Amino acid dipepetide frequency for Atopobium vaginae DSM 15829

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.65AlaAla: 8.65 ± 0.214
2.185AlaCys: 2.185 ± 0.086
5.035AlaAsp: 5.035 ± 0.121
4.113AlaGlu: 4.113 ± 0.11
3.434AlaPhe: 3.434 ± 0.098
5.798AlaGly: 5.798 ± 0.131
3.224AlaHis: 3.224 ± 0.092
4.897AlaIle: 4.897 ± 0.128
4.458AlaLys: 4.458 ± 0.142
10.156AlaLeu: 10.156 ± 0.234
2.297AlaMet: 2.297 ± 0.077
2.888AlaAsn: 2.888 ± 0.079
3.207AlaPro: 3.207 ± 0.104
5.69AlaGln: 5.69 ± 0.129
5.173AlaArg: 5.173 ± 0.143
5.793AlaSer: 5.793 ± 0.126
4.906AlaThr: 4.906 ± 0.116
5.564AlaVal: 5.564 ± 0.134
0.915AlaTrp: 0.915 ± 0.051
3.296AlaTyr: 3.296 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
2.292CysAla: 2.292 ± 0.094
0.291CysCys: 0.291 ± 0.026
1.346CysAsp: 1.346 ± 0.071
1.082CysGlu: 1.082 ± 0.051
0.581CysPhe: 0.581 ± 0.038
1.423CysGly: 1.423 ± 0.067
0.3CysHis: 0.3 ± 0.025
1.313CysIle: 1.313 ± 0.06
0.789CysLys: 0.789 ± 0.045
1.349CysLeu: 1.349 ± 0.062
0.489CysMet: 0.489 ± 0.036
0.57CysAsn: 0.57 ± 0.036
0.703CysPro: 0.703 ± 0.047
0.431CysGln: 0.431 ± 0.036
0.581CysArg: 0.581 ± 0.041
1.113CysSer: 1.113 ± 0.057
1.018CysThr: 1.018 ± 0.055
1.773CysVal: 1.773 ± 0.077
0.129CysTrp: 0.129 ± 0.017
0.417CysTyr: 0.417 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
5.702AspAla: 5.702 ± 0.138
0.801AspCys: 0.801 ± 0.048
3.551AspAsp: 3.551 ± 0.119
4.699AspGlu: 4.699 ± 0.112
2.497AspPhe: 2.497 ± 0.074
3.708AspGly: 3.708 ± 0.139
1.22AspHis: 1.22 ± 0.059
4.201AspIle: 4.201 ± 0.11
3.665AspLys: 3.665 ± 0.132
4.949AspLeu: 4.949 ± 0.128
1.601AspMet: 1.601 ± 0.061
2.4AspAsn: 2.4 ± 0.094
2.462AspPro: 2.462 ± 0.089
1.561AspGln: 1.561 ± 0.067
2.173AspArg: 2.173 ± 0.08
3.56AspSer: 3.56 ± 0.101
3.86AspThr: 3.86 ± 0.1
4.799AspVal: 4.799 ± 0.109
0.593AspTrp: 0.593 ± 0.04
1.842AspTyr: 1.842 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
4.973GluAla: 4.973 ± 0.131
0.67GluCys: 0.67 ± 0.041
3.103GluAsp: 3.103 ± 0.093
3.36GluGlu: 3.36 ± 0.122
2.195GluPhe: 2.195 ± 0.079
3.107GluGly: 3.107 ± 0.102
2.047GluHis: 2.047 ± 0.065
3.522GluIle: 3.522 ± 0.101
3.503GluLys: 3.503 ± 0.112
6.177GluLeu: 6.177 ± 0.143
1.365GluMet: 1.365 ± 0.056
2.304GluAsn: 2.304 ± 0.075
1.806GluPro: 1.806 ± 0.072
2.986GluGln: 2.986 ± 0.097
3.007GluArg: 3.007 ± 0.092
2.857GluSer: 2.857 ± 0.094
2.695GluThr: 2.695 ± 0.081
3.796GluVal: 3.796 ± 0.103
0.388GluTrp: 0.388 ± 0.031
1.632GluTyr: 1.632 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.479PheAla: 3.479 ± 0.096
0.753PheCys: 0.753 ± 0.045
2.838PheAsp: 2.838 ± 0.077
2.331PheGlu: 2.331 ± 0.077
1.604PhePhe: 1.604 ± 0.079
2.96PheGly: 2.96 ± 0.094
0.689PheHis: 0.689 ± 0.042
2.721PheIle: 2.721 ± 0.089
2.004PheLys: 2.004 ± 0.077
3.188PheLeu: 3.188 ± 0.104
1.106PheMet: 1.106 ± 0.05
1.518PheAsn: 1.518 ± 0.071
1.213PhePro: 1.213 ± 0.053
0.996PheGln: 0.996 ± 0.044
1.296PheArg: 1.296 ± 0.056
3.098PheSer: 3.098 ± 0.101
2.428PheThr: 2.428 ± 0.088
3.315PheVal: 3.315 ± 0.098
0.374PheTrp: 0.374 ± 0.03
1.301PheTyr: 1.301 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
5.676GlyAla: 5.676 ± 0.122
1.206GlyCys: 1.206 ± 0.057
3.527GlyAsp: 3.527 ± 0.113
3.172GlyGlu: 3.172 ± 0.085
3.0GlyPhe: 3.0 ± 0.09
4.146GlyGly: 4.146 ± 0.113
1.415GlyHis: 1.415 ± 0.061
5.004GlyIle: 5.004 ± 0.128
4.12GlyLys: 4.12 ± 0.114
5.912GlyLeu: 5.912 ± 0.139
1.697GlyMet: 1.697 ± 0.061
2.402GlyAsn: 2.402 ± 0.082
1.489GlyPro: 1.489 ± 0.068
1.923GlyGln: 1.923 ± 0.063
2.686GlyArg: 2.686 ± 0.092
4.366GlySer: 4.366 ± 0.106
4.111GlyThr: 4.111 ± 0.099
5.128GlyVal: 5.128 ± 0.121
0.729GlyTrp: 0.729 ± 0.063
2.571GlyTyr: 2.571 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
2.79HisAla: 2.79 ± 0.093
0.329HisCys: 0.329 ± 0.029
1.668HisAsp: 1.668 ± 0.069
1.735HisGlu: 1.735 ± 0.067
1.018HisPhe: 1.018 ± 0.048
1.742HisGly: 1.742 ± 0.069
0.686HisHis: 0.686 ± 0.039
1.897HisIle: 1.897 ± 0.074
1.58HisLys: 1.58 ± 0.06
2.026HisLeu: 2.026 ± 0.062
0.951HisMet: 0.951 ± 0.049
1.23HisAsn: 1.23 ± 0.055
1.132HisPro: 1.132 ± 0.061
0.839HisGln: 0.839 ± 0.047
1.015HisArg: 1.015 ± 0.052
1.356HisSer: 1.356 ± 0.063
1.875HisThr: 1.875 ± 0.069
2.223HisVal: 2.223 ± 0.079
0.2HisTrp: 0.2 ± 0.02
0.767HisTyr: 0.767 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
6.258IleAla: 6.258 ± 0.15
1.396IleCys: 1.396 ± 0.073
4.013IleAsp: 4.013 ± 0.099
3.481IleGlu: 3.481 ± 0.109
2.266IlePhe: 2.266 ± 0.076
4.144IleGly: 4.144 ± 0.112
1.456IleHis: 1.456 ± 0.064
3.817IleIle: 3.817 ± 0.13
3.384IleLys: 3.384 ± 0.1
5.221IleLeu: 5.221 ± 0.135
1.575IleMet: 1.575 ± 0.072
2.5IleAsn: 2.5 ± 0.088
2.821IlePro: 2.821 ± 0.088
2.157IleGln: 2.157 ± 0.068
2.695IleArg: 2.695 ± 0.095
4.885IleSer: 4.885 ± 0.116
3.946IleThr: 3.946 ± 0.111
4.663IleVal: 4.663 ± 0.131
0.534IleTrp: 0.534 ± 0.035
1.904IleTyr: 1.904 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.563LysAla: 4.563 ± 0.152
0.531LysCys: 0.531 ± 0.04
4.156LysAsp: 4.156 ± 0.158
3.446LysGlu: 3.446 ± 0.109
1.532LysPhe: 1.532 ± 0.066
3.369LysGly: 3.369 ± 0.128
1.747LysHis: 1.747 ± 0.067
3.219LysIle: 3.219 ± 0.088
3.856LysLys: 3.856 ± 0.132
5.19LysLeu: 5.19 ± 0.108
1.256LysMet: 1.256 ± 0.06
2.504LysAsn: 2.504 ± 0.096
2.485LysPro: 2.485 ± 0.09
2.707LysGln: 2.707 ± 0.098
3.243LysArg: 3.243 ± 0.103
3.458LysSer: 3.458 ± 0.089
3.929LysThr: 3.929 ± 0.12
3.288LysVal: 3.288 ± 0.123
0.393LysTrp: 0.393 ± 0.036
1.387LysTyr: 1.387 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
9.005LeuAla: 9.005 ± 0.173
1.964LeuCys: 1.964 ± 0.082
5.867LeuAsp: 5.867 ± 0.118
5.111LeuGlu: 5.111 ± 0.147
3.441LeuPhe: 3.441 ± 0.114
6.384LeuGly: 6.384 ± 0.144
2.476LeuHis: 2.476 ± 0.076
5.843LeuIle: 5.843 ± 0.153
5.102LeuLys: 5.102 ± 0.112
8.395LeuLeu: 8.395 ± 0.196
2.433LeuMet: 2.433 ± 0.084
3.396LeuAsn: 3.396 ± 0.101
3.777LeuPro: 3.777 ± 0.097
3.427LeuGln: 3.427 ± 0.094
4.175LeuArg: 4.175 ± 0.112
7.32LeuSer: 7.32 ± 0.161
5.369LeuThr: 5.369 ± 0.125
6.744LeuVal: 6.744 ± 0.141
0.751LeuTrp: 0.751 ± 0.042
2.795LeuTyr: 2.795 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
2.049MetAla: 2.049 ± 0.068
0.534MetCys: 0.534 ± 0.035
1.315MetAsp: 1.315 ± 0.053
1.18MetGlu: 1.18 ± 0.052
1.006MetPhe: 1.006 ± 0.052
1.742MetGly: 1.742 ± 0.068
0.758MetHis: 0.758 ± 0.043
1.535MetIle: 1.535 ± 0.062
1.466MetLys: 1.466 ± 0.056
2.607MetLeu: 2.607 ± 0.087
0.639MetMet: 0.639 ± 0.048
1.201MetAsn: 1.201 ± 0.047
1.18MetPro: 1.18 ± 0.046
1.22MetGln: 1.22 ± 0.059
1.427MetArg: 1.427 ± 0.068
1.942MetSer: 1.942 ± 0.072
1.11MetThr: 1.11 ± 0.055
1.647MetVal: 1.647 ± 0.074
0.272MetTrp: 0.272 ± 0.026
0.813MetTyr: 0.813 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.617AsnAla: 3.617 ± 0.124
0.496AsnCys: 0.496 ± 0.038
2.261AsnAsp: 2.261 ± 0.097
2.118AsnGlu: 2.118 ± 0.076
1.404AsnPhe: 1.404 ± 0.059
2.385AsnGly: 2.385 ± 0.099
0.987AsnHis: 0.987 ± 0.047
2.478AsnIle: 2.478 ± 0.081
2.335AsnLys: 2.335 ± 0.08
3.601AsnLeu: 3.601 ± 0.092
1.101AsnMet: 1.101 ± 0.047
1.668AsnAsn: 1.668 ± 0.082
2.192AsnPro: 2.192 ± 0.075
1.427AsnGln: 1.427 ± 0.065
1.532AsnArg: 1.532 ± 0.065
2.364AsnSer: 2.364 ± 0.082
2.371AsnThr: 2.371 ± 0.092
2.712AsnVal: 2.712 ± 0.096
0.398AsnTrp: 0.398 ± 0.036
1.268AsnTyr: 1.268 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
3.36ProAla: 3.36 ± 0.108
0.648ProCys: 0.648 ± 0.048
2.338ProAsp: 2.338 ± 0.093
2.242ProGlu: 2.242 ± 0.084
1.687ProPhe: 1.687 ± 0.075
2.071ProGly: 2.071 ± 0.083
1.256ProHis: 1.256 ± 0.05
1.947ProIle: 1.947 ± 0.07
1.89ProLys: 1.89 ± 0.076
3.636ProLeu: 3.636 ± 0.109
0.727ProMet: 0.727 ± 0.044
1.451ProAsn: 1.451 ± 0.066
0.82ProPro: 0.82 ± 0.048
2.269ProGln: 2.269 ± 0.068
1.573ProArg: 1.573 ± 0.067
2.852ProSer: 2.852 ± 0.087
2.431ProThr: 2.431 ± 0.083
2.817ProVal: 2.817 ± 0.096
0.396ProTrp: 0.396 ± 0.03
1.551ProTyr: 1.551 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
4.313GlnAla: 4.313 ± 0.128
0.348GlnCys: 0.348 ± 0.025
2.545GlnAsp: 2.545 ± 0.085
2.516GlnGlu: 2.516 ± 0.081
1.263GlnPhe: 1.263 ± 0.057
2.807GlnGly: 2.807 ± 0.083
1.153GlnHis: 1.153 ± 0.056
2.223GlnIle: 2.223 ± 0.07
2.886GlnLys: 2.886 ± 0.087
3.493GlnLeu: 3.493 ± 0.095
0.948GlnMet: 0.948 ± 0.048
1.902GlnAsn: 1.902 ± 0.068
1.43GlnPro: 1.43 ± 0.071
2.185GlnGln: 2.185 ± 0.116
1.99GlnArg: 1.99 ± 0.081
2.395GlnSer: 2.395 ± 0.089
3.219GlnThr: 3.219 ± 0.097
2.469GlnVal: 2.469 ± 0.078
0.274GlnTrp: 0.274 ± 0.029
0.898GlnTyr: 0.898 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
4.392ArgAla: 4.392 ± 0.124
0.696ArgCys: 0.696 ± 0.043
2.397ArgAsp: 2.397 ± 0.091
2.838ArgGlu: 2.838 ± 0.095
1.871ArgPhe: 1.871 ± 0.062
2.74ArgGly: 2.74 ± 0.086
1.018ArgHis: 1.018 ± 0.053
3.212ArgIle: 3.212 ± 0.105
2.457ArgLys: 2.457 ± 0.083
4.716ArgLeu: 4.716 ± 0.121
1.461ArgMet: 1.461 ± 0.067
1.647ArgAsn: 1.647 ± 0.067
1.563ArgPro: 1.563 ± 0.061
1.549ArgGln: 1.549 ± 0.066
2.514ArgArg: 2.514 ± 0.099
2.7ArgSer: 2.7 ± 0.087
2.364ArgThr: 2.364 ± 0.083
3.813ArgVal: 3.813 ± 0.12
0.417ArgTrp: 0.417 ± 0.033
1.585ArgTyr: 1.585 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
6.117SerAla: 6.117 ± 0.13
1.427SerCys: 1.427 ± 0.058
3.987SerAsp: 3.987 ± 0.126
3.296SerGlu: 3.296 ± 0.088
3.081SerPhe: 3.081 ± 0.1
4.351SerGly: 4.351 ± 0.103
1.914SerHis: 1.914 ± 0.073
4.099SerIle: 4.099 ± 0.103
3.441SerLys: 3.441 ± 0.104
6.124SerLeu: 6.124 ± 0.147
1.663SerMet: 1.663 ± 0.059
2.452SerAsn: 2.452 ± 0.088
2.006SerPro: 2.006 ± 0.074
2.95SerGln: 2.95 ± 0.081
2.855SerArg: 2.855 ± 0.119
5.65SerSer: 5.65 ± 0.143
4.003SerThr: 4.003 ± 0.104
4.928SerVal: 4.928 ± 0.118
0.784SerTrp: 0.784 ± 0.048
2.64SerTyr: 2.64 ± 0.083
0.0SerXaa: 0.0 ± 0.0
Thr
4.363ThrAla: 4.363 ± 0.103
1.249ThrCys: 1.249 ± 0.058
3.081ThrAsp: 3.081 ± 0.11
2.397ThrGlu: 2.397 ± 0.089
2.564ThrPhe: 2.564 ± 0.081
4.049ThrGly: 4.049 ± 0.11
1.966ThrHis: 1.966 ± 0.075
3.846ThrIle: 3.846 ± 0.097
3.234ThrLys: 3.234 ± 0.095
6.162ThrLeu: 6.162 ± 0.124
1.325ThrMet: 1.325 ± 0.061
2.314ThrAsn: 2.314 ± 0.096
3.215ThrPro: 3.215 ± 0.117
2.891ThrGln: 2.891 ± 0.099
2.64ThrArg: 2.64 ± 0.084
4.466ThrSer: 4.466 ± 0.116
3.929ThrThr: 3.929 ± 0.112
3.572ThrVal: 3.572 ± 0.115
0.574ThrTrp: 0.574 ± 0.032
2.252ThrTyr: 2.252 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
6.324ValAla: 6.324 ± 0.121
1.863ValCys: 1.863 ± 0.082
4.439ValAsp: 4.439 ± 0.114
3.953ValGlu: 3.953 ± 0.123
2.981ValPhe: 2.981 ± 0.086
4.556ValGly: 4.556 ± 0.092
1.692ValHis: 1.692 ± 0.069
4.756ValIle: 4.756 ± 0.125
3.484ValLys: 3.484 ± 0.112
7.07ValLeu: 7.07 ± 0.154
1.944ValMet: 1.944 ± 0.069
2.502ValAsn: 2.502 ± 0.088
2.898ValPro: 2.898 ± 0.095
2.45ValGln: 2.45 ± 0.074
3.346ValArg: 3.346 ± 0.119
5.331ValSer: 5.331 ± 0.118
3.827ValThr: 3.827 ± 0.113
5.793ValVal: 5.793 ± 0.139
0.615ValTrp: 0.615 ± 0.03
2.319ValTyr: 2.319 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.612TrpAla: 0.612 ± 0.037
0.174TrpCys: 0.174 ± 0.023
0.543TrpAsp: 0.543 ± 0.041
0.503TrpGlu: 0.503 ± 0.037
0.465TrpPhe: 0.465 ± 0.049
0.677TrpGly: 0.677 ± 0.049
0.279TrpHis: 0.279 ± 0.025
0.581TrpIle: 0.581 ± 0.039
0.57TrpLys: 0.57 ± 0.047
0.872TrpLeu: 0.872 ± 0.058
0.26TrpMet: 0.26 ± 0.025
0.438TrpAsn: 0.438 ± 0.034
0.265TrpPro: 0.265 ± 0.025
0.353TrpGln: 0.353 ± 0.031
0.467TrpArg: 0.467 ± 0.038
0.56TrpSer: 0.56 ± 0.039
0.484TrpThr: 0.484 ± 0.035
0.577TrpVal: 0.577 ± 0.039
0.133TrpTrp: 0.133 ± 0.018
0.357TrpTyr: 0.357 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.143TyrAla: 3.143 ± 0.099
0.429TyrCys: 0.429 ± 0.032
1.835TyrAsp: 1.835 ± 0.082
1.923TyrGlu: 1.923 ± 0.077
1.323TyrPhe: 1.323 ± 0.064
2.121TyrGly: 2.121 ± 0.077
0.777TyrHis: 0.777 ± 0.044
2.004TyrIle: 2.004 ± 0.085
2.04TyrLys: 2.04 ± 0.097
2.929TyrLeu: 2.929 ± 0.088
0.801TyrMet: 0.801 ± 0.042
1.43TyrAsn: 1.43 ± 0.064
1.296TyrPro: 1.296 ± 0.063
1.249TyrGln: 1.249 ± 0.062
1.558TyrArg: 1.558 ± 0.055
1.704TyrSer: 1.704 ± 0.061
2.211TyrThr: 2.211 ± 0.097
2.524TyrVal: 2.524 ± 0.082
0.3TyrTrp: 0.3 ± 0.035
1.001TyrTyr: 1.001 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1243 proteins (419650 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski