.272 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.394TyrAla: 2.394 ± 0.026	0.27TyrCys: 0.27 ± 0.01	1.188TyrAsp: 1.188 ± 0.019	1.128TyrGlu: 1.128 ± 0.021	0.772TyrPhe: 0.772 ± 0.015	1.61TyrGly: 1.61 ± 0.028	0.453TyrHis: 0.453 ± 0.012	0.702TyrIle: 0.702 ± 0.017	0.636TyrLys: 0.636 ± 0.013	1.833TyrLeu: 1.833 ± 0.023	0.37TyrMet: 0.37 ± 0.011	0.563TyrAsn: 0.563 ± 0.011	0.929TyrPro: 0.929 ± 0.016	0.607TyrGln: 0.607 ± 0.012	1.219TyrArg: 1.219 ± 0.021	1.369TyrSer: 1.369 ± 0.025	1.031TyrThr: 1.031 ± 0.022	1.311TyrVal: 1.311 ± 0.022	0.267TyrTrp: 0.267 ± 0.009	0.536TyrTyr: 0.536 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 7007 proteins (3617120 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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