Amino acid dipepetide frequency for Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.473AlaAla: 9.473 ± 0.122	1.088AlaCys: 1.088 ± 0.029	5.18AlaAsp: 5.18 ± 0.074	5.96AlaGlu: 5.96 ± 0.078	3.568AlaPhe: 3.568 ± 0.054	6.848AlaGly: 6.848 ± 0.085	1.84AlaHis: 1.84 ± 0.042	5.896AlaIle: 5.896 ± 0.08	5.019AlaLys: 5.019 ± 0.101	10.041AlaLeu: 10.041 ± 0.11	2.237AlaMet: 2.237 ± 0.044	4.518AlaAsn: 4.518 ± 0.082	3.57AlaPro: 3.57 ± 0.074	4.259AlaGln: 4.259 ± 0.076	3.929AlaArg: 3.929 ± 0.068	6.482AlaSer: 6.482 ± 0.133	5.215AlaThr: 5.215 ± 0.083	6.392AlaVal: 6.392 ± 0.085	1.126AlaTrp: 1.126 ± 0.038	2.851AlaTyr: 2.851 ± 0.098	0.0AlaXaa: 0.0 ± 0.0
Cys	1.01CysAla: 1.01 ± 0.032	0.16CysCys: 0.16 ± 0.01	0.58CysAsp: 0.58 ± 0.021	0.655CysGlu: 0.655 ± 0.024	0.424CysPhe: 0.424 ± 0.017	0.917CysGly: 0.917 ± 0.029	0.288CysHis: 0.288 ± 0.015	0.628CysIle: 0.628 ± 0.022	0.413CysLys: 0.413 ± 0.017	0.97CysLeu: 0.97 ± 0.032	0.207CysMet: 0.207 ± 0.015	0.401CysAsn: 0.401 ± 0.02	0.406CysPro: 0.406 ± 0.021	0.31CysGln: 0.31 ± 0.017	0.417CysArg: 0.417 ± 0.016	0.728CysSer: 0.728 ± 0.023	0.54CysThr: 0.54 ± 0.024	0.758CysVal: 0.758 ± 0.024	0.157CysTrp: 0.157 ± 0.015	0.31CysTyr: 0.31 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.186AspAla: 5.186 ± 0.174	0.512AspCys: 0.512 ± 0.022	3.156AspAsp: 3.156 ± 0.078	3.674AspGlu: 3.674 ± 0.053	2.417AspPhe: 2.417 ± 0.046	4.359AspGly: 4.359 ± 0.124	0.99AspHis: 0.99 ± 0.027	3.853AspIle: 3.853 ± 0.064	2.781AspLys: 2.781 ± 0.053	5.047AspLeu: 5.047 ± 0.067	1.274AspMet: 1.274 ± 0.031	2.506AspAsn: 2.506 ± 0.057	2.229AspPro: 2.229 ± 0.066	1.794AspGln: 1.794 ± 0.039	2.144AspArg: 2.144 ± 0.04	3.562AspSer: 3.562 ± 0.089	3.196AspThr: 3.196 ± 0.073	4.093AspVal: 4.093 ± 0.079	0.943AspTrp: 0.943 ± 0.027	2.12AspTyr: 2.12 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.605GluAla: 5.605 ± 0.084	0.483GluCys: 0.483 ± 0.022	3.166GluAsp: 3.166 ± 0.087	3.66GluGlu: 3.66 ± 0.07	2.422GluPhe: 2.422 ± 0.045	3.886GluGly: 3.886 ± 0.058	1.45GluHis: 1.45 ± 0.038	3.54GluIle: 3.54 ± 0.055	3.287GluLys: 3.287 ± 0.063	6.565GluLeu: 6.565 ± 0.086	1.364GluMet: 1.364 ± 0.036	2.858GluAsn: 2.858 ± 0.047	2.391GluPro: 2.391 ± 0.068	3.34GluGln: 3.34 ± 0.066	3.126GluArg: 3.126 ± 0.058	3.794GluSer: 3.794 ± 0.062	3.103GluThr: 3.103 ± 0.055	4.2GluVal: 4.2 ± 0.057	0.831GluTrp: 0.831 ± 0.024	1.905GluTyr: 1.905 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.578PheAla: 3.578 ± 0.057	0.502PheCys: 0.502 ± 0.023	2.825PheAsp: 2.825 ± 0.057	2.544PheGlu: 2.544 ± 0.049	1.705PhePhe: 1.705 ± 0.043	3.03PheGly: 3.03 ± 0.058	0.726PheHis: 0.726 ± 0.023	2.617PheIle: 2.617 ± 0.048	1.95PheLys: 1.95 ± 0.047	3.19PheLeu: 3.19 ± 0.06	0.869PheMet: 0.869 ± 0.027	2.185PheAsn: 2.185 ± 0.046	1.389PhePro: 1.389 ± 0.035	1.057PheGln: 1.057 ± 0.027	1.49PheArg: 1.49 ± 0.037	3.33PheSer: 3.33 ± 0.065	2.564PheThr: 2.564 ± 0.053	2.731PheVal: 2.731 ± 0.048	0.556PheTrp: 0.556 ± 0.021	1.481PheTyr: 1.481 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.149GlyAla: 6.149 ± 0.087	0.885GlyCys: 0.885 ± 0.03	4.221GlyAsp: 4.221 ± 0.093	4.757GlyGlu: 4.757 ± 0.069	3.157GlyPhe: 3.157 ± 0.055	5.558GlyGly: 5.558 ± 0.107	1.383GlyHis: 1.383 ± 0.038	4.186GlyIle: 4.186 ± 0.062	3.626GlyLys: 3.626 ± 0.066	6.795GlyLeu: 6.795 ± 0.089	1.735GlyMet: 1.735 ± 0.039	3.235GlyAsn: 3.235 ± 0.118	1.828GlyPro: 1.828 ± 0.037	2.462GlyGln: 2.462 ± 0.043	3.031GlyArg: 3.031 ± 0.048	4.664GlySer: 4.664 ± 0.109	3.673GlyThr: 3.673 ± 0.102	5.753GlyVal: 5.753 ± 0.074	1.163GlyTrp: 1.163 ± 0.033	2.586GlyTyr: 2.586 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.771HisAla: 1.771 ± 0.039	0.29HisCys: 0.29 ± 0.016	0.966HisAsp: 0.966 ± 0.03	0.994HisGlu: 0.994 ± 0.03	1.02HisPhe: 1.02 ± 0.026	1.395HisGly: 1.395 ± 0.033	0.599HisHis: 0.599 ± 0.024	1.404HisIle: 1.404 ± 0.031	0.997HisLys: 0.997 ± 0.029	2.009HisLeu: 2.009 ± 0.043	0.483HisMet: 0.483 ± 0.018	0.96HisAsn: 0.96 ± 0.026	1.072HisPro: 1.072 ± 0.029	0.804HisGln: 0.804 ± 0.026	1.03HisArg: 1.03 ± 0.028	1.422HisSer: 1.422 ± 0.04	1.299HisThr: 1.299 ± 0.034	1.235HisVal: 1.235 ± 0.032	0.386HisTrp: 0.386 ± 0.019	0.881HisTyr: 0.881 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.404IleAla: 6.404 ± 0.077	0.613IleCys: 0.613 ± 0.022	3.968IleAsp: 3.968 ± 0.066	4.212IleGlu: 4.212 ± 0.062	2.123IlePhe: 2.123 ± 0.048	4.191IleGly: 4.191 ± 0.057	1.233IleHis: 1.233 ± 0.032	3.139IleIle: 3.139 ± 0.057	3.064IleLys: 3.064 ± 0.049	4.68IleLeu: 4.68 ± 0.074	1.047IleMet: 1.047 ± 0.03	3.096IleAsn: 3.096 ± 0.06	2.428IlePro: 2.428 ± 0.041	2.042IleGln: 2.042 ± 0.038	2.726IleArg: 2.726 ± 0.047	4.162IleSer: 4.162 ± 0.069	3.942IleThr: 3.942 ± 0.141	4.138IleVal: 4.138 ± 0.07	0.601IleTrp: 0.601 ± 0.021	1.687IleTyr: 1.687 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.642LysAla: 4.642 ± 0.089	0.329LysCys: 0.329 ± 0.017	2.373LysAsp: 2.373 ± 0.046	2.773LysGlu: 2.773 ± 0.062	1.523LysPhe: 1.523 ± 0.037	2.932LysGly: 2.932 ± 0.053	1.215LysHis: 1.215 ± 0.032	2.891LysIle: 2.891 ± 0.063	2.807LysLys: 2.807 ± 0.066	5.023LysLeu: 5.023 ± 0.083	1.178LysMet: 1.178 ± 0.035	2.356LysAsn: 2.356 ± 0.05	2.417LysPro: 2.417 ± 0.053	2.628LysGln: 2.628 ± 0.048	2.589LysArg: 2.589 ± 0.051	2.835LysSer: 2.835 ± 0.05	2.863LysThr: 2.863 ± 0.047	3.412LysVal: 3.412 ± 0.05	0.574LysTrp: 0.574 ± 0.021	1.413LysTyr: 1.413 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.426LeuAla: 10.426 ± 0.111	1.089LeuCys: 1.089 ± 0.031	5.644LeuAsp: 5.644 ± 0.074	5.746LeuGlu: 5.746 ± 0.081	3.838LeuPhe: 3.838 ± 0.072	6.663LeuGly: 6.663 ± 0.083	1.997LeuHis: 1.997 ± 0.044	5.496LeuIle: 5.496 ± 0.088	4.7LeuLys: 4.7 ± 0.071	9.48LeuLeu: 9.48 ± 0.124	2.109LeuMet: 2.109 ± 0.049	4.625LeuAsn: 4.625 ± 0.069	4.588LeuPro: 4.588 ± 0.071	3.831LeuGln: 3.831 ± 0.064	4.398LeuArg: 4.398 ± 0.064	7.044LeuSer: 7.044 ± 0.089	5.923LeuThr: 5.923 ± 0.099	6.867LeuVal: 6.867 ± 0.084	1.097LeuTrp: 1.097 ± 0.03	2.603LeuTyr: 2.603 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.252MetAla: 2.252 ± 0.044	0.214MetCys: 0.214 ± 0.011	1.14MetAsp: 1.14 ± 0.032	1.197MetGlu: 1.197 ± 0.036	0.774MetPhe: 0.774 ± 0.025	1.604MetGly: 1.604 ± 0.039	0.497MetHis: 0.497 ± 0.02	1.016MetIle: 1.016 ± 0.029	1.021MetLys: 1.021 ± 0.027	2.371MetLeu: 2.371 ± 0.05	0.496MetMet: 0.496 ± 0.019	0.889MetAsn: 0.889 ± 0.022	1.144MetPro: 1.144 ± 0.031	1.029MetGln: 1.029 ± 0.029	1.202MetArg: 1.202 ± 0.03	1.491MetSer: 1.491 ± 0.034	1.152MetThr: 1.152 ± 0.026	1.486MetVal: 1.486 ± 0.03	0.229MetTrp: 0.229 ± 0.013	0.525MetTyr: 0.525 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	4.353AsnAla: 4.353 ± 0.133	0.481AsnCys: 0.481 ± 0.02	2.363AsnAsp: 2.363 ± 0.071	2.429AsnGlu: 2.429 ± 0.045	1.805AsnPhe: 1.805 ± 0.04	3.681AsnGly: 3.681 ± 0.1	0.951AsnHis: 0.951 ± 0.03	3.07AsnIle: 3.07 ± 0.054	2.382AsnLys: 2.382 ± 0.046	4.231AsnLeu: 4.231 ± 0.076	0.948AsnMet: 0.948 ± 0.024	2.629AsnAsn: 2.629 ± 0.059	2.318AsnPro: 2.318 ± 0.042	1.867AsnGln: 1.867 ± 0.04	1.969AsnArg: 1.969 ± 0.04	3.184AsnSer: 3.184 ± 0.075	3.159AsnThr: 3.159 ± 0.061	3.041AsnVal: 3.041 ± 0.06	0.774AsnTrp: 0.774 ± 0.023	1.65AsnTyr: 1.65 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	4.075ProAla: 4.075 ± 0.061	0.318ProCys: 0.318 ± 0.018	2.257ProAsp: 2.257 ± 0.044	3.206ProGlu: 3.206 ± 0.069	1.646ProPhe: 1.646 ± 0.036	2.457ProGly: 2.457 ± 0.055	0.851ProHis: 0.851 ± 0.028	2.475ProIle: 2.475 ± 0.043	1.882ProLys: 1.882 ± 0.043	3.908ProLeu: 3.908 ± 0.058	0.878ProMet: 0.878 ± 0.027	2.09ProAsn: 2.09 ± 0.057	1.474ProPro: 1.474 ± 0.037	1.72ProGln: 1.72 ± 0.044	1.442ProArg: 1.442 ± 0.034	2.886ProSer: 2.886 ± 0.052	2.369ProThr: 2.369 ± 0.062	3.168ProVal: 3.168 ± 0.058	0.536ProTrp: 0.536 ± 0.021	1.277ProTyr: 1.277 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.466GlnAla: 4.466 ± 0.07	0.385GlnCys: 0.385 ± 0.016	1.723GlnAsp: 1.723 ± 0.034	2.169GlnGlu: 2.169 ± 0.052	1.625GlnPhe: 1.625 ± 0.042	2.518GlnGly: 2.518 ± 0.046	1.021GlnHis: 1.021 ± 0.029	2.191GlnIle: 2.191 ± 0.042	1.929GlnLys: 1.929 ± 0.043	4.561GlnLeu: 4.561 ± 0.067	0.879GlnMet: 0.879 ± 0.029	1.667GlnAsn: 1.667 ± 0.037	1.907GlnPro: 1.907 ± 0.048	2.539GlnGln: 2.539 ± 0.055	2.055GlnArg: 2.055 ± 0.046	2.593GlnSer: 2.593 ± 0.037	2.422GlnThr: 2.422 ± 0.057	2.731GlnVal: 2.731 ± 0.047	0.694GlnTrp: 0.694 ± 0.023	1.273GlnTyr: 1.273 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.926ArgAla: 3.926 ± 0.064	0.445ArgCys: 0.445 ± 0.019	2.445ArgAsp: 2.445 ± 0.042	2.928ArgGlu: 2.928 ± 0.053	2.108ArgPhe: 2.108 ± 0.037	2.737ArgGly: 2.737 ± 0.049	0.926ArgHis: 0.926 ± 0.029	2.96ArgIle: 2.96 ± 0.052	2.294ArgLys: 2.294 ± 0.048	4.59ArgLeu: 4.59 ± 0.064	1.082ArgMet: 1.082 ± 0.027	1.935ArgAsn: 1.935 ± 0.037	1.593ArgPro: 1.593 ± 0.035	1.757ArgGln: 1.757 ± 0.042	2.146ArgArg: 2.146 ± 0.051	2.568ArgSer: 2.568 ± 0.049	2.24ArgThr: 2.24 ± 0.043	3.352ArgVal: 3.352 ± 0.054	0.736ArgTrp: 0.736 ± 0.023	1.714ArgTyr: 1.714 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.304SerAla: 6.304 ± 0.077	0.633SerCys: 0.633 ± 0.026	3.871SerAsp: 3.871 ± 0.116	4.077SerGlu: 4.077 ± 0.092	2.843SerPhe: 2.843 ± 0.058	5.555SerGly: 5.555 ± 0.155	1.419SerHis: 1.419 ± 0.036	4.009SerIle: 4.009 ± 0.058	3.018SerLys: 3.018 ± 0.049	6.682SerLeu: 6.682 ± 0.087	1.366SerMet: 1.366 ± 0.034	3.27SerAsn: 3.27 ± 0.081	2.654SerPro: 2.654 ± 0.044	2.599SerGln: 2.599 ± 0.045	2.819SerArg: 2.819 ± 0.053	6.108SerSer: 6.108 ± 0.278	3.708SerThr: 3.708 ± 0.074	4.868SerVal: 4.868 ± 0.086	0.917SerTrp: 0.917 ± 0.032	2.249SerTyr: 2.249 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	5.38ThrAla: 5.38 ± 0.103	0.509ThrCys: 0.509 ± 0.02	3.121ThrAsp: 3.121 ± 0.077	3.05ThrGlu: 3.05 ± 0.057	2.301ThrPhe: 2.301 ± 0.06	4.469ThrGly: 4.469 ± 0.075	1.308ThrHis: 1.308 ± 0.032	3.476ThrIle: 3.476 ± 0.104	2.249ThrLys: 2.249 ± 0.043	6.422ThrLeu: 6.422 ± 0.095	0.989ThrMet: 0.989 ± 0.028	2.528ThrAsn: 2.528 ± 0.06	3.044ThrPro: 3.044 ± 0.068	2.428ThrGln: 2.428 ± 0.049	2.344ThrArg: 2.344 ± 0.044	3.763ThrSer: 3.763 ± 0.083	3.296ThrThr: 3.296 ± 0.059	4.192ThrVal: 4.192 ± 0.109	0.681ThrTrp: 0.681 ± 0.022	1.847ThrTyr: 1.847 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	6.879ValAla: 6.879 ± 0.072	0.769ValCys: 0.769 ± 0.03	4.395ValAsp: 4.395 ± 0.062	4.591ValGlu: 4.591 ± 0.074	2.93ValPhe: 2.93 ± 0.052	4.859ValGly: 4.859 ± 0.071	1.301ValHis: 1.301 ± 0.029	4.303ValIle: 4.303 ± 0.06	3.441ValLys: 3.441 ± 0.067	6.629ValLeu: 6.629 ± 0.087	1.626ValMet: 1.626 ± 0.038	3.449ValAsn: 3.449 ± 0.065	2.649ValPro: 2.649 ± 0.056	2.36ValGln: 2.36 ± 0.043	3.146ValArg: 3.146 ± 0.06	5.015ValSer: 5.015 ± 0.127	4.225ValThr: 4.225 ± 0.102	5.552ValVal: 5.552 ± 0.083	0.823ValTrp: 0.823 ± 0.025	2.105ValTyr: 2.105 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.038TrpAla: 1.038 ± 0.029	0.166TrpCys: 0.166 ± 0.011	0.693TrpAsp: 0.693 ± 0.022	0.654TrpGlu: 0.654 ± 0.024	0.607TrpPhe: 0.607 ± 0.02	0.96TrpGly: 0.96 ± 0.03	0.354TrpHis: 0.354 ± 0.018	0.595TrpIle: 0.595 ± 0.023	0.464TrpLys: 0.464 ± 0.018	1.773TrpLeu: 1.773 ± 0.04	0.333TrpMet: 0.333 ± 0.016	0.6TrpAsn: 0.6 ± 0.024	0.534TrpPro: 0.534 ± 0.018	1.025TrpGln: 1.025 ± 0.032	0.724TrpArg: 0.724 ± 0.026	0.825TrpSer: 0.825 ± 0.027	0.562TrpThr: 0.562 ± 0.023	1.034TrpVal: 1.034 ± 0.026	0.23TrpTrp: 0.23 ± 0.015	0.405TrpTyr: 0.405 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.573TyrAla: 2.573 ± 0.045	0.407TyrCys: 0.407 ± 0.017	1.749TyrAsp: 1.749 ± 0.058	1.7TyrGlu: 1.7 ± 0.037	1.483TyrPhe: 1.483 ± 0.034	2.23TyrGly: 2.23 ± 0.045	0.668TyrHis: 0.668 ± 0.019	1.753TyrIle: 1.753 ± 0.044	1.45TyrLys: 1.45 ± 0.037	3.197TyrLeu: 3.197 ± 0.052	0.628TyrMet: 0.628 ± 0.021	1.488TyrAsn: 1.488 ± 0.056	1.277TyrPro: 1.277 ± 0.029	1.495TyrGln: 1.495 ± 0.038	1.754TyrArg: 1.754 ± 0.04	2.513TyrSer: 2.513 ± 0.092	1.948TyrThr: 1.948 ± 0.042	2.043TyrVal: 2.043 ± 0.043	0.525TyrTrp: 0.525 ± 0.022	1.167TyrTyr: 1.167 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3999 proteins (1456122 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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