Amino acid dipepetide frequency for Streptococcus phage Javan274

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.743AlaAla: 4.743 ± 0.803
0.456AlaCys: 0.456 ± 0.212
5.108AlaAsp: 5.108 ± 0.636
5.016AlaGlu: 5.016 ± 0.604
3.01AlaPhe: 3.01 ± 0.435
4.56AlaGly: 4.56 ± 0.968
1.094AlaHis: 1.094 ± 0.299
5.655AlaIle: 5.655 ± 0.946
7.114AlaLys: 7.114 ± 0.876
5.655AlaLeu: 5.655 ± 0.869
2.463AlaMet: 2.463 ± 0.553
3.101AlaAsn: 3.101 ± 0.579
1.277AlaPro: 1.277 ± 0.365
2.28AlaGln: 2.28 ± 0.523
2.007AlaArg: 2.007 ± 0.332
4.469AlaSer: 4.469 ± 0.756
3.922AlaThr: 3.922 ± 0.71
4.104AlaVal: 4.104 ± 0.776
0.73AlaTrp: 0.73 ± 0.287
2.007AlaTyr: 2.007 ± 0.401
0.0AlaXaa: 0.0 ± 0.0
Cys
0.274CysAla: 0.274 ± 0.127
0.0CysCys: 0.0 ± 0.0
0.365CysAsp: 0.365 ± 0.199
0.547CysGlu: 0.547 ± 0.269
0.274CysPhe: 0.274 ± 0.161
0.091CysGly: 0.091 ± 0.093
0.091CysHis: 0.091 ± 0.076
0.456CysIle: 0.456 ± 0.19
0.274CysLys: 0.274 ± 0.155
0.274CysLeu: 0.274 ± 0.173
0.182CysMet: 0.182 ± 0.14
0.0CysAsn: 0.0 ± 0.0
0.547CysPro: 0.547 ± 0.25
0.456CysGln: 0.456 ± 0.26
0.274CysArg: 0.274 ± 0.142
0.274CysSer: 0.274 ± 0.163
0.182CysThr: 0.182 ± 0.136
0.456CysVal: 0.456 ± 0.177
0.091CysTrp: 0.091 ± 0.076
0.547CysTyr: 0.547 ± 0.247
0.0CysXaa: 0.0 ± 0.0
Asp
3.101AspAla: 3.101 ± 0.565
0.274AspCys: 0.274 ± 0.166
5.108AspAsp: 5.108 ± 0.785
4.378AspGlu: 4.378 ± 0.691
3.74AspPhe: 3.74 ± 0.526
4.652AspGly: 4.652 ± 0.686
0.547AspHis: 0.547 ± 0.242
5.655AspIle: 5.655 ± 0.962
4.834AspLys: 4.834 ± 0.742
4.652AspLeu: 4.652 ± 0.535
2.007AspMet: 2.007 ± 0.389
2.827AspAsn: 2.827 ± 0.647
0.73AspPro: 0.73 ± 0.306
1.368AspGln: 1.368 ± 0.331
1.368AspArg: 1.368 ± 0.385
4.652AspSer: 4.652 ± 0.567
3.375AspThr: 3.375 ± 0.523
4.013AspVal: 4.013 ± 0.619
1.003AspTrp: 1.003 ± 0.281
3.557AspTyr: 3.557 ± 0.697
0.0AspXaa: 0.0 ± 0.0
Glu
5.199GluAla: 5.199 ± 0.839
0.456GluCys: 0.456 ± 0.238
4.104GluAsp: 4.104 ± 0.59
6.111GluGlu: 6.111 ± 0.665
2.463GluPhe: 2.463 ± 0.476
3.283GluGly: 3.283 ± 0.501
0.821GluHis: 0.821 ± 0.266
5.837GluIle: 5.837 ± 0.564
6.658GluLys: 6.658 ± 0.873
7.661GluLeu: 7.661 ± 0.934
2.28GluMet: 2.28 ± 0.538
4.56GluAsn: 4.56 ± 0.695
1.368GluPro: 1.368 ± 0.318
3.283GluGln: 3.283 ± 0.492
3.557GluArg: 3.557 ± 0.46
3.01GluSer: 3.01 ± 0.628
4.469GluThr: 4.469 ± 0.684
5.746GluVal: 5.746 ± 0.698
1.368GluTrp: 1.368 ± 0.265
2.463GluTyr: 2.463 ± 0.44
0.0GluXaa: 0.0 ± 0.0
Phe
3.192PheAla: 3.192 ± 0.536
0.182PheCys: 0.182 ± 0.143
3.648PheAsp: 3.648 ± 0.759
3.466PheGlu: 3.466 ± 0.534
1.915PhePhe: 1.915 ± 0.456
2.919PheGly: 2.919 ± 0.398
0.73PheHis: 0.73 ± 0.218
2.827PheIle: 2.827 ± 0.652
3.74PheLys: 3.74 ± 0.579
2.919PheLeu: 2.919 ± 0.482
1.003PheMet: 1.003 ± 0.258
2.827PheAsn: 2.827 ± 0.566
1.551PhePro: 1.551 ± 0.418
1.186PheGln: 1.186 ± 0.342
1.459PheArg: 1.459 ± 0.277
3.557PheSer: 3.557 ± 0.479
2.189PheThr: 2.189 ± 0.354
1.915PheVal: 1.915 ± 0.473
0.456PheTrp: 0.456 ± 0.225
1.642PheTyr: 1.642 ± 0.426
0.0PheXaa: 0.0 ± 0.0
Gly
3.01GlyAla: 3.01 ± 0.643
0.365GlyCys: 0.365 ± 0.199
3.283GlyAsp: 3.283 ± 0.715
4.013GlyGlu: 4.013 ± 0.609
3.01GlyPhe: 3.01 ± 0.542
3.375GlyGly: 3.375 ± 0.658
1.277GlyHis: 1.277 ± 0.336
5.837GlyIle: 5.837 ± 0.791
5.016GlyLys: 5.016 ± 0.589
5.381GlyLeu: 5.381 ± 0.515
1.277GlyMet: 1.277 ± 0.324
3.466GlyAsn: 3.466 ± 0.667
0.912GlyPro: 0.912 ± 0.323
3.101GlyGln: 3.101 ± 0.581
2.736GlyArg: 2.736 ± 0.457
4.378GlySer: 4.378 ± 0.675
3.922GlyThr: 3.922 ± 0.566
3.375GlyVal: 3.375 ± 0.758
0.821GlyTrp: 0.821 ± 0.342
3.01GlyTyr: 3.01 ± 0.624
0.0GlyXaa: 0.0 ± 0.0
His
1.003HisAla: 1.003 ± 0.252
0.091HisCys: 0.091 ± 0.091
0.547HisAsp: 0.547 ± 0.282
0.912HisGlu: 0.912 ± 0.318
1.094HisPhe: 1.094 ± 0.326
1.003HisGly: 1.003 ± 0.246
0.821HisHis: 0.821 ± 0.256
1.733HisIle: 1.733 ± 0.47
0.912HisLys: 0.912 ± 0.313
1.368HisLeu: 1.368 ± 0.34
0.365HisMet: 0.365 ± 0.16
1.277HisAsn: 1.277 ± 0.342
0.547HisPro: 0.547 ± 0.22
0.73HisGln: 0.73 ± 0.263
0.182HisArg: 0.182 ± 0.126
0.547HisSer: 0.547 ± 0.218
0.73HisThr: 0.73 ± 0.283
0.73HisVal: 0.73 ± 0.228
0.274HisTrp: 0.274 ± 0.148
1.094HisTyr: 1.094 ± 0.366
0.0HisXaa: 0.0 ± 0.0
Ile
6.02IleAla: 6.02 ± 0.72
0.365IleCys: 0.365 ± 0.197
5.746IleAsp: 5.746 ± 0.848
6.202IleGlu: 6.202 ± 0.894
2.736IlePhe: 2.736 ± 0.47
4.743IleGly: 4.743 ± 0.502
1.733IleHis: 1.733 ± 0.385
5.837IleIle: 5.837 ± 0.731
6.749IleLys: 6.749 ± 0.722
4.743IleLeu: 4.743 ± 0.592
2.28IleMet: 2.28 ± 0.391
5.199IleAsn: 5.199 ± 0.63
2.827IlePro: 2.827 ± 0.569
2.554IleGln: 2.554 ± 0.467
3.01IleArg: 3.01 ± 0.511
5.837IleSer: 5.837 ± 0.731
5.472IleThr: 5.472 ± 0.804
3.922IleVal: 3.922 ± 0.611
0.912IleTrp: 0.912 ± 0.366
2.371IleTyr: 2.371 ± 0.518
0.0IleXaa: 0.0 ± 0.0
Lys
6.202LysAla: 6.202 ± 0.613
0.456LysCys: 0.456 ± 0.205
4.287LysAsp: 4.287 ± 0.805
6.567LysGlu: 6.567 ± 0.685
2.189LysPhe: 2.189 ± 0.408
4.013LysGly: 4.013 ± 0.617
1.642LysHis: 1.642 ± 0.407
7.297LysIle: 7.297 ± 1.223
7.388LysLys: 7.388 ± 1.472
6.841LysLeu: 6.841 ± 0.799
2.28LysMet: 2.28 ± 0.533
5.564LysAsn: 5.564 ± 0.662
2.919LysPro: 2.919 ± 0.511
3.466LysGln: 3.466 ± 0.602
3.922LysArg: 3.922 ± 0.533
4.469LysSer: 4.469 ± 0.582
5.837LysThr: 5.837 ± 0.756
5.472LysVal: 5.472 ± 0.783
0.456LysTrp: 0.456 ± 0.186
2.645LysTyr: 2.645 ± 0.537
0.0LysXaa: 0.0 ± 0.0
Leu
6.293LeuAla: 6.293 ± 1.181
0.638LeuCys: 0.638 ± 0.244
5.564LeuAsp: 5.564 ± 0.926
6.02LeuGlu: 6.02 ± 0.602
3.831LeuPhe: 3.831 ± 0.495
5.472LeuGly: 5.472 ± 0.626
0.912LeuHis: 0.912 ± 0.262
4.834LeuIle: 4.834 ± 0.676
6.111LeuLys: 6.111 ± 0.573
5.837LeuLeu: 5.837 ± 0.671
1.551LeuMet: 1.551 ± 0.327
4.196LeuAsn: 4.196 ± 0.526
3.192LeuPro: 3.192 ± 0.475
2.645LeuGln: 2.645 ± 0.379
4.196LeuArg: 4.196 ± 0.556
6.932LeuSer: 6.932 ± 1.167
6.385LeuThr: 6.385 ± 0.689
3.831LeuVal: 3.831 ± 0.545
0.73LeuTrp: 0.73 ± 0.27
1.824LeuTyr: 1.824 ± 0.383
0.0LeuXaa: 0.0 ± 0.0
Met
2.007MetAla: 2.007 ± 0.384
0.091MetCys: 0.091 ± 0.104
1.551MetAsp: 1.551 ± 0.306
2.189MetGlu: 2.189 ± 0.425
1.277MetPhe: 1.277 ± 0.372
1.733MetGly: 1.733 ± 0.375
0.0MetHis: 0.0 ± 0.0
2.007MetIle: 2.007 ± 0.437
1.459MetLys: 1.459 ± 0.339
2.189MetLeu: 2.189 ± 0.409
0.912MetMet: 0.912 ± 0.248
1.733MetAsn: 1.733 ± 0.436
1.186MetPro: 1.186 ± 0.259
0.547MetGln: 0.547 ± 0.245
1.003MetArg: 1.003 ± 0.289
2.189MetSer: 2.189 ± 0.427
2.007MetThr: 2.007 ± 0.446
0.912MetVal: 0.912 ± 0.247
0.456MetTrp: 0.456 ± 0.175
0.456MetTyr: 0.456 ± 0.178
0.0MetXaa: 0.0 ± 0.0
Asn
4.834AsnAla: 4.834 ± 0.856
0.365AsnCys: 0.365 ± 0.17
2.736AsnAsp: 2.736 ± 0.481
3.283AsnGlu: 3.283 ± 0.438
2.919AsnPhe: 2.919 ± 0.777
4.56AsnGly: 4.56 ± 0.729
0.638AsnHis: 0.638 ± 0.229
4.104AsnIle: 4.104 ± 0.598
4.56AsnLys: 4.56 ± 0.475
4.013AsnLeu: 4.013 ± 0.654
1.094AsnMet: 1.094 ± 0.282
3.283AsnAsn: 3.283 ± 0.675
2.645AsnPro: 2.645 ± 0.46
2.827AsnGln: 2.827 ± 0.567
1.642AsnArg: 1.642 ± 0.35
3.922AsnSer: 3.922 ± 0.587
2.645AsnThr: 2.645 ± 0.456
3.74AsnVal: 3.74 ± 0.548
0.638AsnTrp: 0.638 ± 0.297
2.645AsnTyr: 2.645 ± 0.556
0.0AsnXaa: 0.0 ± 0.0
Pro
1.003ProAla: 1.003 ± 0.386
0.182ProCys: 0.182 ± 0.156
1.824ProAsp: 1.824 ± 0.439
2.28ProGlu: 2.28 ± 0.523
1.186ProPhe: 1.186 ± 0.421
1.642ProGly: 1.642 ± 0.629
1.003ProHis: 1.003 ± 0.303
3.01ProIle: 3.01 ± 0.458
2.827ProLys: 2.827 ± 0.572
2.098ProLeu: 2.098 ± 0.441
0.456ProMet: 0.456 ± 0.165
1.824ProAsn: 1.824 ± 0.467
0.73ProPro: 0.73 ± 0.3
0.912ProGln: 0.912 ± 0.292
0.638ProArg: 0.638 ± 0.234
2.371ProSer: 2.371 ± 0.589
2.371ProThr: 2.371 ± 0.461
1.551ProVal: 1.551 ± 0.37
0.182ProTrp: 0.182 ± 0.153
1.003ProTyr: 1.003 ± 0.278
0.0ProXaa: 0.0 ± 0.0
Gln
3.192GlnAla: 3.192 ± 0.499
0.182GlnCys: 0.182 ± 0.145
1.824GlnAsp: 1.824 ± 0.409
2.189GlnGlu: 2.189 ± 0.377
2.007GlnPhe: 2.007 ± 0.481
1.277GlnGly: 1.277 ± 0.282
0.456GlnHis: 0.456 ± 0.272
2.463GlnIle: 2.463 ± 0.514
2.919GlnLys: 2.919 ± 0.506
4.925GlnLeu: 4.925 ± 0.748
1.003GlnMet: 1.003 ± 0.267
1.642GlnAsn: 1.642 ± 0.361
0.638GlnPro: 0.638 ± 0.251
1.642GlnGln: 1.642 ± 0.37
1.733GlnArg: 1.733 ± 0.413
1.551GlnSer: 1.551 ± 0.334
2.827GlnThr: 2.827 ± 0.496
2.28GlnVal: 2.28 ± 0.449
0.182GlnTrp: 0.182 ± 0.11
0.912GlnTyr: 0.912 ± 0.275
0.0GlnXaa: 0.0 ± 0.0
Arg
3.192ArgAla: 3.192 ± 0.547
0.274ArgCys: 0.274 ± 0.165
2.554ArgAsp: 2.554 ± 0.465
2.554ArgGlu: 2.554 ± 0.515
2.007ArgPhe: 2.007 ± 0.464
1.551ArgGly: 1.551 ± 0.36
0.73ArgHis: 0.73 ± 0.255
2.827ArgIle: 2.827 ± 0.747
2.463ArgLys: 2.463 ± 0.504
3.101ArgLeu: 3.101 ± 0.535
1.459ArgMet: 1.459 ± 0.335
2.463ArgAsn: 2.463 ± 0.448
1.368ArgPro: 1.368 ± 0.345
1.459ArgGln: 1.459 ± 0.422
1.459ArgArg: 1.459 ± 0.368
2.098ArgSer: 2.098 ± 0.56
2.28ArgThr: 2.28 ± 0.508
1.642ArgVal: 1.642 ± 0.447
0.365ArgTrp: 0.365 ± 0.153
1.824ArgTyr: 1.824 ± 0.425
0.0ArgXaa: 0.0 ± 0.0
Ser
3.922SerAla: 3.922 ± 0.859
0.091SerCys: 0.091 ± 0.085
4.652SerAsp: 4.652 ± 0.608
5.108SerGlu: 5.108 ± 1.036
2.554SerPhe: 2.554 ± 0.382
4.925SerGly: 4.925 ± 0.827
1.003SerHis: 1.003 ± 0.326
4.378SerIle: 4.378 ± 0.951
5.564SerLys: 5.564 ± 0.756
5.29SerLeu: 5.29 ± 0.712
1.003SerMet: 1.003 ± 0.293
3.557SerAsn: 3.557 ± 0.66
1.277SerPro: 1.277 ± 0.458
2.371SerGln: 2.371 ± 0.438
2.371SerArg: 2.371 ± 0.435
4.104SerSer: 4.104 ± 0.699
3.466SerThr: 3.466 ± 0.674
4.56SerVal: 4.56 ± 0.581
1.003SerTrp: 1.003 ± 0.294
2.371SerTyr: 2.371 ± 0.52
0.0SerXaa: 0.0 ± 0.0
Thr
3.466ThrAla: 3.466 ± 0.654
0.547ThrCys: 0.547 ± 0.225
2.919ThrAsp: 2.919 ± 0.434
4.925ThrGlu: 4.925 ± 0.538
3.192ThrPhe: 3.192 ± 0.643
4.652ThrGly: 4.652 ± 0.717
1.003ThrHis: 1.003 ± 0.235
6.202ThrIle: 6.202 ± 0.751
6.111ThrLys: 6.111 ± 0.825
4.469ThrLeu: 4.469 ± 0.585
1.824ThrMet: 1.824 ± 0.411
3.01ThrAsn: 3.01 ± 0.579
2.007ThrPro: 2.007 ± 0.599
2.007ThrGln: 2.007 ± 0.42
1.642ThrArg: 1.642 ± 0.338
3.648ThrSer: 3.648 ± 0.562
5.29ThrThr: 5.29 ± 1.193
5.928ThrVal: 5.928 ± 1.021
0.912ThrTrp: 0.912 ± 0.325
1.915ThrTyr: 1.915 ± 0.294
0.0ThrXaa: 0.0 ± 0.0
Val
5.837ValAla: 5.837 ± 0.728
0.365ValCys: 0.365 ± 0.166
3.101ValAsp: 3.101 ± 0.502
4.469ValGlu: 4.469 ± 0.638
2.189ValPhe: 2.189 ± 0.319
3.648ValGly: 3.648 ± 0.6
0.547ValHis: 0.547 ± 0.24
5.655ValIle: 5.655 ± 0.796
5.016ValLys: 5.016 ± 0.731
4.104ValLeu: 4.104 ± 0.557
1.733ValMet: 1.733 ± 0.334
3.375ValAsn: 3.375 ± 0.623
2.007ValPro: 2.007 ± 0.361
1.003ValGln: 1.003 ± 0.304
2.007ValArg: 2.007 ± 0.305
3.557ValSer: 3.557 ± 0.51
5.199ValThr: 5.199 ± 0.858
4.56ValVal: 4.56 ± 0.729
0.638ValTrp: 0.638 ± 0.251
2.098ValTyr: 2.098 ± 0.553
0.0ValXaa: 0.0 ± 0.0
Trp
0.456TrpAla: 0.456 ± 0.172
0.091TrpCys: 0.091 ± 0.091
0.638TrpAsp: 0.638 ± 0.196
1.277TrpGlu: 1.277 ± 0.295
0.274TrpPhe: 0.274 ± 0.127
0.638TrpGly: 0.638 ± 0.433
0.091TrpHis: 0.091 ± 0.086
0.638TrpIle: 0.638 ± 0.234
0.73TrpLys: 0.73 ± 0.24
1.277TrpLeu: 1.277 ± 0.366
0.182TrpMet: 0.182 ± 0.118
1.368TrpAsn: 1.368 ± 0.587
0.182TrpPro: 0.182 ± 0.117
0.638TrpGln: 0.638 ± 0.234
0.638TrpArg: 0.638 ± 0.243
0.73TrpSer: 0.73 ± 0.175
0.821TrpThr: 0.821 ± 0.292
0.365TrpVal: 0.365 ± 0.159
0.091TrpTrp: 0.091 ± 0.074
0.547TrpTyr: 0.547 ± 0.17
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.824TyrAla: 1.824 ± 0.364
0.182TyrCys: 0.182 ± 0.121
2.28TyrAsp: 2.28 ± 0.381
3.192TyrGlu: 3.192 ± 0.589
1.459TyrPhe: 1.459 ± 0.432
2.827TyrGly: 2.827 ± 0.437
0.821TyrHis: 0.821 ± 0.317
2.007TyrIle: 2.007 ± 0.581
3.466TyrLys: 3.466 ± 0.79
4.196TyrLeu: 4.196 ± 0.65
0.456TyrMet: 0.456 ± 0.198
1.824TyrAsn: 1.824 ± 0.53
1.186TyrPro: 1.186 ± 0.32
1.368TyrGln: 1.368 ± 0.303
1.824TyrArg: 1.824 ± 0.393
1.277TyrSer: 1.277 ± 0.392
2.28TyrThr: 2.28 ± 0.492
2.098TyrVal: 2.098 ± 0.485
0.365TyrTrp: 0.365 ± 0.16
1.459TyrTyr: 1.459 ± 0.341
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (10965 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski